Page last updated: 2024-12-11

neotame

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Occurs in Manufacturing Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

Description

neotame: structure in first source [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

neotame : A dipeptide composed of N-(3,3-dimethylbutyl)-L-aspartic acid and methyl L-phenylalanate units joined by a peptide linkage. [Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Cross-References

ID SourceID
PubMed CID9810996
CHEMBL ID3718532
CHEBI ID83503
SCHEMBL ID4311
MeSH IDM0357909

Synonyms (51)

Synonym
neotame [nf]
hsdb 7965
l-phenylalanine, n-(3,3-dimethylbutyl)-l-alpha-aspartyl-, 2-methyl ester
unii-vj597d52ex
vj597d52ex ,
neotame
n-(n-(3,3-dimethylbutyl)-l-alpha-aspartyl)-l-phenylalanine 1-methyl ester
nc 00723
(3s)-4-[[(1s)-1-benzyl-2-methoxy-2-oxo-ethyl]amino]-3-(3,3-dimethylbutylamino)-4-oxo-butanoic acid
165450-17-9
A810640
(s)-3-((3,3-dimethylbutyl)amino)-4-(((s)-1-methoxy-1-oxo-3-phenylpropan-2-yl)amino)-4-oxobutanoic ac
S4442
BCP9000982
(s)-3-((3,3-dimethylbutyl)amino)-4-(((s)-1-methoxy-1-oxo-3-phenylpropan-2-yl)amino)-4-oxobutanoic acid
BCP0726000005
AM84564
(3s)-3-[(3,3-dimethylbutyl)amino]-3-{[(2s)-1-methoxy-1-oxo-3-phenylpropan-2-yl]carbamoyl}propanoic acid
neotame [mi]
neotame [mart.]
nc-00723
n-(n-(3,3-dimethylbutyl)-l-.alpha.-aspartyl)-l-phenylalanine 1-methyl ester
mirasee 200
neotame [fhfi]
l-phenylalanine, n-(n-(3,3-dimethylbutyl)-l-.alpha.-aspartyl)-1-methyl ester
e 961
neotame [fcc]
ins-961
ins no.961
neotame [ii]
neotame [usp-rs]
e-961
neotame [inci]
SCHEMBL4311
methyl n-(3,3-dimethylbutyl)-l-alpha-aspartyl-l-phenylalaninate
n-[n-(3,3-dimethylbutyl)-l-alpha-aspartyl]-l-phenylalanine methyl ester
CHEBI:83503
DTXSID50167950
CHEMBL3718532
GS-3213
neotame, analytical standard
J-010204
(3s)-3-(3,3-dimethylbutylamino)-4-[[(2s)-1-methoxy-1-oxo-3-phenylpropan-2-yl]amino]-4-oxobutanoic acid
CS-W011769
Q415698
HLIAVLHNDJUHFG-HOTGVXAUSA-N
AKOS016842430
HY-W011053
(s)-3-((3,3-dimethylbutyl)amino)-4-(((s)-1-methoxy-1-oxo-3-phenylpropan-2-yl)amino)-4-oxobutanoicacid
neotame 1000 microg/ml in water
N1112

Research Excerpts

Overview

Neotame (NEO) is a new artificial sweetener approved as a food additive in many countries. Neotame is a relatively new low-caloric and high-intensity artificialSweetener.

ExcerptReferenceRelevance
"Neotame is a relatively new low-caloric and high-intensity artificial sweetener, approved by FDA in 2002."( Effects of the Artificial Sweetener Neotame on the Gut Microbiome and Fecal Metabolites in Mice.
Bian, X; Chi, L; Gao, B; Lai, Y; Lu, K; Ru, H; Tu, P, 2018
)
1.48
"Neotame (NEO) is a new artificial sweetener approved as a food additive in many countries. "( Determination of neotame in non-alcoholic beverage by capillary zone electrophoresis.
Gao, Y; Hu, F; Liu, H; Luan, F; Xu, L, 2013
)
2.17

Toxicity

ExcerptReferenceRelevance
" In definitive safety studies, there were no adverse findings related to neotame treatment from clinical observations, physical examinations, water consumption, or clinical pathology evaluations; nor was there morbidity, mortality, organ toxicity, macroscopic or microscopic postmortem findings."( Food consumption and body weight changes with neotame, a new sweetener with intense taste: differentiating effects of palatability from toxicity in dietary safety studies.
Comer, CP; Mayhew, DA; Stargel, WW, 2003
)
0.81
" This study investigates the question of whether the changes in BWG were adverse or secondary to small, long-term decrements in FC."( Long-term food consumption and body weight changes in neotame safety studies are consistent with the allometric relationship observed for other sweeteners and during dietary restrictions.
Blackburn, GL; Comer, CP; Flamm, WG; Mayhew, DA; Stargel, WW, 2003
)
0.57

Dosage Studied

ExcerptRelevanceReference
" Concentrations were increased as animals grew to maintain constant dosing on a "mg/kg bw/day" basis."( Food consumption and body weight changes with neotame, a new sweetener with intense taste: differentiating effects of palatability from toxicity in dietary safety studies.
Comer, CP; Mayhew, DA; Stargel, WW, 2003
)
0.58
" Altogether, our findings indicate that denatonium stimulates CASR by shifting a dose-response curve for the principal CASR agonist Ca(2+) to lower concentrations."( Stimulation of the extracellular Ca²⁺-sensing receptor by denatonium.
Bystrova, MF; Churbanov, GD; Kolesnikov, SS; Rogachevskaja, OA; Romanov, RA, 2011
)
0.37
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Occurs in Manufacturing (109 Product(s))

Product Categories

Product CategoryProducts
Aliments et boissons à base de végétaux, Aliments d'origine végétale, Farines, Fruits à coques et dérivés, Farines de fruits à coques, Amandes en poudre1
Other56
Frozen foods3
Frozen foods, Meals, Soups1
Beverages, Waters2
en:ravioli1
Plant-based foods and beverages, Plant-based foods, Cereals and potatoes, Cereals and their products1
Snacks, Sweet snacks, Cocoa and its products, Confectioneries, Chocolate candies2
Snacks, Sweet snacks, Confectioneries, Candies1
Plant-based foods and beverages, Plant-based foods, Cereals and potatoes, Cereals and their products, Pastas1
Snack, Snack dolci, Biscotti e torte, Biscotti, Canestrelli1
Cibi e bevande a base vegetale, Cibi a base vegetale, Cereali e patate, Pani2
Plant-based foods and beverages, Plant-based foods, Fruits and vegetables based foods, Fruits based foods, Fruits, Apples, en:fresh-apples1
Snacks, Snacks sucrés, Biscuits et gâteaux, Biscuits, Amaretti1
Snacks,Snacks sucrés,Biscuits et gâteaux,Biscuits,Amaretti1
Puffed corn cakes,Puffed corn cakes with black chocolate1
Aliments et boissons à base de végétaux, Aliments d'origine végétale, Aliments à base de fruits et de légumes, Petit-déjeuners, Produits à tartiner, Fruits et produits dérivés, Pâtes à tartiner végétales, Produits à tartiner sucrés, Confitures et marmelad2
Beverages, Dairies, Fermented foods, Desserts, Fermented milk products, Dairy desserts, Dairy drinks, Fermented dairy desserts, Fermented drinks, Flavoured milks, Fermented milk drinks, Yogurts, Drinkable yogurts, Milkshakes1
en:Sweeteners, Cukr, en:Brown sugars1
Milchprodukte, Fermentierte Lebensmittel, Fermentierte Milch, Käse, Geriebener Käse, en:Geriebener Käse, en:Käse, en:Milchprodukte1
en:Plant-based foods and beverages, en:Plant-based foods, en:Breakfasts, en:Cereals and potatoes, en:Cereals and their products, en:Breakfast cereals, en:Mueslis1
en:Plant-based foods and beverages, en:Plant-based foods, en:Breakfasts, en:Cereals and potatoes, Obiloviny, Snídaňové cereálie, Müsli1
Dietary supplements1
en:Condiments, en:Sauces, en:Tomato sauces, en:groceries1
Plant-based foods and beverages, Plant-based foods, Fruits and vegetables based foods, Vegetables based foods, Tomatoes and their products, Tomatoes1
Snacks, Sweet snacks, Biscuits and cakes, Biscuits2
Svačiny, en:Meats and their products, en:Salty snacks, en:Appetizers, en:Meats, en:Pork and its products, en:Pork, en:Bacon1
cs:Sirups, en:flavoured-syrups1
Produits laitiers, Produits fermentés, Produits laitiers fermentés, Fromages, en:cooked-pressed-cheeses, Fromages de France, Comté, en:aoc-cheeses, en:labeled-cheeses1
Pflanzliche Lebensmittel und Getränke, Pflanzliche Lebensmittel, Frühstücke, Getreide und Kartoffeln, Getreideprodukte, Frühstückscerealien, Getreideflocken, Frühstücksflocken, Stranggepresstes Getreide, Extrudierte Flocken, Cornflakes1
Plant-based foods and beverages, Plant-based foods, Cereals and potatoes, Breads1
Viandes et dérivés, Plats préparés, Viandes, Charcuteries, Poissons et viandes et oeufs, Frais, Abats, Plats préparés frais, Réfrigérés, Produits tripiers, Boudins, Boudins noirs, Boudin noir sauté1
Viandes et dérivés, Viandes, Charcuteries, Poissons et viandes et oeufs, Abats, Produits tripiers, Boudins, Boudins noirs, Boudin noir sauté1
Desserts, Frozen foods, Frozen desserts1
Botanas,Snacks dulces,Barritas,Barritas de cereales1
Dairies, Creams1
Beverages, Dairies, Fermented foods, Desserts, Fermented milk products, Dairy desserts, Dairy drinks, Fermented dairy desserts, Fermented drinks, Fermented milk drinks, Yogurts, Drinkable yogurts1
Alimentos e bebidas à base de plantas,Alimentos à base de plantas,Alimentos à base de frutas e legumes,Sobremesas,Alimentos à base de frutas,Alimento para bebés,en:From 12 months old,en:From 8 months,en:Fruits puree without sugar added1
Mléčné výrobky1
Instant meals1
Condiments, Sauces, Sauces salades, Vinaigrettes, en:groceries1
Frutti di mare, Pesci, en:Fatty fishes, Tonno, Filetti di pesce, Filetti di tonno1
en:Plant-based foods and beverages, en:Plant-based foods, en:Cereals and potatoes, Obiloviny, Těstoviny, en:Cereal pastas, en:Durum wheat pasta, en:Spaghetti, en:Durum wheat spaghetti1
Viandes et dérivés, Viandes, Charcuteries, Frais, Jambons, Jambons blancs1
Condiments, Sauces, Pasta sauces, en:tomato-sauces1
Snacks, Sweet snacks, Confectioneries1
Snacks1

Products

ProductBrandCategoryCompounds Matched from IngredientsDate Retrieved
Pecans & honey caramel covered in premium milk chocolateSnacks, Sweet snacks, Cocoa and its products, Confectioneries, Chocolate candiesinvert sugar,vanillin2024-02-12
Organic Vegan Mac (Cheddar Flavor)Annie'sOtherpotassium chloride2024-02-13
La brea bakery, loaf bread, salted caramel pecanLa Brea Bakery, Aryzta LlcPlant-based foods and beverages, Plant-based foods, Cereals and potatoes, Breadsniacin,riboflavin2024-08-22
Pecan BragSweet Shop Candies Inc.Snacksinvert sugar2024-02-09
Sweet Shops, Chocolate Covered OreosSweet Shop Candies Inc.Otherniacin2024-02-09
Cheese Stuffed RigatoniWhole Foods Market, Severino Pasta Mfg.Otherniacin,ferrous sulfate,riboflavin2024-02-09

Roles (3)

RoleDescription
environmental contaminantAny minor or unwanted substance introduced into the environment that can have undesired effects.
xenobioticA xenobiotic (Greek, xenos "foreign"; bios "life") is a compound that is foreign to a living organism. Principal xenobiotics include: drugs, carcinogens and various compounds that have been introduced into the environment by artificial means.
sweetening agentSubstance that sweeten food, beverages, medications, etc.
[role information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Drug Classes (1)

ClassDescription
dipeptideAny molecule that contains two amino-acid residues connected by peptide linkages.
[compound class information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Research

Studies (32)

TimeframeStudies, This Drug (%)All Drugs %
pre-19900 (0.00)18.7374
1990's1 (3.13)18.2507
2000's15 (46.88)29.6817
2010's12 (37.50)24.3611
2020's4 (12.50)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 58.22

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be very strong demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index58.22 (24.57)
Research Supply Index3.56 (2.92)
Research Growth Index5.26 (4.65)
Search Engine Demand Index99.50 (26.88)
Search Engine Supply Index2.17 (0.95)

This Compound (58.22)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials1 (3.03%)5.53%
Reviews3 (9.09%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other29 (87.88%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]