| ID Source | ID |
|---|---|
| PubMed CID | 135564704 |
| MeSH ID | M0065402 |
| Synonym |
|---|
| direct black 3 |
| 2-naphthalenesulfonic acid, 6-amino-4-hydroxy-3-((4-(phenylazo)-1-naphthalenyl)azo)-, monosodium salt |
| unii-88c0ab64k7 |
| c.i. direct black 3, monosodium salt |
| 2-naphthalenesulfonic acid, 6-amino-4-hydroxy-3-(2-(4-(2-phenyldiazenyl)-1-naphthalenyl)diazenyl)-, sodium salt (1:1) |
| 88C0AB64K7 , |
| c.i. 27710 |
| benzo neutral grey rr |
| neutral grey gg |
| ci 27710 |
| c.i. direct black 3 |
| 6227-04-9 |
| Q27269920 |
| sodium 6-amino-4-hydroxy-3-((4-(phenyldiazenyl)naphthalen-1-yl)diazenyl)naphthalene-2-sulfonate |
| DTXSID601024128 |
| Excerpt | Relevance | Reference |
|---|---|---|
| " After 36-h exposure, there was still an indication of a weak dose-response effect between 0 and 5 net nuclear grains (NG)." | ( Induction of unscheduled DNA synthesis in liver and micronucleus in bone marrow of rats exposed in vivo to the benzidine-derived azo dye, Direct Black 38. Beije, B, 1987) | 0.27 |
| Timeframe | Studies, This Drug (%) | All Drugs % |
|---|---|---|
| pre-1990 | 22 (45.83) | 18.7374 |
| 1990's | 1 (2.08) | 18.2507 |
| 2000's | 13 (27.08) | 29.6817 |
| 2010's | 11 (22.92) | 24.3611 |
| 2020's | 1 (2.08) | 2.80 |
| [information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||
| Publication Type | This drug (%) | All Drugs (%) |
|---|---|---|
| Trials | 0 (0.00%) | 5.53% |
| Reviews | 0 (0.00%) | 6.00% |
| Case Studies | 4 (7.84%) | 4.05% |
| Observational | 0 (0.00%) | 0.25% |
| Other | 47 (92.16%) | 84.16% |
| [information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||
| Substance | Relationship Strength | Studies | Trials | Classes | Roles |
|---|---|---|---|---|---|
| methane Methane: The simplest saturated hydrocarbon. It is a colorless, flammable gas, slightly soluble in water. It is one of the chief constituents of natural gas and is formed in the decomposition of organic matter. (Grant & Hackh's Chemical Dictionary, 5th ed). methane : A one-carbon compound in which the carbon is attached by single bonds to four hydrogen atoms. It is a colourless, odourless, non-toxic but flammable gas (b.p. -161degreeC). | 2.02 | 1 | 0 | alkane; gas molecular entity; mononuclear parent hydride; one-carbon compound | bacterial metabolite; fossil fuel; greenhouse gas |
| dimethyl sulfoxide Dimethyl Sulfoxide: A highly polar organic liquid, that is used widely as a chemical solvent. Because of its ability to penetrate biological membranes, it is used as a vehicle for topical application of pharmaceuticals. It is also used to protect tissue during CRYOPRESERVATION. Dimethyl sulfoxide shows a range of pharmacological activity including analgesia and anti-inflammation.. dimethyl sulfoxide : A 2-carbon sulfoxide in which the sulfur atom has two methyl substituents. | 1.96 | 1 | 0 | sulfoxide; volatile organic compound | alkylating agent; antidote; Escherichia coli metabolite; geroprotector; MRI contrast agent; non-narcotic analgesic; polar aprotic solvent; radical scavenger |
| formaldehyde paraform: polymerized formaldehyde; RN given refers to parent cpd; used in root canal therapy | 2.07 | 1 | 0 | aldehyde; one-carbon compound | allergen; carcinogenic agent; disinfectant; EC 3.5.1.4 (amidase) inhibitor; environmental contaminant; Escherichia coli metabolite; mouse metabolite; Saccharomyces cerevisiae metabolite |
| phenol [no description available] | 2.1 | 1 | 0 | phenols | antiseptic drug; disinfectant; human xenobiotic metabolite; mouse metabolite |
| dithionite Dithionite: Dithionite. The dithionous acid ion and its salts. | 1.96 | 1 | 0 | sulfur oxide; sulfur oxoanion | |
| phenobarbital Phenobarbital: A barbituric acid derivative that acts as a nonselective central nervous system depressant. It potentiates GAMMA-AMINOBUTYRIC ACID action on GABA-A RECEPTORS, and modulates chloride currents through receptor channels. It also inhibits glutamate induced depolarizations.. phenobarbital : A member of the class of barbiturates, the structure of which is that of barbituric acid substituted at C-5 by ethyl and phenyl groups. | 7.05 | 1 | 0 | barbiturates | anticonvulsant; drug allergen; excitatory amino acid antagonist; sedative |
| 2,3,4,6-tetrachlorophenol 2,3,4,6-tetrachlorophenol: RN given refers to parent cpd; see also record for tetrachlorophenol with locants for chloro groups not specified. 2,3,4,6-tetrachlorophenol : A tetrachlorophenol in which the chlorines are located at positions 2, 3, 4, and 6. | 2.1 | 1 | 0 | tetrachlorophenol | xenobiotic metabolite |
| p-dimethylaminoazobenzene p-Dimethylaminoazobenzene: A reagent used mainly to induce experimental liver cancer. According to the Fourth Annual Report on Carcinogens (NTP 85-002, p. 89) published in 1985, this compound may reasonably be anticipated to be a carcinogen. (Merck, 11th ed) | 1.97 | 1 | 0 | azobenzenes | |
| 3,3'-dichlorobenzidine 3,3'-Dichlorobenzidine: A material used in the manufacture of azo dyes that is toxic to skin and carcinogenic in several species. | 7.37 | 2 | 0 | biphenyls; monochlorobenzenes; organochlorine compound | |
| 4-biphenylamine 4-biphenylamine: used in detection of sulfates, & as a carcinogen in cancer research; RN given refers to parent cpd; structure. biphenyl-4-amine : An aminobiphenyl that is biphenyl substituted by an amino group at position 4. | 2.67 | 3 | 0 | aminobiphenyl | carcinogenic agent |
| benzidine benzidine: RN given refers to parent cpd. benzidine : A member of the class of biphenyls that is 1,1'-biphenyl in which the hydrogen at the para-position of each phenyl group has been replaced by an amino group. | 3.36 | 7 | 0 | biphenyls; substituted aniline | carcinogenic agent |
| 2-chlorophenol chlorophenol : A halophenol that is any phenol containing one or more covalently bonded chlorine atoms. | 2.1 | 1 | 0 | 2-halophenol; monochlorophenol | |
| dianisidine Dianisidine: Highly toxic compound which can cause skin irritation and sensitization. It is used in manufacture of azo dyes. | 1.96 | 1 | 0 | biphenyls | |
| 2-tolidine 2-tolidine: RN given refers to parent cpd; structure | 1.96 | 1 | 0 | biphenyls | |
| 2-naphthol 2-naphthol: RN given refers to parent cpd. 2-naphthol : A naphthol carrying a hydroxy group at position 2.. naphthols : Any hydroxynaphthalene derivative that has a single hydroxy substituent. | 2.21 | 1 | 0 | naphthol | antinematodal drug; genotoxin; human urinary metabolite; human xenobiotic metabolite; mouse metabolite; radical scavenger |
| thiazoles [no description available] | 1.97 | 1 | 0 | 1,3-thiazoles; mancude organic heteromonocyclic parent; monocyclic heteroarene | |
| eosine yellowish-(ys) Eosine Yellowish-(YS): A versatile red dye used in cosmetics, pharmaceuticals, textiles, etc., and as tissue stain, vital stain, and counterstain with HEMATOXYLIN. It is also used in special culture media.. eosin YS dye : An organic sodium salt that is 2',4',5',7'-tetrabromofluorescein in which the carboxy group and the phenolic hydroxy group have been deprotonated and the resulting charge is neutralised by two sodium ions. | 2 | 1 | 0 | organic sodium salt; organobromine compound | fluorochrome; histological dye |
| 1-phenylazo-2-naphthol 1-phenylazo-2-naphthol: RN given refers to cpd without isomeric designation | 2.21 | 1 | 0 | ||
| potassium hydroxide potassium hydroxide: RN given refers to cpd with MF of K-OH | 2.78 | 3 | 0 | alkali metal hydroxide | |
| direct blue 15 direct blue 15: RN given refers to tetra-Na salt. Pontamine sky blue 5B : An organic sodium salt resulting from the formal condensation of Pontamine sky blue 5B (acid form) with four equivalents of sodium hydroxide. | 1.96 | 1 | 0 | ||
| direct blue 6 [no description available] | 7.65 | 3 | 0 | ||
| c.i. direct blue 1 [no description available] | 2.07 | 1 | 0 | ||
| n-acetylbenzidine [no description available] | 1.96 | 1 | 0 | ||
| 4-acetylaminobiphenyl [no description available] | 1.96 | 1 | 0 | biphenyls | |
| para red para red: a dye; structure in first source | 2.21 | 1 | 0 | ||
| titanium Titanium: A dark-gray, metallic element of widespread distribution but occurring in small amounts with atomic number, 22, atomic weight, 47.867 and symbol, Ti; specific gravity, 4.5; used for fixation of fractures. | 2.49 | 2 | 0 | titanium group element atom | |
| titanium dioxide titanium dioxide: used medically as protectant against externally caused irritation & sunlight; high concentrations of dust may cause irritation to respiratory tract; RN given refers to titanium oxide (TiO2); structure. titanium dioxide : A titanium oxide with the formula TiO2. A naturally occurring oxide sourced from ilmenite, rutile and anatase, it has a wide range of applications. | 2.49 | 2 | 0 | titanium oxides | food colouring |
| n,n-dimethyl-4-(6-benzothiazolylazo)aniline N,N-dimethyl-4-(6-benzothiazolylazo)aniline: do not confuse with 5-isomer (RN: 18463-90-6) also given this name in 9CI; structure | 1.97 | 1 | 0 | ||
| deoxyglucose Deoxyglucose: 2-Deoxy-D-arabino-hexose. An antimetabolite of glucose with antiviral activity.. deoxyglucose : A deoxyhexose comprising glucose having at least one hydroxy group replaced by hydrogen. | 2.02 | 1 | 0 | ||
| 4,4'-bis(2-di(2-hydroxyethyl)amino-4-(3-sulphophenylamino)-1,3,5-triazine-6-ylamino)stilbene-2,2'-disulphonic acid 2,5-bis(5-tert-butylbenzoxazol-2-yl)thiophene: a fluorescent brightener, as well as a photoinitiator of polymerization; structure in first source | 2.02 | 1 | 0 | ||
| eosine i bluish Eosine I Bluish: A red fluorescein dye used as a histologic stain. It may be cytotoxic, mutagenic, and inhibit certain mitochondrial functions. | 2.02 | 1 | 0 | organic sodium salt | fluorescent dye; histological dye |
| aniline blue aniline blue: fluorochrom widely used by botanists | 2.02 | 1 | 0 | ||
| trypan blue Trypan Blue: A diazo-naphthalene sulfonate that is widely used as a stain.. trypan blue : An organosulfonate salt that is the tetrasodium salt of 3,3'-[(3,3'-dimethylbiphenyl-4,4'-diyl)didiazene-2,1-diyl]bis(5-amino-4-hydroxynaphthalene-2,7-disulfonic acid). | 2.75 | 3 | 0 | ||
| direct black 19 direct black 19: RN given refers to di-Na salt; structure given in first source | 1.96 | 1 | 0 |
| Condition | Indicated | Relationship Strength | Studies | Trials |
|---|---|---|---|---|
| Enterobiasis Infection with nematodes of the genus ENTEROBIUS; E. vermicularis, the pinworm of man, causes a crawling sensation and pruritus. This condition results in scratching the area, occasionally causing scarification. | 0 | 2.15 | 1 | 0 |
| Intestinal Diseases, Parasitic Infections of the INTESTINES with PARASITES, commonly involving PARASITIC WORMS. Infections with roundworms (NEMATODE INFECTIONS) and tapeworms (CESTODE INFECTIONS) are also known as HELMINTHIASIS. | 0 | 2.08 | 1 | 0 |
| Dermatomycoses Superficial infections of the skin or its appendages by any of various fungi. | 0 | 2.71 | 3 | 0 |
| Dermatophytoses [description not available] | 0 | 2.49 | 2 | 0 |
| Tinea Fungal infection of keratinized tissues such as hair, skin and nails. The main causative fungi include MICROSPORUM; TRICHOPHYTON; and EPIDERMOPHYTON. | 0 | 2.49 | 2 | 0 |
| Acantholytic Dyskeratotic Epidermal Nevi [description not available] | 0 | 2.1 | 1 | 0 |
| Giardia duodenalis Infection [description not available] | 0 | 2.13 | 1 | 0 |
| Giardiasis An infection of the SMALL INTESTINE caused by the flagellated protozoan GIARDIA. It is spread via contaminated food and water and by direct person-to-person contact. | 0 | 2.13 | 1 | 0 |
| Keratitis, Acanthamoeba [description not available] | 0 | 2.06 | 1 | 0 |
| Acanthamoeba Keratitis Infection of the cornea by an ameboid protozoan which may cause corneal ulceration leading to blindness. | 0 | 2.06 | 1 | 0 |
| Nail Fungus [description not available] | 0 | 2.4 | 2 | 0 |
| Onychomycosis A fungal infection of the nail, usually caused by DERMATOPHYTES; YEASTS; or nondermatophyte MOLDS. | 0 | 2.4 | 2 | 0 |
| Benign Neoplasms, Brain [description not available] | 0 | 1.93 | 1 | 0 |
| Brain Neoplasms Neoplasms of the intracranial components of the central nervous system, including the cerebral hemispheres, basal ganglia, hypothalamus, thalamus, brain stem, and cerebellum. Brain neoplasms are subdivided into primary (originating from brain tissue) and secondary (i.e., metastatic) forms. Primary neoplasms are subdivided into benign and malignant forms. In general, brain tumors may also be classified by age of onset, histologic type, or presenting location in the brain. | 0 | 1.93 | 1 | 0 |
| Mange, Sarcoptic [description not available] | 0 | 2.02 | 1 | 0 |
| Scabies A contagious cutaneous inflammation caused by the bite of the mite SARCOPTES SCABIEI. It is characterized by pruritic papular eruptions and burrows and affects primarily the axillae, elbows, wrists, and genitalia, although it can spread to cover the entire body. | 0 | 2.02 | 1 | 0 |
| Keratitis, Ulcerative [description not available] | 0 | 2.04 | 1 | 0 |
| Fungal Diseases [description not available] | 0 | 2.04 | 1 | 0 |
| Eye Infections, Fungal Infection by a variety of fungi, usually through four possible mechanisms: superficial infection producing conjunctivitis, keratitis, or lacrimal obstruction; extension of infection from neighboring structures - skin, paranasal sinuses, nasopharynx; direct introduction during surgery or accidental penetrating trauma; or via the blood or lymphatic routes in patients with underlying mycoses. | 0 | 2.04 | 1 | 0 |
| Corneal Ulcer Loss of epithelial tissue from the surface of the cornea due to progressive erosion and necrosis of the tissue; usually caused by bacterial, fungal, or viral infection. | 0 | 2.04 | 1 | 0 |
| Mycoses Diseases caused by FUNGI. | 0 | 2.04 | 1 | 0 |
| Sensitivity and Specificity Binary classification measures to assess test results. Sensitivity or recall rate is the proportion of true positives. Specificity is the probability of correctly determining the absence of a condition. (From Last, Dictionary of Epidemiology, 2d ed) | 0 | 2.04 | 1 | 0 |
| Experimental Hepatoma [description not available] | 0 | 1.96 | 1 | 0 |
| Leucocythaemia [description not available] | 0 | 1.96 | 1 | 0 |
| Leukemia A progressive, malignant disease of the blood-forming organs, characterized by distorted proliferation and development of leukocytes and their precursors in the blood and bone marrow. Leukemias were originally termed acute or chronic based on life expectancy but now are classified according to cellular maturity. Acute leukemias consist of predominately immature cells; chronic leukemias are composed of more mature cells. (From The Merck Manual, 2006) | 0 | 1.96 | 1 | 0 |
| Foot Dermatoses Skin diseases of the foot, general or unspecified. | 0 | 1.96 | 1 | 0 |
| Benign Neoplasms [description not available] | 0 | 1.96 | 1 | 0 |
| Experimental Neoplasms [description not available] | 0 | 2.36 | 2 | 0 |
| Diseases, Occupational [description not available] | 0 | 2.37 | 2 | 0 |
| Neoplasms New abnormal growth of tissue. Malignant neoplasms show a greater degree of anaplasia and have the properties of invasion and metastasis, compared to benign neoplasms. | 0 | 1.96 | 1 | 0 |
| Body Weight The mass or quantity of heaviness of an individual. It is expressed by units of pounds or kilograms. | 0 | 1.95 | 1 | 0 |
| Acute Liver Injury, Drug-Induced [description not available] | 0 | 1.95 | 1 | 0 |
| Cancer of Liver [description not available] | 0 | 1.95 | 1 | 0 |
| Liver Neoplasms Tumors or cancer of the LIVER. | 0 | 1.95 | 1 | 0 |
| Chemical and Drug Induced Liver Injury A spectrum of clinical liver diseases ranging from mild biochemical abnormalities to ACUTE LIVER FAILURE, caused by drugs, drug metabolites, herbal and dietary supplements and chemicals from the environment. | 0 | 1.95 | 1 | 0 |
| Bladder Cancer [description not available] | 0 | 1.98 | 1 | 0 |
| Urinary Bladder Neoplasms Tumors or cancer of the URINARY BLADDER. | 0 | 1.98 | 1 | 0 |
| Candida Infection [description not available] | 0 | 1.97 | 1 | 0 |
| Heroin Abuse [description not available] | 0 | 1.97 | 1 | 0 |
| Candidiasis Infection with a fungus of the genus CANDIDA. It is usually a superficial infection of the moist areas of the body and is generally caused by CANDIDA ALBICANS. (Dorland, 27th ed) | 0 | 1.97 | 1 | 0 |
| Heroin Dependence Strong dependence or addiction, both physiological and emotional, upon HEROIN. | 0 | 1.97 | 1 | 0 |