| Assay ID | Title | Year | Journal | Article |
|---|
| AID1297535 | Selectivity index, ratio Ki for human D3 receptor to Ki for human D2 receptor using [3H]N-methylspiperone displacement assay | 2016 | Journal of medicinal chemistry, Apr-14, Volume: 59, Issue:7
| Novel Analogues of (R)-5-(Methylamino)-5,6-dihydro-4H-imidazo[4,5,1-ij]quinolin-2(1H)-one (Sumanirole) Provide Clues to Dopamine D2/D3 Receptor Agonist Selectivity. |
| AID1297546 | Agonist activity at recombinant human D3 receptor expressing in CHOp cells assessed as receptor mediated stimulation of mitogenesis measured as [3H]thymidine incorporation after 24 hrs by scintillation spectrometry relative to dopamine | 2016 | Journal of medicinal chemistry, Apr-14, Volume: 59, Issue:7
| Novel Analogues of (R)-5-(Methylamino)-5,6-dihydro-4H-imidazo[4,5,1-ij]quinolin-2(1H)-one (Sumanirole) Provide Clues to Dopamine D2/D3 Receptor Agonist Selectivity. |
| AID112352 | Hypothermic effects in mice when administered subcutaneously. | 1997 | Journal of medicinal chemistry, Feb-28, Volume: 40, Issue:5
| Synthesis and biological activities of (R)-5,6-dihydro-N,N-dimethyl-4H-imidazo[4,5,1-ij]quinolin-5-amine and its metabolites. |
| AID4447 | Binding affinity towards Serotonin 5-hydroxytryptamine 1A receptor by displacement of [3H]-(+)-8-OH-DPAT. | 1997 | Journal of medicinal chemistry, Feb-28, Volume: 40, Issue:5
| Synthesis and biological activities of (R)-5,6-dihydro-N,N-dimethyl-4H-imidazo[4,5,1-ij]quinolin-5-amine and its metabolites. |
| AID40985 | Percent inhibition of [3H]flunitrazepam binding to GABA-A benzodiazepine receptor at 1 uM | 1997 | Journal of medicinal chemistry, Feb-28, Volume: 40, Issue:5
| Synthesis and biological activities of (R)-5,6-dihydro-N,N-dimethyl-4H-imidazo[4,5,1-ij]quinolin-5-amine and its metabolites. |
| AID1443621 | Agonist activity at renilla luciferase-tagged human dopamine D2 receptor expressed in HEK293 cells coexpressing mVenus-fused beta-arrestin 2 assessed as induction of beta-arrestin 2 recruitment by BRET assay relative to quinpirole | | | |
| AID112350 | Hypothermic effects in mice when administered orally. | 1997 | Journal of medicinal chemistry, Feb-28, Volume: 40, Issue:5
| Synthesis and biological activities of (R)-5,6-dihydro-N,N-dimethyl-4H-imidazo[4,5,1-ij]quinolin-5-amine and its metabolites. |
| AID118326 | The stability relative to the U-93385 compound. | 1997 | Journal of medicinal chemistry, Feb-28, Volume: 40, Issue:5
| Synthesis and biological activities of (R)-5,6-dihydro-N,N-dimethyl-4H-imidazo[4,5,1-ij]quinolin-5-amine and its metabolites. |
| AID1297534 | Displacement of [3H]N-methylspiperone from human D3 receptor transfected in HEK293 cells measured after 60 mins by liquid scintillation counter | 2016 | Journal of medicinal chemistry, Apr-14, Volume: 59, Issue:7
| Novel Analogues of (R)-5-(Methylamino)-5,6-dihydro-4H-imidazo[4,5,1-ij]quinolin-2(1H)-one (Sumanirole) Provide Clues to Dopamine D2/D3 Receptor Agonist Selectivity. |
| AID1443628 | Agonist activity at human dopamine D2 receptor expressed in HEK293 cells coexpressing renilla luciferase-fused GalphaoA/GFP10-fused Ggamma2 by BRET assay | | | |
| AID65774 | Binding affinity towards Dopamine receptor D3 by displacement of [3H](+)-7-OH-DPAT. | 1997 | Journal of medicinal chemistry, Feb-28, Volume: 40, Issue:5
| Synthesis and biological activities of (R)-5,6-dihydro-N,N-dimethyl-4H-imidazo[4,5,1-ij]quinolin-5-amine and its metabolites. |
| AID1297540 | Agonist activity at human D2 receptor transfected in HEK293T cells by BRET based G0 activation assay relative to dopamine | 2016 | Journal of medicinal chemistry, Apr-14, Volume: 59, Issue:7
| Novel Analogues of (R)-5-(Methylamino)-5,6-dihydro-4H-imidazo[4,5,1-ij]quinolin-2(1H)-one (Sumanirole) Provide Clues to Dopamine D2/D3 Receptor Agonist Selectivity. |
| AID1297538 | Selectivity index, ratio Ki for human D3 receptor to Ki for human D2 receptor using [3H]7-OH-DPAT displacement assay | 2016 | Journal of medicinal chemistry, Apr-14, Volume: 59, Issue:7
| Novel Analogues of (R)-5-(Methylamino)-5,6-dihydro-4H-imidazo[4,5,1-ij]quinolin-2(1H)-one (Sumanirole) Provide Clues to Dopamine D2/D3 Receptor Agonist Selectivity. |
| AID63977 | Binding affinity towards Dopamine receptor D2 by displacement of [3H]U-86170. | 1997 | Journal of medicinal chemistry, Feb-28, Volume: 40, Issue:5
| Synthesis and biological activities of (R)-5,6-dihydro-N,N-dimethyl-4H-imidazo[4,5,1-ij]quinolin-5-amine and its metabolites. |
| AID61687 | Percent inhibition against Dopamine receptor D1 using [3H]-SCH- 23990 at 1 uM | 1997 | Journal of medicinal chemistry, Feb-28, Volume: 40, Issue:5
| Synthesis and biological activities of (R)-5,6-dihydro-N,N-dimethyl-4H-imidazo[4,5,1-ij]quinolin-5-amine and its metabolites. |
| AID142897 | Percent inhibition against Muscarinic acetylcholine receptor using [3H]oxotremorine-M at 1 uM | 1997 | Journal of medicinal chemistry, Feb-28, Volume: 40, Issue:5
| Synthesis and biological activities of (R)-5,6-dihydro-N,N-dimethyl-4H-imidazo[4,5,1-ij]quinolin-5-amine and its metabolites. |
| AID1443629 | Agonist activity at human dopamine D2 receptor expressed in HEK293 cells coexpressing renilla luciferase-fused GalphaoA/GFP10-fused Ggamma2 by BRET assay relative to quinpirole | | | |
| AID150416 | Percent inhibition against Opioid receptors using [3H]etorphine at 1 uM | 1997 | Journal of medicinal chemistry, Feb-28, Volume: 40, Issue:5
| Synthesis and biological activities of (R)-5,6-dihydro-N,N-dimethyl-4H-imidazo[4,5,1-ij]quinolin-5-amine and its metabolites. |
| AID1297541 | Agonist activity at human D3 receptor transfected in HEK293T cells by BRET based G0 activation assay | 2016 | Journal of medicinal chemistry, Apr-14, Volume: 59, Issue:7
| Novel Analogues of (R)-5-(Methylamino)-5,6-dihydro-4H-imidazo[4,5,1-ij]quinolin-2(1H)-one (Sumanirole) Provide Clues to Dopamine D2/D3 Receptor Agonist Selectivity. |
| AID36307 | Percent inhibition against alpha-1 adrenergic receptor using [3H]prazosin at 1 uM | 1997 | Journal of medicinal chemistry, Feb-28, Volume: 40, Issue:5
| Synthesis and biological activities of (R)-5,6-dihydro-N,N-dimethyl-4H-imidazo[4,5,1-ij]quinolin-5-amine and its metabolites. |
| AID1443620 | Agonist activity at renilla luciferase-tagged human dopamine D2 receptor expressed in HEK293 cells coexpressing mVenus-fused beta-arrestin 2 assessed as induction of beta-arrestin 2 recruitment by BRET assay | | | |
| AID35645 | Percent inhibition against alpha-2 adrenergic receptor using [3H]clonidine at 1 uM | 1997 | Journal of medicinal chemistry, Feb-28, Volume: 40, Issue:5
| Synthesis and biological activities of (R)-5,6-dihydro-N,N-dimethyl-4H-imidazo[4,5,1-ij]quinolin-5-amine and its metabolites. |
| AID1297542 | Agonist activity at human D3 receptor transfected in HEK293T cells by BRET based G0 activation assay relative to dopamine | 2016 | Journal of medicinal chemistry, Apr-14, Volume: 59, Issue:7
| Novel Analogues of (R)-5-(Methylamino)-5,6-dihydro-4H-imidazo[4,5,1-ij]quinolin-2(1H)-one (Sumanirole) Provide Clues to Dopamine D2/D3 Receptor Agonist Selectivity. |
| AID1443625 | Agonist activity at human dopamine D2 receptor expressed in HEK293 cells coexpressing renilla luciferase-fused Galphai1/GFP10-fused Ggamma2 by BRET assay relative to quinpirole | | | |
| AID1297539 | Agonist activity at human D2 receptor transfected in HEK293T cells by BRET based G0 activation assay | 2016 | Journal of medicinal chemistry, Apr-14, Volume: 59, Issue:7
| Novel Analogues of (R)-5-(Methylamino)-5,6-dihydro-4H-imidazo[4,5,1-ij]quinolin-2(1H)-one (Sumanirole) Provide Clues to Dopamine D2/D3 Receptor Agonist Selectivity. |
| AID5348 | Percent inhibition against 5-hydroxytryptamine 2A receptor using [3H]ketanserin at 1 uM | 1997 | Journal of medicinal chemistry, Feb-28, Volume: 40, Issue:5
| Synthesis and biological activities of (R)-5,6-dihydro-N,N-dimethyl-4H-imidazo[4,5,1-ij]quinolin-5-amine and its metabolites. |
| AID1297543 | Agonist activity at recombinant human D2 receptor expressing in CHOp cells assessed as receptor mediated stimulation of mitogenesis measured as [3H]thymidine incorporation after 24 hrs by scintillation spectrometry | 2016 | Journal of medicinal chemistry, Apr-14, Volume: 59, Issue:7
| Novel Analogues of (R)-5-(Methylamino)-5,6-dihydro-4H-imidazo[4,5,1-ij]quinolin-2(1H)-one (Sumanirole) Provide Clues to Dopamine D2/D3 Receptor Agonist Selectivity. |
| AID1443624 | Agonist activity at human dopamine D2 receptor expressed in HEK293 cells coexpressing renilla luciferase-fused Galphai1/GFP10-fused Ggamma2 by BRET assay | | | |
| AID1297536 | Displacement of [3H]7-OH-DPAT from human D2 receptor transfected in HEK293 cells measured after 60 mins by liquid scintillation counter | 2016 | Journal of medicinal chemistry, Apr-14, Volume: 59, Issue:7
| Novel Analogues of (R)-5-(Methylamino)-5,6-dihydro-4H-imidazo[4,5,1-ij]quinolin-2(1H)-one (Sumanirole) Provide Clues to Dopamine D2/D3 Receptor Agonist Selectivity. |
| AID1443617 | Agonist activity at human dopamine D2 receptor expressed in HEK293 cells assessed as cAMP inhibition by BRET assay relative to quinpirole | | | |
| AID1297544 | Agonist activity at recombinant human D2 receptor expressing in CHOp cells assessed as receptor mediated stimulation of mitogenesis measured as [3H]thymidine incorporation after 24 hrs by scintillation spectrometry relative to dopamine | 2016 | Journal of medicinal chemistry, Apr-14, Volume: 59, Issue:7
| Novel Analogues of (R)-5-(Methylamino)-5,6-dihydro-4H-imidazo[4,5,1-ij]quinolin-2(1H)-one (Sumanirole) Provide Clues to Dopamine D2/D3 Receptor Agonist Selectivity. |
| AID41894 | Inhibition of [3H]dihydroalprenolol binding to beta adrenergic receptor at 1 uM | 1997 | Journal of medicinal chemistry, Feb-28, Volume: 40, Issue:5
| Synthesis and biological activities of (R)-5,6-dihydro-N,N-dimethyl-4H-imidazo[4,5,1-ij]quinolin-5-amine and its metabolites. |
| AID1297533 | Displacement of [3H]N-methylspiperone from human D2 receptor transfected in HEK293 cells measured after 60 mins by liquid scintillation counter | 2016 | Journal of medicinal chemistry, Apr-14, Volume: 59, Issue:7
| Novel Analogues of (R)-5-(Methylamino)-5,6-dihydro-4H-imidazo[4,5,1-ij]quinolin-2(1H)-one (Sumanirole) Provide Clues to Dopamine D2/D3 Receptor Agonist Selectivity. |
| AID1297537 | Displacement of [3H]7-OH-DPAT from human D3 receptor transfected in HEK293 cells measured after 60 mins by liquid scintillation counter | 2016 | Journal of medicinal chemistry, Apr-14, Volume: 59, Issue:7
| Novel Analogues of (R)-5-(Methylamino)-5,6-dihydro-4H-imidazo[4,5,1-ij]quinolin-2(1H)-one (Sumanirole) Provide Clues to Dopamine D2/D3 Receptor Agonist Selectivity. |
| AID1297545 | Agonist activity at recombinant human D3 receptor expressing in CHOp cells assessed as receptor mediated stimulation of mitogenesis measured as [3H]thymidine incorporation after 24 hrs by scintillation spectrometry | 2016 | Journal of medicinal chemistry, Apr-14, Volume: 59, Issue:7
| Novel Analogues of (R)-5-(Methylamino)-5,6-dihydro-4H-imidazo[4,5,1-ij]quinolin-2(1H)-one (Sumanirole) Provide Clues to Dopamine D2/D3 Receptor Agonist Selectivity. |
| AID63839 | Percent inhibition against Dopamine receptor D4 using [3H]spiperone at 1 uM | 1997 | Journal of medicinal chemistry, Feb-28, Volume: 40, Issue:5
| Synthesis and biological activities of (R)-5,6-dihydro-N,N-dimethyl-4H-imidazo[4,5,1-ij]quinolin-5-amine and its metabolites. |
| AID1443616 | Agonist activity at human dopamine D2 receptor expressed in HEK293 cells assessed as cAMP inhibition by BRET assay | | | |
| [information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023] |