| Substance | Relationship Strength | Studies | Trials | Classes | Roles |
|---|
putrescine
[no description available] | 7.43 | 2 | 0 | alkane-alpha,omega-diamine | antioxidant;
fundamental metabolite |
deferoxamine
Deferoxamine: Natural product isolated from Streptomyces pilosus. It forms iron complexes and is used as a chelating agent, particularly in the mesylate form.. desferrioxamine B : An acyclic desferrioxamine that is butanedioic acid in which one of the carboxy groups undergoes formal condensation with the primary amino group of N-(5-aminopentyl)-N-hydroxyacetamide and the second carboxy group undergoes formal condensation with the hydroxyamino group of N(1)-(5-aminopentyl)-N(1)-hydroxy-N(4)-[5-(hydroxyamino)pentyl]butanediamide. It is a siderophore native to Streptomyces pilosus biosynthesised by the DesABCD enzyme cluster as a high affinity Fe(III) chelator. | 3.51 | 2 | 0 | acyclic desferrioxamine | bacterial metabolite;
ferroptosis inhibitor;
iron chelator;
siderophore |
magnesium sulfate
Magnesium Sulfate: A small colorless crystal used as an anticonvulsant, a cathartic, and an electrolyte replenisher in the treatment of pre-eclampsia and eclampsia. It causes direct inhibition of action potentials in myometrial muscle cells. Excitation and contraction are uncoupled, which decreases the frequency and force of contractions. (From AMA Drug Evaluations Annual, 1992, p1083). magnesium sulfate : A magnesium salt having sulfate as the counterion. | 1.98 | 1 | 0 | magnesium salt;
metal sulfate;
organic magnesium salt | anaesthetic;
analgesic;
anti-arrhythmia drug;
anticonvulsant;
calcium channel blocker;
cardiovascular drug;
fertilizer;
tocolytic agent |
transferrin
Transferrin: An iron-binding beta1-globulin that is synthesized in the LIVER and secreted into the blood. It plays a central role in the transport of IRON throughout the circulation. A variety of transferrin isoforms exist in humans, including some that are considered markers for specific disease states. | 2.04 | 1 | 0 | | |
enterobactin
[no description available] | 4.72 | 5 | 0 | catechols;
crown compound;
macrotriolide;
polyphenol | bacterial metabolite;
siderophore |
aerobactin
[no description available] | 3.12 | 1 | 0 | L-lysine derivative | Escherichia coli metabolite;
siderophore;
virulence factor |
bisucaberin
bisucaberin: structure given in first source; isolated from broth of Alteromonas haloplanktis SB-1123 | 2.1 | 1 | 0 | azamacrocycle;
keratan 6'-sulfate | |
1,4-diaminobutanone
1,4-diaminobutanone: RN given refers to parent cpd | 1.99 | 1 | 0 | | |
rhodotorulic acid
rhodotorulic acid: RN given refers to (1S-cis)-isomer; structure. rhodotorulic acid : A member of the class of 2,5-diketopiperazines obtained by cyclodimerisation of N(5)-acetyl-N(5)-hydroxy-L-ornithine. | 2.41 | 2 | 0 | 2,5-diketopiperazines;
hydroxamic acid;
L-ornithine derivative | fungal metabolite;
siderophore |
vibrioferrin
vibrioferrin: structure in first source. vibrioferrin : A tricarboxylic acid that is citric acid in which the pro-R carboxy group has been esterified with the primary hydroxy group of 2-hydroxy-1-{(2S)-1-[(2-hydroxyethyl)amino]-1-oxopropan-2-yl}-5-oxoproline. It is a siderophore isolated from bacteria closely associated or symbiotic with toxic, bloom-forming dinoflagellates. | 3.12 | 1 | 0 | carboxylic ester;
N-acyl hemiaminal;
pyrrolidin-2-ones;
tertiary alcohol;
tricarboxylic acid | marine metabolite;
siderophore |
putrebactin
putrebactin: an iron-chelating agent isolated from Shewanella putrefaciens; structure in first source | 2.1 | 1 | 0 | cyclic hydroxamic acid | |
achromobactin
achromobactin: isolated from Erwinia chrysanthemi; structure in first source. achromobactin : A citrate siderophore possessing four carboxylate groups suitable for iron coordination. | 3.12 | 1 | 0 | tetracarboxylic acid anion | siderophore |
heme
Heme: The color-furnishing portion of hemoglobin. It is found free in tissues and as the prosthetic group in many hemeproteins.. ferroheme : Any iron(II)--porphyrin coordination complex.. ferroheme b : Heme b in which the iron has oxidation state +2.. heme : A heme is any tetrapyrrolic chelate of iron. | 4.34 | 3 | 0 | | |
lactoferrin
Lactoferrin: An iron-binding protein that was originally characterized as a milk protein. It is widely distributed in secretory fluids and is found in the neutrophilic granules of LEUKOCYTES. The N-terminal part of lactoferrin possesses a serine protease which functions to inactivate the TYPE III SECRETION SYSTEM used by bacteria to export virulence proteins for host cell invasion. | 1.98 | 1 | 0 | | |