Page last updated: 2024-09-28

Hemorrhagic Fever, American

Diseases caused by American hemorrhagic fever viruses (ARENAVIRUSES, NEW WORLD).

Synonyms(3)

Synonym
Hemorrhagic Fever, Bolivian
Hemorrhagic Fever, Argentinian
Hemorrhagic Fever, American

Research

Studies (63)

TimeframeStudies, This Condition (%)All Conditions %
pre-199036 (57.14)23.3326
1990's13 (20.63)12.5806
2000's2 (3.17)18.1394
2010's9 (14.29)28.8240
2020's3 (4.76)9.53
DrugIndicatedRelationship StrengthStudiesTrials
formaldehyde0low10
caffeine0low10
gentamicin0low10
2-(4-morpholinyl)-8-phenyl-4h-1-benzopyran-4-one0low20
tilorone0low10
adenosine diphosphate0low10
desoxycorticosterone0low10
cytarabine0low30
thiazoles0low10
pyrazines0low60
fluorescein-5-isothiocyanate0low10
levamisole0low10
phenyl acetate0low10
cetylpyridinium chloride anhydrous0low10
oxisuran0low10
ribavirin0low160
fomesafen0low10
trazodone hydrochloride0low10
fibrinogen0low30
selenazofurin0low10
1-hexadecyl-2-acetyl-glycero-3-phosphocholine0low20
arachidonic acid0low10
taribavirin0low10
favipiravir0low60
thiourea0low10
asialo gm1 ganglioside0low10
g(m1) ganglioside0low10
calcimycin0low10
acid phosphatase0low10
atrial natriuretic factor0low10
ristocetin0low10
interleukin-80low10
muramidase0low10

Protein Targets (434)

ProteinPotency MeasurementsInhibition MeasurementsActivation MeasurementsDrugs
Chain A, MAJOR APURINIC/APYRIMIDINIC ENDONUCLEASE4004
Chain A, Cruzipain4004
regulator of G-protein signaling 44004
Platelet-activating factor receptor0202
Inositol monophosphatase 13003
Chain A, Proto-oncogene serine/threonine-protein kinase Pim-10101
Chain A, Proto-oncogene serine/threonine-protein kinase Pim-10101
Chain A, HADH2 protein3003
Chain B, HADH2 protein3003
Chain A, 2-oxoglutarate Oxygenase4004
Chain A, Methyltransferase Wbdd0101
thioredoxin reductase5005
15-lipoxygenase, partial2002
ATAD5 protein, partial2002
NFKB1 protein, partial1001
TDP1 protein9009
Thrombopoietin2002
aldehyde dehydrogenase 1 family, member A16006
hypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)1001
thyroid stimulating hormone receptor4004
EWS/FLI fusion protein2002
67.9K protein5005
Parkin2002
euchromatic histone-lysine N-methyltransferase 27007
cytochrome P450 2D6 isoform 11001
cellular tumor antigen p53 isoform a2002
cytochrome P450 2C19 precursor1001
cytochrome P450 2C9 precursor1001
chromobox protein homolog 16006
flap endonuclease 13003
serine/threonine-protein kinase mTOR isoform 13003
survival motor neuron protein isoform d5005
cytochrome P450 3A4 isoform 13003
M-phase phosphoprotein 81001
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform0102
cGMP-dependent 3',5'-cyclic phosphodiesterase0101
Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit alpha0101
Serine/threonine-protein kinase PLK40101
Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit beta0101
Gamma-aminobutyric acid receptor subunit pi3003
Polyunsaturated fatty acid lipoxygenase ALOX15B2002
Bromodomain-containing protein 40101
5-hydroxytryptamine receptor 40202
cGMP-specific 3',5'-cyclic phosphodiesterase0101
Integrin beta-31001
Cytochrome P450 1A20101
Integrin alpha-IIb1001
Neuronal acetylcholine receptor subunit alpha-40101
Serine/threonine-protein kinase pim-10101
Neuronal acetylcholine receptor subunit beta-20101
Gamma-aminobutyric acid receptor subunit beta-13003
Gamma-aminobutyric acid receptor subunit delta3003
Gamma-aminobutyric acid receptor subunit gamma-23003
Casein kinase II subunit alpha'0101
Gamma-aminobutyric acid receptor subunit alpha-53003
Gamma-aminobutyric acid receptor subunit alpha-33003
Gamma-aminobutyric acid receptor subunit gamma-13003
Gamma-aminobutyric acid receptor subunit alpha-23003
Proteinase-activated receptor 10001
Bromodomain-containing protein 20101
Phosphatidylinositol 3-kinase regulatory subunit alpha0102
5-hydroxytryptamine receptor 2A0202
5-hydroxytryptamine receptor 2C0202
Gamma-aminobutyric acid receptor subunit alpha-43003
Gamma-aminobutyric acid receptor subunit gamma-33003
Gamma-aminobutyric acid receptor subunit alpha-63003
Sodium-dependent serotonin transporter0202
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform0101
Type-1 angiotensin II receptor0101
5-hydroxytryptamine receptor 2B0202
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform0203
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform 0101
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform0103
Serine/threonine-protein kinase mTOR0202
Serine/threonine-protein kinase mTOR0101
Histamine H2 receptor2002
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform 0203
Glycogen synthase kinase-3 beta0101
D(1A) dopamine receptor3003
Serine/threonine-protein kinase PLK10202
Gamma-aminobutyric acid receptor subunit alpha-13003
Gamma-aminobutyric acid receptor subunit beta-33003
Gamma-aminobutyric acid receptor subunit beta-23003
Casein kinase II subunit beta0101
Casein kinase II subunit alpha0101
DNA-dependent protein kinase catalytic subunit0303
Mu-type opioid receptor0101
Serine-protein kinase ATM0303
cGMP-inhibited 3',5'-cyclic phosphodiesterase B0101
Serine/threonine-protein kinase ATR0303
cGMP-inhibited 3',5'-cyclic phosphodiesterase A0101
Bromodomain-containing protein 30101
Serine/threonine-protein kinase pim-30101
Phosphoinositide 3-kinase regulatory subunit 50101
GABA theta subunit3003
Gamma-aminobutyric acid receptor subunit epsilon3003
Serine/threonine-protein kinase PLK30202
Serine/threonine-protein kinase PLK20101
ATP-dependent phosphofructokinase5005
Chain A, Heat Shock Protein 900011
Chain A, GLUTAMINE PHOSPHORIBOSYLPYROPHOSPHATE AMIDOTRANSFERASE0011
Chain B, GLUTAMINE PHOSPHORIBOSYLPYROPHOSPHATE AMIDOTRANSFERASE0011
Chain A, EOSINOPHIL-DERIVED NEUROTOXIN0101
Chain A, EOSINOPHIL-DERIVED NEUROTOXIN0101
Chain A, EOSINOPHIL-DERIVED NEUROTOXIN0101
Chain A, Myosin Ie Heavy Chain0011
Chain A, Preprotein translocase secA0011
Chain A, Ribonuclease pancreatic0101
Chain A, Ribonuclease pancreatic0101
Chain A, Ribonuclease pancreatic0101
Chain A, Ribonuclease pancreatic0101
Chain A, Ribonuclease pancreatic0101
Chain A, Phosphoribosylformylglycinamidine synthase0101
Chain A, nucleoside diphosphate kinase A0011
Chain B, nucleoside diphosphate kinase A0011
Chain D, DNA polymerase III subunit gamma0011
Chain D, DNA polymerase III subunit gamma0011
Chain A [Pyruvate dehydrogenase [lipoamide]] kinase isozyme 30011
Chain A [Pyruvate dehydrogenase [lipoamide]] kinase isozyme 30011
Chain A, Kinesin-like protein KIF110101
HPr kinase/phosphorylase0011
Mitogen-activated protein kinase kinase kinase 70011
ATP-dependent molecular chaperone HSP820001
Heat shock protein HSP 90-alpha0113
Heat shock protein HSP 90-beta0113
2-dehydropantoate 2-reductase0112
Heat shock 70 kDa protein 1A 0112
Endoplasmic reticulum chaperone BiP0011
Heat shock cognate 71 kDa protein0011
Pyruvate kinase PKM 0001
Pyruvate kinase PKLR 0001
Endoplasmin0001
Heat shock cognate 71 kDa protein0011
5'-nucleotidase0202
Mu-type opioid receptor0011
Delta-type opioid receptor0011
Kappa-type opioid receptor0011
Endoplasmin0112
P2Y purinoceptor 20011
Phosphatidylinositol 4-kinase alpha0202
P2X purinoceptor 10011
P2Y purinoceptor 10011
P2Y purinoceptor 10011
P2X purinoceptor 10011
P2X purinoceptor 40011
P2X purinoceptor 50011
P2X purinoceptor 60011
P2X purinoceptor 30011
Heat shock protein 75 kDa, mitochondrial0101
P2Y purinoceptor 60011
Phosphatidylinositol 4-kinase type 2-beta0202
P2Y purinoceptor 110011
Phosphatidylinositol 4-kinase type 2-alpha0202
P2Y purinoceptor 120011
Sensor protein kinase WalK0101
Phosphatidylinositol 4-kinase beta0202
P2X purinoceptor 20011
Chain A, ADIPOCYTE LIPID-BINDING PROTEIN0011
Chain A, SERUM ALBUMIN0011
Chain A, SERUM ALBUMIN0011
Chain A, TYROSYL-DNA PHOSPHODIESTERASE2002
Chain A, Beta-lactamase1001
Chain A, ATP-DEPENDENT DNA HELICASE Q12002
phosphopantetheinyl transferase4004
USP1 protein, partial5005
Microtubule-associated protein tau5005
thioredoxin glutathione reductase1001
heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa)3003
Bloom syndrome protein isoform 12002
15-hydroxyprostaglandin dehydrogenase [NAD(+)] isoform 13003
vitamin D3 receptor isoform VDRA3003
ubiquitin carboxyl-terminal hydrolase 2 isoform a1001
nuclear receptor ROR-gamma isoform 15005
lethal(3)malignant brain tumor-like protein 1 isoform I1001
DNA polymerase kappa isoform 13003
histone acetyltransferase KAT2A isoform 12002
DNA dC->dU-editing enzyme APOBEC-3G isoform 11001
caspase-1 isoform alpha precursor1001
lamin isoform A-delta104004
Fatty-acid amide hydrolase 10101
Prostaglandin G/H synthase 1 0001
Trypsin0101
Coagulation factor VII0101
60 kDa chaperonin0101
60 kDa heat shock protein, mitochondrial0101
Aromatase0101
Tissue factor0101
Fatty acid-binding protein, adipocyte0112
Prostaglandin G/H synthase 20012
Nuclear receptor subfamily 4 group A member 20011
10 kDa heat shock protein, mitochondrial0101
Calmodulin 0001
Disintegrin and metalloproteinase domain-containing protein 171001
Prostaglandin G/H synthase 20001
Solute carrier organic anion transporter family member 2A10001
Fatty acid-binding protein 50101
Fatty acid-binding protein 50011
Thiosulfate sulfurtransferase0101
Lanosterol 14-alpha demethylase0101
60 kDa chaperonin 0101
10 kDa chaperonin 0101
Solute carrier organic anion transporter family member 1B30202
Cytosolic phospholipase A2 gamma0101
Transient receptor potential cation channel subfamily V member 20101
Solute carrier organic anion transporter family member 1B10202
Atrial natriuretic peptide receptor 10011
Atrial natriuretic peptide receptor 1 0011
Chain A, Glycogen Phosphorylase0101
Chain A, Glycogen phosphorylase, liver form0011
Chain A, glycogen phosphorylase, liver form0011
Chain A, Glycogen phosphorylase, liver form0011
Chain A, Glycogen phosphorylase, liver form0011
Chain A, Chitinase0101
RAR-related orphan receptor gamma6006
GLS protein2002
GLI family zinc finger 35005
AR protein8008
nuclear receptor subfamily 1, group I, member 37007
glucocorticoid receptor [Homo sapiens]5005
retinoic acid nuclear receptor alpha variant 16006
retinoid X nuclear receptor alpha5005
estrogen-related nuclear receptor alpha110011
farnesoid X nuclear receptor4004
pregnane X nuclear receptor6006
estrogen nuclear receptor alpha100010
thyroid stimulating hormone receptor2002
v-jun sarcoma virus 17 oncogene homolog (avian)3003
atrial natriuretic peptide receptor 1 precursor2002
thyroid hormone receptor beta isoform a2002
thyroid hormone receptor beta isoform 26006
DNA polymerase beta1001
nuclear factor erythroid 2-related factor 2 isoform 17007
geminin7007
muscarinic acetylcholine receptor M12002
lethal factor (plasmid)1001
ATP-binding cassette sub-family C member 30505
Multidrug resistance-associated protein 40505
Voltage-dependent calcium channel gamma-2 subunit6006
Potassium channel subfamily K member 20011
Bile salt export pump0707
Glycogen phosphorylase, muscle form0101
Renin0101
Carbonic anhydrase 10101
Carbonic anhydrase 20101
Cholinesterase0101
Glycogen phosphorylase, liver form0101
Glycogen phosphorylase, muscle form0101
Replicase polyprotein 1ab0112
Adenosine receptor A30202
Replicase polyprotein 1ab0213
Glutamate receptor 26006
Amine oxidase [flavin-containing] A0101
Acetylcholinesterase0101
Adenosine receptor A10203
Amine oxidase [flavin-containing] B0202
cAMP-specific 3',5'-cyclic phosphodiesterase 4A0101
Adenosine receptor A30101
Adenosine receptor A2a0315
Adenosine receptor A2b0102
Adenosine receptor A2b0203
Adenosine receptor A10215
Adenosine receptor A2a0204
Vasopressin V2 receptor0001
Adenosine receptor A2a0101
Adenosine receptor A10101
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B0101
Adenylate cyclase type 10001
Chitotriosidase-10101
Adenosine receptor A2b0102
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1C0101
Palmitoleoyl-protein carboxylesterase NOTUM0123
Endochitinase B10101
Muscarinic acetylcholine receptor0001
Canalicular multispecific organic anion transporter 10404
Phosphodiesterase 0101
Broad substrate specificity ATP-binding cassette transporter ABCG20101
Guanine deaminase0101
Chain A, Putative fructose-1,6-bisphosphate aldolase1001
Chain A, JmjC domain-containing histone demethylation protein 3A1001
Chain A, Ferritin light chain3003
acid sphingomyelinase2002
endonuclease IV2002
glp-1 receptor, partial2002
ClpP1001
electroneutral potassium-chloride cotransporter KCC20011
Fumarate hydratase2002
TSHR protein1001
Smad31001
apical membrane antigen 1, AMA11001
nonstructural protein 11001
polyprotein2002
glucocerebrosidase1001
arylsulfatase A2002
LacZ protein (plasmid)0011
XBP10101
IDH12002
serine-protein kinase ATM isoform a2002
lysosomal alpha-glucosidase preproprotein1001
hexokinase-4 isoform 11001
NPC intracellular cholesterol transporter 1 precursor1001
peripheral myelin protein 22 isoform 12002
type-1 angiotensin II receptor0101
D(1A) dopamine receptor1001
nuclear factor erythroid 2-related factor 2 isoform 24004
parathyroid hormone/parathyroid hormone-related peptide receptor precursor1001
potassium voltage-gated channel subfamily H member 2 isoform d2002
glucokinase regulatory protein1001
huntingtin isoform 21001
mitogen-activated protein kinase 13003
ras-related protein Rab-9A1001
serine/threonine-protein kinase PLK11001
apelin receptor0101
heat shock protein HSP 90-alpha isoform 20001
DNA polymerase iota isoform a (long)2002
DNA damage-inducible transcript 3 protein0101
urokinase-type plasminogen activator precursor3003
plasminogen precursor3003
urokinase plasminogen activator surface receptor precursor3003
Vpr1001
streptokinase A precursor0011
neuropeptide S receptor isoform A1001
Rap guanine nucleotide exchange factor 32002
Amyloid-beta precursor protein1001
Alpha-synuclein1001
Guanine nucleotide-binding protein G1001
TAR DNA-binding protein 432002
Ataxin-24004
HSP40, subfamily A [Plasmodium falciparum 3D7]0001
heat shock protein 90, putative0001
acetylcholinesterase2002
hypoxia-inducible factor 1 alpha subunit3003
SMAD family member 22002
SMAD family member 32002
caspase 7, apoptosis-related cysteine protease1001
estrogen receptor 2 (ER beta)2002
progesterone receptor5005
peroxisome proliferator-activated receptor delta4004
peroxisome proliferator activated receptor gamma5005
vitamin D (1,25- dihydroxyvitamin D3) receptor5005
caspase-31001
cytochrome P450, family 19, subfamily A, polypeptide 1, isoform CRA_a4004
activating transcription factor 62002
thyrotropin-releasing hormone receptor2002
heat shock protein beta-12002
Cellular tumor antigen p535005
Caspase-20011
ATPase family AAA domain-containing protein 51001
cytochrome P450 family 3 subfamily A polypeptide 44004
G1001
LMP1 [Human herpesvirus 4]0002
Histone H2A.x5005
nuclear receptor coactivator 1 isoform 1 [Homo sapiens]0101
peptidyl-prolyl cis-trans isomerase NIMA-interacting 11001
transactivating tegument protein VP16 [Human herpesvirus 1]0101
peripheral myelin protein 222002
nuclear receptor coactivator 3 isoform a0101
Thymidine kinase 2, mitochondrial0101
Interferon beta3003
HLA class I histocompatibility antigen, B alpha chain 1001
Thymidine kinase, cytosolic0101
Thymidine kinase0101
Thymidylate synthase0001
Cytochrome P450 3A40101
Thymidine kinase0101
Deoxycytidine kinase0001
Probable deoxycytidylate deaminase0001
Cytidine deaminase0102
E3 ubiquitin-protein ligase Mdm20101
Enoyl-[acyl-carrier-protein] reductase [NADH] 0101
Inositol hexakisphosphate kinase 11001
Thymidine kinase0101
Deoxynucleoside kinase0101
cytochrome P450 2C9, partial1001
GALC protein1001
nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 (p105), isoform CRA_a3003
nuclear receptor subfamily 1, group I, member 21001
Solute carrier family 22 member 30101
Sex hormone-binding globulin0011
Corticosteroid-binding globulin0101
Solute carrier family 22 member 20101
Luciferase2002
dopamine D1 receptor1001
cytochrome P450 2D62002
Alkaline phosphatase, tissue-nonspecific isozyme0202
Alkaline phosphatase, placental type0101
Alkaline phosphatase, tissue-nonspecific isozyme 0202
Intestinal-type alkaline phosphatase0101
Intestinal-type alkaline phosphatase0101
Phospholipase A-2-activating protein0101
NS5 0011
interleukin 81001
alpha-galactosidase1001
Spike glycoprotein0011
Replicase polyprotein 1ab0011
glycogen synthase kinase-3 beta isoform 10011
Transmembrane protease serine 20011
Voltage-dependent L-type calcium channel subunit alpha-1F0101
Polymerase basic protein 20011
RNA-directed RNA polymerase catalytic subunit0011
Polymerase acidic protein0011
Procathepsin L0011
Replicase polyprotein 1a0011
Replicase polyprotein 1ab0011
Adenosylhomocysteinase0002
Nuclear receptor ROR-gamma2002
Spike glycoprotein0011
Voltage-dependent L-type calcium channel subunit alpha-1D 0101
Voltage-dependent L-type calcium channel subunit alpha-1S0101
Voltage-dependent L-type calcium channel subunit alpha-1C0101
Adenosine receptor A10101
Genome polyprotein0011
Angiotensin-converting enzyme 2 0011
isocitrate dehydrogenase 1, partial1001
aryl hydrocarbon receptor1001
Alcohol dehydrogenase E chain0101
Alcohol dehydrogenase S chain0101
Urease0203
5-hydroxytryptamine receptor 2A0101
Urease subunit alpha0101
D(3) dopamine receptor0101
5-hydroxytryptamine receptor 1A0101
Urease subunit alpha0101
Urease subunit beta0101
Urease subunit beta 0101
cystic fibrosis transmembrane conductance regulator0101
histone-lysine N-methyltransferase 2A isoform 2 precursor1001
Neuronal acetylcholine receptor subunit beta-20011
Neuronal acetylcholine receptor subunit beta-40011
Neuronal acetylcholine receptor subunit alpha-30011
Neuronal acetylcholine receptor subunit alpha-70011
Neuronal acetylcholine receptor subunit alpha-40011
DNA primase0101
Neuronal acetylcholine receptor subunit alpha-70011
HLA class I histocompatibility antigen, A alpha chain 0011
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]