protein transport into plasma membrane raft

Definition

Target type: biologicalprocess

The directed movement of a protein into a plasma membrane raft. [GOC:jl]

Protein transport into plasma membrane rafts is a complex process involving multiple steps and cellular machinery. It begins with the synthesis of the target protein in the endoplasmic reticulum (ER). The protein then undergoes folding and quality control, ensuring its proper structure before being transported to the Golgi apparatus. In the Golgi, the protein undergoes further modifications, such as glycosylation, which are crucial for its targeting to rafts.

Next, the protein is packaged into transport vesicles, which bud from the Golgi and travel towards the plasma membrane. Raft-targeting signals, often found in the protein's transmembrane domain, guide the vesicle to specific microdomains within the plasma membrane called lipid rafts. These rafts are enriched in cholesterol and sphingolipids, creating a distinct environment that favors the incorporation of specific proteins.

Upon reaching the plasma membrane, the vesicle fuses with the raft domain, releasing the protein into the membrane. This fusion process is facilitated by specific proteins called SNAREs, which act as molecular "zippers" to ensure accurate docking and fusion.

The final step involves the lateral diffusion of the protein within the raft. This movement is driven by the fluidity of the membrane and the interaction of the protein with other raft-associated molecules. This lateral diffusion allows the protein to reach its final destination within the raft and perform its specific functions.

Overall, protein transport into plasma membrane rafts is a tightly regulated process that ensures the correct localization and function of specific proteins in the cell membrane. This process plays a crucial role in various cellular functions, including cell signaling, membrane trafficking, and immune response.'
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Proteins (1)

Compounds (14)