Compounds > Calactin
Page last updated: 2024-12-08

Calactin

Cross-References

ID SourceID
PubMed CID441849
CHEMBL ID502127
CHEBI ID3299
SCHEMBL ID24394828

Synonyms (18)

Synonym
hsdb 3467
pecilocerin b
card-20(22)-enolide, 3-((4,6-dideoxy-beta-d-erythro-hexopyranos-2-ulos-1-yl)oxy)-2,14-dihydroxy-19-oxo-, (2alpha,3beta,5alpha)-
pokilocerin b
poekilocerin b
pekilocerin b
20304-47-6
C08854
calactin
chebi:3299 ,
CHEMBL502127
unii-6299v7szxg
6299v7szxg ,
card-20(22)-enolide, 14-hydroxy-19-oxo-2,3-(((2s,3s,4r,6r)-tetrahydro-3,4-dihydroxy-6-methyl-2h-pyran-3,2-diyl)bis(oxy))-, (2.alpha.,3.beta.,5.alpha.)-
DTXSID80174192
Q27106014
(1s,3r,5s,7r,9r,10s,12r,14r,15s,18r,19r,22s,23r)-9,10,22-trihydroxy-7,18-dimethyl-19-(5-oxo-2h-furan-3-yl)-4,6,11-trioxahexacyclo[12.11.0.03,12.05,10.015,23.018,22]pentacosane-14-carbaldehyde
SCHEMBL24394828
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Drug Classes (1)

ClassDescription
cardenolide glycosideAny member of the class of cardenolides with glycosyl residues attached to position 3.
[compound class information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Bioassays (30)

Assay IDTitleYearJournalArticle
AID378472Induction of apoptosis in human KS cells assessed as DNA fragmentation at 10 uM after 12 hrs by FACS relative to control2006Journal of natural products, Sep, Volume: 69, Issue:9
Cardenolide glycosides from Pergularia tomentosa and their proapoptotic activity in Kaposi's sarcoma cells.
AID378431Cytotoxicity against human KB cells by SRB assay2006Journal of natural products, Aug, Volume: 69, Issue:8
19-Nor- and 18,20-epoxy-cardenolides from the leaves of Calotropis gigantea.
AID378473Induction of apoptosis in human KS cells assessed as caspase 3 activity at 10 uM by DEVD-AFC fluorimetric assay2006Journal of natural products, Sep, Volume: 69, Issue:9
Cardenolide glycosides from Pergularia tomentosa and their proapoptotic activity in Kaposi's sarcoma cells.
AID1247882Antimicrobial activity against Escherichia coli after 16 hrs by broth microdilution method2015Bioorganic & medicinal chemistry letters, Oct-15, Volume: 25, Issue:20
Cytotoxic cardenolides from the latex of Calotropis procera.
AID378469Cytotoxicity against human KS cells after 24 hrs by XTT assay2006Journal of natural products, Sep, Volume: 69, Issue:9
Cardenolide glycosides from Pergularia tomentosa and their proapoptotic activity in Kaposi's sarcoma cells.
AID378468Cytotoxicity against human KS cells after 24 hrs by coulter counter2006Journal of natural products, Sep, Volume: 69, Issue:9
Cardenolide glycosides from Pergularia tomentosa and their proapoptotic activity in Kaposi's sarcoma cells.
AID426217Antiproliferative activity against human LoVo cells after 72 hrs by MTT assay2009Journal of natural products, Jun, Volume: 72, Issue:6
Cardenolides from Pergularia tomentosa display cytotoxic activity resulting from their potent inhibition of Na+/K+-ATPase.
AID426221Antiproliferative activity against human MCF7 cells after 72 hrs by MTT assay2009Journal of natural products, Jun, Volume: 72, Issue:6
Cardenolides from Pergularia tomentosa display cytotoxic activity resulting from their potent inhibition of Na+/K+-ATPase.
AID426218Antiproliferative activity against human A549 cells after 72 hrs by MTT assay2009Journal of natural products, Jun, Volume: 72, Issue:6
Cardenolides from Pergularia tomentosa display cytotoxic activity resulting from their potent inhibition of Na+/K+-ATPase.
AID1575480Antiproliferative activity against human HeLa cells after 72 hrs by MTT assay2019Journal of natural products, 01-25, Volume: 82, Issue:1
Antiproliferative Cardenolides from the Aerial Parts of Pergularia tomentosa.
AID1575481Antiproliferative activity against human MCF7 cells after 72 hrs by MTT assay2019Journal of natural products, 01-25, Volume: 82, Issue:1
Antiproliferative Cardenolides from the Aerial Parts of Pergularia tomentosa.
AID1247880Antimicrobial activity against methicillin-resistant Staphylococcus aureus after 16 hrs by broth microdilution method2015Bioorganic & medicinal chemistry letters, Oct-15, Volume: 25, Issue:20
Cytotoxic cardenolides from the latex of Calotropis procera.
AID378470Cytotoxicity against human KS cells at >1 uM after 24 hrs2006Journal of natural products, Sep, Volume: 69, Issue:9
Cardenolide glycosides from Pergularia tomentosa and their proapoptotic activity in Kaposi's sarcoma cells.
AID1575482Antiproliferative activity against human Calu1 cells after 72 hrs by MTT assay2019Journal of natural products, 01-25, Volume: 82, Issue:1
Antiproliferative Cardenolides from the Aerial Parts of Pergularia tomentosa.
AID403697Cytotoxicity against human MCF7 cells after 3 days by MTT assay2005Journal of natural products, Oct, Volume: 68, Issue:10
Cytotoxic principles from the formosan milkweed, Asclepias curassavica.
AID1247881Antimicrobial activity against Bacillus subtilis after 16 hrs by broth microdilution method2015Bioorganic & medicinal chemistry letters, Oct-15, Volume: 25, Issue:20
Cytotoxic cardenolides from the latex of Calotropis procera.
AID1575479Antiproliferative activity against human PC3 cells after 72 hrs by MTT assay2019Journal of natural products, 01-25, Volume: 82, Issue:1
Antiproliferative Cardenolides from the Aerial Parts of Pergularia tomentosa.
AID426220Antiproliferative activity against human PC3 cells after 72 hrs by MTT assay2009Journal of natural products, Jun, Volume: 72, Issue:6
Cardenolides from Pergularia tomentosa display cytotoxic activity resulting from their potent inhibition of Na+/K+-ATPase.
AID426219Antiproliferative activity against human BxPC3 cells after 72 hrs by MTT assay2009Journal of natural products, Jun, Volume: 72, Issue:6
Cardenolides from Pergularia tomentosa display cytotoxic activity resulting from their potent inhibition of Na+/K+-ATPase.
AID1247883Antimicrobial activity against Mycobacterium bovis BCG after 3 days by broth microdilution method2015Bioorganic & medicinal chemistry letters, Oct-15, Volume: 25, Issue:20
Cytotoxic cardenolides from the latex of Calotropis procera.
AID426223Inhibition of pig cerebral cortex Na+/K+-ATPase by colorimetric microplate-based assay2009Journal of natural products, Jun, Volume: 72, Issue:6
Cardenolides from Pergularia tomentosa display cytotoxic activity resulting from their potent inhibition of Na+/K+-ATPase.
AID403698Cytotoxicity against human HepG2 cells after 3 days by MTT assay2005Journal of natural products, Oct, Volume: 68, Issue:10
Cytotoxic principles from the formosan milkweed, Asclepias curassavica.
AID403696Cytotoxicity against human MDA-MB-231 cells after 3 days by MTT assay2005Journal of natural products, Oct, Volume: 68, Issue:10
Cytotoxic principles from the formosan milkweed, Asclepias curassavica.
AID1247884Antimicrobial activity against Candida albicans after 16 hrs by broth microdilution method2015Bioorganic & medicinal chemistry letters, Oct-15, Volume: 25, Issue:20
Cytotoxic cardenolides from the latex of Calotropis procera.
AID378437Antimalarial activity after 48 hrs against multidrug-resistant Plasmodium falciparum K12006Journal of natural products, Aug, Volume: 69, Issue:8
19-Nor- and 18,20-epoxy-cardenolides from the leaves of Calotropis gigantea.
AID426222Antiproliferative activity against human U373 cells after 72 hrs by MTT assay2009Journal of natural products, Jun, Volume: 72, Issue:6
Cardenolides from Pergularia tomentosa display cytotoxic activity resulting from their potent inhibition of Na+/K+-ATPase.
AID378432Cytotoxicity against human BC cells by SRB assay2006Journal of natural products, Aug, Volume: 69, Issue:8
19-Nor- and 18,20-epoxy-cardenolides from the leaves of Calotropis gigantea.
AID378433Cytotoxicity against human NCI-H187 cells by SRB assay2006Journal of natural products, Aug, Volume: 69, Issue:8
19-Nor- and 18,20-epoxy-cardenolides from the leaves of Calotropis gigantea.
AID403695Cytotoxicity against human A549 cells after 3 days by MTT assay2005Journal of natural products, Oct, Volume: 68, Issue:10
Cytotoxic principles from the formosan milkweed, Asclepias curassavica.
AID1575483Antiproliferative activity against human U251MG cells after 72 hrs by MTT assay2019Journal of natural products, 01-25, Volume: 82, Issue:1
Antiproliferative Cardenolides from the Aerial Parts of Pergularia tomentosa.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (6)

TimeframeStudies, This Drug (%)All Drugs %
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's4 (66.67)29.6817
2010's2 (33.33)24.3611
2020's0 (0.00)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 29.61

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be moderate demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index29.61 (24.57)
Research Supply Index1.95 (2.92)
Research Growth Index4.37 (4.65)
Search Engine Demand Index34.37 (26.88)
Search Engine Supply Index2.00 (0.95)

This Compound (29.61)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews0 (0.00%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other6 (100.00%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]
SubstanceRelationship StrengthStudiesTrialsClassesRoles
ellipticine
ellipticine : A organic heterotetracyclic compound that is pyrido[4,3-b]carbazole carrying two methyl substituents at positions 5 and 11.		2.0310indole alkaloid;
organic heterotetracyclic compound;
organonitrogen heterocyclic compound;
polycyclic heteroarene		antineoplastic agent;
plant metabolite
calotropin
calotropin: structure in first source		2.4320cardenolide glycoside
uzarigenin
[no description available]		2.2110
docetaxel anhydrous
Docetaxel: A semisynthetic analog of PACLITAXEL used in the treatment of locally advanced or metastatic BREAST NEOPLASMS and NON-SMALL CELL LUNG CANCER.. docetaxel anhydrous : A tetracyclic diterpenoid that is paclitaxel with the N-benzyloxycarbonyl group replaced by N-tert-butoxycarbonyl, and the acetoxy group at position 10 replaced by a hydroxy group.		2.2110secondary alpha-hydroxy ketone;
tetracyclic diterpenoid		antimalarial;
antineoplastic agent;
photosensitizing agent
ouabain
Ouabain: A cardioactive glycoside consisting of rhamnose and ouabagenin, obtained from the seeds of Strophanthus gratus and other plants of the Apocynaceae; used like DIGITALIS. It is commonly used in cell biological studies as an inhibitor of the NA(+)-K(+)-EXCHANGING ATPASE.. cardiac glycoside : Steroid lactones containing sugar residues that act on the contractile force of the cardiac muscles.. ouabain : A steroid hormone that is a multi-hydroxylated alpha-L-rhamnosyl cardenoloide. It binds to and inhibits the plasma membrane Na(+)/K(+)-ATPase (sodium pump). It has been isolated naturally from Strophanthus gratus.		2.051011alpha-hydroxy steroid;
14beta-hydroxy steroid;
5beta-hydroxy steroid;
alpha-L-rhamnoside;
cardenolide glycoside;
steroid hormone		anti-arrhythmia drug;
cardiotonic drug;
EC 2.3.3.1 [citrate (Si)-synthase] inhibitor;
EC 3.1.3.41 (4-nitrophenylphosphatase) inhibitor;
EC 3.6.3.10 (H(+)/K(+)-exchanging ATPase) inhibitor;
EC 3.6.3.9 (Na(+)/K(+)-transporting ATPase) inhibitor;
ion transport inhibitor;
plant metabolite
digitoxigenin
Digitoxigenin: 3 beta,14-Dihydroxy-5 beta-card-20(22)enolide. A cardenolide which is the aglycon of digitoxin. Synonyms: Cerberigenin; Echujetin; Evonogenin; Thevetigenin.. digitoxigenin : A 5beta-cardenolide that is 5beta-cardanolide with hydroxy substituents at the 3beta- and 14beta-positions and double bond unsaturation at C(20)-C(22).		2.432014beta-hydroxy steroid;
3beta-hydroxy steroid
ConditionIndicatedRelationship StrengthStudiesTrials
Kaposi Sarcoma
[description not available]		02.0310
Sarcoma, Kaposi
A multicentric, malignant neoplastic vascular proliferation characterized by the development of bluish-red cutaneous nodules, usually on the lower extremities, most often on the toes or feet, and slowly increasing in size and number and spreading to more proximal areas. The tumors have endothelium-lined channels and vascular spaces admixed with variably sized aggregates of spindle-shaped cells, and often remain confined to the skin and subcutaneous tissue, but widespread visceral involvement may occur. Kaposi's sarcoma occurs spontaneously in Jewish and Italian males in Europe and the United States. An aggressive variant in young children is endemic in some areas of Africa. A third form occurs in about 0.04% of kidney transplant patients. There is also a high incidence in AIDS patients. (From Dorland, 27th ed & Holland et al., Cancer Medicine, 3d ed, pp2105-7) HHV-8 is the suspected cause.		02.0310
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