Compounds > 22-epi-hippuristanol
Page last updated: 2024-12-08

22-epi-hippuristanol

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

Cross-References

ID SourceID
PubMed CID330750
CHEMBL ID458245
MeSH IDM0497846

Synonyms (8)

Synonym
nsc-320006
desacetoxyhippurin-1 (b710962k323)
nsc320006
CHEMBL458245
epihippuristanol
22-epi-hippuristanol
HPHXKNOXVBFETI-FELJEYOCSA-N
bdbm50482567
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Protein Targets (1)

Inhibition Measurements

ProteinTaxonomyMeasurementAverageMin (ref.)Avg (ref.)Max (ref.)Bioassay(s)
Eukaryotic initiation factor 4A-IMus musculus (house mouse)IC50 (µMol)100.00000.40000.40000.4000AID503175
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Ceullar Components (1)

Processvia Protein(s)Taxonomy
cytosolEukaryotic initiation factor 4A-IMus musculus (house mouse)
[Information is prepared from geneontology information from the June-17-2024 release]

Bioassays (13)

Assay IDTitleYearJournalArticle
AID1129018Inhibition of translation in rabbit reticulocyte lysates using SP6 RNA polymerase at 10 uM by FF/HCV/Ren reporter gene assay2014Journal of medicinal chemistry, Mar-27, Volume: 57, Issue:6
Synthesis of the antiproliferative agent hippuristanol and its analogues from hydrocortisone via Hg(II)-catalyzed spiroketalization: structure-activity relationship.
AID503175Inhibition of eIF4A-mediated cap-dependent protein synthesis in FF-HCV-Ren mRNA transfected Swiss mouse Krebs2 cell extract by [35S]methionine metabolic labeling study2006Nature chemical biology, Apr, Volume: 2, Issue:4
Functional characterization of IRESes by an inhibitor of the RNA helicase eIF4A.
AID397142Cytotoxicity against human A549 cells after 48 hrs by MTT assay1993Journal of natural products, Jun, Volume: 56, Issue:6
Evaluation of marine sponge metabolites for cytotoxicity and signal transduction activity.
AID456441Growth inhibition of human A549 cells after 72 hrs by sulforhodamine B assay2010Bioorganic & medicinal chemistry, Jan-01, Volume: 18, Issue:1
Synthesis of a new cytotoxic cephalostatin/ritterazine analogue from hecogenin and 22-epi-hippuristanol.
AID456440Growth inhibition of human MDA-MB-231 cells after 72 hrs by sulforhodamine B assay2010Bioorganic & medicinal chemistry, Jan-01, Volume: 18, Issue:1
Synthesis of a new cytotoxic cephalostatin/ritterazine analogue from hecogenin and 22-epi-hippuristanol.
AID397143Cytotoxicity against human HT-29 cells after 48 hrs by MTT assay1993Journal of natural products, Jun, Volume: 56, Issue:6
Evaluation of marine sponge metabolites for cytotoxicity and signal transduction activity.
AID402291Cytotoxicity against human MDA-MB-231 cells after 3 days by MTT assay2005Journal of natural products, Jun, Volume: 68, Issue:6
Polyoxygenated steroids from the gorgonian Isis hippuris.
AID402290Cytotoxicity against human MCF7 cells after 3 days by MTT assay2005Journal of natural products, Jun, Volume: 68, Issue:6
Polyoxygenated steroids from the gorgonian Isis hippuris.
AID397144Cytotoxicity against mouse P388 cells after 48 hrs by MTT assay1993Journal of natural products, Jun, Volume: 56, Issue:6
Evaluation of marine sponge metabolites for cytotoxicity and signal transduction activity.
AID456442Growth inhibition of human HT-29 cells after 72 hrs by sulforhodamine B assay2010Bioorganic & medicinal chemistry, Jan-01, Volume: 18, Issue:1
Synthesis of a new cytotoxic cephalostatin/ritterazine analogue from hecogenin and 22-epi-hippuristanol.
AID397145Cytotoxicity against mouse EL-4.IL-2 cells after 3 to 4 days by Trypan blue exclusion test1993Journal of natural products, Jun, Volume: 56, Issue:6
Evaluation of marine sponge metabolites for cytotoxicity and signal transduction activity.
AID402288Cytotoxicity against human HepG2 cells after 3 days by MTT assay2005Journal of natural products, Jun, Volume: 68, Issue:6
Polyoxygenated steroids from the gorgonian Isis hippuris.
AID402289Cytotoxicity against human Hep3B cells after 3 days by MTT assay2005Journal of natural products, Jun, Volume: 68, Issue:6
Polyoxygenated steroids from the gorgonian Isis hippuris.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (5)

TimeframeStudies, This Drug (%)All Drugs %
pre-19900 (0.00)18.7374
1990's1 (20.00)18.2507
2000's2 (40.00)29.6817
2010's2 (40.00)24.3611
2020's0 (0.00)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 12.87

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be weak demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index12.87 (24.57)
Research Supply Index1.79 (2.92)
Research Growth Index4.66 (4.65)
Search Engine Demand Index0.00 (26.88)
Search Engine Supply Index0.00 (0.95)

This Compound (12.87)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews0 (0.00%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other5 (100.00%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]
SubstanceRelationship StrengthStudiesTrialsClassesRoles
meridine
meridine: polycyclic alkaloid derived from the marine sponge Corticium sp; structure given in first source		1.9810
puupehenone
[no description available]		1.9810
hippurin
hippurin: from gorgonian Isis hippuris; structure given in first source		2.4320oxaspiro compound;
steroid
anisomycin
Anisomycin: An antibiotic isolated from various Streptomyces species. It interferes with protein and DNA synthesis by inhibiting peptidyl transferase or the 80S ribosome system.. (-)-anisomycin : An antibiotic isolated from various Streptomyces species. It interferes with protein and DNA synthesis by inhibiting peptidyl transferase or the 80S ribosome system.		2.110monohydroxypyrrolidine;
organonitrogen heterocyclic antibiotic		anticoronaviral agent;
antimicrobial agent;
antineoplastic agent;
antiparasitic agent;
bacterial metabolite;
DNA synthesis inhibitor;
protein synthesis inhibitor
latrunculin a
latrunculin A: 16-membered macrolide attached to 2-thiazolidinone moiety; from Red Sea sponge Latrunculia magnifica; see also latrunculin B; structure given in first source. latrunculin A : A bicyclic macrolide natural product consisting of a 16-membered bicyclic lactone attached to the rare 2-thiazolidinone moiety. It is obtained from the Red Sea sponge Latrunculia magnifica and from the Fiji Islands sponge Cacospongia mycofijiensis. Latrunculin A inhibits actin polymerisation, microfilament organsation and microfilament-mediated processes.		1.9810cyclic hemiketal;
macrolide;
oxabicycloalkane;
thiazolidinone		actin polymerisation inhibitor;
metabolite;
toxin
manzamine a
manzamine A: RN given refers to (1R-(1R*,9Z,13S*,13aR*,20aR*,21aR*)-isomer; RN for cpd without isomeric designation not avail 12/92. manzamine A : An alkaloid of the class of beta-carbolines isolated from Haliclona and Acanthostrongylophora. It exhibits inhibitory activity against Glycogen Synthase Kinase-3 (EC 2.7.11.26).		1.9810alkaloid;
beta-carbolines;
isoquinolines		animal metabolite;
anti-HSV-1 agent;
antimalarial;
antineoplastic agent;
EC 2.7.11.26 (tau-protein kinase) inhibitor;
marine metabolite
discorhabdin p
discorhabdin P: sulfur-containing pyrroloiminoquinone alkaloid (or benzothiazepine); an enzyme inhibitor from a deep-water caribbean sponge of the Genus batzella; structure in first source		1.9810
manzamine b
manzamine B: from an Indonesian Acanthostrongylophora sponge with activity against infectious, tropical parasitic, and Alzheimer's diseases; structure in first source		1.9810
hippuristanol
hippuristanol: from the gorgonian Isis hippuris		2.4620
demethyloxyaaptamine
demethyloxyaaptamine: from Hymeniacidon sp.; structure in first source		1.9810
(1S,3aR,4S,6S,6aS,9aS,9bS)-9a-isocyano-6-(2-isocyano-2-methylpropyl)-1,4-dimethyl-7-methylidene-2,3,3a,4,5,6,6a,8,9,9b-decahydro-1H-phenalene
[no description available]		1.9810diterpenoidmetabolite
ConditionIndicatedRelationship StrengthStudiesTrials
Leukemia P388
An experimental lymphocytic leukemia originally induced in DBA/2 mice by painting with methylcholanthrene.		01.9810
Breast Cancer
[description not available]		02.0510
Carcinoma, Anaplastic
[description not available]		02.0510
Cancer of Lung
[description not available]		02.0510
Colorectal Cancer
[description not available]		02.0510
Breast Neoplasms
Tumors or cancer of the human BREAST.		02.0510
Carcinoma
A malignant neoplasm made up of epithelial cells tending to infiltrate the surrounding tissues and give rise to metastases. It is a histological type of neoplasm and not a synonym for cancer.		02.0510
Lung Neoplasms
Tumors or cancer of the LUNG.		02.0510
Colorectal Neoplasms
Tumors or cancer of the COLON or the RECTUM or both. Risk factors for colorectal cancer include chronic ULCERATIVE COLITIS; FAMILIAL POLYPOSIS COLI; exposure to ASBESTOS; and irradiation of the CERVIX UTERI.		02.0510