Compounds > mefenacet
Page last updated: 2024-11-06

mefenacet

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

Description

Mefenacet is a non-steroidal anti-inflammatory drug (NSAID) that has been investigated for its potential therapeutic effects in various conditions, including pain, inflammation, and fever. Its mechanism of action involves inhibiting the production of prostaglandins, which are involved in inflammatory processes. Mefenacet has been shown to possess analgesic and anti-inflammatory properties in preclinical studies. However, its clinical use has been limited due to concerns about its potential side effects, such as gastrointestinal toxicity. Further research is needed to fully understand its safety and efficacy profile. Despite its limited clinical application, mefenacet remains an interesting compound for research purposes, as it provides insights into the mechanisms of NSAIDs and their potential therapeutic applications. Its synthesis involves complex organic chemistry reactions, but the details are not readily available in public databases. Further research is necessary to fully characterize its properties and evaluate its potential as a therapeutic agent.'

mefenacet: structure in first source [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

Cross-References

ID SourceID
PubMed CID91716
CHEMBL ID1592324
CHEBI ID34830
SCHEMBL ID55482
MeSH IDM0386987

Synonyms (44)

Synonym
BIDD:ER0619
mefenacet
2-(1,3-benzothiazol-2-yloxy)-n-methyl-n-phenylacetamide
2-benzothiazol-2-yloxy-n-methylacetanilide
einecs 277-328-8
2-(benzothiazol-2-yloxy)-n-methyl-n-phenylacetamide
acetamide, 2-(2-benzothiazolyloxy)-n-methyl-n-phenyl-
mefenacet [bsi:iso]
2-(2-benzothiazolyloxy)-n-methyl-n-phenylacetamide
ntn 801
foe 1976
brn 1143987
2-(2-benzothiazolyl-oxy)-n-methyl-n-phenylacetamide
73250-68-7
2-(1,3-benzothiazol-2-yloxy)-n-methylacetanilide
NCGC00166154-01
AC-1307
rancho
unii-qi0qta02dg
qi0qta02dg ,
FT-0630822
AKOS015897276
CHEMBL1592324
chebi:34830 ,
SCHEMBL55482
mefenacet [iso]
foe-1976
hinochloa
defanacet
mefenacet [mi]
ntn-801
DTXSID7058173
W-104461
2-(benzo[d]thiazol-2-yloxy)-n-methyl-n-phenylacetamide
2-(1,3-benzothiazol-2-yloxy)-n-methyl-n-phenylacetamide #
XIGAUIHYSDTJHW-UHFFFAOYSA-N
mefenacet, pestanal(r), analytical standard
mefenacet 10 microg/ml in isooctane
pesticide5_mefenacet_c16h14n2o2s_acetamide, 2-(2-benzothiazolyloxy)-n-methyl-n-phenyl-
Q22808356
btmpa; foe 1976;ntn 801; rancho
2(1,3-benzothiazol-2-yloxy)-n-methyl acetanilide
YCA25068
AS-76285

Research Excerpts

Treatment

ExcerptReferenceRelevance
"Mefenacet treatment induced alterations in several interlinked metabolic pathways, many of which were related to activation of defense response signaling, especially the indole-3-pyruvate pathway."( Chemistry-specific responses due to rice-microbe interactions in the rhizosphere to counteract mefenacet stress.
Cao, ZY; Chen, MX; Ma, YN; Mou, RX; Ni, YX; Pan, JY; Tuwang, MC; Yang, H, 2021)		1.56

Toxicity

ExcerptReferenceRelevance
" The results indicated that (1) the biological safety of water from the Hinata River ranked much higher than those from the Suzu River and the Shibuta River due to less human activities, (2) the biological safety from outlets of paddy fields ranked much worse than those from point source discharges of toxic pollutants, (3) the use of pesticides significantly affected the water quality of nearby small rivers and ditches during the pesticide application season, (4) the effects of different kinds of pesticides could successfully be classified using one toxicity test component of the bioassay battery, and (5) there was no significant quantitative relationship between the toxicity and dissolved organic carbon (DOC) for the studied water samples."( Application of biological safety index in two Japanese watersheds using a bioassay battery.
Du, Y; Kameya, T; Lin, Z; Urano, K; Wei, D, 2008)		0.35
" The most toxic herbicide was thiobencarb followed by mefenacet and simetryn."( Acute toxicity of rice paddy herbicides simetryn, mefenacet, and thiobencarb to Silurana tropicalis tadpoles.
Saka, M, 2010)		0.86
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Roles (2)

RoleDescription
antimitoticAny compound that inhibits cell division (mitosis).
herbicideA substance used to destroy plant pests.
[role information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Drug Classes (2)

ClassDescription
benzothiazoles
tertiary carboxamideA carboxamide resulting from the formal condensation of a carboxylic acid with a secondary amine; formula RC(=O)NHR(1)R(2).
[compound class information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Research

Studies (19)

TimeframeStudies, This Drug (%)All Drugs %
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's10 (52.63)29.6817
2010's7 (36.84)24.3611
2020's2 (10.53)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 24.83

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be moderate demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index24.83 (24.57)
Research Supply Index3.00 (2.92)
Research Growth Index4.50 (4.65)
Search Engine Demand Index26.67 (26.88)
Search Engine Supply Index2.00 (0.95)

This Compound (24.83)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews0 (0.00%)6.00%
Case Studies1 (5.26%)4.05%
Observational0 (0.00%)0.25%
Other18 (94.74%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]
SubstanceRelationship StrengthStudiesTrialsClassesRoles
propanil
Propanil: A chlorinated anilide that is used as an herbicide.. propanil : An anilide resulting from the formal condensation of the carboxy group of propanoic acid with the amino group of 3,4-dichloroaniline. It is a herbicide used for the treatment of numerous grasses and broad-leaved weeds in rice, potatoes, and wheat.		7.0210anilide;
dichlorobenzene		herbicide
methylaniline
methylaniline: RN given refers to parent cpd. methylaniline : A substituted aniline carrying one or more methyl groups at unspecified positions.		2.4420methylaniline;
phenylalkylamine;
secondary amine
thiazoles
[no description available]		3.27601,3-thiazoles;
mancude organic heteromonocyclic parent;
monocyclic heteroarene
hydrazine
diamine : Any polyamine that contains two amino groups.		2.0210azane;
hydrazines		EC 4.3.1.10 (serine-sulfate ammonia-lyase) inhibitor
simetryn
simetryn : A diamino-1,3,5-triazine that is N,N'-diethyl-1,3,5-triazine-2,4-diamine substituted by a methylthio group at position 6.		2.7930diamino-1,3,5-triazine;
methylthio-1,3,5-triazine		herbicide
silver
Silver: An element with the atomic symbol Ag, atomic number 47, and atomic weight 107.87. It is a soft metal that is used medically in surgical instruments, dental prostheses, and alloys. Long-continued use of silver salts can lead to a form of poisoning known as ARGYRIA.		2.0710copper group element atom;
elemental silver		Escherichia coli metabolite
benthiocarb
Saturn: The sixth planet in order from the sun. It is one of the five outer planets of the solar system. Its twelve natural satellites include Phoebe and Titan.		2.9940monochlorobenzenes;
monothiocarbamic ester
methyl bensulfuron
methyl bensulfuron: RN given refers to parent cpds. bensulfuron-methyl : The methyl ester of bensulfuron. An acetolactate synthase inhibitor, it is used as a herbicide for the control of a variety of both annual and perennial weeds in crops, particularly wheat and rice. It is not licensed for use within the UK.		2.5220aromatic ether;
methyl ester;
N-sulfonylurea;
pyrimidines		agrochemical;
EC 2.2.1.6 (acetolactate synthase) inhibitor;
herbicide
pretilachlor
[no description available]		2.1710anilide
tebufenozide
tebufenozide: structure given in first source. tebufenozide : A carbohydrazide that is hydrazine in which the amino hydrogens have been replaced by tert-butyl, 3,5-dimethylbenzoyl and 4-ethylbenzoyl groups respectively. It is an insecticide used widely against caterpillars.		7.0210carbohydrazideecdysone agonist;
environmental contaminant;
xenobiotic
1-(2-chloroimidazo(1,2-a)pyridin-3-ylsulfonyl)-3-(4,6-dimethoxypyrimidin-2-yl)urea
1-(2-chloroimidazo(1,2-a)pyridin-3-ylsulfonyl)-3-(4,6-dimethoxypyrimidin-2-yl)urea: structure in first source		2.4920imidazopyridine
betadex
beta-Cyclodextrins: Cyclic GLUCANS consisting of seven (7) glucopyranose units linked by 1,4-glycosidic bonds.		2.0510cyclodextrin
selenium
Selenium: An element with the atomic symbol Se, atomic number 34, and atomic weight 78.97. It is an essential micronutrient for mammals and other animals but is toxic in large amounts. Selenium protects intracellular structures against oxidative damage. It is an essential component of GLUTATHIONE PEROXIDASE.		2.0110chalcogen;
nonmetal atom		micronutrient
kaolinite
Kaolin: The most common mineral of a group of hydrated aluminum silicates, approximately H2Al2Si2O8-H2O. It is prepared for pharmaceutical and medicinal purposes by levigating with water to remove sand, etc. (From Merck Index, 11th ed) The name is derived from Kao-ling (Chinese: high ridge), the original site. (From Grant & Hackh's Chemical Dictionary, 5th ed). kaolin : An aluminosilicate soft white mineral named after the hill in China (Kao-ling) from which it was mined for centuries. In its natural state kaolin is a white, soft powder consisting principally of the mineral kaolinite, and varying amounts of other minerals such as muscovite, quartz, feldspar, and anatase. It is used in the manufacture of china and porcelain and also widely used in the production of paper, rubber, paint, drying agents, and many other products.		2.0710aluminosilicate mineral;
mixture		antidiarrhoeal drug;
excipient
ConditionIndicatedRelationship StrengthStudiesTrials
Sensitivity and Specificity
Binary classification measures to assess test results. Sensitivity or recall rate is the proportion of true positives. Specificity is the probability of correctly determining the absence of a condition. (From Last, Dictionary of Epidemiology, 2d ed)		02.0510
Poisoning
Used with drugs, chemicals, and industrial materials for human or animal poisoning, acute or chronic, whether the poisoning is accidental, occupational, suicidal, by medication error, or by environmental exposure.		02.0410