Compounds > britannin
Page last updated: 2024-11-12

britannin

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

Description

britannin: from Inula aucheriana; structure in first source [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

FloraRankFlora DefinitionFamilyFamily Definition
InulagenusA plant genus of the family ASTERACEAE. Members contain INULIN, alantol, helenin, alantic acid, and acrid resin.[MeSH]AsteraceaeA large plant family of the order Asterales, subclass Asteridae, class Magnoliopsida. The family is also known as Compositae. Flower petals are joined near the base and stamens alternate with the corolla lobes. The common name of daisy refers to several genera of this family including Aster; CHRYSANTHEMUM; RUDBECKIA; TANACETUM.[MeSH]

Cross-References

ID SourceID
PubMed CID14466541
CHEMBL ID1165708
SCHEMBL ID16677163
MeSH IDM0577837

Synonyms (10)

Synonym
CHEMBL1165708
AC-31292
britannin
SCHEMBL16677163
[(3as,5r,5as,6s,8s,8as,9s,9ar)-9-acetyloxy-8-hydroxy-5,8a-dimethyl-1-methylidene-2-oxo-4,5,5a,6,7,8,9,9a-octahydro-3ah-azuleno[6,5-b]furan-6-yl] acetate
AKOS037514495
CS-0022906
HY-N3005
MS-25860
EX-A6710

Research Excerpts

Overview

Britannin is a natural sesquiterpene lactone. Its profound anticancer properties were revealed in our previous study.

ExcerptReferenceRelevance
"Britannin is a natural sesquiterpene lactone that its profound anticancer properties were revealed in our previous study."( Anticancer activity of britannin through the downregulation of cyclin D1 and CDK4 in human breast cancer cells.
Abdolmoham Madi, MH; Aghaei, M; Fallahian, F; Hamzeloo-Moghadam, M, )		1.16
"Britannin is a natural product with anticancer pharmacological effects."( Britannin stabilizes T cell activity and inhibits proliferation and angiogenesis by targeting PD-L1 via abrogation of the crosstalk between Myc and HIF-1α in cancer.
Jin, CH; Jin, HL; Jin, X; Li, MY; Ma, J; Piao, LX; Ri, M; Wang, JY; Xing, Y; Xu, GH; Zhang, YF; Zhang, ZH; Zuo, HX, 2021)		2.79

Actions

ExcerptReferenceRelevance
"Britannin could inhibit cell growth and G2/M arrest in TNBC cells. "( Study on inhibition of Britannin on triple-negative breast carcinoma through degrading ZEB1 proteins.
Hong, M; Lu, H; Wang, Y; Wu, Z; Zhang, B; Zhao, D, 2022)		2.47
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Bioassays (2)

Assay IDTitleYearJournalArticle
AID487369Cytotoxicity against mouse RAW264.7 cells at concentration required inhibit NO synthesis by MTT assay2010Journal of natural products, Jun-25, Volume: 73, Issue:6
Sesquiterpenoids from Inula lineariifolia inhibit nitric oxide production.
AID487368Inhibition of LPS-induced NO production in mouse RAW264.7 cells measured after 24 hrs2010Journal of natural products, Jun-25, Volume: 73, Issue:6
Sesquiterpenoids from Inula lineariifolia inhibit nitric oxide production.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (17)

TimeframeStudies, This Drug (%)All Drugs %
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's0 (0.00)29.6817
2010's9 (52.94)24.3611
2020's8 (47.06)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 23.46

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be moderate demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index23.46 (24.57)
Research Supply Index2.94 (2.92)
Research Growth Index5.82 (4.65)
Search Engine Demand Index21.17 (26.88)
Search Engine Supply Index2.00 (0.95)

This Compound (23.46)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews0 (0.00%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other18 (100.00%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]
SubstanceRelationship StrengthStudiesTrialsClassesRoles
pimagedine
pimagedine: diamine oxidase & nitric oxide synthase inhibitor; an advanced glycosylation end product inhibitor; used in the treatment of diabetic complications; structure. aminoguanidine : A one-carbon compound whose unique structure renders it capable of acting as a derivative of hydrazine, guanidine or formamide.		2.0510guanidines;
one-carbon compound		EC 1.14.13.39 (nitric oxide synthase) inhibitor;
EC 1.4.3.4 (monoamine oxidase) inhibitor
acetylcysteine
N-acetyl-L-cysteine : An N-acetyl-L-amino acid that is the N-acetylated derivative of the natural amino acid L-cysteine.		2.3110acetylcysteine;
L-cysteine derivative;
N-acetyl-L-amino acid		antidote to paracetamol poisoning;
antiinfective agent;
antioxidant;
antiviral drug;
ferroptosis inhibitor;
geroprotector;
human metabolite;
mucolytic;
radical scavenger;
vulnerary
tetradecanoylphorbol acetate
Tetradecanoylphorbol Acetate: A phorbol ester found in CROTON OIL with very effective tumor promoting activity. It stimulates the synthesis of both DNA and RNA.. phorbol ester : Esters of phorbol, originally found in croton oil (from Croton tiglium, of the family Euphorbiaceae). A number of phorbol esters possess activity as tumour promoters and activate the mechanisms associated with cell growth. Some of these are used in experiments as activators of protein kinase C.. phorbol 13-acetate 12-myristate : A phorbol ester that is phorbol in which the hydroxy groups at the cyclopropane ring juction (position 13) and the adjacent carbon (position 12) have been converted into the corresponding acetate and myristate esters. It is a major active constituent of the seed oil of Croton tiglium. It has been used as a tumour promoting agent for skin carcinogenesis in rodents and is associated with increased cell proliferation of malignant cells. However its function is controversial since a decrease in cell proliferation has also been observed in several cancer cell types.		2.110acetate ester;
diester;
phorbol ester;
tertiary alpha-hydroxy ketone;
tetradecanoate ester		antineoplastic agent;
apoptosis inducer;
carcinogenic agent;
mitogen;
plant metabolite;
protein kinase C agonist;
reactive oxygen species generator
phorbolol myristate acetate
[no description available]		2.110
tomentosin
tomentosin: isolated from fresh Inula viscosa (Asteraceae) flowers; structure in first source		2.0510sesquiterpene lactone
gaillardin
gaillardin: isolated from the aerial parts of Inula oculus-christi; structure in first source		2.0510sesquiterpene lactone
sesquiterpenes
[no description available]		4.32160
ovalbumin
Ovalbumin: An albumin obtained from the white of eggs. It is a member of the serpin superfamily.		2.1310
dinoprostone
prostaglandin E2 : Prostaglandin F2alpha in which the hydroxy group at position 9 has been oxidised to the corresponding ketone. Prostaglandin E2 is the most common and most biologically potent of mammalian prostaglandins.		2.0810prostaglandins Ehuman metabolite;
mouse metabolite;
oxytocic
calcimycin
Calcimycin: An ionophorous, polyether antibiotic from Streptomyces chartreusensis. It binds and transports CALCIUM and other divalent cations across membranes and uncouples oxidative phosphorylation while inhibiting ATPase of rat liver mitochondria. The substance is used mostly as a biochemical tool to study the role of divalent cations in various biological systems.		2.110benzoxazole
ConditionIndicatedRelationship StrengthStudiesTrials
Acute Lymphoid Leukemia
[description not available]		02.7620
Precursor Cell Lymphoblastic Leukemia-Lymphoma
A neoplasm characterized by abnormalities of the lymphoid cell precursors leading to excessive lymphoblasts in the marrow and other organs. It is the most common cancer in children and accounts for the vast majority of all childhood leukemias.		02.7620
ER-Negative PR-Negative HER2-Negative Breast Cancer
[description not available]		02.4110
Cancer of Lung
[description not available]		02.4110
Lung Neoplasms
Tumors or cancer of the LUNG.		02.4110
Triple Negative Breast Neoplasms
Breast neoplasms that do not express ESTROGEN RECEPTORS; PROGESTERONE RECEPTORS; and do not overexpress the NEU RECEPTOR/HER-2 PROTO-ONCOGENE PROTEIN.		02.4110
Cancer of Stomach
[description not available]		02.7620
Stomach Neoplasms
Tumors or cancer of the STOMACH.		02.7620
Hepatocellular Carcinoma
[description not available]		02.2510
Cancer of Liver
[description not available]		02.6120
Experimental Hepatoma
[description not available]		02.2510
Carcinoma, Hepatocellular
A primary malignant neoplasm of epithelial liver cells. It ranges from a well-differentiated tumor with EPITHELIAL CELLS indistinguishable from normal HEPATOCYTES to a poorly differentiated neoplasm. The cells may be uniform or markedly pleomorphic, or form GIANT CELLS. Several classification schemes have been suggested.		02.2510
Liver Neoplasms
Tumors or cancer of the LIVER.		02.6120
Cancer of Pancreas
[description not available]		02.5920
Pancreatic Neoplasms
Tumors or cancer of the PANCREAS. Depending on the types of ISLET CELLS present in the tumors, various hormones can be secreted: GLUCAGON from PANCREATIC ALPHA CELLS; INSULIN from PANCREATIC BETA CELLS; and SOMATOSTATIN from the SOMATOSTATIN-SECRETING CELLS. Most are malignant except the insulin-producing tumors (INSULINOMA).		02.5920
Angiogenesis, Pathologic
[description not available]		02.3110
Atopic Hypersensitivity
[description not available]		02.110
Innate Inflammatory Response
[description not available]		02.5220
Inflammation
A pathological process characterized by injury or destruction of tissues caused by a variety of cytologic and chemical reactions. It is usually manifested by typical signs of pain, heat, redness, swelling, and loss of function.		02.5220
Breast Cancer
[description not available]		07.1110
Breast Neoplasms
Tumors or cancer of the human BREAST.		02.1110
Asthma, Bronchial
[description not available]		02.1310
Disease Models, Animal
Naturally-occurring or experimentally-induced animal diseases with pathological processes analogous to human diseases.		02.1310
Asthma
A form of bronchial disorder with three distinct components: airway hyper-responsiveness (RESPIRATORY HYPERSENSITIVITY), airway INFLAMMATION, and intermittent AIRWAY OBSTRUCTION. It is characterized by spasmodic contraction of airway smooth muscle, WHEEZING, and dyspnea (DYSPNEA, PAROXYSMAL).		02.1310
Cerebral Ischemia
[description not available]		02.1510
Injury, Ischemia-Reperfusion
[description not available]		02.1510
Brain Ischemia
Localized reduction of blood flow to brain tissue due to arterial obstruction or systemic hypoperfusion. This frequently occurs in conjunction with brain hypoxia (HYPOXIA, BRAIN). Prolonged ischemia is associated with BRAIN INFARCTION.		02.1510
Reperfusion Injury
Adverse functional, metabolic, or structural changes in tissues that result from the restoration of blood flow to the tissue (REPERFUSION) following ISCHEMIA.		02.1510