N-heptanoyl-homoserine lactone: structure in first source [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]
| ID Source | ID |
|---|---|
| PubMed CID | 443437 |
| CHEMBL ID | 584972 |
| CHEBI ID | 29644 |
| SCHEMBL ID | 1448957 |
| MeSH ID | M0489296 |
| Synonym |
|---|
| n-heptanoyl-homoserine lactone |
| LMFA08030006 |
| n-heptanoylhomoserine lactone |
| CHEMBL584972 , |
| chebi:29644 , |
| n-[(3s)-2-oxooxolan-3-yl]heptanamide |
| bdbm50300132 |
| n-heptanoyl-l-homoserine lactone |
| SCHEMBL1448957 |
| 177158-20-2 |
| FTMZLSDESAOPSZ-VIFPVBQESA-N |
| n-[(3s)-tetrahydro-2-oxo-3-furanyl]heptanamide |
| DTXSID90332084 |
| mfcd11113138 |
| n-heptanoyl-l-homoserine lactone, >=96% (hplc) |
| J-011254 |
| Q27110200 |
| heptanamide, n-[(3s)-tetrahydro-2-oxo-3-furanyl]- |
| n- [(3s)- tetrahydro- 2- oxo- 3- furanyl]- heptanamide |
| c7-hsl |
| n-heptanoyl homoserine lactone |
| HY-115393A |
| CS-0129207 |
| n-heptanoyl-l-homoserinelactone |
| Class | Description |
|---|---|
| N-acyl-amino acid | A carboxamide resulting from the formal condensation of a carboxylic acid with the amino group of an amino acid. |
| [compound class information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res] | |
| Protein | Taxonomy | Measurement | Average | Min (ref.) | Avg (ref.) | Max (ref.) | Bioassay(s) |
|---|---|---|---|---|---|---|---|
| Transcriptional activator protein LuxR | Aliivibrio fischeri | IC50 (µMol) | 1.3800 | 1.3600 | 3.2533 | 7.0000 | AID1604875; AID615221 |
| Transcriptional activator protein LasR | Pseudomonas aeruginosa PAO1 | IC50 (µMol) | 75.7500 | 0.1100 | 3.1583 | 9.0000 | AID1604885; AID442670 |
| Transcriptional activator protein TraR | Agrobacterium tumefaciens | IC50 (µMol) | 0.4100 | 0.1300 | 0.4100 | 0.6900 | AID442669; AID615222 |
| [prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023] | |||||||
| Assay ID | Title | Year | Journal | Article |
|---|---|---|---|---|
| AID615222 | Antagonist activity at Agrobacterium tumefaciens TraR receptor in presence of 100 nM 3-oxo-C8-HSL | 2010 | Journal of medicinal chemistry, Nov-11, Volume: 53, Issue:21 | Medicinal chemistry as a conduit for the modulation of quorum sensing. |
| AID1604887 | Inhibition of LasR in Escherichia coli JLD271 harboring pSC11/pJN105L using CPRG as substrate incubated for 4 hrs by Miller assay method | 2020 | Bioorganic & medicinal chemistry, 02-01, Volume: 28, Issue:3 | Impact of the structure-activity relationship of AHL analogues on quorum sensing in Gram-negative bacteria. |
| AID442669 | Inhibition of Agrobacterium tumefaciens TraR | 2010 | European journal of medicinal chemistry, Feb, Volume: 45, Issue:2 | Theoretical and structural analysis of the active site of the transcriptional regulators LasR and TraR, using molecular docking methodology for identifying potential analogues of acyl homoserine lactones (AHLs) with anti-quorum sensing activity. |
| AID1604885 | Inhibition of LasR in Pseudomonas aeruginosa PAO-JP2 harboring plasI-LVAgfp incubated for 6 hrs by fluorescence method | 2020 | Bioorganic & medicinal chemistry, 02-01, Volume: 28, Issue:3 | Impact of the structure-activity relationship of AHL analogues on quorum sensing in Gram-negative bacteria. |
| AID615272 | Antagonist activity at Pseudomonas aeruginosa LasR receptor expressed in Escherichia coli in presence of 7.5 nM natural auto-inducer 3-oxo-C12-HSL | 2010 | Journal of medicinal chemistry, Nov-11, Volume: 53, Issue:21 | Medicinal chemistry as a conduit for the modulation of quorum sensing. |
| AID1604875 | Antagonist activity at Aliivibrio fischeri ES114 LuxR after 4 to 8 hrs by luminescence method | 2020 | Bioorganic & medicinal chemistry, 02-01, Volume: 28, Issue:3 | Impact of the structure-activity relationship of AHL analogues on quorum sensing in Gram-negative bacteria. |
| AID615221 | Antagonist activity at Vibrio fischeri luxR receptor in presence of 5 uM 3-oxo-C6-HSL | 2010 | Journal of medicinal chemistry, Nov-11, Volume: 53, Issue:21 | Medicinal chemistry as a conduit for the modulation of quorum sensing. |
| AID442670 | Inhibition of Pseudomonas aeruginosa LasR | 2010 | European journal of medicinal chemistry, Feb, Volume: 45, Issue:2 | Theoretical and structural analysis of the active site of the transcriptional regulators LasR and TraR, using molecular docking methodology for identifying potential analogues of acyl homoserine lactones (AHLs) with anti-quorum sensing activity. |
| [information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||||
| Timeframe | Studies, This Drug (%) | All Drugs % |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 2 (25.00) | 29.6817 |
| 2010's | 5 (62.50) | 24.3611 |
| 2020's | 1 (12.50) | 2.80 |
| [information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||
According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be weak demand-to-supply ratio for research on this compound.
| This Compound (12.31) All Compounds (24.57) |
| Publication Type | This drug (%) | All Drugs (%) |
|---|---|---|
| Trials | 0 (0.00%) | 5.53% |
| Reviews | 1 (12.50%) | 6.00% |
| Case Studies | 0 (0.00%) | 4.05% |
| Observational | 0 (0.00%) | 0.25% |
| Other | 7 (87.50%) | 84.16% |
| [information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||