Eukaryotic initiation factor 4A-II

A eukaryotic initiation factor 4A-II that is encoded in the genome of human. [PRO:DNx]

eIF-4A-II;
eIF4A-II;
EC 3.6.4.13;
ATP-dependent RNA helicase eIF4A-2

Research

Drug	Taxonomy	Measurement	Average (mM)	Bioassay(s)	Publication(s)
hippuristanol	Homo sapiens (human)	IC50	18.0000	1	1

This protein enables 7 target(s):

Target	Category	Definition
RNA binding	molecular function	Binding to an RNA molecule or a portion thereof. [GOC:jl, GOC:mah]
RNA helicase activity	molecular function	Unwinding of an RNA helix, driven by ATP hydrolysis. [GOC:jl, PMID:19158098]
helicase activity	molecular function	Catalysis of the reaction: ATP + H2O = ADP + phosphate, to drive the unwinding of a DNA or RNA helix. [GOC:jl]
protein binding	molecular function	Binding to a protein. [GOC:go_curators]
ATP binding	molecular function	Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. [ISBN:0198506732]
ATP hydrolysis activity	molecular function	Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient. [RHEA:13065]
translation initiation factor activity	molecular function	Functions in the initiation of ribosome-mediated translation of mRNA into a polypeptide. [ISBN:0198506732]

This protein is located in 2 target(s):

Target	Category	Definition
cytosol	cellular component	The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. [GOC:hjd, GOC:jl]
perinuclear region of cytoplasm	cellular component	Cytoplasm situated near, or occurring around, the nucleus. [GOC:jid]

This protein is part of 1 target(s):

Target	Category	Definition
eukaryotic translation initiation factor 4F complex	cellular component	The eukaryotic translation initiation factor 4F complex is composed of eIF4E, eIF4A and eIF4G; it is involved in the recognition of the mRNA cap, ATP-dependent unwinding of the 5'-terminal secondary structure and recruitment of the mRNA to the ribosome. [GOC:hb, PMID:32883864, PMID:8449919]

This protein is involved in 5 target(s):

Target	Category	Definition
translational initiation	biological process	The process preceding formation of the peptide bond between the first two amino acids of a protein. This includes the formation of a complex of the ribosome, mRNA or circRNA, and an initiation complex that contains the first aminoacyl-tRNA. [ISBN:019879276X]
regulation of translational initiation	biological process	Any process that modulates the frequency, rate or extent of translational initiation. [GOC:go_curators]
negative regulation of RNA-dependent RNA polymerase activity	biological process	Any process that stops, prevents or reduces the frequency, rate or extent of RNA-directed 5'-3' RNA polymerase activity. [GOC:pf, GOC:TermGenie]
cellular response to leukemia inhibitory factor	biological process	Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a leukemia inhibitory factor stimulus. [PMID:12801913]
cytoplasmic translational initiation	biological process	The process preceding formation of the peptide bond between the first two amino acids of a protein in the cytoplasm. This includes the formation of a complex of the ribosome, mRNA or circRNA, and an initiation complex that contains the first aminoacyl-tRNA. [GOC:hjd]