negative regulation of cell adhesion involved in substrate-bound cell migration

Definition

Target type: biologicalprocess

The disassembly of adhesions at the front and rear of a migrating cell. At the leading edge, adhesion disassembly accompanies the formation of new protrusions; at the cell rear, it promotes tail retraction. [GOC:dph, GOC:tb, ISBN:0815316194, PMID:11944043, PMID:14657486]

Negative regulation of cell adhesion involved in substrate-bound cell migration is a complex process that controls the movement of cells on a surface. It involves a series of steps, beginning with the detachment of the cell from the substrate. This detachment is often mediated by the downregulation of cell adhesion molecules, such as integrins, cadherins, and selectins. These molecules are responsible for adhering cells to the substrate and to each other. When their expression or function is reduced, the cell can detach and begin to migrate.

Once the cell has detached, it extends protrusions, such as filopodia and lamellipodia, which probe the surrounding environment. These protrusions are driven by the polymerization of actin filaments, which are components of the cytoskeleton. The cell then attaches to the substrate at new locations using new adhesion molecules. This process of detachment, protrusion, and reattachment is repeated as the cell migrates.

There are many factors that can influence the negative regulation of cell adhesion involved in substrate-bound cell migration. These include:

* **Signaling pathways:** Cells receive signals from their environment that can activate or inhibit cell adhesion. For example, growth factors can stimulate cell migration by promoting the detachment of cells from the substrate.
* **Cytoskeletal dynamics:** The rearrangement of the cytoskeleton is essential for cell migration. The polymerization and depolymerization of actin filaments and microtubules play a crucial role in driving protrusion and retraction, respectively.
* **Extracellular matrix (ECM) components:** The ECM provides a scaffold for cells to adhere to and migrate on. Different ECM components, such as collagen, fibronectin, and laminin, can influence the adhesion and migration of cells.
* **Cell-cell interactions:** Cells can also interact with each other through cell-cell adhesion molecules, such as cadherins. These interactions can influence cell migration by modulating cell-substrate adhesion.

Negative regulation of cell adhesion involved in substrate-bound cell migration is essential for many biological processes, including wound healing, immune responses, and development. Dysregulation of this process can lead to diseases such as cancer metastasis.

This is a detailed overview of the biological process. For more specific information, you can refer to scientific literature or databases on cell biology and cell migration.'
"

Proteins (1)

Compounds (10)