Compounds > selenazofurin
Page last updated: 2024-12-07

selenazofurin

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Description

Selenazofurin is a synthetic nucleoside analog that has shown promising antitumor activity in preclinical studies. It is a structural analog of the natural nucleoside inosine, and it inhibits the synthesis of purine nucleotides, which are essential for cell growth and proliferation. Selenazofurin has been shown to have activity against a variety of human cancers, including leukemia, lymphoma, and solid tumors. The mechanism of action of selenazofurin is thought to involve the inhibition of inosine monophosphate dehydrogenase (IMPDH), an enzyme that is essential for the synthesis of guanine nucleotides. IMPDH is overexpressed in many cancer cells, and the inhibition of this enzyme by selenazofurin can lead to the depletion of guanine nucleotides and the inhibition of cell growth. Selenazofurin is currently being studied in clinical trials as a potential treatment for cancer. The compound is well-tolerated by patients, and it has shown promising antitumor activity in early clinical studies. However, further research is needed to determine the optimal dose and schedule of selenazofurin for the treatment of cancer. The study of selenazofurin is important because it has the potential to be a new and effective treatment for cancer.'

selenazofurin: selenazole analog of tiazofurin [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

Cross-References

ID SourceID
PubMed CID100665
CHEMBL ID3144001
SCHEMBL ID3051767
MeSH IDM0117190

Synonyms (25)

Synonym
brn 4198668
2-beta-d-ribofuranosyl-4-selenazolecarboxamide
4-selenazolecarboxamide, 2-beta-d-ribofuranosyl-
nsc 340847
selenazofurin
2-(3,4-dihydroxy-5-hydroxymethyl-tetrahydro-furan-2-yl)-selenazole-4-carboxylic acid amide
2-[(2r,3r,4s,5r)-3,4-dihydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl]-1,3-selenazole-4-carboxamide
pd-111232
ci-935
nsc340847
nsc-340847
4-selenazolecarboxamide, 2-.beta.-d-ribofuranosyl-
83705-13-9
2-[(2r,3r,4s,5r)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]-1,3-selenazole-4-carboxamide
unii-i5r2v02e8z
i5r2v02e8z ,
selenofurin
CKMBACZHCFMPLQ-DBRKOABJSA-N
2-beta-d-ribofuranosylselenazole-4-carboxamide
SCHEMBL3051767
DTXSID80232569
CHEMBL3144001
ci 935; nsc 340847; pd 111232; selenazofurin
Q27280480
AKOS040749475

Research Excerpts

[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Bioassays (55)

Assay IDTitleYearJournalArticle
AID219233Compound was tested for antiproliferative activity against Wil2-NS, human splenic lymphoblastoid cells1997Journal of medicinal chemistry, May-23, Volume: 40, Issue:11
Synthesis, structure, and antiproliferative activity of selenophenfurin, an inosine 5'-monophosphate dehydrogenase inhibitor analogue of selenazofurin.
AID217585In vitro antiviral activity against Parainfluenza type 3 was evaluated.1985Journal of medicinal chemistry, Aug, Volume: 28, Issue:8
Synthesis and biological activity of 6-azacadeguomycin and certain 3,4,6-trisubstituted pyrazolo[3,4-d]pyrimidine ribonucleosides.
AID152419Evaluated for cytotoxicity against P-388 cells1983Journal of medicinal chemistry, Mar, Volume: 26, Issue:3
Synthesis and antitumor activity of 2-beta-D-ribofuranosylselenazole-4- carboxamide and related derivatives.
AID110645Evaluated for cures in the total number of mice tested at a dose of 12 mg/kg (Experiment-2); 9/101983Journal of medicinal chemistry, Mar, Volume: 26, Issue:3
Synthesis and antitumor activity of 2-beta-D-ribofuranosylselenazole-4- carboxamide and related derivatives.
AID94625Compound was tested for its influence on the GMP (Glucose monophosphate) ribonucleotide level in K562 cells1997Journal of medicinal chemistry, May-23, Volume: 40, Issue:11
Synthesis, structure, and antiproliferative activity of selenophenfurin, an inosine 5'-monophosphate dehydrogenase inhibitor analogue of selenazofurin.
AID116089Evaluated for median life span in mice inoculated with lewis lung carcinoma at a dose of 100 mg/kg (Experiment-1)1983Journal of medicinal chemistry, Mar, Volume: 26, Issue:3
Synthesis and antitumor activity of 2-beta-D-ribofuranosylselenazole-4- carboxamide and related derivatives.
AID115815Evaluated for increase in life span in mice inoculated with lewis lung carcinoma at a dose of 3 mg/kg (Experiment-2)1983Journal of medicinal chemistry, Mar, Volume: 26, Issue:3
Synthesis and antitumor activity of 2-beta-D-ribofuranosylselenazole-4- carboxamide and related derivatives.
AID115813Evaluated for increase in life span in mice inoculated with lewis lung carcinoma at a dose of 24 mg/kg (Experiment-2)1983Journal of medicinal chemistry, Mar, Volume: 26, Issue:3
Synthesis and antitumor activity of 2-beta-D-ribofuranosylselenazole-4- carboxamide and related derivatives.
AID98381Compound was tested for antiproliferative activity against L1210, murine lymphocytic leukemia1997Journal of medicinal chemistry, May-23, Volume: 40, Issue:11
Synthesis, structure, and antiproliferative activity of selenophenfurin, an inosine 5'-monophosphate dehydrogenase inhibitor analogue of selenazofurin.
AID116096Evaluated for median life span in mice inoculated with lewis lung carcinoma at a dose of 25 mg/kg (Experiment-1)1983Journal of medicinal chemistry, Mar, Volume: 26, Issue:3
Synthesis and antitumor activity of 2-beta-D-ribofuranosylselenazole-4- carboxamide and related derivatives.
AID91398Compound was tested for its inhibition against IMPDH from human myelogenous leukemia in K562 cells1997Journal of medicinal chemistry, May-23, Volume: 40, Issue:11
Synthesis, structure, and antiproliferative activity of selenophenfurin, an inosine 5'-monophosphate dehydrogenase inhibitor analogue of selenazofurin.
AID116093Evaluated for median life span in mice inoculated with lewis lung carcinoma at a dose of 200 mg/kg (Experiment-1)1983Journal of medicinal chemistry, Mar, Volume: 26, Issue:3
Synthesis and antitumor activity of 2-beta-D-ribofuranosylselenazole-4- carboxamide and related derivatives.
AID115811Evaluated for increase in life span in mice inoculated with lewis lung carcinoma at a dose of 12 mg/kg (Experiment-2)1983Journal of medicinal chemistry, Mar, Volume: 26, Issue:3
Synthesis and antitumor activity of 2-beta-D-ribofuranosylselenazole-4- carboxamide and related derivatives.
AID43683Compound was tested for antiproliferative activity against CCRF-CEM, human acute T-lymphoblastic leukemia1997Journal of medicinal chemistry, May-23, Volume: 40, Issue:11
Synthesis, structure, and antiproliferative activity of selenophenfurin, an inosine 5'-monophosphate dehydrogenase inhibitor analogue of selenazofurin.
AID217587In vitro antiviral activity against herpes simplex virus type 2 virus was evaluated.1985Journal of medicinal chemistry, Aug, Volume: 28, Issue:8
Synthesis and biological activity of 6-azacadeguomycin and certain 3,4,6-trisubstituted pyrazolo[3,4-d]pyrimidine ribonucleosides.
AID98674Evaluated for cytotoxicity against P-388 cells1983Journal of medicinal chemistry, Mar, Volume: 26, Issue:3
Synthesis and antitumor activity of 2-beta-D-ribofuranosylselenazole-4- carboxamide and related derivatives.
AID110643Evaluated for cures in the total number of mice tested at a dose of 100 mg/kg (Experiment-1); 3/101983Journal of medicinal chemistry, Mar, Volume: 26, Issue:3
Synthesis and antitumor activity of 2-beta-D-ribofuranosylselenazole-4- carboxamide and related derivatives.
AID115808Evaluated for increase in life span in mice inoculated with lewis lung carcinoma at a dose of 1.5 mg/kg (Experiment-2)1983Journal of medicinal chemistry, Mar, Volume: 26, Issue:3
Synthesis and antitumor activity of 2-beta-D-ribofuranosylselenazole-4- carboxamide and related derivatives.
AID9872Compound was tested for antiproliferative activity against ACHN, human renal adenocarcinoma1997Journal of medicinal chemistry, May-23, Volume: 40, Issue:11
Synthesis, structure, and antiproliferative activity of selenophenfurin, an inosine 5'-monophosphate dehydrogenase inhibitor analogue of selenazofurin.
AID115817Evaluated for increase in life span in mice inoculated with lewis lung carcinoma at a dose of 6 mg/kg (Experiment-2)1983Journal of medicinal chemistry, Mar, Volume: 26, Issue:3
Synthesis and antitumor activity of 2-beta-D-ribofuranosylselenazole-4- carboxamide and related derivatives.
AID88522Compound was tested for antiproliferative activity against HeLa, human cervix carcinoma1997Journal of medicinal chemistry, May-23, Volume: 40, Issue:11
Synthesis, structure, and antiproliferative activity of selenophenfurin, an inosine 5'-monophosphate dehydrogenase inhibitor analogue of selenazofurin.
AID116095Evaluated for median life span in mice inoculated with lewis lung carcinoma at a dose of 24 mg/kg (Experiment-2)1983Journal of medicinal chemistry, Mar, Volume: 26, Issue:3
Synthesis and antitumor activity of 2-beta-D-ribofuranosylselenazole-4- carboxamide and related derivatives.
AID110650Evaluated for cures in the total number of mice tested at a dose of 25 mg/kg (Experiment-1); 7/101983Journal of medicinal chemistry, Mar, Volume: 26, Issue:3
Synthesis and antitumor activity of 2-beta-D-ribofuranosylselenazole-4- carboxamide and related derivatives.
AID116100Evaluated for median life span in mice inoculated with lewis lung carcinoma at a dose of 50 mg/kg (Experiment-1)1983Journal of medicinal chemistry, Mar, Volume: 26, Issue:3
Synthesis and antitumor activity of 2-beta-D-ribofuranosylselenazole-4- carboxamide and related derivatives.
AID116090Evaluated for median life span in mice inoculated with lewis lung carcinoma at a dose of 12 mg/kg (Experiment-1)1983Journal of medicinal chemistry, Mar, Volume: 26, Issue:3
Synthesis and antitumor activity of 2-beta-D-ribofuranosylselenazole-4- carboxamide and related derivatives.
AID98672Evaluated for cytotoxicity against L1210 cells1983Journal of medicinal chemistry, Mar, Volume: 26, Issue:3
Synthesis and antitumor activity of 2-beta-D-ribofuranosylselenazole-4- carboxamide and related derivatives.
AID115810Evaluated for increase in life span in mice inoculated with lewis lung carcinoma at a dose of 12 mg/kg (Experiment-1)1983Journal of medicinal chemistry, Mar, Volume: 26, Issue:3
Synthesis and antitumor activity of 2-beta-D-ribofuranosylselenazole-4- carboxamide and related derivatives.
AID91395Compound was tested for its effect on IMPDH (Inosine 5`-monophosphate dehydrogenase) activity in K562 cells1997Journal of medicinal chemistry, May-23, Volume: 40, Issue:11
Synthesis, structure, and antiproliferative activity of selenophenfurin, an inosine 5'-monophosphate dehydrogenase inhibitor analogue of selenazofurin.
AID116101Evaluated for median life span in mice inoculated with lewis lung carcinoma at a dose of 6 mg/kg (Experiment-2)1983Journal of medicinal chemistry, Mar, Volume: 26, Issue:3
Synthesis and antitumor activity of 2-beta-D-ribofuranosylselenazole-4- carboxamide and related derivatives.
AID116088Evaluated for median life span in mice inoculated with lewis lung carcinoma at a dose of 1.5 mg/kg (Experiment-2)1983Journal of medicinal chemistry, Mar, Volume: 26, Issue:3
Synthesis and antitumor activity of 2-beta-D-ribofuranosylselenazole-4- carboxamide and related derivatives.
AID94628Compound was tested for its influence on the IMP (Inosine 5`-monophosphate) ribonucleotide level of K562 cells in culture1997Journal of medicinal chemistry, May-23, Volume: 40, Issue:11
Synthesis, structure, and antiproliferative activity of selenophenfurin, an inosine 5'-monophosphate dehydrogenase inhibitor analogue of selenazofurin.
AID45414Compound was tested for antiproliferative activity against CHO-K1, Chinese hamster ovary1997Journal of medicinal chemistry, May-23, Volume: 40, Issue:11
Synthesis, structure, and antiproliferative activity of selenophenfurin, an inosine 5'-monophosphate dehydrogenase inhibitor analogue of selenazofurin.
AID217589In vitro antiviral activity against measles virus was evaluated.1985Journal of medicinal chemistry, Aug, Volume: 28, Issue:8
Synthesis and biological activity of 6-azacadeguomycin and certain 3,4,6-trisubstituted pyrazolo[3,4-d]pyrimidine ribonucleosides.
AID105294Compound was tested for antiproliferative activity against MOLT-4, human acute T-lymphoblastic leukemia1997Journal of medicinal chemistry, May-23, Volume: 40, Issue:11
Synthesis, structure, and antiproliferative activity of selenophenfurin, an inosine 5'-monophosphate dehydrogenase inhibitor analogue of selenazofurin.
AID115816Evaluated for increase in life span in mice inoculated with lewis lung carcinoma at a dose of 50 mg/kg (Experiment-1)1983Journal of medicinal chemistry, Mar, Volume: 26, Issue:3
Synthesis and antitumor activity of 2-beta-D-ribofuranosylselenazole-4- carboxamide and related derivatives.
AID110653Evaluated for cures in the total number of mice tested at a dose of 50 mg/kg (Experiment-1); 6/101983Journal of medicinal chemistry, Mar, Volume: 26, Issue:3
Synthesis and antitumor activity of 2-beta-D-ribofuranosylselenazole-4- carboxamide and related derivatives.
AID165775Compound was tested for antiproliferative activity against Raji, human Burkitt lymphoma1997Journal of medicinal chemistry, May-23, Volume: 40, Issue:11
Synthesis, structure, and antiproliferative activity of selenophenfurin, an inosine 5'-monophosphate dehydrogenase inhibitor analogue of selenazofurin.
AID110644Evaluated for cures in the total number of mice tested at a dose of 12 mg/kg (Experiment-1); 8/101983Journal of medicinal chemistry, Mar, Volume: 26, Issue:3
Synthesis and antitumor activity of 2-beta-D-ribofuranosylselenazole-4- carboxamide and related derivatives.
AID94793Compound was tested for antiproliferative activity against K562, human erythroid leukemia1997Journal of medicinal chemistry, May-23, Volume: 40, Issue:11
Synthesis, structure, and antiproliferative activity of selenophenfurin, an inosine 5'-monophosphate dehydrogenase inhibitor analogue of selenazofurin.
AID7221Compound was tested for antiproliferative activity against 5637, human bladder carcinoma cell line1997Journal of medicinal chemistry, May-23, Volume: 40, Issue:11
Synthesis, structure, and antiproliferative activity of selenophenfurin, an inosine 5'-monophosphate dehydrogenase inhibitor analogue of selenazofurin.
AID110642Evaluated for cures in the total number of mice tested at a dose of 1.5 mg/kg (Experiment-2); 0/101983Journal of medicinal chemistry, Mar, Volume: 26, Issue:3
Synthesis and antitumor activity of 2-beta-D-ribofuranosylselenazole-4- carboxamide and related derivatives.
AID44367Compound was tested for antiproliferative activity against CCRF-SB, human acute B-lymphoblastic leukemia1997Journal of medicinal chemistry, May-23, Volume: 40, Issue:11
Synthesis, structure, and antiproliferative activity of selenophenfurin, an inosine 5'-monophosphate dehydrogenase inhibitor analogue of selenazofurin.
AID94624Compound was tested for its influence on the GDP (Glucose diphosphate) ribonucleotide level in K562 cells1997Journal of medicinal chemistry, May-23, Volume: 40, Issue:11
Synthesis, structure, and antiproliferative activity of selenophenfurin, an inosine 5'-monophosphate dehydrogenase inhibitor analogue of selenazofurin.
AID94626Compound was tested for its influence on the GTP (Glucose triphosphate) ribonucleotide level in K562 cells1997Journal of medicinal chemistry, May-23, Volume: 40, Issue:11
Synthesis, structure, and antiproliferative activity of selenophenfurin, an inosine 5'-monophosphate dehydrogenase inhibitor analogue of selenazofurin.
AID116091Evaluated for median life span in mice inoculated with lewis lung carcinoma at a dose of 12 mg/kg (Experiment-2)1983Journal of medicinal chemistry, Mar, Volume: 26, Issue:3
Synthesis and antitumor activity of 2-beta-D-ribofuranosylselenazole-4- carboxamide and related derivatives.
AID217592In vitro antiviral activity against vaccinia virus was evaluated.1985Journal of medicinal chemistry, Aug, Volume: 28, Issue:8
Synthesis and biological activity of 6-azacadeguomycin and certain 3,4,6-trisubstituted pyrazolo[3,4-d]pyrimidine ribonucleosides.
AID110649Evaluated for cures in the total number of mice tested at a dose of 24 mg/kg (Experiment-2); 9/101983Journal of medicinal chemistry, Mar, Volume: 26, Issue:3
Synthesis and antitumor activity of 2-beta-D-ribofuranosylselenazole-4- carboxamide and related derivatives.
AID110655Evaluated for cures in the total number of mice tested at a dose of 6 mg/kg (Experiment-2); 5/101983Journal of medicinal chemistry, Mar, Volume: 26, Issue:3
Synthesis and antitumor activity of 2-beta-D-ribofuranosylselenazole-4- carboxamide and related derivatives.
AID115814Evaluated for increase in life span in mice inoculated with lewis lung carcinoma at a dose of 25 mg/kg (Experiment-1)1983Journal of medicinal chemistry, Mar, Volume: 26, Issue:3
Synthesis and antitumor activity of 2-beta-D-ribofuranosylselenazole-4- carboxamide and related derivatives.
AID110647Evaluated for cures in the total number of mice tested at a dose of 200 mg/kg (Experiment-1); 0/101983Journal of medicinal chemistry, Mar, Volume: 26, Issue:3
Synthesis and antitumor activity of 2-beta-D-ribofuranosylselenazole-4- carboxamide and related derivatives.
AID115809Evaluated for increase in life span in mice inoculated with lewis lung carcinoma at a dose of 100 mg/kg (Experiment-1)1983Journal of medicinal chemistry, Mar, Volume: 26, Issue:3
Synthesis and antitumor activity of 2-beta-D-ribofuranosylselenazole-4- carboxamide and related derivatives.
AID86105Compound was tested for antiproliferative activity against HT29, human colon adenocarcinoma1997Journal of medicinal chemistry, May-23, Volume: 40, Issue:11
Synthesis, structure, and antiproliferative activity of selenophenfurin, an inosine 5'-monophosphate dehydrogenase inhibitor analogue of selenazofurin.
AID218072Toxicity level was reported; none1985Journal of medicinal chemistry, Aug, Volume: 28, Issue:8
Synthesis and biological activity of 6-azacadeguomycin and certain 3,4,6-trisubstituted pyrazolo[3,4-d]pyrimidine ribonucleosides.
AID116098Evaluated for median life span in mice inoculated with lewis lung carcinoma at a dose of 3 mg/kg (Experiment-2)1983Journal of medicinal chemistry, Mar, Volume: 26, Issue:3
Synthesis and antitumor activity of 2-beta-D-ribofuranosylselenazole-4- carboxamide and related derivatives.
AID110652Evaluated for cures in the total number of mice tested at a dose of 3 mg/kg (Experiment-2); 0/101983Journal of medicinal chemistry, Mar, Volume: 26, Issue:3
Synthesis and antitumor activity of 2-beta-D-ribofuranosylselenazole-4- carboxamide and related derivatives.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (30)

TimeframeStudies, This Drug (%)All Drugs %
pre-199020 (66.67)18.7374
1990's5 (16.67)18.2507
2000's5 (16.67)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 10.76

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be weak demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index10.76 (24.57)
Research Supply Index3.43 (2.92)
Research Growth Index4.20 (4.65)
Search Engine Demand Index0.00 (26.88)
Search Engine Supply Index0.00 (0.95)

This Compound (10.76)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews2 (6.67%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other28 (93.33%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]
SubstanceRelationship StrengthStudiesTrialsClassesRoles
niacinamide
nicotinamide : A pyridinecarboxamide that is pyridine in which the hydrogen at position 3 is replaced by a carboxamide group.		2.0110pyridine alkaloid;
pyridinecarboxamide;
vitamin B3		anti-inflammatory agent;
antioxidant;
cofactor;
EC 2.4.2.30 (NAD(+) ADP-ribosyltransferase) inhibitor;
EC 3.5.1.98 (histone deacetylase) inhibitor;
Escherichia coli metabolite;
geroprotector;
human urinary metabolite;
metabolite;
mouse metabolite;
neuroprotective agent;
Saccharomyces cerevisiae metabolite;
Sir2 inhibitor
amantadine
amant: an antiviral compound consisting of an adamantane derivative chemically linked to a water-solube polyanioic matrix; structure in first source		1.9610adamantanes;
primary aliphatic amine		analgesic;
antiparkinson drug;
antiviral drug;
dopaminergic agent;
NMDA receptor antagonist;
non-narcotic analgesic
chlorambucil
Chlorambucil: A nitrogen mustard alkylating agent used as antineoplastic for chronic lymphocytic leukemia, Hodgkin's disease, and others. Although it is less toxic than most other nitrogen mustards, it has been listed as a known carcinogen in the Fourth Annual Report on Carcinogens (NTP 85-002, 1985). (Merck Index, 11th ed). chlorambucil : A monocarboxylic acid that is butanoic acid substituted at position 4 by a 4-[bis(2-chloroethyl)amino]phenyl group. A chemotherapy drug that can be used in combination with the antibody obinutuzumab for the treatment of chronic lymphocytic leukemia.		2.0110aromatic amine;
monocarboxylic acid;
nitrogen mustard;
organochlorine compound;
tertiary amino compound		alkylating agent;
antineoplastic agent;
carcinogenic agent;
drug allergen;
immunosuppressive agent
azauridine
Azauridine: A triazine nucleoside used as an antineoplastic antimetabolite. It interferes with pyrimidine biosynthesis thereby preventing formation of cellular nucleic acids. As the triacetate, it is also effective as an antipsoriatic.		2.0210N-glycosyl-1,2,4-triazineantimetabolite;
antineoplastic agent;
drug metabolite
uridine
[no description available]		1.9610uridinesdrug metabolite;
fundamental metabolite;
human metabolite
oxazoles
Oxazoles: Five-membered heterocyclic ring structures containing an oxygen in the 1-position and a nitrogen in the 3-position, in distinction from ISOXAZOLES where they are at the 1,2 positions.. 1,3-oxazole : A five-membered monocyclic heteroarene that is an analogue of cyclopentadiene with O in place of CH2 at position 1 and N in place of CH at position 3.. oxazole : An azole based on a five-membered heterocyclic aromatic skeleton containing one N and one O atom.		3.1101,3-oxazoles;
mancude organic heteromonocyclic parent;
monocyclic heteroarene
neutral red
Neutral Red: A vital dye used as an indicator and biological stain. Various adverse effects have been observed in biological systems.. neutral red : A hydrochloride obtained by combining the free base of neutral red with one equivalent of hydrochloric acid. Neutral red acts as a pH indicator, changing from red to yellow between pH 6.8 and 8.0.		2.0210hydrochlorideacid-base indicator;
dye;
two-colour indicator
ribavirin
Rebetron: Rebetron is tradename		6.292901-ribosyltriazole;
aromatic amide;
monocarboxylic acid amide;
primary carboxamide		anticoronaviral agent;
antiinfective agent;
antimetabolite;
antiviral agent;
EC 2.7.7.49 (RNA-directed DNA polymerase) inhibitor
phorbol 12,13-dibutyrate
Phorbol 12,13-Dibutyrate: A phorbol ester found in CROTON OIL which, in addition to being a potent skin tumor promoter, is also an effective activator of calcium-activated, phospholipid-dependent protein kinase (protein kinase C). Due to its activation of this enzyme, phorbol 12,13-dibutyrate profoundly affects many different biological systems.		1.9710butyrate ester;
phorbol ester;
tertiary alpha-hydroxy ketone
ribavirin 5'-triphosphate
ribavirin 5'-triphosphate: structure given in first source. ribavirin 5'-triphosphate : A 1-ribosyltriazole that is ribavirin in which the hydroxy group at the 5'-position is replaced by a triphosphate group. It is the active metabolite of the antiviral agent ribavirin.		1.96101-ribosyltriazole;
aromatic amide;
monocarboxylic acid amide;
primary carboxamide;
ribose triphosphate		antiviral agent;
drug metabolite;
EC 2.7.7.48 (RNA-directed RNA polymerase) inhibitor;
eukaryotic initiation factor 4F inhibitor;
human blood serum metabolite
3-deazaguanosine
3-deazaguanosine: structure		1.9610
nicotinamide-beta-riboside
N-ribosylnicotinamide : A pyridine nucleoside consisting of nicotinamide with a beta-D-ribofuranosyl moiety at the 1-position.		2.0110N-glycosylnicotinamide;
pyridine nucleoside		geroprotector;
human metabolite;
mouse metabolite;
Saccharomyces cerevisiae metabolite
mycophenolic acid
Mycophenolic Acid: Compound derived from Penicillium stoloniferum and related species. It blocks de novo biosynthesis of purine nucleotides by inhibition of the enzyme inosine monophosphate dehydrogenase (IMP DEHYDROGENASE). Mycophenolic acid exerts selective effects on the immune system in which it prevents the proliferation of T-CELLS, LYMPHOCYTES, and the formation of antibodies from B-CELLS. It may also inhibit recruitment of LEUKOCYTES to sites of INFLAMMATION.. mycophenolate : A monocarboxylic acid anion resulting from the removal of a proton from the carboxy group of mycophenolic acid.. mycophenolic acid : A member of the class of 2-benzofurans that is 2-benzofuran-1(3H)-one which is substituted at positions 4, 5, 6, and 7 by methyl, methoxy, (2E)-5-carboxy-3-methylpent-2-en-1-yl, and hydroxy groups, respectively. It is an antibiotic produced by Penicillium brevi-compactum, P. stoloniferum, P. echinulatum and related species. An immunosuppressant, it is widely used (partiularly as its sodium salt and as the 2-(morpholin-4-yl)ethyl ester prodrug, mycophenolate mofetil) to prevent tissue rejection following organ transplants and for the treatment of certain autoimmune diseases.		9402-benzofurans;
gamma-lactone;
monocarboxylic acid;
phenols		anticoronaviral agent;
antimicrobial agent;
antineoplastic agent;
EC 1.1.1.205 (IMP dehydrogenase) inhibitor;
environmental contaminant;
immunosuppressive agent;
mycotoxin;
Penicillium metabolite;
xenobiotic
taribavirin
[no description available]		2.420nucleobase-containing molecular entity
tiazofurin
tiazofurin: RN given refers to (beta-D)-isomer; structure given in first source. tiazofurine : A C-glycosyl compound that is 1,3-thiazole-4-carboxamide in which the hydrogen at position 2 has been replaced by a beta-D-ribofuranosyl group. It is metabolised to thiazole-4-carboxamide adenine dinucleotide (TAD), a selective inhibitor of inosine monophosphate dehydrogenase (IMP dehydrogenase).		5.982101,3-thiazoles;
C-glycosyl compound;
monocarboxylic acid amide		antineoplastic agent;
EC 1.1.1.205 (IMP dehydrogenase) inhibitor;
prodrug
3-(1-deoxyribofuranosyl)benzamide
3-(1-deoxyribofuranosyl)benzamide: structure given in first source		3.7930
selenium
Selenium: An element with the atomic symbol Se, atomic number 34, and atomic weight 78.97. It is an essential micronutrient for mammals and other animals but is toxic in large amounts. Selenium protects intracellular structures against oxidative damage. It is an essential component of GLUTATHIONE PEROXIDASE.		4.21180chalcogen;
nonmetal atom		micronutrient
dolichol monophosphate mannose
Dolichol Monophosphate Mannose: A lipophilic glycosyl carrier of the monosaccharide mannose in the biosynthesis of oligosaccharide phospholipids and glycoproteins.		1.9610
thiophenfurin
thiophenfurin: a tiazofurin analog; structure given in first source		3.520
ribose
ribopyranose : The pyranose form of ribose.		3.110D-ribose;
ribopyranose
nad
NAD(1-) : An anionic form of nicotinamide adenine dinucleotide arising from deprotonation of the two OH groups of the diphosphate moiety.		2.8940organophosphate oxoanioncofactor;
human metabolite;
hydrogen acceptor;
Saccharomyces cerevisiae metabolite
cyclic gmp
Cyclic GMP: Guanosine cyclic 3',5'-(hydrogen phosphate). A guanine nucleotide containing one phosphate group which is esterified to the sugar moiety in both the 3'- and 5'-positions. It is a cellular regulatory agent and has been described as a second messenger. Its levels increase in response to a variety of hormones, including acetylcholine, insulin, and oxytocin and it has been found to activate specific protein kinases. (From Merck Index, 11th ed). 3',5'-cyclic GMP : A 3',5'-cyclic purine nucleotide in which the purine nucleobase is specified as guanidine.		1.97103',5'-cyclic purine nucleotide;
guanyl ribonucleotide		Escherichia coli metabolite;
human metabolite;
mouse metabolite;
plant metabolite;
Saccharomyces cerevisiae metabolite
guanosine monophosphate
Guanosine Monophosphate: A guanine nucleotide containing one phosphate group esterified to the sugar moiety and found widely in nature.. guanosine 5'-monophosphate : A purine ribonucleoside 5'-monophosphate having guanine as the nucleobase.		1.9710guanosine 5'-phosphate;
purine ribonucleoside 5'-monophosphate		biomarker;
Escherichia coli metabolite;
metabolite;
mouse metabolite
guanosine triphosphate
Guanosine Triphosphate: Guanosine 5'-(tetrahydrogen triphosphate). A guanine nucleotide containing three phosphate groups esterified to the sugar moiety.		4.1850guanosine 5'-phosphate;
purine ribonucleoside 5'-triphosphate		Escherichia coli metabolite;
mouse metabolite;
uncoupling protein inhibitor
guanine
[no description available]		1.96102-aminopurines;
oxopurine;
purine nucleobase		algal metabolite;
Escherichia coli metabolite;
human metabolite;
mouse metabolite;
Saccharomyces cerevisiae metabolite
guanosine
ribonucleoside : Any nucleoside where the sugar component is D-ribose.		2.6630guanosines;
purines D-ribonucleoside		fundamental metabolite
hypoxanthine
[no description available]		1.9610nucleobase analogue;
oxopurine;
purine nucleobase		fundamental metabolite
inosinic acid
Inosine Monophosphate: Inosine 5'-Monophosphate. A purine nucleotide which has hypoxanthine as the base and one phosphate group esterified to the sugar moiety.		2.3820inosine phosphate;
purine ribonucleoside 5'-monophosphate		Escherichia coli metabolite;
human metabolite;
mouse metabolite
methylnitronitrosoguanidine
Methylnitronitrosoguanidine: A nitrosoguanidine derivative with potent mutagenic and carcinogenic properties.. N-methyl-N'-nitro-N-nitrosoguanidine : An N-nitroguanidine compound having nitroso and methyl substituents at the N'-position		2.0110nitroso compoundalkylating agent
ConditionIndicatedRelationship StrengthStudiesTrials
Experimental Leukemia
[description not available]		02.6530
Cancer of Lung
[description not available]		01.9610
Lung Neoplasms
Tumors or cancer of the LUNG.		01.9610
Leucocythaemia
[description not available]		01.9910
Germinoblastoma
[description not available]		02.3820
Benign Neoplasms
[description not available]		03.5930
Leukemia
A progressive, malignant disease of the blood-forming organs, characterized by distorted proliferation and development of leukocytes and their precursors in the blood and bone marrow. Leukemias were originally termed acute or chronic based on life expectancy but now are classified according to cellular maturity. Acute leukemias consist of predominately immature cells; chronic leukemias are composed of more mature cells. (From The Merck Manual, 2006)		01.9910
Lymphoma
A general term for various neoplastic diseases of the lymphoid tissue.		07.3820
Neoplasms
New abnormal growth of tissue. Malignant neoplasms show a greater degree of anaplasia and have the properties of invasion and metastasis, compared to benign neoplasms.		03.5930
Leukemia, Acute Monocytic
[description not available]		02.0110
B-Cell Chronic Lymphocytic Leukemia
[description not available]		02.0110
Leukemia, Monocytic, Acute
An acute myeloid leukemia in which 80% or more of the leukemic cells are of monocytic lineage including monoblasts, promonocytes, and MONOCYTES.		02.0110
Leukemia, Lymphocytic, Chronic, B-Cell
A chronic leukemia characterized by abnormal B-lymphocytes and often generalized lymphadenopathy. In patients presenting predominately with blood and bone marrow involvement it is called chronic lymphocytic leukemia (CLL); in those predominately with enlarged lymph nodes it is called small lymphocytic lymphoma. These terms represent spectrums of the same disease.		02.0110
Leukemia P388
An experimental lymphocytic leukemia originally induced in DBA/2 mice by painting with methylcholanthrene.		02.6530
Leukemia L 1210
[description not available]		02.6630
Acute Myelogenous Leukemia
[description not available]		02.3720
Leukemia, Myeloid, Acute
Clonal expansion of myeloid blasts in bone marrow, blood, and other tissue. Myeloid leukemias develop from changes in cells that normally produce NEUTROPHILS; BASOPHILS; EOSINOPHILS; and MONOCYTES.		02.3720
Hemorrhagic Fever, American
Diseases caused by American hemorrhagic fever viruses (ARENAVIRUSES, NEW WORLD).		01.9810
Granulocytic Leukemia
[description not available]		02.9110
Cancer of Ovary
[description not available]		02.9110
Leukemia, Myeloid
Form of leukemia characterized by an uncontrolled proliferation of the myeloid lineage and their precursors (MYELOID PROGENITOR CELLS) in the bone marrow and other sites.		02.9110
Ovarian Neoplasms
Tumors or cancer of the OVARY. These neoplasms can be benign or malignant. They are classified according to the tissue of origin, such as the surface EPITHELIUM, the stromal endocrine cells, and the totipotent GERM CELLS.		02.9110
Sarcoma, Epithelioid
[description not available]		02.0110
Central Nervous System Neoplasm
[description not available]		02.0110
Sarcoma
A connective tissue neoplasm formed by proliferation of mesodermal cells; it is usually highly malignant.		02.0110
Central Nervous System Neoplasms
Benign and malignant neoplastic processes that arise from or secondarily involve the brain, spinal cord, or meninges.		02.0110
Experimental Hepatoma
[description not available]		01.9710
Infections, Orthomyxoviridae
[description not available]		01.9610
Orthomyxoviridae Infections
Virus diseases caused by the ORTHOMYXOVIRIDAE.		01.9610