positive regulation of transcription of Notch receptor target

Definition

Target type: biologicalprocess

The activation of transcription of specific genes as a result of Notch signaling, mediated by the Notch intracellular domain. [PMID:12651094]

The process of positive regulation of transcription of Notch receptor target involves a complex interplay of signaling pathways and transcription factors. Notch signaling is a highly conserved cell-cell communication mechanism that plays a crucial role in diverse developmental processes, from cell fate specification to tissue patterning. The Notch receptor is a transmembrane protein that exists in a heterodimeric form on the cell surface. Upon binding to its ligand, which is expressed on a neighboring cell, the receptor undergoes a series of proteolytic cleavages. This cleavage releases the Notch intracellular domain (NICD) which translocates to the nucleus and interacts with transcription factors like CSL (CBF1/RBP-Jκ/Su(H)). CSL is a DNA-binding protein that functions as a transcriptional repressor in the absence of NICD. However, when NICD binds to CSL, it recruits other co-activator proteins such as MAML (Mastermind-like) and p300/CBP (CREB-binding protein). This complex acts as a transcriptional activator, promoting the expression of Notch target genes. The transcription of Notch target genes is positively regulated by the presence of NICD, which directly interacts with CSL, leading to the recruitment of co-activators and the formation of a functional transcription complex. This complex promotes the transcription of downstream genes involved in various developmental processes, including cell fate determination, proliferation, and differentiation. Importantly, the positive regulation of Notch target gene transcription is highly dynamic and can be influenced by a multitude of factors, including the nature of the ligand, the cellular context, and the expression levels of various regulatory proteins.'
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Proteins (1)

Compounds (1)