retinal cone cell differentiation

Definition

Target type: biologicalprocess

The process in which a relatively unspecialized cell acquires the specialized features of a retinal cone cell. [GOC:go_curators]

Retinal cone cell differentiation is a complex process that begins with the specification of retinal progenitor cells into a cone cell fate. This involves the activation of specific transcription factors, such as Math5, which are essential for cone cell development. The next step is the formation of the outer segment, a specialized structure that captures light. This is achieved through the elongation of the apical region of the cell and the formation of discs, membrane-bound structures that contain photopigments. The inner segment, which contains the cell's nucleus and other organelles, develops in parallel. Cone cells also undergo a process called photoreceptor outer segment renewal, where old discs are shed and replaced with new ones. This process ensures that the photoreceptors maintain their sensitivity to light. Cone cell differentiation is influenced by a variety of factors, including the expression of specific genes, interactions with neighboring cells, and the presence of growth factors. Mutations in genes involved in cone cell differentiation can lead to various eye diseases.'
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Proteins (1)

Compounds (1)