Page last updated: 2024-12-11

papulacandin b

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

Description

papulacandin B: from Papularia sphaerosperma; inhibits growth of Candida albicans [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

papulacandin B : A papulacandin that is papulacandin A in which the (2E,4E)-deca-2,4-dienoyl chain at the O-(6') position is replaced by a (2E,4Z,6E)-8-hydroxydeca-2,4,6-trienoyl chain. It is the major carbohydrate-containing antibiotic from the deuteromycetous fungus Papularia sphaerosperma which shows potent antifungal activity against Candida albicans. [Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Cross-References

ID SourceID
PubMed CID6436198
CHEMBL ID448981
MeSH IDM0074907

Synonyms (12)

Synonym
d-glucopyranose, 1,1(sup 6)-anhydro-1-c-(2,4-dihydroxy-6-(hydroxymethyl)phenyl)-4-o-(6-o-(8-hydroxy-1-oxo-2,4,6-decatrienyl)-beta-d-galactopyranosyl)-, 3-(7-hydroxy-8,14-dimethyl-2,4,8,10-hexadecatetraenoate)
alpha-d-glucopyranose, 1,16-anhydro-1-c-(2,4-dihydroxy-6-(hydroxymethyl)phenyl)-4-o-(6-o-(8-hydroxy-1-oxo-2,4,6-decatrienyl)-beta-d-galactopyranosyl)-, 3-(7-hydroxy-8,14-dimethyl-2,4,8,10-hexadecatetraenoate)
61032-80-2
a-32283-b
[(3s,3'r,4'r,5'r,6'r)-3',4,6-trihydroxy-6'-(hydroxymethyl)-5'-[(2s,3r,4s,5r,6r)-3,4,5-trihydroxy-6-[[(2e,4e,6e)-8-hydroxydeca-2,4,6-trienoyl]oxymethyl]tetrahydropyran-2-yl]oxy-spiro[1h-isobenzofuran-3,2'-tetrahydropyran]-4'-yl] (2e,4e,8e,10e)-7-hydroxy-8,
papulacandin b
.alpha.-d-glucopyranose, 1,16-anhydro-1-c-[2,4-dihydroxy-6-(hydroxymethyl)phenyl]-4-o-[6-o-(8-hydroxy-1-oxo-2,4,6-decatrienyl)-.beta.-d-galactopyranosyl]-, 3-(7-hydroxy-8,14-dimethyl-2,4,8,10-hexadecatetraenoate)
CHEMBL448981
[(3s,3'r,4'r,5'r,6'r)-3',4,6-trihydroxy-6'-(hydroxymethyl)-5'-[(2s,3r,4s,5r,6r)-3,4,5-trihydroxy-6-[[(2e,4e,6e)-8-hydroxydeca-2,4,6-trienoyl]oxymethyl]oxan-2-yl]oxyspiro[1h-2-benzofuran-3,2'-oxane]-4'-yl] (2e,4e,8e,10e)-7-hydroxy-8,14-dimethylhexadeca-2,4
UJLFRJFJTPPIOK-DOERTBJDSA-N
Q7133221
DTXSID001027536
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Bioassays (6)

Assay IDTitleYearJournalArticle
AID391501Effect on chitin synthase 1-mediated incorporation of [14C]N-acetylglucosamine in Saccharomyces cerevisiae assessed as residual activity after 90 mins2008Journal of natural products, Oct, Volume: 71, Issue:10
Evidence for the mechanism of action of the antifungal phytolaccoside B isolated from Phytolacca tetramera Hauman.
AID391500Inhibition of (1->3)-beta-D-glucan synthase in Saccharomyces cerevisiae assessed as incorporation of [14C]-Glucose after 30 mins2008Journal of natural products, Oct, Volume: 71, Issue:10
Evidence for the mechanism of action of the antifungal phytolaccoside B isolated from Phytolacca tetramera Hauman.
AID391504Inhibition of chitin synthase 1 in Saccharomyces cerevisiae after 90 mins in presence of trypsin2008Journal of natural products, Oct, Volume: 71, Issue:10
Evidence for the mechanism of action of the antifungal phytolaccoside B isolated from Phytolacca tetramera Hauman.
AID391502Effect on chitin synthase 1-mediated incorporation of [14C]N-Acetylglucosamine in Saccharomyces cerevisiae assessed as residual activity after 90 mins in presence of trypsin2008Journal of natural products, Oct, Volume: 71, Issue:10
Evidence for the mechanism of action of the antifungal phytolaccoside B isolated from Phytolacca tetramera Hauman.
AID391499Effect on (1->3)-beta-D-glucan synthase-mediated [14C]-Glucose incorporation in Saccharomyces cerevisiae assessed as residual activity after 30 mins2008Journal of natural products, Oct, Volume: 71, Issue:10
Evidence for the mechanism of action of the antifungal phytolaccoside B isolated from Phytolacca tetramera Hauman.
AID391503Inhibition of chitin synthase 1 in Saccharomyces cerevisiae assessed as incorporation of [14C]N-Acetylglucosamine after 90 mins2008Journal of natural products, Oct, Volume: 71, Issue:10
Evidence for the mechanism of action of the antifungal phytolaccoside B isolated from Phytolacca tetramera Hauman.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (33)

TimeframeStudies, This Drug (%)All Drugs %
pre-199012 (36.36)18.7374
1990's20 (60.61)18.2507
2000's1 (3.03)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 10.77

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be weak demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index10.77 (24.57)
Research Supply Index3.53 (2.92)
Research Growth Index4.30 (4.65)
Search Engine Demand Index0.00 (26.88)
Search Engine Supply Index0.00 (0.95)

This Compound (10.77)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews1 (3.03%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other32 (96.97%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]