cellular response to tumor cell

Definition

Target type: biologicalprocess

Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus from a tumor cell. [GOC:mah]

Cellular response to tumor cell is a complex and multifaceted process involving a wide range of cellular and molecular events. It encompasses the coordinated actions of various cell types, including immune cells, stromal cells, and tumor cells themselves. The response is initiated by the recognition of tumor-associated antigens or danger signals released by the tumor. Immune cells, particularly T cells, natural killer (NK) cells, and macrophages, play a crucial role in eliminating tumor cells. They recognize tumor antigens through specific receptors and mount an immune response that can involve direct cytotoxicity, antibody-dependent cell-mediated cytotoxicity (ADCC), or the production of cytokines. The immune response is influenced by the tumor microenvironment, which can be immunosuppressive, promoting tumor evasion from immune surveillance. Stromal cells, such as fibroblasts and endothelial cells, contribute to tumor growth and spread by providing structural support, angiogenesis, and growth factors. In addition to immune responses, cellular responses to tumor cells also involve non-immune mechanisms. Tumor cells can induce cellular senescence, a state of permanent cell cycle arrest, in neighboring cells, thereby limiting tumor growth. They can also trigger apoptosis, programmed cell death, in nearby cells, further hindering tumor progression. However, tumor cells can evolve strategies to evade these responses, such as expressing immunosuppressive molecules or promoting the formation of a tumor microenvironment that is unfavorable for immune cells. Overall, cellular response to tumor cells is a dynamic and complex interplay between various cell types and signaling pathways. The outcome of this interaction determines the fate of the tumor, influencing its growth, spread, and response to treatment.'
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Proteins (1)

Compounds (1)