Compounds > n-benzylglycine
Page last updated: 2024-11-06

n-benzylglycine

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

n-Benzylglycine, also known as phenylglycine, is a non-proteinogenic amino acid. It is a key precursor in the synthesis of the artificial sweetener aspartame. It is also used in the production of other pharmaceuticals and agricultural chemicals. Research into n-benzylglycine focuses on its role in aspartame production, its potential applications in other synthetic processes, and its environmental impact.'

Cross-References

ID SourceID
PubMed CID86965
CHEMBL ID453029
SCHEMBL ID156664
MeSH IDM0384039

Synonyms (52)

Synonym
EU-0096385
AC-2979
n-benzyl glycine
AKOS002392487
nsc166840
17136-36-6
nsc-166840
n-(phenylmethyl)glycine
n-benzylglycine
2-(benzylazaniumyl)acetate
CHEMBL453029
2-(benzylamino)acetic acid
A18302
unii-dpa13kz0sr
einecs 241-194-9
nsc 166840
dpa13kz0sr ,
A825260
2-[(phenylmethyl)amino]acetic acid
2-[(phenylmethyl)amino]ethanoic acid
2-(benzylamino)-acetic acid
AM803326
FT-0637505
AB04524
(benzylamino)acetic acid
AB01319804-02
n -benzylglycine
benzylglycine
n-benzylglycin
benzyl glycine
SCHEMBL156664
mfcd00190772
SY003481
TS-00128
W-107874
STR07545
(benzylamino)acetic acid #
glycine, n-(phenylmethyl)-
DTXSID10169071
F0917-2364
SR-01000579522-1
sr-01000579522
CS-W016075
(n-benzylamino)acetic acid
AB6138
Q27449843
NCGC00324683-01
SB76749
EN300-56244
2-(benzylamino)aceticacid
HY-W015359
PD196966
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Protein Targets (1)

Other Measurements

ProteinTaxonomyMeasurementAverageMin (ref.)Avg (ref.)Max (ref.)Bioassay(s)
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Bioassays (2)

Assay IDTitleYearJournalArticle
AID388280Inhibition of Blattella germanica peptidylamidoglycolate lyase assessed as ascorbate-independent dealkylation of alpha-hydroxy-hipurate2008Bioorganic & medicinal chemistry, Dec-01, Volume: 16, Issue:23
Substituted hippurates and hippurate analogs as substrates and inhibitors of peptidylglycine alpha-hydroxylating monooxygenase (PHM).
AID388275Inhibition of rat recombinant peptidylglycine alpha-amidating monooxygenase assessed as inhibition of N-dansyl-Tyr-Val-Gly amidation2008Bioorganic & medicinal chemistry, Dec-01, Volume: 16, Issue:23
Substituted hippurates and hippurate analogs as substrates and inhibitors of peptidylglycine alpha-hydroxylating monooxygenase (PHM).
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (6)

TimeframeStudies, This Drug (%)All Drugs %
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's4 (66.67)29.6817
2010's2 (33.33)24.3611
2020's0 (0.00)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 25.53

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be moderate demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index25.53 (24.57)
Research Supply Index1.95 (2.92)
Research Growth Index4.28 (4.65)
Search Engine Demand Index19.78 (26.88)
Search Engine Supply Index2.00 (0.95)

This Compound (25.53)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews0 (0.00%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other6 (100.00%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]
SubstanceRelationship StrengthStudiesTrialsClassesRoles
formaldehyde
paraform: polymerized formaldehyde; RN given refers to parent cpd; used in root canal therapy		210aldehyde;
one-carbon compound		allergen;
carcinogenic agent;
disinfectant;
EC 3.5.1.4 (amidase) inhibitor;
environmental contaminant;
Escherichia coli metabolite;
mouse metabolite;
Saccharomyces cerevisiae metabolite
glycine
[no description available]		3.1350alpha-amino acid;
amino acid zwitterion;
proteinogenic amino acid;
serine family amino acid		EC 2.1.2.1 (glycine hydroxymethyltransferase) inhibitor;
fundamental metabolite;
hepatoprotective agent;
micronutrient;
neurotransmitter;
NMDA receptor agonist;
nutraceutical
sarcosine
cocobetaine: N-alkyl-betaine; cause of shampoo dermatitis		210N-alkylglycine zwitterion;
N-alkylglycine;
N-methyl-amino acid;
N-methylglycines		Escherichia coli metabolite;
glycine receptor agonist;
glycine transporter 1 inhibitor;
human metabolite;
mouse metabolite
p-aminohippuric acid
p-Aminohippuric Acid: The glycine amide of 4-aminobenzoic acid. Its sodium salt is used as a diagnostic aid to measure effective renal plasma flow (ERPF) and excretory capacity.. p-aminohippurate : A hippurate that is the conjugate base of p-aminohippuric acid, arising from deprotonation of the carboxy group.. p-aminohippuric acid : An N-acylglycine that is the 4-amino derivative of hippuric acid; used as a diagnostic agent in the measurement of renal plasma flow.		2.0410N-acylglycineDaphnia magna metabolite
alanine
Alanine: A non-essential amino acid that occurs in high levels in its free state in plasma. It is produced from pyruvate by transamination. It is involved in sugar and acid metabolism, increases IMMUNITY, and provides energy for muscle tissue, BRAIN, and the CENTRAL NERVOUS SYSTEM.. alanine : An alpha-amino acid that consists of propionic acid bearing an amino substituent at position 2.		7.0210alanine zwitterion;
alanine;
L-alpha-amino acid;
proteinogenic amino acid;
pyruvate family amino acid		EC 4.3.1.15 (diaminopropionate ammonia-lyase) inhibitor;
fundamental metabolite
phenylalanine
Phenylalanine: An essential aromatic amino acid that is a precursor of MELANIN; DOPAMINE; noradrenalin (NOREPINEPHRINE), and THYROXINE.. L-phenylalanine : The L-enantiomer of phenylalanine.. phenylalanine : An aromatic amino acid that is alanine in which one of the methyl hydrogens is substituted by a phenyl group.		710amino acid zwitterion;
erythrose 4-phosphate/phosphoenolpyruvate family amino acid;
L-alpha-amino acid;
phenylalanine;
proteinogenic amino acid		algal metabolite;
EC 3.1.3.1 (alkaline phosphatase) inhibitor;
Escherichia coli metabolite;
human xenobiotic metabolite;
micronutrient;
mouse metabolite;
nutraceutical;
plant metabolite;
Saccharomyces cerevisiae metabolite
threonine
Threonine: An essential amino acid occurring naturally in the L-form, which is the active form. It is found in eggs, milk, gelatin, and other proteins.. threonine : An alpha-amino acid in which one of the hydrogens attached to the alpha-carbon of glycine is substituted by a 1-hydroxyethyl group.		210amino acid zwitterion;
aspartate family amino acid;
L-alpha-amino acid;
proteinogenic amino acid;
threonine		algal metabolite;
Escherichia coli metabolite;
human metabolite;
micronutrient;
mouse metabolite;
nutraceutical;
plant metabolite;
Saccharomyces cerevisiae metabolite
tryptophan
Tryptophan: An essential amino acid that is necessary for normal growth in infants and for NITROGEN balance in adults. It is a precursor of INDOLE ALKALOIDS in plants. It is a precursor of SEROTONIN (hence its use as an antidepressant and sleep aid). It can be a precursor to NIACIN, albeit inefficiently, in mammals.. tryptophan : An alpha-amino acid that is alanine bearing an indol-3-yl substituent at position 3.		210erythrose 4-phosphate/phosphoenolpyruvate family amino acid;
L-alpha-amino acid zwitterion;
L-alpha-amino acid;
proteinogenic amino acid;
tryptophan zwitterion;
tryptophan		antidepressant;
Escherichia coli metabolite;
human metabolite;
micronutrient;
mouse metabolite;
nutraceutical;
plant metabolite;
Saccharomyces cerevisiae metabolite
arginine
Arginine: An essential amino acid that is physiologically active in the L-form.. arginine : An alpha-amino acid that is glycine in which the alpha-is substituted by a 3-guanidinopropyl group.		2.1310arginine;
glutamine family amino acid;
L-alpha-amino acid;
proteinogenic amino acid		biomarker;
Escherichia coli metabolite;
micronutrient;
mouse metabolite;
nutraceutical
iodohippuric acid
Iodohippuric Acid: An iodine-containing compound used in pyelography as a radiopaque medium. If labeled with radioiodine, it can be used for studies of renal function.. 2-iodohippuric acid : A member of the class of benzamides resulting from the formal condensation of the carboxy group of 2-iodobenzoic acid with the amino group of glycine.		2.0410benzamides;
N-acylglycine;
organoiodine compound
salicylurate
salicylurate: RN given refers to parent cpd. salicyluric acid : An N-acylglycine in which the acyl group is specified as 2-hydroxybenzoyl.. salicylurate : A monocarboxylic acid anion that is the conjugate base of salicyluric acid, obtained by deprotonation of the carboxy group; major species at pH 7.3.		2.0410N-acylglycine;
secondary carboxamide		human xenobiotic metabolite;
uremic toxin
aceturic acid
aceturic acid: structure. N-acetylglycine : An N-acylglycine where the acyl group is specified as acetyl.		2.0410N-acetyl-amino acid;
N-acylglycine		human metabolite
n-benzyloxycarbonylglycine
N-benzyloxycarbonylglycine: structure given in first source. N-benzyloxycarbonylglycine : A derivative of glycine having a benzyloxycarbonyl protecting group attached to the nitrogen.		2.0410N-acylglycine
4-nitrohippuric acid
4-nitrohippuric acid: major metabolite of 4-nitrobenzoic acid		2.0410
furoylglycine
furoylglycine: structure given in first source. N-(2-furoyl)glycine : A glycine derivative that is the carboxamide obtained by the formal condensation of the amino group of glycine with 2-furoic acid.		2.0410furans;
N-acylglycine		human metabolite
4-chlorohippuric acid
4-chlorohippuric acid: metabolite of zomepirac; RN given refers to parent cpd		2.0410
thiophenoxyacetic acid
thiophenoxyacetic acid: structure		2.0410
salicylhydroxamic acid
[no description available]		2.0410hydroxamic acid;
phenols		antibacterial drug;
EC 1.11.2.2 (myeloperoxidase) inhibitor;
EC 3.5.1.5 (urease) inhibitor;
trypanocidal drug
phenylacetylglycine
phenylacetylglycine : A N-acylglycine that is glycine substituted on nitrogen with a phenylacetyl group.		2.0410monocarboxylic acid amide;
monocarboxylic acid;
N-acylglycine		human metabolite;
mouse metabolite
nicotinuric acid
nicotinuric acid: RN given refers to parent cpd. N-nicotinoylglycine : An N-acylglycine having nicotinoyl as the acyl substituent.		2.0410N-acylglycinehuman urinary metabolite
benzoylpropionic acid
benzoylpropionic acid: structure in first source. 4-oxo-4-phenylbutyric acid : A 4-oxo monocarboxylic acid that is butyric acid bearing oxo and phenyl substituents at position 4.		2.04104-oxo monocarboxylic acidhapten
boc-glycine
BOC-glycine: RN given refers to parent cpd		2.0410
2-methylhippuric acid
2-methylhippuric acid: urinary metabolite of o-xylene. o-methylhippuric acid : An N-acylglycine that is the ortho-methyl derivative of hippuric acid.		2.0410N-acylglycinemetabolite
hippuryl-glycyl-glycine
hippuryl-glycyl-glycine: RN given refers to parent cpd; N1 from 9th CI Form Index		2.0410
4-methylhippuric acid
4-methylhippuric acid: urinary metabolite of p-xylene. p-methylhippuric acid : An N-acylglycine in which the acyl group is specified as 4-methylbenzoyl.		2.0410N-acylglycinemetabolite
3-methylhippuric acid
3-methylhippuric acid: urinary metabolite of m-xylene. m-methylhippuric acid : An N-acylglycine that is the 3-methyl derivative of hippuric acid.		2.0410N-acylglycinemetabolite
tryptophan methyl ester
tryptophan methyl ester: RN given refers to parent cpd(DL)-isomer		210
4-methyoxybenzoyl-n-glycine
[no description available]		2.0410N-acylglycine
proline
Proline: A non-essential amino acid that is synthesized from GLUTAMIC ACID. It is an essential component of COLLAGEN and is important for proper functioning of joints and tendons.. proline : An alpha-amino acid that is pyrrolidine bearing a carboxy substituent at position 2.		2.1310amino acid zwitterion;
glutamine family amino acid;
L-alpha-amino acid;
proline;
proteinogenic amino acid		algal metabolite;
compatible osmolytes;
Escherichia coli metabolite;
micronutrient;
mouse metabolite;
nutraceutical;
Saccharomyces cerevisiae metabolite
4-hydroxyhippuric acid
p-hydroxyhippuric acid : An N-acylglycine that is the 4-hydroxy derivative of hippuric acid.		2.0410N-acylglycinehuman blood serum metabolite
bradykinin
[no description available]		2.4220oligopeptidehuman blood serum metabolite;
vasodilator agent
cinnamoylglycine
cinnamoylglycine: structure given in first source. N-cinnamoylglycine : An N-acylglycine in which the acyl group is specified as (2E)-3-phenylprop-2-enoyl (cinnamoyl).		2.0410N-acylglycinemetabolite
2-aminohippuric acid
[no description available]		2.0410N-acylglycine
fenretinide
Fenretinide: A synthetic retinoid that is used orally as a chemopreventive against prostate cancer and in women at risk of developing contralateral breast cancer. It is also effective as an antineoplastic agent.. 4-hydroxyphenyl retinamide : A retinoid obtained by formal condensation of the carboxy group of all-trans retinoic acid and the anilino group of 4-hydroxyaniline. Synthetic retinoid agonist. Antiproliferative, antioxidant and anticancer agent with a long half-life in vivo. Apoptotic effects appear to be mediated by a mechanism distinct from that of 'classical' retinoids.		2.0410monocarboxylic acid amide;
retinoid		antineoplastic agent;
antioxidant
ConditionIndicatedRelationship StrengthStudiesTrials