stemoninine: an antitussive agent isolated from the roots of Stemona tuberosa; structure in first source [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]
| Flora | Rank | Flora Definition | Family | Family Definition |
|---|---|---|---|---|
| Stemona | genus | A plant genus of the family Stemonaceae. Members contain STILBENES and phenyl BENZOFURANS.[MeSH] | Stemonaceae | A small plant family of the order Liliales, subclass Liliidae, class Liliopsida (monocotyledons).[MeSH] |
| ID Source | ID |
|---|---|
| PubMed CID | 15983991 |
| CHEMBL ID | 482474 |
| SCHEMBL ID | 12920090 |
| MeSH ID | M0558784 |
| Synonym |
|---|
| stemoninine |
| CHEMBL482474 |
| SCHEMBL12920090 |
| (1s,2r,3s,4r,6r,11s)-3-ethyl-3'-methyl-11-[(2s,4s)-4-methyl-5-oxooxolan-2-yl]spiro[5-oxa-10-azatricyclo[8.3.0.02,6]tridecane-4,5'-furan]-2'-one |
| Assay ID | Title | Year | Journal | Article |
|---|---|---|---|---|
| AID405501 | Antitussive activity in guinea pig assessed as inhibition of citric acid-induced coughing at 0.26 mmol/kg, ip administered as single dose after 30 mins | 2008 | Journal of natural products, Jun, Volume: 71, Issue:6 | Antitussive stemoninine alkaloids from the roots of Stemona tuberosa. |
| AID405499 | Antitussive activity in guinea pig assessed as inhibition of citric acid-induced coughing | 2008 | Journal of natural products, Jun, Volume: 71, Issue:6 | Antitussive stemoninine alkaloids from the roots of Stemona tuberosa. |
| AID405503 | Antitussive activity in guinea pig assessed as inhibition of citric acid-induced coughing at 0.26 mmol/kg, po administered as single dose after 30 mins | 2008 | Journal of natural products, Jun, Volume: 71, Issue:6 | Antitussive stemoninine alkaloids from the roots of Stemona tuberosa. |
| AID405504 | Antitussive activity in guinea pig assessed as inhibition of citric acid-induced coughing at 0.25 umol, intracerebroventricularly administered as single dose after 3 mins relative to control | 2008 | Journal of natural products, Jun, Volume: 71, Issue:6 | Antitussive stemoninine alkaloids from the roots of Stemona tuberosa. |
| [information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||||
| Timeframe | Studies, This Drug (%) | All Drugs % |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 1 (20.00) | 29.6817 |
| 2010's | 3 (60.00) | 24.3611 |
| 2020's | 1 (20.00) | 2.80 |
| [information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||
According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be weak demand-to-supply ratio for research on this compound.
| This Compound (13.28) All Compounds (24.57) |
| Publication Type | This drug (%) | All Drugs (%) |
|---|---|---|
| Trials | 0 (0.00%) | 5.53% |
| Reviews | 0 (0.00%) | 6.00% |
| Case Studies | 0 (0.00%) | 4.05% |
| Observational | 0 (0.00%) | 0.25% |
| Other | 5 (100.00%) | 84.16% |
| [information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||