Compounds > thiophenfurin
Page last updated: 2024-12-11

thiophenfurin

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Description

thiophenfurin: a tiazofurin analog; structure given in first source [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

Cross-References

ID SourceID
PubMed CID9816617
CHEMBL ID3143993
SCHEMBL ID3051763
MeSH IDM0252138

Synonyms (14)

Synonym
3-thiophenecarboxamide, 5-.beta.-d-ribofuranosyl-
161407-67-6
thiophenfurin
5-(beta-d-ribofuranosyl)thiophene-3-carboxamide
43c65zs2xk ,
3-thiophenecarboxamide, 5-beta-d-ribofuranosyl-
unii-43c65zs2xk
SCHEMBL3051763
CHEMBL3143993
5-.beta.-d-ribofuranosyl-3-thiophenecarboxamide
5-[(2r,3r,4s,5r)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]thiophene-3-carboxamide
3-thiophenecarboxamide, 5-|a-d-ribofuranosyl-
5-((2r,3r,4s,5r)-3,4-dihydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)thiophene-3-carboxamide
A883105

Research Excerpts

Compound-Compound Interactions

ExcerptReferenceRelevance
" When HL60 cells were treated with thiophenfurin in combination with retinoids, the effects on cell growth were additive or synergistic, depending on the kind of retinoid used and the sequence of treatment."( The synergistic apoptotic effects of thiophenfurin, an inosine monophosphate dehydrogenase inhibitor, in combination with retinoids in HL60 cells.
Aiello, S; Cappellacci, L; Dusonchet, L; Franchetti, P; Grifantini, M; Invidiata, FP; Meli, M; Simoni, D; Tolomeo, M, 2007)		0.89
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Bioassays (92)

Assay IDTitleYearJournalArticle
AID95993Compound was tested for its effect on UTP ribonucleotide levels of K562 cell at 10 uM concentration1995Journal of medicinal chemistry, Sep-15, Volume: 38, Issue:19
Furanfurin and thiophenfurin: two novel tiazofurin analogues. Synthesis, structure, antitumor activity, and interactions with inosine monophosphate dehydrogenase.
AID95998compound was tested for its effect on IMPDH activity against K562 cells at 10 uM concentration1995Journal of medicinal chemistry, Sep-15, Volume: 38, Issue:19
Furanfurin and thiophenfurin: two novel tiazofurin analogues. Synthesis, structure, antitumor activity, and interactions with inosine monophosphate dehydrogenase.
AID90123Inhibitory concentration range against human bone marrow1995Journal of medicinal chemistry, Sep-15, Volume: 38, Issue:19
Furanfurin and thiophenfurin: two novel tiazofurin analogues. Synthesis, structure, antitumor activity, and interactions with inosine monophosphate dehydrogenase.
AID81641Inhibitory concentration against human HL-60 cell line(activity expressed as range)1995Journal of medicinal chemistry, Sep-15, Volume: 38, Issue:19
Furanfurin and thiophenfurin: two novel tiazofurin analogues. Synthesis, structure, antitumor activity, and interactions with inosine monophosphate dehydrogenase.
AID95959Compound was tested for its effect on GDP ribonucleotide levels of K562 cell at 50 uM concentration1995Journal of medicinal chemistry, Sep-15, Volume: 38, Issue:19
Furanfurin and thiophenfurin: two novel tiazofurin analogues. Synthesis, structure, antitumor activity, and interactions with inosine monophosphate dehydrogenase.
AID94836Tested for the influence on the ribonucleotide (IMP) concentration in myelogenous leukemia K562 cell culture.2000Journal of medicinal chemistry, Apr-06, Volume: 43, Issue:7
Synthesis, conformational analysis, and biological activity of C-thioribonucleosides related to tiazofurin.
AID91400Compound was tested for its inhibition against IMPDH from human myelogenous leukemia in K562 cells1997Journal of medicinal chemistry, May-23, Volume: 40, Issue:11
Synthesis, structure, and antiproliferative activity of selenophenfurin, an inosine 5'-monophosphate dehydrogenase inhibitor analogue of selenazofurin.
AID94835Tested for the influence on the ribonucleotide (GTP) concentration in myelogenous leukemia K562 cell culture.2000Journal of medicinal chemistry, Apr-06, Volume: 43, Issue:7
Synthesis, conformational analysis, and biological activity of C-thioribonucleosides related to tiazofurin.
AID94625Compound was tested for its influence on the GMP (Glucose monophosphate) ribonucleotide level in K562 cells1997Journal of medicinal chemistry, May-23, Volume: 40, Issue:11
Synthesis, structure, and antiproliferative activity of selenophenfurin, an inosine 5'-monophosphate dehydrogenase inhibitor analogue of selenazofurin.
AID86105Compound was tested for antiproliferative activity against HT29, human colon adenocarcinoma1997Journal of medicinal chemistry, May-23, Volume: 40, Issue:11
Synthesis, structure, and antiproliferative activity of selenophenfurin, an inosine 5'-monophosphate dehydrogenase inhibitor analogue of selenazofurin.
AID95997compound was tested for its effect on IMPDH activity against K562 cells at 100 uM concentration1995Journal of medicinal chemistry, Sep-15, Volume: 38, Issue:19
Furanfurin and thiophenfurin: two novel tiazofurin analogues. Synthesis, structure, antitumor activity, and interactions with inosine monophosphate dehydrogenase.
AID95795Compound was tested for its effect on ADP ribonucleotide levels of K562 cell at 10 uM concentration1995Journal of medicinal chemistry, Sep-15, Volume: 38, Issue:19
Furanfurin and thiophenfurin: two novel tiazofurin analogues. Synthesis, structure, antitumor activity, and interactions with inosine monophosphate dehydrogenase.
AID45415Compound was tested for antiproliferative activity against CHO-K1, Chinese hamster ovary cells1997Journal of medicinal chemistry, May-23, Volume: 40, Issue:11
Synthesis, structure, and antiproliferative activity of selenophenfurin, an inosine 5'-monophosphate dehydrogenase inhibitor analogue of selenazofurin.
AID95976Compound was tested for its effect on NAD ribonucleotide levels of K562 cell at 100 uM concentration1995Journal of medicinal chemistry, Sep-15, Volume: 38, Issue:19
Furanfurin and thiophenfurin: two novel tiazofurin analogues. Synthesis, structure, antitumor activity, and interactions with inosine monophosphate dehydrogenase.
AID43684Compound was tested for antiproliferative activity against CCRF-CEM, human acute T-lymphoblastic leukemia1997Journal of medicinal chemistry, May-23, Volume: 40, Issue:11
Synthesis, structure, and antiproliferative activity of selenophenfurin, an inosine 5'-monophosphate dehydrogenase inhibitor analogue of selenazofurin.
AID95986Compound was tested for its effect on UMP ribonucleotide levels of K562 cell at 100 uM concentration1995Journal of medicinal chemistry, Sep-15, Volume: 38, Issue:19
Furanfurin and thiophenfurin: two novel tiazofurin analogues. Synthesis, structure, antitumor activity, and interactions with inosine monophosphate dehydrogenase.
AID95803Compound was tested for its effect on AMP ribonucleotide levels of K562 cell at 50 uM concentration1995Journal of medicinal chemistry, Sep-15, Volume: 38, Issue:19
Furanfurin and thiophenfurin: two novel tiazofurin analogues. Synthesis, structure, antitumor activity, and interactions with inosine monophosphate dehydrogenase.
AID44367Compound was tested for antiproliferative activity against CCRF-SB, human acute B-lymphoblastic leukemia1997Journal of medicinal chemistry, May-23, Volume: 40, Issue:11
Synthesis, structure, and antiproliferative activity of selenophenfurin, an inosine 5'-monophosphate dehydrogenase inhibitor analogue of selenazofurin.
AID100222Inhibitory concentration against LLC Lewis lung carcinoma1995Journal of medicinal chemistry, Sep-15, Volume: 38, Issue:19
Furanfurin and thiophenfurin: two novel tiazofurin analogues. Synthesis, structure, antitumor activity, and interactions with inosine monophosphate dehydrogenase.
AID90124Inhibitory concentration range against human bone marrow1995Journal of medicinal chemistry, Sep-15, Volume: 38, Issue:19
Furanfurin and thiophenfurin: two novel tiazofurin analogues. Synthesis, structure, antitumor activity, and interactions with inosine monophosphate dehydrogenase.
AID95964Compound was tested for its effect on GMP ribonucleotide levels of K562 cell at 50 uM concentration1995Journal of medicinal chemistry, Sep-15, Volume: 38, Issue:19
Furanfurin and thiophenfurin: two novel tiazofurin analogues. Synthesis, structure, antitumor activity, and interactions with inosine monophosphate dehydrogenase.
AID95966Compound was tested for its effect on GTP ribonucleotide levels of K562 cell at 100 uM concentration1995Journal of medicinal chemistry, Sep-15, Volume: 38, Issue:19
Furanfurin and thiophenfurin: two novel tiazofurin analogues. Synthesis, structure, antitumor activity, and interactions with inosine monophosphate dehydrogenase.
AID95991Compound was tested for its effect on UTP ribonucleotide levels of K562 cell at 100 uM concentration1995Journal of medicinal chemistry, Sep-15, Volume: 38, Issue:19
Furanfurin and thiophenfurin: two novel tiazofurin analogues. Synthesis, structure, antitumor activity, and interactions with inosine monophosphate dehydrogenase.
AID95777Compound was tested for its effect on IMPDH activity against K562 cells at 100 uM concentration1995Journal of medicinal chemistry, Sep-15, Volume: 38, Issue:19
Furanfurin and thiophenfurin: two novel tiazofurin analogues. Synthesis, structure, antitumor activity, and interactions with inosine monophosphate dehydrogenase.
AID229974IC90 ratio against bone marrow samples to HL-601995Journal of medicinal chemistry, Sep-15, Volume: 38, Issue:19
Furanfurin and thiophenfurin: two novel tiazofurin analogues. Synthesis, structure, antitumor activity, and interactions with inosine monophosphate dehydrogenase.
AID95969Compound was tested for its effect on GTP ribonucleotide levels of K562 cell at 50 uM concentration1995Journal of medicinal chemistry, Sep-15, Volume: 38, Issue:19
Furanfurin and thiophenfurin: two novel tiazofurin analogues. Synthesis, structure, antitumor activity, and interactions with inosine monophosphate dehydrogenase.
AID150671Inhibitory concentration against P388 murine lymphocytic leukemia cell lines1995Journal of medicinal chemistry, Sep-15, Volume: 38, Issue:19
Furanfurin and thiophenfurin: two novel tiazofurin analogues. Synthesis, structure, antitumor activity, and interactions with inosine monophosphate dehydrogenase.
AID95817Compound was tested for its effect on CTP ribonucleotide levels of K562 cell at 10 uM concentration1995Journal of medicinal chemistry, Sep-15, Volume: 38, Issue:19
Furanfurin and thiophenfurin: two novel tiazofurin analogues. Synthesis, structure, antitumor activity, and interactions with inosine monophosphate dehydrogenase.
AID94649Formation of NAD analogue by compound at 100 uM concentration against human myelogenous leukemia K5621995Journal of medicinal chemistry, Sep-15, Volume: 38, Issue:19
Furanfurin and thiophenfurin: two novel tiazofurin analogues. Synthesis, structure, antitumor activity, and interactions with inosine monophosphate dehydrogenase.
AID94627Compound was tested for its influence on the IMP (Inosine 5`-monophosphate) ribonucleotide level in K562 cells1997Journal of medicinal chemistry, May-23, Volume: 40, Issue:11
Synthesis, structure, and antiproliferative activity of selenophenfurin, an inosine 5'-monophosphate dehydrogenase inhibitor analogue of selenazofurin.
AID219233Compound was tested for antiproliferative activity against Wil2-NS, human splenic lymphoblastoid cells1997Journal of medicinal chemistry, May-23, Volume: 40, Issue:11
Synthesis, structure, and antiproliferative activity of selenophenfurin, an inosine 5'-monophosphate dehydrogenase inhibitor analogue of selenazofurin.
AID95810Compound was tested for its effect on CDP ribonucleotide levels of K562 cell at 100 uM concentration1995Journal of medicinal chemistry, Sep-15, Volume: 38, Issue:19
Furanfurin and thiophenfurin: two novel tiazofurin analogues. Synthesis, structure, antitumor activity, and interactions with inosine monophosphate dehydrogenase.
AID81480Inhibitory concentration against human HL-60 cell line(activity expressed as range)1995Journal of medicinal chemistry, Sep-15, Volume: 38, Issue:19
Furanfurin and thiophenfurin: two novel tiazofurin analogues. Synthesis, structure, antitumor activity, and interactions with inosine monophosphate dehydrogenase.
AID98382Compound was tested for antiproliferative activity against L1210, murine lymphocytic leukemia1997Journal of medicinal chemistry, May-23, Volume: 40, Issue:11
Synthesis, structure, and antiproliferative activity of selenophenfurin, an inosine 5'-monophosphate dehydrogenase inhibitor analogue of selenazofurin.
AID95978Compound was tested for its effect on NAD ribonucleotide levels of K562 cell at 10 uM concentration1995Journal of medicinal chemistry, Sep-15, Volume: 38, Issue:19
Furanfurin and thiophenfurin: two novel tiazofurin analogues. Synthesis, structure, antitumor activity, and interactions with inosine monophosphate dehydrogenase.
AID95994Compound was tested for its effect on UTP ribonucleotide levels of K562 cell at 50 uM concentration1995Journal of medicinal chemistry, Sep-15, Volume: 38, Issue:19
Furanfurin and thiophenfurin: two novel tiazofurin analogues. Synthesis, structure, antitumor activity, and interactions with inosine monophosphate dehydrogenase.
AID7221Compound was tested for antiproliferative activity against 5637, human bladder carcinoma cell line1997Journal of medicinal chemistry, May-23, Volume: 40, Issue:11
Synthesis, structure, and antiproliferative activity of selenophenfurin, an inosine 5'-monophosphate dehydrogenase inhibitor analogue of selenazofurin.
AID95963Compound was tested for its effect on GMP ribonucleotide levels of K562 cell at 10 uM concentration1995Journal of medicinal chemistry, Sep-15, Volume: 38, Issue:19
Furanfurin and thiophenfurin: two novel tiazofurin analogues. Synthesis, structure, antitumor activity, and interactions with inosine monophosphate dehydrogenase.
AID81483Inhibitory concentration against HL-60 human promyelocytic leukemia1995Journal of medicinal chemistry, Sep-15, Volume: 38, Issue:19
Furanfurin and thiophenfurin: two novel tiazofurin analogues. Synthesis, structure, antitumor activity, and interactions with inosine monophosphate dehydrogenase.
AID95812Compound was tested for its effect on CDP ribonucleotide levels of K562 cell at 10 uM concentration1995Journal of medicinal chemistry, Sep-15, Volume: 38, Issue:19
Furanfurin and thiophenfurin: two novel tiazofurin analogues. Synthesis, structure, antitumor activity, and interactions with inosine monophosphate dehydrogenase.
AID95989Compound was tested for its effect on UMP ribonucleotide levels of K562 cell at 50 uM concentration1995Journal of medicinal chemistry, Sep-15, Volume: 38, Issue:19
Furanfurin and thiophenfurin: two novel tiazofurin analogues. Synthesis, structure, antitumor activity, and interactions with inosine monophosphate dehydrogenase.
AID95820Compound was tested for its effect on GDP ribonucleotide levels of K562 cell at 100 uM concentration1995Journal of medicinal chemistry, Sep-15, Volume: 38, Issue:19
Furanfurin and thiophenfurin: two novel tiazofurin analogues. Synthesis, structure, antitumor activity, and interactions with inosine monophosphate dehydrogenase.
AID94993Concentration required to inhibit 50% of the cell proliferation of the Human myelogenous leukemia K562 cells.2000Journal of medicinal chemistry, Apr-06, Volume: 43, Issue:7
Synthesis, conformational analysis, and biological activity of C-thioribonucleosides related to tiazofurin.
AID95796Compound was tested for its effect on ADP ribonucleotide levels of K562 cell at 100 uM concentration1995Journal of medicinal chemistry, Sep-15, Volume: 38, Issue:19
Furanfurin and thiophenfurin: two novel tiazofurin analogues. Synthesis, structure, antitumor activity, and interactions with inosine monophosphate dehydrogenase.
AID95805Compound was tested for its effect on ATP ribonucleotide levels of K562 cell at 100 uM concentration1995Journal of medicinal chemistry, Sep-15, Volume: 38, Issue:19
Furanfurin and thiophenfurin: two novel tiazofurin analogues. Synthesis, structure, antitumor activity, and interactions with inosine monophosphate dehydrogenase.
AID94624Compound was tested for its influence on the GDP (Glucose diphosphate) ribonucleotide level in K562 cells1997Journal of medicinal chemistry, May-23, Volume: 40, Issue:11
Synthesis, structure, and antiproliferative activity of selenophenfurin, an inosine 5'-monophosphate dehydrogenase inhibitor analogue of selenazofurin.
AID95979Compound was tested for its effect on NAD ribonucleotide levels of K562 cell at 50 uM concentration1995Journal of medicinal chemistry, Sep-15, Volume: 38, Issue:19
Furanfurin and thiophenfurin: two novel tiazofurin analogues. Synthesis, structure, antitumor activity, and interactions with inosine monophosphate dehydrogenase.
AID121005Compound was tested for ratio of survival time of treated to control mice x100 at 6.2 mg/kg dose1995Journal of medicinal chemistry, Sep-15, Volume: 38, Issue:19
Furanfurin and thiophenfurin: two novel tiazofurin analogues. Synthesis, structure, antitumor activity, and interactions with inosine monophosphate dehydrogenase.
AID94793Compound was tested for antiproliferative activity against K562, human erythroid leukemia1997Journal of medicinal chemistry, May-23, Volume: 40, Issue:11
Synthesis, structure, and antiproliferative activity of selenophenfurin, an inosine 5'-monophosphate dehydrogenase inhibitor analogue of selenazofurin.
AID110745Average weight change of mice from onset to termination of drug treatment at 25 mg/kg dose1995Journal of medicinal chemistry, Sep-15, Volume: 38, Issue:19
Furanfurin and thiophenfurin: two novel tiazofurin analogues. Synthesis, structure, antitumor activity, and interactions with inosine monophosphate dehydrogenase.
AID95961Compound was tested for its effect on GMP ribonucleotide levels of K562 cell at 100 uM concentration1995Journal of medicinal chemistry, Sep-15, Volume: 38, Issue:19
Furanfurin and thiophenfurin: two novel tiazofurin analogues. Synthesis, structure, antitumor activity, and interactions with inosine monophosphate dehydrogenase.
AID95973Compound was tested for its effect on IMP ribonucleotide levels of K562 cell at 10 uM concentration1995Journal of medicinal chemistry, Sep-15, Volume: 38, Issue:19
Furanfurin and thiophenfurin: two novel tiazofurin analogues. Synthesis, structure, antitumor activity, and interactions with inosine monophosphate dehydrogenase.
AID229951IC50 ratio against bone marrow samples to HL-601995Journal of medicinal chemistry, Sep-15, Volume: 38, Issue:19
Furanfurin and thiophenfurin: two novel tiazofurin analogues. Synthesis, structure, antitumor activity, and interactions with inosine monophosphate dehydrogenase.
AID229260Ratio of IC50 against HL-601995Journal of medicinal chemistry, Sep-15, Volume: 38, Issue:19
Furanfurin and thiophenfurin: two novel tiazofurin analogues. Synthesis, structure, antitumor activity, and interactions with inosine monophosphate dehydrogenase.
AID105295Compound was tested for antiproliferative activity against MOLT-4, human acute T-lymphoblastic leukemia1997Journal of medicinal chemistry, May-23, Volume: 40, Issue:11
Synthesis, structure, and antiproliferative activity of selenophenfurin, an inosine 5'-monophosphate dehydrogenase inhibitor analogue of selenazofurin.
AID95999compound was tested for its effect on IMPDH activity against K562 cells at 50 uM concentration1995Journal of medicinal chemistry, Sep-15, Volume: 38, Issue:19
Furanfurin and thiophenfurin: two novel tiazofurin analogues. Synthesis, structure, antitumor activity, and interactions with inosine monophosphate dehydrogenase.
AID95808Compound was tested for its effect on ATP ribonucleotide levels of K562 cell at 50 uM concentration1995Journal of medicinal chemistry, Sep-15, Volume: 38, Issue:19
Furanfurin and thiophenfurin: two novel tiazofurin analogues. Synthesis, structure, antitumor activity, and interactions with inosine monophosphate dehydrogenase.
AID110744Average weight change of mice from onset to termination of drug treatment at 100 mg/kg dose; early death due to toxicity1995Journal of medicinal chemistry, Sep-15, Volume: 38, Issue:19
Furanfurin and thiophenfurin: two novel tiazofurin analogues. Synthesis, structure, antitumor activity, and interactions with inosine monophosphate dehydrogenase.
AID95798Compound was tested for its effect on ADP ribonucleotide levels of K562 cell at 50 uM concentration1995Journal of medicinal chemistry, Sep-15, Volume: 38, Issue:19
Furanfurin and thiophenfurin: two novel tiazofurin analogues. Synthesis, structure, antitumor activity, and interactions with inosine monophosphate dehydrogenase.
AID110747Average weight change of mice from onset to termination of drug treatment at 6.2 mg/kg dose1995Journal of medicinal chemistry, Sep-15, Volume: 38, Issue:19
Furanfurin and thiophenfurin: two novel tiazofurin analogues. Synthesis, structure, antitumor activity, and interactions with inosine monophosphate dehydrogenase.
AID95968Compound was tested for its effect on GTP ribonucleotide levels of K562 cell at 10 uM concentration1995Journal of medicinal chemistry, Sep-15, Volume: 38, Issue:19
Furanfurin and thiophenfurin: two novel tiazofurin analogues. Synthesis, structure, antitumor activity, and interactions with inosine monophosphate dehydrogenase.
AID96164Inhibitory concentration against K562 human myelogenous leukemia cell line1995Journal of medicinal chemistry, Sep-15, Volume: 38, Issue:19
Furanfurin and thiophenfurin: two novel tiazofurin analogues. Synthesis, structure, antitumor activity, and interactions with inosine monophosphate dehydrogenase.
AID101496Ability to inhibit the growth of human myelogenous leukemia K562 cells2001Bioorganic & medicinal chemistry letters, Jan-08, Volume: 11, Issue:1
A new C-nucleoside analogue of tiazofurin: synthesis and biological evaluation of 2-beta-D-ribofuranosylimidazole-4-carboxamide (imidazofurin).
AID9872Compound was tested for antiproliferative activity against ACHN, human renal adenocarcinoma1997Journal of medicinal chemistry, May-23, Volume: 40, Issue:11
Synthesis, structure, and antiproliferative activity of selenophenfurin, an inosine 5'-monophosphate dehydrogenase inhibitor analogue of selenazofurin.
AID95984Compound was tested for its effect on UDP ribonucleotide levels of K562 cell at 50 uM concentration1995Journal of medicinal chemistry, Sep-15, Volume: 38, Issue:19
Furanfurin and thiophenfurin: two novel tiazofurin analogues. Synthesis, structure, antitumor activity, and interactions with inosine monophosphate dehydrogenase.
AID95988Compound was tested for its effect on UMP ribonucleotide levels of K562 cell at 10 uM concentration1995Journal of medicinal chemistry, Sep-15, Volume: 38, Issue:19
Furanfurin and thiophenfurin: two novel tiazofurin analogues. Synthesis, structure, antitumor activity, and interactions with inosine monophosphate dehydrogenase.
AID95815Compound was tested for its effect on CTP ribonucleotide levels of K562 cell at 100 uM concentration1995Journal of medicinal chemistry, Sep-15, Volume: 38, Issue:19
Furanfurin and thiophenfurin: two novel tiazofurin analogues. Synthesis, structure, antitumor activity, and interactions with inosine monophosphate dehydrogenase.
AID95802Compound was tested for its effect on AMP ribonucleotide levels of K562 cell at 10 uM concentration1995Journal of medicinal chemistry, Sep-15, Volume: 38, Issue:19
Furanfurin and thiophenfurin: two novel tiazofurin analogues. Synthesis, structure, antitumor activity, and interactions with inosine monophosphate dehydrogenase.
AID94650Formation of NAD analogue by compound at 50 uM concentration against human myelogenous leukemia K5621995Journal of medicinal chemistry, Sep-15, Volume: 38, Issue:19
Furanfurin and thiophenfurin: two novel tiazofurin analogues. Synthesis, structure, antitumor activity, and interactions with inosine monophosphate dehydrogenase.
AID121004Compound was tested for ratio of survival time of treated to control mice x100 at 400 mg/kg dose1995Journal of medicinal chemistry, Sep-15, Volume: 38, Issue:19
Furanfurin and thiophenfurin: two novel tiazofurin analogues. Synthesis, structure, antitumor activity, and interactions with inosine monophosphate dehydrogenase.
AID88522Compound was tested for antiproliferative activity against HeLa, human cervix carcinoma1997Journal of medicinal chemistry, May-23, Volume: 40, Issue:11
Synthesis, structure, and antiproliferative activity of selenophenfurin, an inosine 5'-monophosphate dehydrogenase inhibitor analogue of selenazofurin.
AID95818Compound was tested for its effect on CTP ribonucleotide levels of K562 cell at 50 uM concentration1995Journal of medicinal chemistry, Sep-15, Volume: 38, Issue:19
Furanfurin and thiophenfurin: two novel tiazofurin analogues. Synthesis, structure, antitumor activity, and interactions with inosine monophosphate dehydrogenase.
AID95778Compound was tested for its effect on IMPDH activity against K562 cells at 10 uM concentration1995Journal of medicinal chemistry, Sep-15, Volume: 38, Issue:19
Furanfurin and thiophenfurin: two novel tiazofurin analogues. Synthesis, structure, antitumor activity, and interactions with inosine monophosphate dehydrogenase.
AID95981Compound was tested for its effect on UDP ribonucleotide levels of K562 cell at 100 uM concentration1995Journal of medicinal chemistry, Sep-15, Volume: 38, Issue:19
Furanfurin and thiophenfurin: two novel tiazofurin analogues. Synthesis, structure, antitumor activity, and interactions with inosine monophosphate dehydrogenase.
AID121003Compound was tested for ratio of survival time of treated to control mice x100 at 25 mg/kg dose1995Journal of medicinal chemistry, Sep-15, Volume: 38, Issue:19
Furanfurin and thiophenfurin: two novel tiazofurin analogues. Synthesis, structure, antitumor activity, and interactions with inosine monophosphate dehydrogenase.
AID95807Compound was tested for its effect on ATP ribonucleotide levels of K562 cell at 10 uM concentration1995Journal of medicinal chemistry, Sep-15, Volume: 38, Issue:19
Furanfurin and thiophenfurin: two novel tiazofurin analogues. Synthesis, structure, antitumor activity, and interactions with inosine monophosphate dehydrogenase.
AID165775Compound was tested for antiproliferative activity against Raji, human Burkitt lymphoma1997Journal of medicinal chemistry, May-23, Volume: 40, Issue:11
Synthesis, structure, and antiproliferative activity of selenophenfurin, an inosine 5'-monophosphate dehydrogenase inhibitor analogue of selenazofurin.
AID98926Inhibitory concentration against L1210 murine lymphocytic leukemia1995Journal of medicinal chemistry, Sep-15, Volume: 38, Issue:19
Furanfurin and thiophenfurin: two novel tiazofurin analogues. Synthesis, structure, antitumor activity, and interactions with inosine monophosphate dehydrogenase.
AID94626Compound was tested for its influence on the GTP (Glucose triphosphate) ribonucleotide level in K562 cells1997Journal of medicinal chemistry, May-23, Volume: 40, Issue:11
Synthesis, structure, and antiproliferative activity of selenophenfurin, an inosine 5'-monophosphate dehydrogenase inhibitor analogue of selenazofurin.
AID95974Compound was tested for its effect on IMP ribonucleotide levels of K562 cell at 50 uM concentration1995Journal of medicinal chemistry, Sep-15, Volume: 38, Issue:19
Furanfurin and thiophenfurin: two novel tiazofurin analogues. Synthesis, structure, antitumor activity, and interactions with inosine monophosphate dehydrogenase.
AID110746Average weight change of mice from onset to termination of drug treatment at 400 mg/kg dose; early death due to toxicity1995Journal of medicinal chemistry, Sep-15, Volume: 38, Issue:19
Furanfurin and thiophenfurin: two novel tiazofurin analogues. Synthesis, structure, antitumor activity, and interactions with inosine monophosphate dehydrogenase.
AID95813Compound was tested for its effect on CDP ribonucleotide levels of K562 cell at 50 uM concentration1995Journal of medicinal chemistry, Sep-15, Volume: 38, Issue:19
Furanfurin and thiophenfurin: two novel tiazofurin analogues. Synthesis, structure, antitumor activity, and interactions with inosine monophosphate dehydrogenase.
AID121002Compound was tested for ratio of survival time of treated to control mice x100 at 100 mg/kg dose1995Journal of medicinal chemistry, Sep-15, Volume: 38, Issue:19
Furanfurin and thiophenfurin: two novel tiazofurin analogues. Synthesis, structure, antitumor activity, and interactions with inosine monophosphate dehydrogenase.
AID92485Inhibitory activity against Inosine-5'-monophosphate dehydrogenase in human myelogenous leukemia K562 cells in culture.2000Journal of medicinal chemistry, Apr-06, Volume: 43, Issue:7
Synthesis, conformational analysis, and biological activity of C-thioribonucleosides related to tiazofurin.
AID39253Inhibitory concentration against B16 melanoma cell lines1995Journal of medicinal chemistry, Sep-15, Volume: 38, Issue:19
Furanfurin and thiophenfurin: two novel tiazofurin analogues. Synthesis, structure, antitumor activity, and interactions with inosine monophosphate dehydrogenase.
AID95822Compound was tested for its effect on GDP ribonucleotide levels of K562 cell at 10 uM concentration1995Journal of medicinal chemistry, Sep-15, Volume: 38, Issue:19
Furanfurin and thiophenfurin: two novel tiazofurin analogues. Synthesis, structure, antitumor activity, and interactions with inosine monophosphate dehydrogenase.
AID95971Compound was tested for its effect on IMP ribonucleotide levels of K562 cell at 100 uM concentration1995Journal of medicinal chemistry, Sep-15, Volume: 38, Issue:19
Furanfurin and thiophenfurin: two novel tiazofurin analogues. Synthesis, structure, antitumor activity, and interactions with inosine monophosphate dehydrogenase.
AID95983Compound was tested for its effect on UDP ribonucleotide levels of K562 cell at 10 uM concentration1995Journal of medicinal chemistry, Sep-15, Volume: 38, Issue:19
Furanfurin and thiophenfurin: two novel tiazofurin analogues. Synthesis, structure, antitumor activity, and interactions with inosine monophosphate dehydrogenase.
AID102181Inhibitory concentration against LoVo human colon adenocarcinoma cell lines1995Journal of medicinal chemistry, Sep-15, Volume: 38, Issue:19
Furanfurin and thiophenfurin: two novel tiazofurin analogues. Synthesis, structure, antitumor activity, and interactions with inosine monophosphate dehydrogenase.
AID95800Compound was tested for its effect on AMP ribonucleotide levels of K562 cell at 100 uM concentration1995Journal of medicinal chemistry, Sep-15, Volume: 38, Issue:19
Furanfurin and thiophenfurin: two novel tiazofurin analogues. Synthesis, structure, antitumor activity, and interactions with inosine monophosphate dehydrogenase.
AID95779Compound was tested for its effect on IMPDH activity against K562 cells at 50 uM concentration1995Journal of medicinal chemistry, Sep-15, Volume: 38, Issue:19
Furanfurin and thiophenfurin: two novel tiazofurin analogues. Synthesis, structure, antitumor activity, and interactions with inosine monophosphate dehydrogenase.
AID91396Compound was tested for its effect on IMPDH (Inosine 5`-monophosphate dehydrogenase) activity in K562 cells in culture.1997Journal of medicinal chemistry, May-23, Volume: 40, Issue:11
Synthesis, structure, and antiproliferative activity of selenophenfurin, an inosine 5'-monophosphate dehydrogenase inhibitor analogue of selenazofurin.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (7)

TimeframeStudies, This Drug (%)All Drugs %
pre-19900 (0.00)18.7374
1990's4 (57.14)18.2507
2000's3 (42.86)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 12.15

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be weak demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index12.15 (24.57)
Research Supply Index2.08 (2.92)
Research Growth Index4.23 (4.65)
Search Engine Demand Index0.00 (26.88)
Search Engine Supply Index0.00 (0.95)

This Compound (12.15)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews1 (14.29%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other6 (85.71%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]
SubstanceRelationship StrengthStudiesTrialsClassesRoles
oxazoles
Oxazoles: Five-membered heterocyclic ring structures containing an oxygen in the 1-position and a nitrogen in the 3-position, in distinction from ISOXAZOLES where they are at the 1,2 positions.. 1,3-oxazole : A five-membered monocyclic heteroarene that is an analogue of cyclopentadiene with O in place of CH2 at position 1 and N in place of CH at position 3.. oxazole : An azole based on a five-membered heterocyclic aromatic skeleton containing one N and one O atom.		3.1101,3-oxazoles;
mancude organic heteromonocyclic parent;
monocyclic heteroarene
ribavirin
Rebetron: Rebetron is tradename		3.49201-ribosyltriazole;
aromatic amide;
monocarboxylic acid amide;
primary carboxamide		anticoronaviral agent;
antiinfective agent;
antimetabolite;
antiviral agent;
EC 2.7.7.49 (RNA-directed DNA polymerase) inhibitor
selenazofurin
selenazofurin: selenazole analog of tiazofurin		3.520
tretinoin
Tretinoin: An important regulator of GENE EXPRESSION during growth and development, and in NEOPLASMS. Tretinoin, also known as retinoic acid and derived from maternal VITAMIN A, is essential for normal GROWTH; and EMBRYONIC DEVELOPMENT. An excess of tretinoin can be teratogenic. It is used in the treatment of PSORIASIS; ACNE VULGARIS; and several other SKIN DISEASES. It has also been approved for use in promyelocytic leukemia (LEUKEMIA, PROMYELOCYTIC, ACUTE).. retinoic acid : A retinoid consisting of 3,7-dimethylnona-2,4,6,8-tetraenoic acid substituted at position 9 by a 2,6,6-trimethylcyclohex-1-en-1-yl group (geometry of the four exocyclic double bonds is not specified).. all-trans-retinoic acid : A retinoic acid in which all four exocyclic double bonds have E- (trans-) geometry.		2.0310retinoic acid;
vitamin A		anti-inflammatory agent;
antineoplastic agent;
antioxidant;
AP-1 antagonist;
human metabolite;
keratolytic drug;
retinoic acid receptor agonist;
retinoid X receptor agonist;
signalling molecule
mycophenolic acid
Mycophenolic Acid: Compound derived from Penicillium stoloniferum and related species. It blocks de novo biosynthesis of purine nucleotides by inhibition of the enzyme inosine monophosphate dehydrogenase (IMP DEHYDROGENASE). Mycophenolic acid exerts selective effects on the immune system in which it prevents the proliferation of T-CELLS, LYMPHOCYTES, and the formation of antibodies from B-CELLS. It may also inhibit recruitment of LEUKOCYTES to sites of INFLAMMATION.. mycophenolate : A monocarboxylic acid anion resulting from the removal of a proton from the carboxy group of mycophenolic acid.. mycophenolic acid : A member of the class of 2-benzofurans that is 2-benzofuran-1(3H)-one which is substituted at positions 4, 5, 6, and 7 by methyl, methoxy, (2E)-5-carboxy-3-methylpent-2-en-1-yl, and hydroxy groups, respectively. It is an antibiotic produced by Penicillium brevi-compactum, P. stoloniferum, P. echinulatum and related species. An immunosuppressant, it is widely used (partiularly as its sodium salt and as the 2-(morpholin-4-yl)ethyl ester prodrug, mycophenolate mofetil) to prevent tissue rejection following organ transplants and for the treatment of certain autoimmune diseases.		3.1102-benzofurans;
gamma-lactone;
monocarboxylic acid;
phenols		anticoronaviral agent;
antimicrobial agent;
antineoplastic agent;
EC 1.1.1.205 (IMP dehydrogenase) inhibitor;
environmental contaminant;
immunosuppressive agent;
mycotoxin;
Penicillium metabolite;
xenobiotic
tiazofurin
tiazofurin: RN given refers to (beta-D)-isomer; structure given in first source. tiazofurine : A C-glycosyl compound that is 1,3-thiazole-4-carboxamide in which the hydrogen at position 2 has been replaced by a beta-D-ribofuranosyl group. It is metabolised to thiazole-4-carboxamide adenine dinucleotide (TAD), a selective inhibitor of inosine monophosphate dehydrogenase (IMP dehydrogenase).		8.78301,3-thiazoles;
C-glycosyl compound;
monocarboxylic acid amide		antineoplastic agent;
EC 1.1.1.205 (IMP dehydrogenase) inhibitor;
prodrug
ribose
ribopyranose : The pyranose form of ribose.		3.110D-ribose;
ribopyranose
nad
NAD(1-) : An anionic form of nicotinamide adenine dinucleotide arising from deprotonation of the two OH groups of the diphosphate moiety.		2.3920organophosphate oxoanioncofactor;
human metabolite;
hydrogen acceptor;
Saccharomyces cerevisiae metabolite
inosinic acid
Inosine Monophosphate: Inosine 5'-Monophosphate. A purine nucleotide which has hypoxanthine as the base and one phosphate group esterified to the sugar moiety.		1.9810inosine phosphate;
purine ribonucleoside 5'-monophosphate		Escherichia coli metabolite;
human metabolite;
mouse metabolite
ConditionIndicatedRelationship StrengthStudiesTrials
Benign Neoplasms
[description not available]		02.3920
Neoplasms
New abnormal growth of tissue. Malignant neoplasms show a greater degree of anaplasia and have the properties of invasion and metastasis, compared to benign neoplasms.		02.3920
Leucocythaemia
[description not available]		01.9910
Germinoblastoma
[description not available]		01.9910
Leukemia
A progressive, malignant disease of the blood-forming organs, characterized by distorted proliferation and development of leukocytes and their precursors in the blood and bone marrow. Leukemias were originally termed acute or chronic based on life expectancy but now are classified according to cellular maturity. Acute leukemias consist of predominately immature cells; chronic leukemias are composed of more mature cells. (From The Merck Manual, 2006)		01.9910
Lymphoma
A general term for various neoplastic diseases of the lymphoid tissue.		01.9910