engeletin and Lung-Neoplasms

Phytochemicals belonging to the class of flavonoids have been used in medicine for the treatment of different kinds of human health complications. Flavonoids have beneficial health aspects in medicine mainly due to their anti-microbial, anti-diabetic, anti-inflammatory, anticancer, and anti-carcinogenic activities. They have been scientifically investigated for their health benefit and pharmacological activities in medicine. Engeletin is a pure flavanonol class phytocompound present in the skin of white grapes and white wine. Engeletin has numerous pharmacological activities in medicine.. In order to know the beneficial health aspects of engeletin in medicine, scientific data on engeletin have been collected from different literature sources and analyzed in the present work. The present work summarized the important findings of engeletin with respect to its medicinal uses, pharmacological activities, and analytical aspects in medicine. All the scientific data were collected from PubMed, Google, Scopus, Science Direct and Google Scholar and analyzed in the present work.. Scientific data analysis of research works revealed the biological importance and therapeutic benefit of engeletin in medicine. Engeletin has attracted scientific attention mainly due to its antiinflammatory and anti-tumor potential. Engeletin could inhibit the occurrence of cervical cancer and delay the development of liver damage and lung cancer in mice. Engeletin was found to inhibit lipopolysaccharides- induced endometritis in mice by inhibiting the inflammatory response. Pharmacological data analysis revealed the therapeutic importance of engeletin against acute lung injury, inflammatory diseases, liver injury, pulmonary fibrogenesis, Alzheimer's disease, endometritis, cervical carcinogenesis, lung cancer, and osteoarthritis. Analytical data signified the importance of modern analytical tools for separating, isolating, and identifying engeletin.. Scientific data analysis revealed the biological importance and therapeutic benefit of engeletin in medicine and other allied health sectors.

Topics: Animals; Anti-Inflammatory Agents; Endometritis; Female; Flavonols; Humans; Lung Neoplasms; Medicine, Traditional; Mice

Lung cancer is a leading cause of human death worldwide. Nevertheless, the outcome of present therapeutic options is still not satisfying. Engeletin (ENG, dihydrokaempferol 3-rhamnoside) is a flavanonol glycoside, showing anticancer activities in some tumors. But the exact molecular mechanism of ENG is not fully understood. In our present study, we found that ENG significantly induced apoptotic cell death in lung cancer cells through reducing X-linked inhibitor apoptosis (XIAP) expression from the post-translational levels. However, the XIAP ubiquitination was obviously up-regulated by ENG. In addition, second mitochondria-derived activator of caspase (SMAC) expression levels were increased by ENG in lung cancer cells. Notably, SMAC inhibition significantly abrogated ENG-inhibited expression of XIAP. Furthermore, ENG enhanced the interaction between XIAP and SMAC through increasing SMAC secretion from mitochondria to the cytoplasm. Moreover, endoplasmic-reticulum (ER) stress was highly induced by ENG, and we found that inhibiting C/-EBP homologous protein (CHOP), the transcription factor of ER stress, eliminated the regulatory effects of ENG on the expression of SMAC and XIAP. The in vitro analysis showed that ENG treatment caused apparent mitochondrial dysfunction in lung cancer cells. Finally, we showed that ENG effectively reduced the growth of xenograft tumors derived from cell lines with limited toxicity. Taken together, ENG had therapeutic potential against lung cancer progression.

Topics: A549 Cells; Animals; Antineoplastic Agents, Phytogenic; Apoptosis; Apoptosis Regulatory Proteins; Disease Progression; Endoplasmic Reticulum Stress; Flavonols; Gene Expression Regulation, Neoplastic; Glycosides; Humans; Lung Neoplasms; Male; Mice; Mitochondria; Mitochondrial Proteins; Signal Transduction; Transcription Factor CHOP; Tumor Burden; X-Linked Inhibitor of Apoptosis Protein; Xenograft Model Antitumor Assays