An ATP-dependent RNA helicase DHX29 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q7Z478]
EC 3.6.4.13;
DEAH box protein 29;
Nucleic acid helicase DDXx
| Timeframe | Studies on this Protein(%) | All Drugs % |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 1 (100.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Drug | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Publication(s) |
|---|---|---|---|---|---|
| hippuristanol | Homo sapiens (human) | IC50 | 30.0000 | 1 | 1 |
This protein enables 10 target(s):
| Target | Category | Definition |
|---|---|---|
| RNA binding | molecular function | Binding to an RNA molecule or a portion thereof. [GOC:jl, GOC:mah] |
| RNA helicase activity | molecular function | Unwinding of an RNA helix, driven by ATP hydrolysis. [GOC:jl, PMID:19158098] |
| translation initiation factor activity | molecular function | Functions in the initiation of ribosome-mediated translation of mRNA into a polypeptide. [ISBN:0198506732] |
| ATP binding | molecular function | Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. [ISBN:0198506732] |
| translation activator activity | molecular function | Any of a group of soluble proteins functioning in the activation of ribosome-mediated translation of mRNA into a polypeptide. [GOC:ai] |
| ATP hydrolysis activity | molecular function | Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient. [RHEA:13065] |
| ribonucleoside triphosphate phosphatase activity | molecular function | Catalysis of the reaction: a ribonucleoside triphosphate + H2O = a ribonucleoside diphosphate + H+ + phosphate. [RHEA:23680] |
| ribosomal small subunit binding | molecular function | Binding to a small ribosomal subunit. [GOC:go_curators] |
| cadherin binding | molecular function | Binding to cadherin, a type I membrane protein involved in cell adhesion. [GOC:bf] |
| helicase activity | molecular function | Catalysis of the reaction: ATP + H2O = ADP + phosphate, to drive the unwinding of a DNA or RNA helix. [GOC:jl] |
This protein is active in 1 target(s):
| Target | Category | Definition |
|---|---|---|
| intracellular anatomical structure | cellular component | A component of a cell contained within (but not including) the plasma membrane. In eukaryotes it includes the nucleus and cytoplasm. [ISBN:0198506732] |
This protein is part of 2 target(s):
| Target | Category | Definition |
|---|---|---|
| eukaryotic 43S preinitiation complex | cellular component | A protein complex composed of the 40S ribosomal subunit plus eIF1, eIF1A, eIF3, eIF5, and eIF2-GTP-bound methionyl-initiator methionine tRNA. [GOC:hjd, PMID:15145049, PMID:16510876, PMID:25742741, PMID:29735639] |
| cytosolic small ribosomal subunit | cellular component | The small subunit of a ribosome located in the cytosol. [GOC:mtg_sensu] |
This protein is involved in 3 target(s):
| Target | Category | Definition |
|---|---|---|
| formation of translation preinitiation complex | biological process | The joining of the small ribosomal subunit, ternary complex, and mRNA. [GOC:hjd] |
| ribosome assembly | biological process | The aggregation, arrangement and bonding together of the mature ribosome and of its subunits. [GOC:ma, PMID:30467428] |
| positive regulation of translational initiation | biological process | Any process that activates or increases the frequency, rate or extent of translational initiation. [GOC:go_curators] |