hippuristanol has been researched along with Breast-Neoplasms* in 2 studies
2 other study(ies) available for hippuristanol and Breast-Neoplasms
| Article | Year |
|---|---|
Design of Development Candidate eFT226, a First in Class Inhibitor of Eukaryotic Initiation Factor 4A RNA Helicase.
Dysregulation of protein translation is a key driver for the pathogenesis of many cancers. Eukaryotic initiation factor 4A (eIF4A), an ATP-dependent DEAD-box RNA helicase, is a critical component of the eIF4F complex, which regulates cap-dependent protein synthesis. The flavagline class of natural products ( Topics: Animals; Benzofurans; Binding Sites; Breast Neoplasms; Cell Line, Tumor; Crystallography, X-Ray; Drug Design; Eukaryotic Initiation Factor-4A; Female; Half-Life; Humans; Ligands; Mice; Mice, Nude; Molecular Dynamics Simulation; Mutagenesis, Site-Directed; Protein Structure, Tertiary; Rats; RNA, Messenger; Structure-Activity Relationship | 2020 |
Synthesis of a new cytotoxic cephalostatin/ritterazine analogue from hecogenin and 22-epi-hippuristanol.
A new cephalostatin/ritterazine analogue was prepared from the commercially available hecogenin acetate and the natural cytotoxic steroid 22-epi-hippuristanol. The method involved the reductive dimerization of enaminoketones (condensation of alpha-aminoketones) and condensation between an enaminoketone and an alpha-hydroxyketone. The new analogue showed higher cytotoxic activity than the cytotoxic 22-epi-hippuristanol against MDA-MB-231, A-549 and HT-29 cultured tumor cell lines. Topics: Antineoplastic Agents; Breast Neoplasms; Carcinoma; Cell Line, Tumor; Cell Proliferation; Colorectal Neoplasms; Cytotoxins; Female; Humans; Inhibitory Concentration 50; Lung Neoplasms; Phenazines; Sapogenins; Spiro Compounds; Steroids; Sterols | 2010 |