1,1-dimethoxyethane profile

1,1-Dimethoxyethane, also known as **methylal**, is an organic compound with the formula CH₃OCH₂OCH₃. It is a colorless liquid with a sweet, ether-like odor.

**Importance in Research:**

1,1-Dimethoxyethane is primarily used as a **solvent** and **reagent** in various research fields, including:

* **Organic Synthesis:**
* It is a versatile solvent for a wide range of reactions, particularly those involving organometallic reagents and Grignard reagents.
* Its low boiling point and miscibility with water make it suitable for extractions and purifications.
* **Polymer Chemistry:**
* It is used as a solvent for the polymerization of various monomers, including vinyl monomers and acrylic monomers.
* **Pharmaceutical Research:**
* Methylal is used in the synthesis of several pharmaceuticals, including antihistamines, anticonvulsants, and analgesics.
* **Spectroscopy:**
* It is a useful solvent for various spectroscopic techniques, such as nuclear magnetic resonance (NMR) and infrared (IR) spectroscopy.
* **Materials Science:**
* Methylal is used as a precursor for the production of various materials, including resins, polymers, and adhesives.

**Other Applications:**

* **Fuel Additive:** Methylal can be used as a gasoline additive to improve combustion efficiency and reduce emissions.
* **Extraction Agent:** It is used for the extraction of essential oils and other natural products.
* **Chemical Intermediate:** Methylal serves as a chemical intermediate for the synthesis of other organic compounds.

**Safety Considerations:**

Methylal is considered a moderately hazardous substance. It is flammable and should be handled with care. Inhalation or skin contact can cause irritation, and ingestion can be toxic. Proper safety precautions should always be taken when working with this compound.

**In summary, 1,1-dimethoxyethane (methylal) is an important research compound with wide-ranging applications as a solvent, reagent, and intermediate. Its versatility and unique properties make it a valuable tool for various scientific disciplines.**

1,1-dimethoxyethane : An acetal that is dimethoxymethane substituted by a methyl group at position 1. [Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

ID Source	ID
PubMed CID	10795
CHEMBL ID	3183607
CHEBI ID	178404
MeSH ID	M0164379

Synonym
1,1-dimethoxyethane [un2377] [flammable liquid]
zo2aw8ur5t ,
unii-zo2aw8ur5t
CHEBI:178404
acetaldehyde, dimethyl acetal
ethane, 1,1-dimethoxy-
1,1-dimethoxyethane
fema no. 3426
methyl formyl
einecs 208-589-8
ai3-24137
acetaldehyde dimethyl acetal
dimethyl acetal
3-methyl-2,4-dioxapentane
dimethyl aldehyde
ethylidene dimethyl ether
1,1-dimethoxyethane [un2377] [flammable liquid]
hsdb 5427
brn 1697039
un2377
acetaldehyde methyl acetal
dimethylacetal
inchi=1/c4h10o2/c1-4(5-2)6-3/h4h,1-3h
534-15-6
1,1-dimethoxyethane, >=97%, fg
acetaldehyde dimethyl acetal, 95%
D0633
AKOS000269040
NCGC00248807-01
tox21_200713
dtxcid207178
cas-534-15-6
NCGC00258267-01
dtxsid7027178 ,
ethane, dimethoxy-
25154-53-4
FT-0606128
dimethylacetal [mi]
1,1-dimethoxyethane [fhfi]
1,1-dimethoxyethane [hsdb]
dimethoxyethane, 1,1-
dimethoxylethane
dimethyloxyethane
acetaldehyde dimethylacetal
2,2-dimethoxyethane
dimethoxy-ethane
acetaldehyde-dimethylacetal
dimethyoxyethane
ch3ch(och3)2
un 2377
1219798-83-0
acetaldehyde dimethyl acetal-d10
W-109005
CHEMBL3183607
mfcd00008493
1,1-dimethoxy-ethane
1,1-dimethoxyethane, 9ci
fema 3426
1,1'-dimethoxyetiane
Q27295796
2,2-dimethoxy ethane
2-dimethoxyethane
D89692
?1,1-dimethoxyethane
acetaldehydedimethylacetal-d10
EN300-100625

Role	Description
flavouring agent	A food additive that is used to added improve the taste or odour of a food.
plant metabolite	Any eukaryotic metabolite produced during a metabolic reaction in plants, the kingdom that include flowering plants, conifers and other gymnosperms.
[role information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Class	Description
acetal	An organooxygen compound having the structure RR'C(OR'')(OR''') (R'', R''' =/= H). Mixed acetals have R'' and R''' groups which differ.
diether	A polyether in which the number of ether linkages is 2.
[compound class information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Protein	Taxonomy	Measurement	Average (µ)	Min (ref.)	Avg (ref.)	Max (ref.)	Bioassay(s)
RAR-related orphan receptor gamma	Mus musculus (house mouse)	Potency	7.0240	0.0060	38.0041	19,952.5996	AID1159521; AID1159523
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Timeframe	Studies, This Drug (%)	All Drugs %
pre-1990	2 (8.33)	18.7374
1990's	2 (8.33)	18.2507
2000's	9 (37.50)	29.6817
2010's	7 (29.17)	24.3611
2020's	4 (16.67)	2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Publication Type	This drug (%)	All Drugs (%)
Trials	0 (0.00%)	5.53%
Reviews	0 (0.00%)	6.00%
Case Studies	0 (0.00%)	4.05%
Observational	0 (0.00%)	0.25%
Other	24 (100.00%)	84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Substance	Relationship Strength	Studies	Classes	Roles
acetaldehyde Acetaldehyde: A colorless, flammable liquid used in the manufacture of acetic acid, perfumes, and flavors. It is also an intermediate in the metabolism of alcohol. It has a general narcotic action and also causes irritation of mucous membranes. Large doses may cause death from respiratory paralysis.. acetaldehyde : The aldehyde formed from acetic acid by reduction of the carboxy group. It is the most abundant carcinogen in tobacco smoke.. aldehyde : A compound RC(=O)H, in which a carbonyl group is bonded to one hydrogen atom and to one R group.. acetyl group : A group, formally derived from acetic acid by dehydroxylation, which is fundamental to the biochemistry of all forms of life. When bound to coenzyme A, it is central to the metabolism of carbohydrates and fats.	2.41	1	aldehyde	carcinogenic agent; EC 3.5.1.4 (amidase) inhibitor; electron acceptor; Escherichia coli metabolite; human metabolite; mouse metabolite; mutagen; oxidising agent; Saccharomyces cerevisiae metabolite; teratogenic agent
benzaldehyde [no description available]	2.46	2	benzaldehydes	EC 3.1.1.3 (triacylglycerol lipase) inhibitor; EC 3.5.5.1 (nitrilase) inhibitor; flavouring agent; fragrance; odorant receptor agonist; plant metabolite
methane Methane: The simplest saturated hydrocarbon. It is a colorless, flammable gas, slightly soluble in water. It is one of the chief constituents of natural gas and is formed in the decomposition of organic matter. (Grant & Hackh's Chemical Dictionary, 5th ed). methane : A one-carbon compound in which the carbon is attached by single bonds to four hydrogen atoms. It is a colourless, odourless, non-toxic but flammable gas (b.p. -161degreeC).	2.05	1	alkane; gas molecular entity; mononuclear parent hydride; one-carbon compound	bacterial metabolite; fossil fuel; greenhouse gas
chlorine chloride : A halide anion formed when chlorine picks up an electron to form an an anion.	2.06	1	halide anion; monoatomic chlorine	cofactor; Escherichia coli metabolite; human metabolite
hydrogen sulfide Hydrogen Sulfide: A flammable, poisonous gas with a characteristic odor of rotten eggs. It is used in the manufacture of chemicals, in metallurgy, and as an analytical reagent. (From Merck Index, 11th ed). hydrogen sulfide : A sulfur hydride consisting of a single sulfur atom bonded to two hydrogen atoms. A highly poisonous, flammable gas with a characteristic odour of rotten eggs, it is often produced by bacterial decomposition of organic matter in the absence of oxygen.. thiol : An organosulfur compound in which a thiol group, -SH, is attached to a carbon atom of any aliphatic or aromatic moiety.	2.03	1	gas molecular entity; hydracid; mononuclear parent hydride; sulfur hydride	Escherichia coli metabolite; genotoxin; metabolite; signalling molecule; toxin; vasodilator agent
methanol Methanol: A colorless, flammable liquid used in the manufacture of FORMALDEHYDE and ACETIC ACID, in chemical synthesis, antifreeze, and as a solvent. Ingestion of methanol is toxic and may cause blindness.. primary alcohol : A primary alcohol is a compound in which a hydroxy group, -OH, is attached to a saturated carbon atom which has either three hydrogen atoms attached to it or only one other carbon atom and two hydrogen atoms attached to it.. methanol : The primary alcohol that is the simplest aliphatic alcohol, comprising a methyl and an alcohol group.	1.97	1	alkyl alcohol; one-carbon compound; primary alcohol; volatile organic compound	amphiprotic solvent; Escherichia coli metabolite; fuel; human metabolite; mouse metabolite; Mycoplasma genitalium metabolite
hexadecanal [no description available]	1.94	1	2,3-saturated fatty aldehyde; long-chain fatty aldehyde	human metabolite; mouse metabolite; Saccharomyces cerevisiae metabolite
phenylacetaldehyde [no description available]	2.41	1	alpha-CH2-containing aldehyde; phenylacetaldehydes	Escherichia coli metabolite; human metabolite; mouse metabolite; Saccharomyces cerevisiae metabolite
toluene methylbenzene : Any alkylbenzene that is benzene substituted with one or more methyl groups.	2.03	1	methylbenzene; toluenes; volatile organic compound	cholinergic antagonist; fuel additive; neurotoxin; non-polar solvent
lactose Lactose: A disaccharide of GLUCOSE and GALACTOSE in human and cow milk. It is used in pharmacy for tablets, in medicine as a nutrient, and in industry.. lactose : A glycosylglucose disaccharide, found most notably in milk, that consists of D-galactose and D-glucose fragments bonded through a beta-1->4 glycosidic linkage. The glucose fragment can be in either the alpha- or beta-pyranose form, whereas the galactose fragment can only have the beta-pyranose form.. beta-lactose : The beta-anomer of lactose.	2	1	lactose
2,2-dimethoxypropane 2,2-dimethoxypropane: dehydrating agent in electron microscopy specimen preparation; structure	2.01	1
acetophenone acetophenone : A methyl ketone that is acetone in which one of the methyl groups has been replaced by a phenyl group.	2.04	1	acetophenones	animal metabolite; photosensitizing agent; xenobiotic
3-hydroxybutanal [no description available]	2.04	1
dimethoxymethane dimethoxymethane : An acetal that is the dimethyl acetal derivative of formaldehyde.	2.01	1	acetal; diether
cyclohexene cyclohexene : A cycloalkene that is cylohexane with a single double bond.	2.03	1	cycloalkene
propylene propylene: structure	2	1	alkene; gas molecular entity	refrigerant; xenobiotic
ferric chloride ferric chloride: RN given refers to cpd with MF of Fe-Cl3; used to induce experimental arterial thrombosis to evaluate antithrombotic agents	2.06	1	iron coordination entity	astringent; Lewis acid
dimethylacetamide hallucinogen : Drugs capable of inducing illusions, hallucinations, delusions, paranoid ideations and other alterations of mood and thinking.. N,N-dimethylacetamide : A member of the class of acetamides that is acetamide in which the hydrogens attached to the N atom have been replaced by two methyl groups respectively. Metabolite observed in cancer metabolism.	2.06	1	acetamides; monocarboxylic acid amide	human metabolite
alkenes [no description available]	2.39	2
trimethylsilyl trifluoromethanesulfonate trimethylsilyl trifluoromethanesulfonate: deprotecting cpd for peptides	2.04	1
acetamidine acetamidine: bovine trypsin inhibitor; RN given refers to parent cpd; structure	2.06	1	carboxamidine
hydroxyl radical Hydroxyl Radical: The univalent radical OH. Hydroxyl radical is a potent oxidizing agent.	2.03	1	oxygen hydride; oxygen radical; reactive oxygen species
oleic acid Oleic Acid: An unsaturated fatty acid that is the most widely distributed and abundant fatty acid in nature. It is used commercially in the preparation of oleates and lotions, and as a pharmaceutical solvent. (Stedman, 26th ed). oleic acid : An octadec-9-enoic acid in which the double bond at C-9 has Z (cis) stereochemistry.	2.17	1	octadec-9-enoic acid	antioxidant; Daphnia galeata metabolite; EC 3.1.1.1 (carboxylesterase) inhibitor; Escherichia coli metabolite; mouse metabolite; plant metabolite; solvent
glycosides [no description available]	2.06	1
2-pentylcinnamaldehyde 2-pentylcinnamaldehyde: jasmine-like odor, widely used synthetic fragrance & suspected allergen; structure given in first source	2.31	1	cinnamaldehydes
alpha-linolenic acid linolenic acid : A two-membered subclass of octadecatrienoic acid comprising the (9Z,12Z,15Z)- and (6Z,9Z,12Z)-isomers. Linolenic acids are nutrients essential to the formation of prostaglandins and are also used in making paints and synthetic resins.. linolenate : A polyunsaturated fatty acid anion obtained by deprotonation of the carboxy group of either alpha- or gamma-linolenic acid.	2.17	1	linolenic acid; omega-3 fatty acid	micronutrient; mouse metabolite; nutraceutical
4-hydroxy-2-nonenal 4-hydroxy-2-nonenal: cytotoxic product from peroxidation of liver microsomal lipids; RN given refers to cpd without isomeric designation. 4-hydroxynon-2-enal : An enal consisting of non-2-ene having an oxo group at the 1-position and a hydroxy group at the 4-position.. 4-hydroxynonenal : A monounsaturated fatty aldehyde that is nonanal that has undergone dehydrogenation to introduce a double bond at any position in the aliphatic chain and in which a hydrogen at position 4 has been replaced by a hydroxy group.	2.41	2	4-hydroxynon-2-enal; 4-hydroxynonenal
malealdehyde malealdehyde: RN given refers to cpd without isomeric designation; fumaraldehyde refers to (E)-isomer	1.99	1	but-2-enedial
scyphostatin scyphostatin: a neutral sphingomyelinase inhibitor isolated from Trichopeziza mollissima; structure in first source	2.03	1	cyclohexenones
phosphatidylcholines Phosphatidylcholines: Derivatives of PHOSPHATIDIC ACIDS in which the phosphoric acid is bound in ester linkage to a CHOLINE moiety.	2.46	2	1,2-diacyl-sn-glycero-3-phosphocholine

Condition	Relationship Strength	Studies
Autism [description not available]	2.05	1
Autistic Disorder A disorder beginning in childhood. It is marked by the presence of markedly abnormal or impaired development in social interaction and communication and a markedly restricted repertoire of activity and interest. Manifestations of the disorder vary greatly depending on the developmental level and chronological age of the individual. (DSM-V)	2.05	1
Edema-Proteinuria-Hypertension Gestosis [description not available]	2.07	1
Pre-Eclampsia A complication of PREGNANCY, characterized by a complex of symptoms including maternal HYPERTENSION and PROTEINURIA with or without pathological EDEMA. Symptoms may range between mild and severe. Pre-eclampsia usually occurs after the 20th week of gestation, but may develop before this time in the presence of trophoblastic disease.	2.07	1
Pregnancy The status during which female mammals carry their developing young (EMBRYOS or FETUSES) in utero before birth, beginning from FERTILIZATION to BIRTH.	2.07	1
Pigmentary Retinopathy [description not available]	1.98	1
Retinitis Pigmentosa Hereditary, progressive degeneration of the retina due to death of ROD PHOTORECEPTORS initially and subsequent death of CONE PHOTORECEPTORS. It is characterized by deposition of pigment in the retina.	1.98	1

1,1-dimethoxyethane

Description

Cross-References

Synonyms (66)

Roles (2)

Drug Classes (2)

Protein Targets (1)

Potency Measurements

Research

Studies (24)

Market Indicators

Research Demand Index: 37.54

Study Types