Target type: biologicalprocess
The regionalization process in which embryonic segments are divided into compartments that will result in differences in cell differentiation. [http://fly.ebi.ac.uk/allied-data/lk/interactive-fly/aimain/1aahome.htm, ISBN:0879694238]
Compartment pattern specification is a fundamental process in developmental biology that establishes the distinct regions or compartments within an organism. This process is essential for the proper organization and differentiation of tissues and organs.
Here's a detailed breakdown of the process:
1. **Initial Establishment of Compartments:** Compartment boundaries are often established early in development by signaling pathways. These pathways involve the exchange of molecular signals between cells, leading to the activation of specific transcription factors.
2. **Transcription Factor Expression:** Different compartments express unique sets of transcription factors. These factors bind to regulatory regions of genes, controlling their expression. This differential gene expression defines the character of each compartment.
3. **Cell Fate Determination:** The expression of specific transcription factors in each compartment influences the developmental fate of the cells within that region. For example, one compartment might give rise to muscle cells, while another might give rise to neural cells.
4. **Maintenance of Compartment Boundaries:** Compartment boundaries are maintained by a variety of mechanisms, including:
* **Cell Adhesion:** Cells within a compartment exhibit stronger adhesion to each other than to cells in neighboring compartments. This helps to maintain the physical separation between the compartments.
* **Cell Signaling:** Signals exchanged between cells within a compartment can reinforce the expression of compartment-specific genes, thus preserving the distinct character of each region.
5. **Morphogenesis:** Compartments often play a role in shaping the organism. Differences in cell division rates or cell migration patterns between compartments can contribute to the formation of structures like limbs, organs, or body segments.
6. **Evolutionary Importance:** Compartment pattern specification is a highly conserved process across different organisms, highlighting its essential role in development. Variations in compartment specification can lead to diverse body plans and evolutionary adaptations.
7. **Examples:**
* **Drosophila:** In fruit flies, the development of the wing and legs is governed by compartmentalization.
* **Vertebrates:** The formation of the body axis and the segmentation of the spine involve compartmentalization.
In summary, compartment pattern specification is a tightly regulated process that involves signaling pathways, gene expression, cell fate determination, and cell adhesion, all contributing to the precise organization and development of an organism.'
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Protein | Definition | Taxonomy |
---|---|---|
Neurogenic locus notch homolog protein 1 | A neurogenic locus notch homolog protein 1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:P46531] | Homo sapiens (human) |
Compound | Definition | Classes | Roles |
---|---|---|---|
calotropin | calotropin: structure in first source | cardenolide glycoside |