| Assay ID | Title | Year | Journal | Article |
|---|
| AID232160 | Ratio of 50% fall in heart rate to that of fall in rhythmic slow wave activity in anesthetized rats | 1997 | Journal of medicinal chemistry, Dec-19, Volume: 40, Issue:26
| Design of [R-(Z)]-(+)-alpha-(methoxyimino)-1-azabicyclo[2.2.2]octane-3-acetonitri le (SB 202026), a functionally selective azabicyclic muscarinic M1 agonist incorporating the N-methoxy imidoyl nitrile group as a novel ester bioisostere. |
| AID1247230 | Agonist activity at human muscarinic M2 receptor expressed in CHO cells after 30 mins by GTPgamma35S binding assay | 2015 | Bioorganic & medicinal chemistry letters, Oct-01, Volume: 25, Issue:19
| Design and synthesis of N-[6-(Substituted Aminoethylideneamino)-2-Hydroxyindan-1-yl]arylamides as selective and potent muscarinic M₁ agonists. |
| AID141660 | In vitro affinity evaluated using [3H]- quinuclidinyl benzilate as radioligand in rat cerebral cortex for muscarinic acetylcholine receptor | 1997 | Journal of medicinal chemistry, Dec-19, Volume: 40, Issue:26
| Design of [R-(Z)]-(+)-alpha-(methoxyimino)-1-azabicyclo[2.2.2]octane-3-acetonitri le (SB 202026), a functionally selective azabicyclic muscarinic M1 agonist incorporating the N-methoxy imidoyl nitrile group as a novel ester bioisostere. |
| AID732915 | Partial agonist activity at human M4 receptor co-expressed with Galpha16 in CHO cells assessed as calcium mobilization after 60 mins by FLIPR assay | 2013 | ACS medicinal chemistry letters, Feb-14, Volume: 4, Issue:2
| Discovery of novel N-substituted oxindoles as selective m1 and m4 muscarinic acetylcholine receptors partial agonists. |
| AID142394 | In vitro affinity is evaluated, using quinuclidynyl benzylate (QNB) as radioligand in human cloned Muscarinic acetylcholine receptor M2 | 1997 | Journal of medicinal chemistry, Dec-19, Volume: 40, Issue:26
| Design of [R-(Z)]-(+)-alpha-(methoxyimino)-1-azabicyclo[2.2.2]octane-3-acetonitri le (SB 202026), a functionally selective azabicyclic muscarinic M1 agonist incorporating the N-methoxy imidoyl nitrile group as a novel ester bioisostere. |
| AID176904 | Dose producing 50 % fall in heart rate in anesthetized rats | 1997 | Journal of medicinal chemistry, Dec-19, Volume: 40, Issue:26
| Design of [R-(Z)]-(+)-alpha-(methoxyimino)-1-azabicyclo[2.2.2]octane-3-acetonitri le (SB 202026), a functionally selective azabicyclic muscarinic M1 agonist incorporating the N-methoxy imidoyl nitrile group as a novel ester bioisostere. |
| AID1247228 | Agonist activity at human muscarinic M1 receptor expressed in CHO cells after 30 mins by GTPgamma35S binding assay | 2015 | Bioorganic & medicinal chemistry letters, Oct-01, Volume: 25, Issue:19
| Design and synthesis of N-[6-(Substituted Aminoethylideneamino)-2-Hydroxyindan-1-yl]arylamides as selective and potent muscarinic M₁ agonists. |
| AID181415 | Hippocampal rhythmical slow wave activity in rat was determined | 1997 | Journal of medicinal chemistry, Dec-19, Volume: 40, Issue:26
| Design of [R-(Z)]-(+)-alpha-(methoxyimino)-1-azabicyclo[2.2.2]octane-3-acetonitri le (SB 202026), a functionally selective azabicyclic muscarinic M1 agonist incorporating the N-methoxy imidoyl nitrile group as a novel ester bioisostere. |
| AID176905 | Dose producing 50 % fall in mean blood pressure in anesthetized rats | 1997 | Journal of medicinal chemistry, Dec-19, Volume: 40, Issue:26
| Design of [R-(Z)]-(+)-alpha-(methoxyimino)-1-azabicyclo[2.2.2]octane-3-acetonitri le (SB 202026), a functionally selective azabicyclic muscarinic M1 agonist incorporating the N-methoxy imidoyl nitrile group as a novel ester bioisostere. |
| AID141349 | In vitro affinity is evaluated, using quinuclidynyl benzylate (QNB) as radioligand in human cloned Muscarinic acetylcholine receptor M3 | 1997 | Journal of medicinal chemistry, Dec-19, Volume: 40, Issue:26
| Design of [R-(Z)]-(+)-alpha-(methoxyimino)-1-azabicyclo[2.2.2]octane-3-acetonitri le (SB 202026), a functionally selective azabicyclic muscarinic M1 agonist incorporating the N-methoxy imidoyl nitrile group as a novel ester bioisostere. |
| AID181289 | Dose inducing hippocampal rhythmic slow wave activity | 1997 | Journal of medicinal chemistry, Dec-19, Volume: 40, Issue:26
| Design of [R-(Z)]-(+)-alpha-(methoxyimino)-1-azabicyclo[2.2.2]octane-3-acetonitri le (SB 202026), a functionally selective azabicyclic muscarinic M1 agonist incorporating the N-methoxy imidoyl nitrile group as a novel ester bioisostere. |
| AID1247232 | Agonist activity at human muscarinic M3 receptor expressed in CHO cells after 30 mins by GTPgamma35S binding assay | 2015 | Bioorganic & medicinal chemistry letters, Oct-01, Volume: 25, Issue:19
| Design and synthesis of N-[6-(Substituted Aminoethylideneamino)-2-Hydroxyindan-1-yl]arylamides as selective and potent muscarinic M₁ agonists. |
| AID176571 | Extrapyramidal effects was assessed from the dose producing tremors in anesthetized rats | 1997 | Journal of medicinal chemistry, Dec-19, Volume: 40, Issue:26
| Design of [R-(Z)]-(+)-alpha-(methoxyimino)-1-azabicyclo[2.2.2]octane-3-acetonitri le (SB 202026), a functionally selective azabicyclic muscarinic M1 agonist incorporating the N-methoxy imidoyl nitrile group as a novel ester bioisostere. |
| AID181416 | Hippocampal rhythmical slow wave activity in rat was determined; Range 0.012-0.024 | 1997 | Journal of medicinal chemistry, Dec-19, Volume: 40, Issue:26
| Design of [R-(Z)]-(+)-alpha-(methoxyimino)-1-azabicyclo[2.2.2]octane-3-acetonitri le (SB 202026), a functionally selective azabicyclic muscarinic M1 agonist incorporating the N-methoxy imidoyl nitrile group as a novel ester bioisostere. |
| AID1247231 | Agonist activity at human muscarinic M2 receptor expressed in CHO cells after 30 mins by GTPgamma35S binding assay relative to acetylcholine | 2015 | Bioorganic & medicinal chemistry letters, Oct-01, Volume: 25, Issue:19
| Design and synthesis of N-[6-(Substituted Aminoethylideneamino)-2-Hydroxyindan-1-yl]arylamides as selective and potent muscarinic M₁ agonists. |
| AID732914 | Antipsychotic activity in Sprague-Dawley rats assessed as reversal of methamphetamine-induced hyperlocomotion at 0.1 to 1 mg/kg, po administered 60 mins prior to methamphetamine injection measured for 80 mins from 10 mins after methamphetamine challenge | 2013 | ACS medicinal chemistry letters, Feb-14, Volume: 4, Issue:2
| Discovery of novel N-substituted oxindoles as selective m1 and m4 muscarinic acetylcholine receptors partial agonists. |
| AID1247235 | Agonist activity at human muscarinic M4 receptor expressed in CHO cells after 30 mins by GTPgamma35S binding assay relative to acetylcholine | 2015 | Bioorganic & medicinal chemistry letters, Oct-01, Volume: 25, Issue:19
| Design and synthesis of N-[6-(Substituted Aminoethylideneamino)-2-Hydroxyindan-1-yl]arylamides as selective and potent muscarinic M₁ agonists. |
| AID110542 | Extrapyramidal effects is assessed from the dose producing tremors | 1997 | Journal of medicinal chemistry, Dec-19, Volume: 40, Issue:26
| Design of [R-(Z)]-(+)-alpha-(methoxyimino)-1-azabicyclo[2.2.2]octane-3-acetonitri le (SB 202026), a functionally selective azabicyclic muscarinic M1 agonist incorporating the N-methoxy imidoyl nitrile group as a novel ester bioisostere. |
| AID1247233 | Agonist activity at human muscarinic M3 receptor expressed in CHO cells after 30 mins by GTPgamma35S binding assay relative to acetylcholine | 2015 | Bioorganic & medicinal chemistry letters, Oct-01, Volume: 25, Issue:19
| Design and synthesis of N-[6-(Substituted Aminoethylideneamino)-2-Hydroxyindan-1-yl]arylamides as selective and potent muscarinic M₁ agonists. |
| AID141659 | In vitro affinity evaluated using [3H]- oxotremorine as radioligand in rat cerebral cortex for muscarinic acetylcholine receptor | 1997 | Journal of medicinal chemistry, Dec-19, Volume: 40, Issue:26
| Design of [R-(Z)]-(+)-alpha-(methoxyimino)-1-azabicyclo[2.2.2]octane-3-acetonitri le (SB 202026), a functionally selective azabicyclic muscarinic M1 agonist incorporating the N-methoxy imidoyl nitrile group as a novel ester bioisostere. |
| AID322940 | Binding affinity to human cloned muscarinic M1 receptor expressed in CHO cells | 2008 | Bioorganic & medicinal chemistry, Mar-15, Volume: 16, Issue:6
| Docking analyses on human muscarinic receptors: unveiling the subtypes peculiarities in agonists binding. |
| AID112393 | Tremorigenic effects were assessed in mice after subcutaneous administration of the compound | 1997 | Journal of medicinal chemistry, Dec-19, Volume: 40, Issue:26
| Design of [R-(Z)]-(+)-alpha-(methoxyimino)-1-azabicyclo[2.2.2]octane-3-acetonitri le (SB 202026), a functionally selective azabicyclic muscarinic M1 agonist incorporating the N-methoxy imidoyl nitrile group as a novel ester bioisostere. |
| AID232606 | Ratio of IC50 QNB to that of OXO-M was determined | 1997 | Journal of medicinal chemistry, Dec-19, Volume: 40, Issue:26
| Design of [R-(Z)]-(+)-alpha-(methoxyimino)-1-azabicyclo[2.2.2]octane-3-acetonitri le (SB 202026), a functionally selective azabicyclic muscarinic M1 agonist incorporating the N-methoxy imidoyl nitrile group as a novel ester bioisostere. |
| AID322941 | Binding affinity to human cloned muscarinic M2 receptor expressed in CHO cells | 2008 | Bioorganic & medicinal chemistry, Mar-15, Volume: 16, Issue:6
| Docking analyses on human muscarinic receptors: unveiling the subtypes peculiarities in agonists binding. |
| AID141875 | In vitro affinity is evaluated, using quinuclidynyl benzylate (QNB) as radioligand in human cloned Muscarinic acetylcholine receptor M4 | 1997 | Journal of medicinal chemistry, Dec-19, Volume: 40, Issue:26
| Design of [R-(Z)]-(+)-alpha-(methoxyimino)-1-azabicyclo[2.2.2]octane-3-acetonitri le (SB 202026), a functionally selective azabicyclic muscarinic M1 agonist incorporating the N-methoxy imidoyl nitrile group as a novel ester bioisostere. |
| AID1247229 | Agonist activity at human muscarinic M1 receptor expressed in CHO cells after 30 mins by GTPgamma35S binding assay relative to acetylcholine | 2015 | Bioorganic & medicinal chemistry letters, Oct-01, Volume: 25, Issue:19
| Design and synthesis of N-[6-(Substituted Aminoethylideneamino)-2-Hydroxyindan-1-yl]arylamides as selective and potent muscarinic M₁ agonists. |
| AID1247236 | Agonist activity at human muscarinic M5 receptor expressed in CHO cells after 30 mins by GTPgamma35S binding assay | 2015 | Bioorganic & medicinal chemistry letters, Oct-01, Volume: 25, Issue:19
| Design and synthesis of N-[6-(Substituted Aminoethylideneamino)-2-Hydroxyindan-1-yl]arylamides as selective and potent muscarinic M₁ agonists. |
| AID1247234 | Agonist activity at human muscarinic M4 receptor expressed in CHO cells after 30 mins by GTPgamma35S binding assay | 2015 | Bioorganic & medicinal chemistry letters, Oct-01, Volume: 25, Issue:19
| Design and synthesis of N-[6-(Substituted Aminoethylideneamino)-2-Hydroxyindan-1-yl]arylamides as selective and potent muscarinic M₁ agonists. |
| AID1247237 | Agonist activity at human muscarinic M5 receptor expressed in CHO cells after 30 mins by GTPgamma35S binding assay relative to acetylcholine | 2015 | Bioorganic & medicinal chemistry letters, Oct-01, Volume: 25, Issue:19
| Design and synthesis of N-[6-(Substituted Aminoethylideneamino)-2-Hydroxyindan-1-yl]arylamides as selective and potent muscarinic M₁ agonists. |
| AID732893 | Agonist activity at M3 receptor in guinea pig ileum assessed as contraction at 0.3 to 3 uM | 2013 | ACS medicinal chemistry letters, Feb-14, Volume: 4, Issue:2
| Discovery of novel N-substituted oxindoles as selective m1 and m4 muscarinic acetylcholine receptors partial agonists. |
| AID232158 | Ratio of 50% fall blood pressure to that of rhythmic slow wave activity in anesthetized rats | 1997 | Journal of medicinal chemistry, Dec-19, Volume: 40, Issue:26
| Design of [R-(Z)]-(+)-alpha-(methoxyimino)-1-azabicyclo[2.2.2]octane-3-acetonitri le (SB 202026), a functionally selective azabicyclic muscarinic M1 agonist incorporating the N-methoxy imidoyl nitrile group as a novel ester bioisostere. |
| AID141052 | In vitro affinity against human Muscarinic acetylcholine receptor M1 using quinuclidynyl benzylate (QNB) | 1997 | Journal of medicinal chemistry, Dec-19, Volume: 40, Issue:26
| Design of [R-(Z)]-(+)-alpha-(methoxyimino)-1-azabicyclo[2.2.2]octane-3-acetonitri le (SB 202026), a functionally selective azabicyclic muscarinic M1 agonist incorporating the N-methoxy imidoyl nitrile group as a novel ester bioisostere. |
| [information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023] |