Page last updated: 2024-11-12

britannin

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

Description

britannin: from Inula aucheriana; structure in first source [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

Flora	Rank	Flora Definition	Family	Family Definition
Inula	genus	A plant genus of the family ASTERACEAE. Members contain INULIN, alantol, helenin, alantic acid, and acrid resin.[MeSH]	Asteraceae	A large plant family of the order Asterales, subclass Asteridae, class Magnoliopsida. The family is also known as Compositae. Flower petals are joined near the base and stamens alternate with the corolla lobes. The common name of daisy refers to several genera of this family including Aster; CHRYSANTHEMUM; RUDBECKIA; TANACETUM.[MeSH]

Cross-References

ID Source	ID
PubMed CID	14466541
CHEMBL ID	1165708
SCHEMBL ID	16677163
MeSH ID	M0577837

Synonyms (10)

Synonym
CHEMBL1165708
AC-31292
britannin
SCHEMBL16677163
[(3as,5r,5as,6s,8s,8as,9s,9ar)-9-acetyloxy-8-hydroxy-5,8a-dimethyl-1-methylidene-2-oxo-4,5,5a,6,7,8,9,9a-octahydro-3ah-azuleno[6,5-b]furan-6-yl] acetate
AKOS037514495
CS-0022906
HY-N3005
MS-25860
EX-A6710

Research Excerpts

Overview

Britannin is a natural sesquiterpene lactone. Its profound anticancer properties were revealed in our previous study.

Excerpt	Reference	Relevance
"Britannin is a natural sesquiterpene lactone that its profound anticancer properties were revealed in our previous study."	( Anticancer activity of britannin through the downregulation of cyclin D1 and CDK4 in human breast cancer cells. Abdolmoham Madi, MH; Aghaei, M; Fallahian, F; Hamzeloo-Moghadam, M, )	1.16
"Britannin is a natural product with anticancer pharmacological effects."	( Britannin stabilizes T cell activity and inhibits proliferation and angiogenesis by targeting PD-L1 via abrogation of the crosstalk between Myc and HIF-1α in cancer. Jin, CH; Jin, HL; Jin, X; Li, MY; Ma, J; Piao, LX; Ri, M; Wang, JY; Xing, Y; Xu, GH; Zhang, YF; Zhang, ZH; Zuo, HX, 2021)	2.79

Actions

Excerpt	Reference	Relevance
"Britannin could inhibit cell growth and G2/M arrest in TNBC cells. "	( Study on inhibition of Britannin on triple-negative breast carcinoma through degrading ZEB1 proteins. Hong, M; Lu, H; Wang, Y; Wu, Z; Zhang, B; Zhao, D, 2022)	2.47

[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Bioassays (2)

Assay ID	Title	Year	Journal	Article
AID487369	Cytotoxicity against mouse RAW264.7 cells at concentration required inhibit NO synthesis by MTT assay	2010	Journal of natural products, Jun-25, Volume: 73, Issue:6	Sesquiterpenoids from Inula lineariifolia inhibit nitric oxide production.
AID487368	Inhibition of LPS-induced NO production in mouse RAW264.7 cells measured after 24 hrs	2010	Journal of natural products, Jun-25, Volume: 73, Issue:6	Sesquiterpenoids from Inula lineariifolia inhibit nitric oxide production.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (17)

Timeframe	Studies, This Drug (%)	All Drugs %
pre-1990	0 (0.00)	18.7374
1990's	0 (0.00)	18.2507
2000's	0 (0.00)	29.6817
2010's	9 (52.94)	24.3611
2020's	8 (47.06)	2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 23.46

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be moderate demand-to-supply ratio for research on this compound.

Metric	This Compound (vs All)
Research Demand Index	23.46 (24.57)
Research Supply Index	2.94 (2.92)
Research Growth Index	5.82 (4.65)
Search Engine Demand Index	21.17 (26.88)
Search Engine Supply Index	2.00 (0.95)

This Compound (23.46)

All Compounds (24.57)

Study Types

Publication Type	This drug (%)	All Drugs (%)
Trials	0 (0.00%)	5.53%
Reviews	0 (0.00%)	6.00%
Case Studies	0 (0.00%)	4.05%
Observational	0 (0.00%)	0.25%
Other	18 (100.00%)	84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Substance	Relationship Strength	Studies	Classes	Roles
pimagedine pimagedine: diamine oxidase & nitric oxide synthase inhibitor; an advanced glycosylation end product inhibitor; used in the treatment of diabetic complications; structure. aminoguanidine : A one-carbon compound whose unique structure renders it capable of acting as a derivative of hydrazine, guanidine or formamide.	2.05	1	guanidines; one-carbon compound	EC 1.14.13.39 (nitric oxide synthase) inhibitor; EC 1.4.3.4 (monoamine oxidase) inhibitor
acetylcysteine N-acetyl-L-cysteine : An N-acetyl-L-amino acid that is the N-acetylated derivative of the natural amino acid L-cysteine.	2.31	1	acetylcysteine; L-cysteine derivative; N-acetyl-L-amino acid	antidote to paracetamol poisoning; antiinfective agent; antioxidant; antiviral drug; ferroptosis inhibitor; geroprotector; human metabolite; mucolytic; radical scavenger; vulnerary
tetradecanoylphorbol acetate Tetradecanoylphorbol Acetate: A phorbol ester found in CROTON OIL with very effective tumor promoting activity. It stimulates the synthesis of both DNA and RNA.. phorbol ester : Esters of phorbol, originally found in croton oil (from Croton tiglium, of the family Euphorbiaceae). A number of phorbol esters possess activity as tumour promoters and activate the mechanisms associated with cell growth. Some of these are used in experiments as activators of protein kinase C.. phorbol 13-acetate 12-myristate : A phorbol ester that is phorbol in which the hydroxy groups at the cyclopropane ring juction (position 13) and the adjacent carbon (position 12) have been converted into the corresponding acetate and myristate esters. It is a major active constituent of the seed oil of Croton tiglium. It has been used as a tumour promoting agent for skin carcinogenesis in rodents and is associated with increased cell proliferation of malignant cells. However its function is controversial since a decrease in cell proliferation has also been observed in several cancer cell types.	2.1	1	acetate ester; diester; phorbol ester; tertiary alpha-hydroxy ketone; tetradecanoate ester	antineoplastic agent; apoptosis inducer; carcinogenic agent; mitogen; plant metabolite; protein kinase C agonist; reactive oxygen species generator
phorbolol myristate acetate [no description available]	2.1	1
tomentosin tomentosin: isolated from fresh Inula viscosa (Asteraceae) flowers; structure in first source	2.05	1	sesquiterpene lactone
gaillardin gaillardin: isolated from the aerial parts of Inula oculus-christi; structure in first source	2.05	1	sesquiterpene lactone
sesquiterpenes [no description available]	4.32	16
ovalbumin Ovalbumin: An albumin obtained from the white of eggs. It is a member of the serpin superfamily.	2.13	1
dinoprostone prostaglandin E2 : Prostaglandin F2alpha in which the hydroxy group at position 9 has been oxidised to the corresponding ketone. Prostaglandin E2 is the most common and most biologically potent of mammalian prostaglandins.	2.08	1	prostaglandins E	human metabolite; mouse metabolite; oxytocic
calcimycin Calcimycin: An ionophorous, polyether antibiotic from Streptomyces chartreusensis. It binds and transports CALCIUM and other divalent cations across membranes and uncouples oxidative phosphorylation while inhibiting ATPase of rat liver mitochondria. The substance is used mostly as a biochemical tool to study the role of divalent cations in various biological systems.	2.1	1	benzoxazole

Condition	Relationship Strength	Studies
Acute Lymphoid Leukemia [description not available]	2.76	2
Precursor Cell Lymphoblastic Leukemia-Lymphoma A neoplasm characterized by abnormalities of the lymphoid cell precursors leading to excessive lymphoblasts in the marrow and other organs. It is the most common cancer in children and accounts for the vast majority of all childhood leukemias.	2.76	2
ER-Negative PR-Negative HER2-Negative Breast Cancer [description not available]	2.41	1
Cancer of Lung [description not available]	2.41	1
Lung Neoplasms Tumors or cancer of the LUNG.	2.41	1
Triple Negative Breast Neoplasms Breast neoplasms that do not express ESTROGEN RECEPTORS; PROGESTERONE RECEPTORS; and do not overexpress the NEU RECEPTOR/HER-2 PROTO-ONCOGENE PROTEIN.	2.41	1
Cancer of Stomach [description not available]	2.76	2
Stomach Neoplasms Tumors or cancer of the STOMACH.	2.76	2
Hepatocellular Carcinoma [description not available]	2.25	1
Cancer of Liver [description not available]	2.61	2
Experimental Hepatoma [description not available]	2.25	1
Carcinoma, Hepatocellular A primary malignant neoplasm of epithelial liver cells. It ranges from a well-differentiated tumor with EPITHELIAL CELLS indistinguishable from normal HEPATOCYTES to a poorly differentiated neoplasm. The cells may be uniform or markedly pleomorphic, or form GIANT CELLS. Several classification schemes have been suggested.	2.25	1
Liver Neoplasms Tumors or cancer of the LIVER.	2.61	2
Cancer of Pancreas [description not available]	2.59	2
Pancreatic Neoplasms Tumors or cancer of the PANCREAS. Depending on the types of ISLET CELLS present in the tumors, various hormones can be secreted: GLUCAGON from PANCREATIC ALPHA CELLS; INSULIN from PANCREATIC BETA CELLS; and SOMATOSTATIN from the SOMATOSTATIN-SECRETING CELLS. Most are malignant except the insulin-producing tumors (INSULINOMA).	2.59	2
Angiogenesis, Pathologic [description not available]	2.31	1
Atopic Hypersensitivity [description not available]	2.1	1
Innate Inflammatory Response [description not available]	2.52	2
Inflammation A pathological process characterized by injury or destruction of tissues caused by a variety of cytologic and chemical reactions. It is usually manifested by typical signs of pain, heat, redness, swelling, and loss of function.	2.52	2
Breast Cancer [description not available]	7.11	1
Breast Neoplasms Tumors or cancer of the human BREAST.	2.11	1
Asthma, Bronchial [description not available]	2.13	1
Disease Models, Animal Naturally-occurring or experimentally-induced animal diseases with pathological processes analogous to human diseases.	2.13	1
Asthma A form of bronchial disorder with three distinct components: airway hyper-responsiveness (RESPIRATORY HYPERSENSITIVITY), airway INFLAMMATION, and intermittent AIRWAY OBSTRUCTION. It is characterized by spasmodic contraction of airway smooth muscle, WHEEZING, and dyspnea (DYSPNEA, PAROXYSMAL).	2.13	1
Cerebral Ischemia [description not available]	2.15	1
Injury, Ischemia-Reperfusion [description not available]	2.15	1
Brain Ischemia Localized reduction of blood flow to brain tissue due to arterial obstruction or systemic hypoperfusion. This frequently occurs in conjunction with brain hypoxia (HYPOXIA, BRAIN). Prolonged ischemia is associated with BRAIN INFARCTION.	2.15	1
Reperfusion Injury Adverse functional, metabolic, or structural changes in tissues that result from the restoration of blood flow to the tissue (REPERFUSION) following ISCHEMIA.	2.15	1

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