translation activator activity

Definition

Target type: molecularfunction

Any of a group of soluble proteins functioning in the activation of ribosome-mediated translation of mRNA into a polypeptide. [GOC:ai]

Translation activator activity refers to the ability of a molecule to enhance the rate of protein synthesis. This enhancement can occur through various mechanisms, including:
* **Recruitment of ribosomes to mRNA:** Translation activators can facilitate the binding of ribosomes to the mRNA molecule, the template for protein synthesis. This binding step is crucial for initiating translation.
* **Regulation of initiation factors:** Translation activators can interact with initiation factors, proteins that are essential for the formation of the translation initiation complex. This interaction can promote the assembly of the complex and stimulate the initiation of protein synthesis.
* **Modulation of mRNA structure:** Some translation activators can alter the structure of mRNA, making it more accessible to ribosomes. This can increase the efficiency of translation.
* **Stabilization of mRNA:** Translation activators can protect mRNA from degradation, ensuring its availability for translation.
* **Enhancement of elongation:** Translation activators can also influence the elongation phase of translation, increasing the rate at which amino acids are added to the growing polypeptide chain.
* **Facilitation of termination:** Translation activators may play a role in the termination of protein synthesis, ensuring the proper release of the completed polypeptide chain from the ribosome.
Translation activators are critical for the regulation of gene expression, ensuring that the appropriate levels of proteins are produced at the right time and place. They are involved in a wide range of cellular processes, including cell growth, development, and response to stress. Dysregulation of translation activator activity can lead to various diseases, including cancer and neurodevelopmental disorders.'
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Proteins (1)

Compounds (1)