papulacandin-b and malonic-acid

papulacandin-b has been researched along with malonic-acid* in 1 studies

Other Studies

1 other study(ies) available for papulacandin-b and malonic-acid

Article	Year
A search for pyrophosphate mimics for the development of substrates and inhibitors of glycosyltransferases. Bioorganic & medicinal chemistry, 1997, Volume: 5, Issue:4 The design and synthesis of several beta-1,4-galactosyltransferase inhibitors are reported. Mimics of the pyrophosphate-Mn2+ complex were the focus of the design. Malonic, tartaric, and monosaccharide moieties were used as replacements of the pyrophosphate moiety, and galactose or azasugars with potent galactosidase inhibitory activity were used as the 'donor' component. Compound 6, in which glucose was used as the pyrophosphate-Mn2+ complex mimic and galactose as the 'donor' component, showed the best inhibitory activity towards the transferase with a Ki of 119.6 microM. Topics: Aminoglycosides; Anti-Bacterial Agents; Antifungal Agents; Antiviral Agents; Binding Sites; Diphosphates; Enzyme Inhibitors; Fucosyltransferases; Malonates; Manganese; Monosaccharides; N-Acetyllactosamine Synthase; Pyrimidine Nucleosides; Substrate Specificity; Tartrates; Tunicamycin	1997

Article

Year

A search for pyrophosphate mimics for the development of substrates and inhibitors of glycosyltransferases.

Bioorganic & medicinal chemistry, 1997, Volume: 5, Issue:4

The design and synthesis of several beta-1,4-galactosyltransferase inhibitors are reported. Mimics of the pyrophosphate-Mn2+ complex were the focus of the design. Malonic, tartaric, and monosaccharide moieties were used as replacements of the pyrophosphate moiety, and galactose or azasugars with potent galactosidase inhibitory activity were used as the 'donor' component. Compound 6, in which glucose was used as the pyrophosphate-Mn2+ complex mimic and galactose as the 'donor' component, showed the best inhibitory activity towards the transferase with a Ki of 119.6 microM.

Topics: Aminoglycosides; Anti-Bacterial Agents; Antifungal Agents; Antiviral Agents; Binding Sites; Diphosphates; Enzyme Inhibitors; Fucosyltransferases; Malonates; Manganese; Monosaccharides; N-Acetyllactosamine Synthase; Pyrimidine Nucleosides; Substrate Specificity; Tartrates; Tunicamycin

1997