Page last updated: 2024-12-11
papulacandin b
Description
Research Excerpts
Clinical Trials
Roles
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Pathways
Study Profile
Bioassays
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Description
papulacandin B: from Papularia sphaerosperma; inhibits growth of Candida albicans [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]
papulacandin B : A papulacandin that is papulacandin A in which the (2E,4E)-deca-2,4-dienoyl chain at the O-(6') position is replaced by a (2E,4Z,6E)-8-hydroxydeca-2,4,6-trienoyl chain. It is the major carbohydrate-containing antibiotic from the deuteromycetous fungus Papularia sphaerosperma which shows potent antifungal activity against Candida albicans. [Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]
Cross-References
| ID Source | ID |
|---|---|
| PubMed CID | 6436198 |
| CHEMBL ID | 448981 |
| MeSH ID | M0074907 |
Synonyms (12)
| Synonym |
|---|
| d-glucopyranose, 1,1(sup 6)-anhydro-1-c-(2,4-dihydroxy-6-(hydroxymethyl)phenyl)-4-o-(6-o-(8-hydroxy-1-oxo-2,4,6-decatrienyl)-beta-d-galactopyranosyl)-, 3-(7-hydroxy-8,14-dimethyl-2,4,8,10-hexadecatetraenoate) |
| alpha-d-glucopyranose, 1,16-anhydro-1-c-(2,4-dihydroxy-6-(hydroxymethyl)phenyl)-4-o-(6-o-(8-hydroxy-1-oxo-2,4,6-decatrienyl)-beta-d-galactopyranosyl)-, 3-(7-hydroxy-8,14-dimethyl-2,4,8,10-hexadecatetraenoate) |
| 61032-80-2 |
| a-32283-b |
| [(3s,3'r,4'r,5'r,6'r)-3',4,6-trihydroxy-6'-(hydroxymethyl)-5'-[(2s,3r,4s,5r,6r)-3,4,5-trihydroxy-6-[[(2e,4e,6e)-8-hydroxydeca-2,4,6-trienoyl]oxymethyl]tetrahydropyran-2-yl]oxy-spiro[1h-isobenzofuran-3,2'-tetrahydropyran]-4'-yl] (2e,4e,8e,10e)-7-hydroxy-8, |
| papulacandin b |
| .alpha.-d-glucopyranose, 1,16-anhydro-1-c-[2,4-dihydroxy-6-(hydroxymethyl)phenyl]-4-o-[6-o-(8-hydroxy-1-oxo-2,4,6-decatrienyl)-.beta.-d-galactopyranosyl]-, 3-(7-hydroxy-8,14-dimethyl-2,4,8,10-hexadecatetraenoate) |
| CHEMBL448981 |
| [(3s,3'r,4'r,5'r,6'r)-3',4,6-trihydroxy-6'-(hydroxymethyl)-5'-[(2s,3r,4s,5r,6r)-3,4,5-trihydroxy-6-[[(2e,4e,6e)-8-hydroxydeca-2,4,6-trienoyl]oxymethyl]oxan-2-yl]oxyspiro[1h-2-benzofuran-3,2'-oxane]-4'-yl] (2e,4e,8e,10e)-7-hydroxy-8,14-dimethylhexadeca-2,4 |
| UJLFRJFJTPPIOK-DOERTBJDSA-N |
| Q7133221 |
| DTXSID001027536 |
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]
Bioassays (6)
| Assay ID | Title | Year | Journal | Article |
|---|---|---|---|---|
| AID391501 | Effect on chitin synthase 1-mediated incorporation of [14C]N-acetylglucosamine in Saccharomyces cerevisiae assessed as residual activity after 90 mins | 2008 | Journal of natural products, Oct, Volume: 71, Issue:10 | Evidence for the mechanism of action of the antifungal phytolaccoside B isolated from Phytolacca tetramera Hauman. |
| AID391500 | Inhibition of (1->3)-beta-D-glucan synthase in Saccharomyces cerevisiae assessed as incorporation of [14C]-Glucose after 30 mins | 2008 | Journal of natural products, Oct, Volume: 71, Issue:10 | Evidence for the mechanism of action of the antifungal phytolaccoside B isolated from Phytolacca tetramera Hauman. |
| AID391504 | Inhibition of chitin synthase 1 in Saccharomyces cerevisiae after 90 mins in presence of trypsin | 2008 | Journal of natural products, Oct, Volume: 71, Issue:10 | Evidence for the mechanism of action of the antifungal phytolaccoside B isolated from Phytolacca tetramera Hauman. |
| AID391502 | Effect on chitin synthase 1-mediated incorporation of [14C]N-Acetylglucosamine in Saccharomyces cerevisiae assessed as residual activity after 90 mins in presence of trypsin | 2008 | Journal of natural products, Oct, Volume: 71, Issue:10 | Evidence for the mechanism of action of the antifungal phytolaccoside B isolated from Phytolacca tetramera Hauman. |
| AID391499 | Effect on (1->3)-beta-D-glucan synthase-mediated [14C]-Glucose incorporation in Saccharomyces cerevisiae assessed as residual activity after 30 mins | 2008 | Journal of natural products, Oct, Volume: 71, Issue:10 | Evidence for the mechanism of action of the antifungal phytolaccoside B isolated from Phytolacca tetramera Hauman. |
| AID391503 | Inhibition of chitin synthase 1 in Saccharomyces cerevisiae assessed as incorporation of [14C]N-Acetylglucosamine after 90 mins | 2008 | Journal of natural products, Oct, Volume: 71, Issue:10 | Evidence for the mechanism of action of the antifungal phytolaccoside B isolated from Phytolacca tetramera Hauman. |
| [information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||||
Research
Studies (33)
| Timeframe | Studies, This Drug (%) | All Drugs % |
|---|---|---|
| pre-1990 | 12 (36.36) | 18.7374 |
| 1990's | 20 (60.61) | 18.2507 |
| 2000's | 1 (3.03) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| [information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||
Market Indicators
Research Demand Index: 10.77
According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be weak demand-to-supply ratio for research on this compound.
| This Compound (10.77) All Compounds (24.57) |
Study Types
| Publication Type | This drug (%) | All Drugs (%) |
|---|---|---|
| Trials | 0 (0.00%) | 5.53% |
| Reviews | 1 (3.03%) | 6.00% |
| Case Studies | 0 (0.00%) | 4.05% |
| Observational | 0 (0.00%) | 0.25% |
| Other | 32 (96.97%) | 84.16% |
| [information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||