Compounds > beta-phenylcysteine
Page last updated: 2024-11-07

beta-phenylcysteine

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

Beta-phenylcysteine is a non-proteinogenic amino acid with a phenyl group at the beta position. It has been synthesized through various methods, including the Strecker reaction and the enzymatic reaction catalyzed by phenylalanine ammonia-lyase. Beta-phenylcysteine is a potential precursor for the synthesis of various bioactive compounds, including beta-lactams and beta-amino acids. Research on beta-phenylcysteine focuses on its potential applications in the development of new drugs and materials, particularly in the field of cancer treatment. Its unique structure and chemical properties make it an attractive target for pharmaceutical and material science applications. Beta-phenylcysteine exhibits various biological activities, including antibacterial, antifungal, and anticancer effects. These effects are attributed to its ability to interfere with the biosynthesis of essential cellular components or to induce apoptosis. The study of beta-phenylcysteine is ongoing, aiming to further understand its mechanisms of action and explore its potential therapeutic applications.'

Cross-References

ID SourceID
PubMed CID119462
CHEMBL ID63062
SCHEMBL ID342512
MeSH IDM0124758

Synonyms (24)

Synonym
s-phenyl-l-cysteine, 97%
34317-61-8
s-phenyl-l-cysteine
CHEMBL63062
(2r)-2-amino-3-phenylsulfanylpropanoic acid
AKOS007930134
AKOS006281414
(r)-2-amino-3-(phenylthio)propanoic acid
A822168
l-cysteine, s-phenyl-
beta-phenylcysteine
SCHEMBL342512
J-700245
XYUBQWNJDIAEES-QMMMGPOBSA-N
FD21309
mfcd01318758
DTXSID20187882
AC-10075
(2r)-2-ammonio-3-(phenylthio)propanoate
h-cys(phenyl)-oh
AS-49032
CS-0033656
(r)-2-amino-3-(phenylthio)propanoicacid
l-s-phenylcysteine

Research Excerpts

Dosage Studied

ExcerptRelevanceReference
" We were able to detect SPC in the hemoglobin of exposed rats and mice, to show the linearity of the exposure dose-response relationship, and to establish the sensitivity limits of this assay."( S-phenylcysteine formation in hemoglobin as a biological exposure index to benzene.
Bechtold, WE; Birnbaum, LS; Henderson, RF; Kasicki, S; Li, GL; Lucier, G; Sun, JD; Yin, SN, 1992)		0.28
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Protein Targets (1)

Inhibition Measurements

ProteinTaxonomyMeasurementAverageMin (ref.)Avg (ref.)Max (ref.)Bioassay(s)
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Bioassays (1)

Assay IDTitleYearJournalArticle
AID44227Specific activity against beta-elimination reaction by rat renal cytosolic beta-lyase after incubation with 0.2 mg of protein/mL for 10 min at 37 degree C using 1 mM substrate conc.1996Journal of medicinal chemistry, May-10, Volume: 39, Issue:10
Synthesis of novel Se-substituted selenocysteine derivatives as potential kidney selective prodrugs of biologically active selenol compounds: evaluation of kinetics of beta-elimination reactions in rat renal cytosol.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (10)

TimeframeStudies, This Drug (%)All Drugs %
pre-19902 (20.00)18.7374
1990's5 (50.00)18.2507
2000's1 (10.00)29.6817
2010's2 (20.00)24.3611
2020's0 (0.00)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 12.26

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be weak demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index12.26 (24.57)
Research Supply Index2.56 (2.92)
Research Growth Index4.83 (4.65)
Search Engine Demand Index0.00 (26.88)
Search Engine Supply Index0.00 (0.95)

This Compound (12.26)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews0 (0.00%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other12 (100.00%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]
SubstanceRelationship StrengthStudiesTrialsClassesRoles
benzene
[no description available]		2.940aromatic annulene;
benzenes;
volatile organic compound		carcinogenic agent;
environmental contaminant;
non-polar solvent
nickel
Nickel: A trace element with the atomic symbol Ni, atomic number 28, and atomic weight 58.69. It is a cofactor of the enzyme UREASE.. nickel ion : A nickel atom having a net electric charge.. nickel atom : Chemical element (nickel group element atom) with atomic number 28.		1.9910metal allergen;
nickel group element atom		epitope;
micronutrient
serine
Serine: A non-essential amino acid occurring in natural form as the L-isomer. It is synthesized from GLYCINE or THREONINE. It is involved in the biosynthesis of PURINES; PYRIMIDINES; and other amino acids.. serine : An alpha-amino acid that is alanine substituted at position 3 by a hydroxy group.		2.5320L-alpha-amino acid;
proteinogenic amino acid;
serine family amino acid;
serine zwitterion;
serine		algal metabolite;
Escherichia coli metabolite;
human metabolite;
mouse metabolite;
Saccharomyces cerevisiae metabolite
styrene oxide
styrene oxide: structure. styrene oxide : An epoxide that is oxirane in which one of the hydrogens has been replaced by a phenyl group.		210epoxidehuman xenobiotic metabolite
styrene
Styrene: A colorless, toxic liquid with a strong aromatic odor. It is used to make rubbers, polymers and copolymers, and polystyrene plastics.. styrene : A vinylarene that is benzene carrying a vinyl group. It has been isolated from the benzoin resin produced by Styrax species.		210styrenes;
vinylarene;
volatile organic compound		mouse metabolite;
mutagen;
plant metabolite
bromobenzene
[no description available]		2.2110bromoarene;
bromobenzenes;
volatile organic compound		hepatotoxic agent;
mouse metabolite;
non-polar solvent
thiophenol
thiophenol : A thiol in which the sulfanyl group is attached to a phenyl group.		2.2110aryl thiol
ammonium chloride
Ammonium Chloride: An acidifying agent that has expectorant and diuretic effects. Also used in etching and batteries and as a flux in electroplating.. ammonium chloride : An inorganic chloride having ammonium as the counterion.		2.0810ammonium salt;
inorganic chloride		ferroptosis inhibitor
1-leucine-4-nitroanilide
1-leucine-4-nitroanilide: substrate for arylamidase; RN given refers to cpd without isomeric designation		1.9610
selenomethylselenocysteine
Se-methylselenocysteine : An alpha-amino acid compound having methylselanylmethyl as the side-chain.. Se-methyl-L-selenocysteine : An L-alpha-amino acid compound having methylselanylmethyl as the side-chain.		1.9910amino acid zwitterion;
L-selenocysteine derivative;
non-proteinogenic L-alpha-amino acid;
Se-methylselenocysteine		antineoplastic agent
s-benzylcysteine
[no description available]		1.9910S-aryl-L-cysteine zwitterion
bromochloroacetic acid
Keratins: A class of fibrous proteins or scleroproteins that represents the principal constituent of EPIDERMIS; HAIR; NAILS; horny tissues, and the organic matrix of tooth ENAMEL. Two major conformational groups have been characterized, alpha-keratin, whose peptide backbone forms a coiled-coil alpha helical structure consisting of TYPE I KERATIN and a TYPE II KERATIN, and beta-keratin, whose backbone forms a zigzag or pleated sheet structure. alpha-Keratins have been classified into at least 20 subtypes. In addition multiple isoforms of subtypes have been found which may be due to GENE DUPLICATION.. bromochloroacetic acid : A monocarboxylic acid that is acetic acid in which one of the methyl hydrogens is replaced by bromine while a second is replaced by chlorine. A low-melting (27.5-31.5degreeC), hygroscopic crystalline solid, it can be formed during the disinfection (by chlorination) of water that contains bromide ions and organic matter, so can occur in drinking water as a byproduct of the disinfection process.		2.08102-bromocarboxylic acid;
monocarboxylic acid;
organochlorine compound
cysteine
Cysteine: A thiol-containing non-essential amino acid that is oxidized to form CYSTINE.. L-cysteinium : The L-enantiomer of cysteinium.. cysteine : A sulfur-containing amino acid that is propanoic acid with an amino group at position 2 and a sulfanyl group at position 3.		8.5990cysteiniumfundamental metabolite
selenocysteine
Selenocysteine: A naturally occurring amino acid in both eukaryotic and prokaryotic organisms. It is found in tRNAs and in the catalytic site of some enzymes. The genes for glutathione peroxidase and formate dehydrogenase contain the TGA codon, which codes for this amino acid.. selenocysteine : An alpha-amino acid that consists of alanine where one of the methyl hydrogens is substituted with a seleno group.		2.0110
tellurium
Tellurium: An element that is a member of the chalcogen family. It has the atomic symbol Te, atomic number 52, and atomic weight 127.60. It has been used as a coloring agent and in the manufacture of electrical equipment. Exposure may cause nausea, vomiting, and CNS depression.		2.0110chalcogen;
metalloid atom
benzene oxide
benzene oxide: RN given refers to parent cpd		2.3920
ConditionIndicatedRelationship StrengthStudiesTrials
Sensitivity and Specificity
Binary classification measures to assess test results. Sensitivity or recall rate is the proportion of true positives. Specificity is the probability of correctly determining the absence of a condition. (From Last, Dictionary of Epidemiology, 2d ed)		01.9910
Diseases, Occupational
[description not available]		01.9810