Page last updated: 2024-09-03

sb 211475 and carvedilol

sb 211475 has been researched along with carvedilol in 4 studies

Compound Research Comparison

Studies
(sb 211475)
Trials
(sb 211475)
Recent Studies (post-2010)
(sb 211475)
Studies
(carvedilol)
Trials
(carvedilol)
Recent Studies (post-2010) (carvedilol)
6012,9336801,052

Protein Interaction Comparison

ProteinTaxonomysb 211475 (IC50)carvedilol (IC50)
Solute carrier family 22 member 2Homo sapiens (human)7.5
Solute carrier family 22 member 1 Homo sapiens (human)3.4
5-hydroxytryptamine receptor 4Cavia porcellus (domestic guinea pig)0.115
Potassium channel subfamily K member 2Homo sapiens (human)1.6
Beta-2 adrenergic receptorHomo sapiens (human)0.0002
Aldo-keto reductase family 1 member B1Rattus norvegicus (Norway rat)0.538
ATP-dependent translocase ABCB1Homo sapiens (human)5.7333
Beta-1 adrenergic receptorHomo sapiens (human)0.0002
Alpha-2A adrenergic receptorHomo sapiens (human)0.106
Angiotensin-converting enzymeOryctolagus cuniculus (rabbit)4.1193
Beta-3 adrenergic receptorHomo sapiens (human)0.0042
D(2) dopamine receptorHomo sapiens (human)0.146
Alpha-2B adrenergic receptorHomo sapiens (human)0.094
Alpha-2C adrenergic receptorHomo sapiens (human)0.09
5-hydroxytryptamine receptor 1ARattus norvegicus (Norway rat)0.0058
D(1A) dopamine receptorHomo sapiens (human)1.498
Sodium-dependent noradrenaline transporter Homo sapiens (human)0.538
Alpha-1D adrenergic receptorHomo sapiens (human)0.0018
5-hydroxytryptamine receptor 2AHomo sapiens (human)0.41
5-hydroxytryptamine receptor 2CHomo sapiens (human)0.115
5-hydroxytryptamine receptor 1BRattus norvegicus (Norway rat)0.0058
Sodium-dependent serotonin transporterHomo sapiens (human)0.221
D(3) dopamine receptorHomo sapiens (human)0.577
5-hydroxytryptamine receptor 2BHomo sapiens (human)0.023
5-hydroxytryptamine receptor 6Homo sapiens (human)1.519
Potassium channel subfamily K member 10Homo sapiens (human)7.6
Sodium-dependent dopamine transporter Homo sapiens (human)0.845
Potassium voltage-gated channel subfamily H member 2Homo sapiens (human)2.2346
Cytochrome P450 1B1Homo sapiens (human)1.1
Nuclear receptor subfamily 3 group C member 3 Bos taurus (cattle)4.1193

Research

Studies (4)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's3 (75.00)18.2507
2000's1 (25.00)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Christopher, TA; Feuerstein, GZ; Lopez, BL; Ma, XL; Ruffolo, RR; Yue, TL1
Brunvand, H; Feuerstein, GZ; Liu, G; Ma, XL; Ruffolo, RR; Yue, TL1
Feuerstein, G; Lysko, KA; Lysko, PG; Mason, PE; Mason, RP; Walter, MF; Webb, CL1
Chen, J; Christopher, TA; Gao, F; Gu, J; Lopez, BL; Lysko, P; Ma, XL; Ohlstein, EH; Ruffolo, RR; Yue, TL1

Other Studies

4 other study(ies) available for sb 211475 and carvedilol

ArticleYear
Effects of a hydroxylated metabolite of the beta-andrenoreceptor antagonist, carvedilol, on post-ischaemic splachnic tissue injury.
    British journal of pharmacology, 1998, Volume: 123, Issue:2

    Topics: Adrenergic beta-Antagonists; Animals; Antioxidants; Blood Pressure; Carbazoles; Carvedilol; Endothelium, Vascular; In Vitro Techniques; Ischemia; Male; Mesenteric Artery, Superior; Muscle Relaxation; Muscle, Smooth, Vascular; Peroxidase; Propanolamines; Rats; Rats, Sprague-Dawley; Reperfusion Injury

1998
SB 211475, a metabolite of carvedilol, reduces infarct size after myocardial ischemic and reperfusion injury in rabbits.
    European journal of pharmacology, 1998, Sep-04, Volume: 356, Issue:2-3

    Topics: Adrenergic alpha-Antagonists; Animals; Antioxidants; Carbazoles; Carvedilol; Dose-Response Relationship, Drug; Hemodynamics; Male; Myocardial Infarction; Myocardial Reperfusion Injury; Peroxidase; Propanolamines; Rabbits

1998
Neuroprotective activities of carvedilol and a hydroxylated derivative: role of membrane biophysical interactions.
    Biochemical pharmacology, 1998, Dec-15, Volume: 56, Issue:12

    Topics: Animals; Antioxidants; Calcium Channel Blockers; Carbazoles; Carvedilol; Cell Membrane; Cells, Cultured; Cerebellum; Dihydropyridines; Free Radical Scavengers; Lipid Bilayers; Models, Molecular; Neurons; Neuroprotective Agents; Propanolamines; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Sodium Channel Blockers; Veratridine; X-Ray Diffraction

1998
Comparison of bisoprolol and carvedilol cardioprotection in a rabbit ischemia and reperfusion model.
    European journal of pharmacology, 2000, Oct-06, Volume: 406, Issue:1

    Topics: Adrenergic beta-Agonists; Adrenergic beta-Antagonists; Animals; Antioxidants; Bisoprolol; Carbazoles; Cardiovascular Agents; Carvedilol; Creatine Kinase; Disease Models, Animal; Dose-Response Relationship, Drug; Heart Rate; Isoproterenol; Lipid Peroxidation; Male; Membrane Lipids; Myocardial Ischemia; Myocardium; Peroxidase; Propanolamines; Rabbits; Reperfusion Injury; Ventricular Pressure

2000