Page last updated: 2024-10-24

negative regulation of cell adhesion molecule production

Definition

Target type: biologicalprocess

Any process that decreases the rate, frequency or extent of cell adhesion molecule production. Cell adhesion molecule production is the appearance of a cell adhesion molecule as a result of its biosynthesis or a decrease in its catabolism. [GOC:BHF, GOC:rl]

Negative regulation of cell adhesion molecule production is a complex biological process that involves a multitude of molecular mechanisms aimed at reducing the synthesis or activity of cell adhesion molecules. These molecules are critical for cell-cell and cell-extracellular matrix interactions, playing crucial roles in tissue formation, development, and immune responses. The downregulation of cell adhesion molecule production can occur through various pathways, including:

1. **Transcriptional regulation**: Transcription factors and signaling pathways can modulate the expression of genes encoding cell adhesion molecules. Repressors can bind to promoter regions of these genes, preventing RNA polymerase from initiating transcription.

2. **Post-transcriptional regulation**: MicroRNAs (miRNAs) can target the mRNAs of cell adhesion molecules, leading to their degradation or translational inhibition.

3. **Post-translational regulation**: Cell adhesion molecules can be subjected to modifications such as phosphorylation, glycosylation, or proteolytic cleavage, which can alter their adhesive properties or stability.

4. **Endocytosis and degradation**: Cell adhesion molecules can be internalized via endocytosis and subsequently degraded in lysosomes, effectively reducing their levels on the cell surface.

5. **Shedding**: Some cell adhesion molecules are cleaved from the cell surface by proteases, releasing soluble forms that can act as signaling molecules or inhibitors of cell adhesion.

The negative regulation of cell adhesion molecule production is essential for maintaining cellular homeostasis and preventing excessive adhesion. Dysregulation of this process can contribute to various pathological conditions, including:

* **Cancer metastasis**: Reduced cell adhesion can facilitate tumor cell invasion and spread to distant sites.
* **Inflammation**: Excessive adhesion can contribute to inflammatory responses and tissue damage.
* **Immunodeficiency**: Decreased adhesion can impair immune cell function and increase susceptibility to infections.

Furthermore, negative regulation of cell adhesion molecule production plays a crucial role in processes like wound healing and tissue regeneration, where controlled cell detachment and migration are required for repair and restoration.

The intricate network of molecular events involved in this regulatory process is a testament to the dynamic nature of cellular interactions and the importance of tightly controlling cell adhesion for proper physiological function.'
"

Proteins (2)

ProteinDefinitionTaxonomy
Neurogenic locus notch homolog protein 1A neurogenic locus notch homolog protein 1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:P46531]Homo sapiens (human)
Interleukin-8An interleukin-8 that is encoded in the genome of human. [PMID:15623624, SALO:AJ]Homo sapiens (human)

Compounds (8)

CompoundDefinitionClassesRoles
diclofenacdiclofenac : A monocarboxylic acid consisting of phenylacetic acid having a (2,6-dichlorophenyl)amino group at the 2-position.

Diclofenac: A non-steroidal anti-inflammatory agent (NSAID) with antipyretic and analgesic actions. It is primarily available as the sodium salt.
amino acid;
aromatic amine;
dichlorobenzene;
monocarboxylic acid;
secondary amino compound
antipyretic;
drug allergen;
EC 1.14.99.1 (prostaglandin-endoperoxide synthase) inhibitor;
environmental contaminant;
non-narcotic analgesic;
non-steroidal anti-inflammatory drug;
xenobiotic
indomethacinindometacin : A member of the class of indole-3-acetic acids that is indole-3-acetic acid in which the indole ring is substituted at positions 1, 2 and 5 by p-chlorobenzoyl, methyl, and methoxy groups, respectively. A non-steroidal anti-inflammatory drug, it is used in the treatment of musculoskeletal and joint disorders including osteoarthritis, rheumatoid arthritis, gout, bursitis and tendinitis.

Indomethacin: A non-steroidal anti-inflammatory agent (NSAID) that inhibits CYCLOOXYGENASE, which is necessary for the formation of PROSTAGLANDINS and other AUTACOIDS. It also inhibits the motility of POLYMORPHONUCLEAR LEUKOCYTES.
aromatic ether;
indole-3-acetic acids;
monochlorobenzenes;
N-acylindole
analgesic;
drug metabolite;
EC 1.14.99.1 (prostaglandin-endoperoxide synthase) inhibitor;
environmental contaminant;
gout suppressant;
non-steroidal anti-inflammatory drug;
xenobiotic;
xenobiotic metabolite
tolmetintolmetin : A monocarboxylic acid that is (1-methylpyrrol-2-yl)acetic acid substituted at position 5 on the pyrrole ring by a 4-methylbenzoyl group. Used in the form of its sodium salt dihydrate as a nonselective nonsteroidal anti-inflammatory drug.

Tolmetin: A non-steroidal anti-inflammatory agent (ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL) similar in mode of action to INDOMETHACIN.
aromatic ketone;
monocarboxylic acid;
pyrroles
EC 1.14.99.1 (prostaglandin-endoperoxide synthase) inhibitor;
non-steroidal anti-inflammatory drug
ibufenacibufenac : A monocarboxylic acid that is acetic acid in which one of the methyl hydrogens is replaced by a 4-isobutylphenyl group. Although it was shown to be effective in treatment of rheumatoid arthritis, the clinical use of ibufenac was discontinued due to hepatotoxic side-effects.

ibufenac: used in the treatment of rheumatism; also possesses antipyretic properties; minor descriptor (75-84); on-line & Index Medicus search PHENYLACETATES (75-84); RN given refers to parent cpd
monocarboxylic acidEC 1.14.99.1 (prostaglandin-endoperoxide synthase) inhibitor;
hepatotoxic agent;
non-narcotic analgesic;
non-steroidal anti-inflammatory drug
calotropincalotropin: structure in first sourcecardenolide glycoside
ibuprofen, (r)-isomeribuprofen
ketoprofen
2-anilinophenylacetic acid2-anilinophenylacetic acid: structure in first source