N,N-dimethyl-4-(6-benzothiazolylazo)aniline: do not confuse with 5-isomer (RN: 18463-90-6) also given this name in 9CI; structure [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]
| ID Source | ID |
|---|---|
| PubMed CID | 29080 |
| MeSH ID | M0058890 |
| Synonym |
|---|
| n,n-dimethyl-p-(6-benzothiazolylazo)aniline |
| 6-(4-dimethylaminophenylazobenzothiazole) |
| 18463-85-9 |
| n,n-dimethyl-4-(6-benzothiazolylazo)aniline |
| 4-(6-benzothiazolylazo)-n,n-dimethylbenzenamine |
| n,n-dimethyl-4(6'-benzthiazolylazo)aniline |
| benzenamine, 4-(6-benzothiazolylazo)-n,n-dimethyl- |
| brn 5389277 |
| 6-dimethylaminophenylazobenzthiazole |
| benzothiazole, 6-((p-(dimethylamino)phenyl)azo)- |
| 6-(p-dimethlaminophenylazo)benzothiazole |
| n,n-dimethyl-p-(6-benzthiazolylazo)aniline |
| ccris 4064 |
| 6-((p-(dimethylamino)phenyl)azo)benzothiazole |
| bt 6 |
| 4-(1,3-benzothiazol-6-yldiazenyl)-n,n-dimethylaniline |
| 6-(p-dimethylaminophenylazo)-benzothiazole |
| DTXSID0075314 |
| Excerpt | Relevance | Reference |
|---|---|---|
| " After 36-h exposure, there was still an indication of a weak dose-response effect between 0 and 5 net nuclear grains (NG)." | ( Induction of unscheduled DNA synthesis in liver and micronucleus in bone marrow of rats exposed in vivo to the benzidine-derived azo dye, Direct Black 38. Beije, B, 1987) | 0.27 |
| "We have investigated levels of transcript homologous with glutathione S-transferase P (GST-P; GST 7-7) in tumours and hyperplastic lesions induced in the livers of rats by long-term gavage dosing with diethylnitrosamine (DEN) and 6-p-dimethylaminophenylazobenzothiazole (6BT)." | ( Long-term dosing studies using mutagenic carcinogens indicate a highly significant correlation between elevations in the level of rat glutathione S-transferase P messenger RNA and liver tumours of hepatocellular origin. Humphries, P; Kelly, M; McQuaid, S; Pearson, C; Russell, SE, 1988) | 0.27 |
| " In this assay, animals are dosed with the test agent and the liver is subsequently assessed for UDS by autoradiography and grain counting." | ( Positive and negative control observations for the in vivo/in vitro rat liver assay for unscheduled DNA synthesis (UDS). Ashby, J; Barber, G; Mohammed, R; Trueman, RW, 1987) | 0.27 |
| " As part of these studies we have determined (a) target organ distribution after oral dosing to rats and (b) covalent binding of 14C-labelled compound to DNA." | ( DNA-binding studies with 6BT and 5I: implications for DNA-binding/carcinogenicity and DNA-binding/mutagenicity correlations. Ashby, J; Combes, RD; Dashwood, RH, 1988) | 0.27 |
| " Cellular change continued after stopping dosing at 2 months such that liver tumours were first observed after only 4 months into the study, and animals examined between 4 months and termination at 6 months showed a 75% and 85% incidence of hepatocellular carcinoma for the Sprague-Dawley and Wistar strains, respectively." | ( 6-p-Dimethylaminophenylazobenzothiazole: a potent hepatocarcinogen in the rat. Ashby, J; Elliott, BM; Robinson, M, 1983) | 0.27 |
| Timeframe | Studies, This Drug (%) | All Drugs % |
|---|---|---|
| pre-1990 | 12 (85.71) | 18.7374 |
| 1990's | 2 (14.29) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| [information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||
According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be weak demand-to-supply ratio for research on this compound.
| This Compound (11.52) All Compounds (24.57) |
| Publication Type | This drug (%) | All Drugs (%) |
|---|---|---|
| Trials | 0 (0.00%) | 5.53% |
| Reviews | 0 (0.00%) | 6.00% |
| Case Studies | 0 (0.00%) | 4.05% |
| Observational | 0 (0.00%) | 0.25% |
| Other | 15 (100.00%) | 84.16% |
| [information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||