Compounds > 3-amino-5-mercapto-1-2-4-triazole

3-amino-5-mercapto-1-2-4-triazole and Glioma

3-amino-5-mercapto-1-2-4-triazole has been researched along with Glioma* in 1 studies

Other Studies

1 other study(ies) available for 3-amino-5-mercapto-1-2-4-triazole and Glioma

Article	Year
New class of fused [3,2-b][1,2,4]triazolothiazoles for targeting glioma in vitro. Bioorganic & medicinal chemistry letters, 2023, 01-15, Volume: 80 Glioma is aggressive malignant tumor with limited therapeutic interventions. Herein we report the synthesis of fused bicyclic 1,2,4-triazolothiazoles by a one-pot multi-component approach and their activity against C6 rat and LN18 human glioma cell lines. The target compounds 2-(6-phenylthiazolo[3,2-b][1,2,4]triazol-2-yl) isoindoline-1,3-diones and (E)-1-phenyl-N-(6-phenylthiazolo[3,2-b][1,2,4]triazol-2-yl) methanimines were obtained by the reaction of 5-amino-4H-1,2,4-triazole-3-thiol with substituted phenacyl bromide, phthalic anhydride, and different aromatic aldehydes in EtOH/HCl under reflux conditions. In C6 rat glioma cell lines, compounds 4g and 6i showed good cytotoxic activity with IC Topics: Animals; Antineoplastic Agents; Apoptosis; Cell Cycle Checkpoints; Cell Line; Cell Line, Tumor; Cell Proliferation; Glioma; Humans; Rats	2023

Article

Year

New class of fused [3,2-b][1,2,4]triazolothiazoles for targeting glioma in vitro.

Bioorganic & medicinal chemistry letters, 2023, 01-15, Volume: 80

Glioma is aggressive malignant tumor with limited therapeutic interventions. Herein we report the synthesis of fused bicyclic 1,2,4-triazolothiazoles by a one-pot multi-component approach and their activity against C6 rat and LN18 human glioma cell lines. The target compounds 2-(6-phenylthiazolo[3,2-b][1,2,4]triazol-2-yl) isoindoline-1,3-diones and (E)-1-phenyl-N-(6-phenylthiazolo[3,2-b][1,2,4]triazol-2-yl) methanimines were obtained by the reaction of 5-amino-4H-1,2,4-triazole-3-thiol with substituted phenacyl bromide, phthalic anhydride, and different aromatic aldehydes in EtOH/HCl under reflux conditions. In C6 rat glioma cell lines, compounds 4g and 6i showed good cytotoxic activity with IC

Topics: Animals; Antineoplastic Agents; Apoptosis; Cell Cycle Checkpoints; Cell Line; Cell Line, Tumor; Cell Proliferation; Glioma; Humans; Rats

2023