Compounds > n-benzyloxycarbonylglycine
Page last updated: 2024-12-05

n-benzyloxycarbonylglycine

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Description

n-Benzyloxycarbonylglycine, also known as Z-glycine, is a protected amino acid derivative commonly used in peptide synthesis. It is synthesized through a reaction between glycine and benzyl chloroformate in the presence of a base. The benzyloxycarbonyl (Z) group acts as a protecting group for the amino group of glycine, preventing unwanted side reactions during peptide coupling. Z-glycine is particularly important in peptide synthesis because it allows for the selective activation and coupling of the carboxyl group, enabling the stepwise assembly of complex peptide chains. The Z group can be easily removed under mild conditions, such as catalytic hydrogenation, to reveal the free amino group for further peptide synthesis. The study of Z-glycine and its use in peptide synthesis is essential for understanding and developing new methods for the synthesis of biologically active peptides and proteins. These peptides are used in various fields, including medicine, biotechnology, and materials science.'

N-benzyloxycarbonylglycine: structure given in first source [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

N-benzyloxycarbonylglycine : A derivative of glycine having a benzyloxycarbonyl protecting group attached to the nitrogen. [Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

FloraRankFlora DefinitionFamilyFamily Definition
GlycinegenusA non-essential amino acid. It is found primarily in gelatin and silk fibroin and used therapeutically as a nutrient. It is also a fast inhibitory neurotransmitter.[MeSH]FabaceaeThe large family of plants characterized by pods. Some are edible and some cause LATHYRISM or FAVISM and other forms of poisoning. Other species yield useful materials like gums from ACACIA and various LECTINS like PHYTOHEMAGGLUTININS from PHASEOLUS. Many of them harbor NITROGEN FIXATION bacteria on their roots. Many but not all species of beans belong to this family.[MeSH]

Cross-References

ID SourceID
PubMed CID14349
CHEMBL ID101287
CHEBI ID16532
SCHEMBL ID126974
MeSH IDM0233061

Synonyms (102)

Synonym
AC-17144
2-phenylmethoxycarbonylamino-acetic acid
carbobenzoxyglycine
glycine, n-benzyl ester
carbobenzyloxyglycine
glycine, n-[(phenylmethoxy)carbonyl]-
(cbz)gly
z-gly
benzyloxycarbonylglycine
nsc-2526
n-carboxyglycine n-benzyl ester
n-carbobenzoxyglycine
nsc2526
n-carbobenzyloxyglycine
CHEBI:16532 ,
carbobenzoxyl glycine
n-(benzyloxycarbonyl)glycine
z-gly-oh
OPREA1_763666
brn 0526877
einecs 214-516-0
n-((phenylmethoxy)carbonyl)glycine
glycine, n-carboxy-, n-benzyl ester
glycine, n-((phenylmethoxy)carbonyl)-
nsc 2526
OPREA1_774492
inchi=1/c10h11no4/c12-9(13)6-11-10(14)15-7-8-4-2-1-3-5-8/h1-5h,6-7h2,(h,11,14)(h,12,13
glycine,n-benzyloxycarbonyl
n-[(benzyloxy)carbonyl]glycine
n-cbz-glycine
C03710
n-benzyloxycarbonylglycine
1138-80-3
benzyloxycarbonylamino-acetic acid anion
z-gly-oh, 99%
AKOS000163682
2-(phenylmethoxycarbonylamino)acetic acid
n-carbobenzoxy-glycine
CHEMBL101287
benzyloxycarbonylamino-acetic acid
A803102
((benzyloxy)carbonyl)glycinate
2-{[(benzyloxy)carbonyl]amino}acetic acid
cbz-gly-oh
cbz-gly
4-06-00-02286 (beilstein handbook reference)
cbz-glycine
FT-0633395
AB00257
n-alpha-cbz-glycine
benzyloxycarbonyl-glycine
cbz glycine
[(benzyloxy)-carbonyl]aminoacetic acid
((benzyloxy)carbonyl)glycine
2-(((benzyloxy)carbonyl)amino)acetic acid
n-cbz-gly-oh
2-(benzyloxycabonylamino)acetic acid
benzyloxycarbonyl glycine
n-z-gly-oh
carbobenzoxy-glycine
carbobenzoxy-glycin
n-(phenylmethoxycarbonyl)glycine
n-(carbobenzoxy)-glycine
n-[(phenylmethoxy)carbonyl]glycine
n-carbobenzyloxy-glycine
n-cbz glycine
n-benzyloxycarbonyl-glycine
n-(benzyloxycarbonyl) glycine
(benzyloxycarbonyl)-glycine
benzyloxycarbonylaminoacetic acid
n-{[(phenylmethyl)oxy]carbonyl}glycine
2-(benzyloxycarbonylamino)acetic acid
n-(benzyloxycarbonyl)-glycine
n-benzyloxycarbonyl glycine
n-benzyloxycarbonyl-glycin
z-glyoh
2-benzyloxycarbonylaminoacetic acid
SCHEMBL126974
z-glycine
AM81784
2P-917
DTXSID8061559
Q-101746
([(benzyloxy)carbonyl]amino)acetic acid #
(carbobenzyloxy)glycine
n-(carbobenzoxy)glycine
mfcd00002691
2-(phenylmethoxycarbonylamino)ethanoic acid
F2191-0118
M03051
bdbm223537
us9321743, cbz-gly
SY006638
CS-W018534
n-[(phenylmethoxy)carbonyl]-glycine
methyl 5-cyano-2,2-diphenylpentanoate
Q27101958
EN300-53412
2-(((benzyloxy)carbonyl)amino)aceticacid
HY-Y0967
glycine-13c2-15n, n-[(phenylmethoxy)carbonyl]-
Z285919546
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Drug Classes (1)

ClassDescription
N-acylglycineAn N-acyl-amino acid in which amino acid specified is glycine.
[compound class information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Protein Targets (2)

Other Measurements

ProteinTaxonomyMeasurementAverageMin (ref.)Avg (ref.)Max (ref.)Bioassay(s)
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Bioassays (17)

Assay IDTitleYearJournalArticle
AID110573The average latency on the onset of the seizures compared to the controls after 3 hr in the strychnine test in mice at a dose of 418 mg/kg, ip; Not determined1998Journal of medicinal chemistry, Jan-01, Volume: 41, Issue:1
N-(benzyloxycarbonyl)glycine esters and amides as new anticonvulsants.
AID388274Ratio of Vm(app) to Km(app) for rat recombinant peptidylglycine alpha-amidating monooxygenase relative to hippuric acid2008Bioorganic & medicinal chemistry, Dec-01, Volume: 16, Issue:23
Substituted hippurates and hippurate analogs as substrates and inhibitors of peptidylglycine alpha-hydroxylating monooxygenase (PHM).
AID110572The average latency on the onset of the seizures compared to the controls after 3 hr in the strychnine test in mice at a dose of 209 mg/kg1998Journal of medicinal chemistry, Jan-01, Volume: 41, Issue:1
N-(benzyloxycarbonyl)glycine esters and amides as new anticonvulsants.
AID155411Papain-catalyzed hydrolysis was expressed as Km1984Journal of medicinal chemistry, Jun, Volume: 27, Issue:6
Vinylogous amino acid esters: a new class of inactivators for thiol proteases.
AID110564The average latency on the onset of the seizures compared to the controls after 30 min in the strychnine test in mice at a dose of 209 mg/kg1998Journal of medicinal chemistry, Jan-01, Volume: 41, Issue:1
N-(benzyloxycarbonyl)glycine esters and amides as new anticonvulsants.
AID120089Percent of the tonic seizures after 30 min in the 3-mercaptopropionic acid test in mice at a dose of 418 mg/kg, ip1998Journal of medicinal chemistry, Jan-01, Volume: 41, Issue:1
N-(benzyloxycarbonyl)glycine esters and amides as new anticonvulsants.
AID120088Percent of the tonic seizures after 30 min in the 3-mercaptopropionic acid test in mice at a dose of 209 mg/kg, ip1998Journal of medicinal chemistry, Jan-01, Volume: 41, Issue:1
N-(benzyloxycarbonyl)glycine esters and amides as new anticonvulsants.
AID120093Percent of the tonic seizures after 3h in the 3-mercaptopropionic acid test in mice at a dose of 209 mg/kg, ip1998Journal of medicinal chemistry, Jan-01, Volume: 41, Issue:1
N-(benzyloxycarbonyl)glycine esters and amides as new anticonvulsants.
AID1148054Antineoplastic activity against mouse EAC allografted in CF1 mouse assessed as tumor growth inhibition on day 7 measured at 33 mg/kg1977Journal of medicinal chemistry, Dec, Volume: 20, Issue:12
Antineoplastic agents. 2. Structure-activity studies on N-protected vinyl, 1,2-dibromoethyl, and cyanomethyl esters of several amino acids.
AID118596Compound was tested for anticonvulsant activity in maximal electroshock seizure(MES) test after 30 min upon intraperitoneal administration to mice at a dose of 84 mg/kg; Animals protected / Animals tested = 2/81998Journal of medicinal chemistry, Jan-01, Volume: 41, Issue:1
N-(benzyloxycarbonyl)glycine esters and amides as new anticonvulsants.
AID1148053Antineoplastic activity against mouse EAC allografted in CF1 mouse assessed as ascites volume on day 7 measured at 33 mg/kg (Rvb = 4.1 +/- 1.24 mL)1977Journal of medicinal chemistry, Dec, Volume: 20, Issue:12
Antineoplastic agents. 2. Structure-activity studies on N-protected vinyl, 1,2-dibromoethyl, and cyanomethyl esters of several amino acids.
AID388272Activity of rat recombinant peptidylglycine alpha-amidating monooxygenase assessed as stimulation of oxygen consumption2008Bioorganic & medicinal chemistry, Dec-01, Volume: 16, Issue:23
Substituted hippurates and hippurate analogs as substrates and inhibitors of peptidylglycine alpha-hydroxylating monooxygenase (PHM).
AID1148052Antineoplastic activity against mouse EAC allografted in CF1 mouse assessed as packed cell volume on day 7 measured at 33 mg/kg (Rvb = 32.75 +/- 7.87%)1977Journal of medicinal chemistry, Dec, Volume: 20, Issue:12
Antineoplastic agents. 2. Structure-activity studies on N-protected vinyl, 1,2-dibromoethyl, and cyanomethyl esters of several amino acids.
AID120094Percent of the tonic seizures after 3h in the 3-mercaptopropionic acid test in mice at a dose of 418mg/kg, ip1998Journal of medicinal chemistry, Jan-01, Volume: 41, Issue:1
N-(benzyloxycarbonyl)glycine esters and amides as new anticonvulsants.
AID388273Ratio of Vm(app) to Km(app) for rat recombinant peptidylglycine alpha-amidating monooxygenase2008Bioorganic & medicinal chemistry, Dec-01, Volume: 16, Issue:23
Substituted hippurates and hippurate analogs as substrates and inhibitors of peptidylglycine alpha-hydroxylating monooxygenase (PHM).
AID110566The average latency on the onset of the seizures compared to the controls after 30 min in the strychnine test in mice at a dose of 418 mg/kg, ip; Not determined1998Journal of medicinal chemistry, Jan-01, Volume: 41, Issue:1
N-(benzyloxycarbonyl)glycine esters and amides as new anticonvulsants.
AID112305Compound was tested for anticonvulsant activity in maximal electroshock seizure(MES) test after 3 hours upon intraperitoneal administration to mice1998Journal of medicinal chemistry, Jan-01, Volume: 41, Issue:1
N-(benzyloxycarbonyl)glycine esters and amides as new anticonvulsants.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (8)

TimeframeStudies, This Drug (%)All Drugs %
pre-19902 (25.00)18.7374
1990's3 (37.50)18.2507
2000's2 (25.00)29.6817
2010's0 (0.00)24.3611
2020's1 (12.50)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 17.39

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be moderate demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index17.39 (24.57)
Research Supply Index2.20 (2.92)
Research Growth Index4.40 (4.65)
Search Engine Demand Index10.37 (26.88)
Search Engine Supply Index2.00 (0.95)

This Compound (17.39)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews0 (0.00%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other8 (100.00%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]
SubstanceRelationship StrengthStudiesTrialsClassesRoles
acetaldehyde
Acetaldehyde: A colorless, flammable liquid used in the manufacture of acetic acid, perfumes, and flavors. It is also an intermediate in the metabolism of alcohol. It has a general narcotic action and also causes irritation of mucous membranes. Large doses may cause death from respiratory paralysis.. acetaldehyde : The aldehyde formed from acetic acid by reduction of the carboxy group. It is the most abundant carcinogen in tobacco smoke.. aldehyde : A compound RC(=O)H, in which a carbonyl group is bonded to one hydrogen atom and to one R group.. acetyl group : A group, formally derived from acetic acid by dehydroxylation, which is fundamental to the biochemistry of all forms of life. When bound to coenzyme A, it is central to the metabolism of carbohydrates and fats.		1.9510aldehydecarcinogenic agent;
EC 3.5.1.4 (amidase) inhibitor;
electron acceptor;
Escherichia coli metabolite;
human metabolite;
mouse metabolite;
mutagen;
oxidising agent;
Saccharomyces cerevisiae metabolite;
teratogenic agent
benzaldehyde
[no description available]		1.9510benzaldehydesEC 3.1.1.3 (triacylglycerol lipase) inhibitor;
EC 3.5.5.1 (nitrilase) inhibitor;
flavouring agent;
fragrance;
odorant receptor agonist;
plant metabolite
glycine
[no description available]		8.1150alpha-amino acid;
amino acid zwitterion;
proteinogenic amino acid;
serine family amino acid		EC 2.1.2.1 (glycine hydroxymethyltransferase) inhibitor;
fundamental metabolite;
hepatoprotective agent;
micronutrient;
neurotransmitter;
NMDA receptor agonist;
nutraceutical
phenytoin
[no description available]		2.420imidazolidine-2,4-dioneanticonvulsant;
drug allergen;
sodium channel blocker;
teratogenic agent
p-aminohippuric acid
p-Aminohippuric Acid: The glycine amide of 4-aminobenzoic acid. Its sodium salt is used as a diagnostic aid to measure effective renal plasma flow (ERPF) and excretory capacity.. p-aminohippurate : A hippurate that is the conjugate base of p-aminohippuric acid, arising from deprotonation of the carboxy group.. p-aminohippuric acid : An N-acylglycine that is the 4-amino derivative of hippuric acid; used as a diagnostic agent in the measurement of renal plasma flow.		2.0410N-acylglycineDaphnia magna metabolite
chlorambucil
Chlorambucil: A nitrogen mustard alkylating agent used as antineoplastic for chronic lymphocytic leukemia, Hodgkin's disease, and others. Although it is less toxic than most other nitrogen mustards, it has been listed as a known carcinogen in the Fourth Annual Report on Carcinogens (NTP 85-002, 1985). (Merck Index, 11th ed). chlorambucil : A monocarboxylic acid that is butanoic acid substituted at position 4 by a 4-[bis(2-chloroethyl)amino]phenyl group. A chemotherapy drug that can be used in combination with the antibody obinutuzumab for the treatment of chronic lymphocytic leukemia.		1.9510aromatic amine;
monocarboxylic acid;
nitrogen mustard;
organochlorine compound;
tertiary amino compound		alkylating agent;
antineoplastic agent;
carcinogenic agent;
drug allergen;
immunosuppressive agent
valproic acid
Valproic Acid: A fatty acid with anticonvulsant and anti-manic properties that is used in the treatment of EPILEPSY and BIPOLAR DISORDER. The mechanisms of its therapeutic actions are not well understood. It may act by increasing GAMMA-AMINOBUTYRIC ACID levels in the brain or by altering the properties of VOLTAGE-GATED SODIUM CHANNELS.. valproic acid : A branched-chain saturated fatty acid that comprises of a propyl substituent on a pentanoic acid stem.		1.9910branched-chain fatty acid;
branched-chain saturated fatty acid		anticonvulsant;
antimanic drug;
EC 3.5.1.98 (histone deacetylase) inhibitor;
GABA agent;
neuroprotective agent;
psychotropic drug;
teratogenic agent
fluorouracil
Fluorouracil: A pyrimidine analog that is an antineoplastic antimetabolite. It interferes with DNA synthesis by blocking the THYMIDYLATE SYNTHETASE conversion of deoxyuridylic acid to thymidylic acid.. 5-fluorouracil : A nucleobase analogue that is uracil in which the hydrogen at position 5 is replaced by fluorine. It is an antineoplastic agent which acts as an antimetabolite - following conversion to the active deoxynucleotide, it inhibits DNA synthesis (by blocking the conversion of deoxyuridylic acid to thymidylic acid by the cellular enzyme thymidylate synthetase) and so slows tumour growth.		1.9510nucleobase analogue;
organofluorine compound		antimetabolite;
antineoplastic agent;
environmental contaminant;
immunosuppressive agent;
radiosensitizing agent;
xenobiotic
2-aminoisobutyric acid
2-aminoisobutyric acid: RN given refers to unlabeled cpd. 2-aminoisobutyric acid : A rare, non-protein amino acid and end-product of pyrimidine metabolism, excreted in urine and found in some antibiotics of fungal origin. With the exception of a few bacteria, it is non-metabolisable, and therefore used in bioassays.		2.25102,2-dialkylglycine zwitterion;
2,2-dialkylglycine
uracil mustard
Uracil Mustard: Nitrogen mustard derivative of URACIL. It is a alkylating antineoplastic agent that is used in lymphatic malignancies, and causes mainly gastrointestinal and bone marrow damage.		1.9510aminouracil;
nitrogen mustard
iodohippuric acid
Iodohippuric Acid: An iodine-containing compound used in pyelography as a radiopaque medium. If labeled with radioiodine, it can be used for studies of renal function.. 2-iodohippuric acid : A member of the class of benzamides resulting from the formal condensation of the carboxy group of 2-iodobenzoic acid with the amino group of glycine.		2.0410benzamides;
N-acylglycine;
organoiodine compound
salicylurate
salicylurate: RN given refers to parent cpd. salicyluric acid : An N-acylglycine in which the acyl group is specified as 2-hydroxybenzoyl.. salicylurate : A monocarboxylic acid anion that is the conjugate base of salicyluric acid, obtained by deprotonation of the carboxy group; major species at pH 7.3.		2.0410N-acylglycine;
secondary carboxamide		human xenobiotic metabolite;
uremic toxin
aceturic acid
aceturic acid: structure. N-acetylglycine : An N-acylglycine where the acyl group is specified as acetyl.		2.0410N-acetyl-amino acid;
N-acylglycine		human metabolite
4-nitrohippuric acid
4-nitrohippuric acid: major metabolite of 4-nitrobenzoic acid		2.0410
furoylglycine
furoylglycine: structure given in first source. N-(2-furoyl)glycine : A glycine derivative that is the carboxamide obtained by the formal condensation of the amino group of glycine with 2-furoic acid.		2.0410furans;
N-acylglycine		human metabolite
4-chlorohippuric acid
4-chlorohippuric acid: metabolite of zomepirac; RN given refers to parent cpd		2.0410
fluorides
[no description available]		210halide anion;
monoatomic fluorine
milacemide
milacemide: ampakine activity at AMPA Receptors; structure given in first source		1.9910
thiophenoxyacetic acid
thiophenoxyacetic acid: structure		2.0410
salicylhydroxamic acid
[no description available]		2.0410hydroxamic acid;
phenols		antibacterial drug;
EC 1.11.2.2 (myeloperoxidase) inhibitor;
EC 3.5.1.5 (urease) inhibitor;
trypanocidal drug
phenylacetylglycine
phenylacetylglycine : A N-acylglycine that is glycine substituted on nitrogen with a phenylacetyl group.		2.0410monocarboxylic acid amide;
monocarboxylic acid;
N-acylglycine		human metabolite;
mouse metabolite
nicotinuric acid
nicotinuric acid: RN given refers to parent cpd. N-nicotinoylglycine : An N-acylglycine having nicotinoyl as the acyl substituent.		2.0410N-acylglycinehuman urinary metabolite
dipropylacetamide
dipropylacetamide: structure. valpromide : A fatty amide derived from valproic acid.		1.9910fatty amidegeroprotector;
metabolite;
teratogenic agent
benzoylpropionic acid
benzoylpropionic acid: structure in first source. 4-oxo-4-phenylbutyric acid : A 4-oxo monocarboxylic acid that is butyric acid bearing oxo and phenyl substituents at position 4.		2.04104-oxo monocarboxylic acidhapten
boc-glycine
BOC-glycine: RN given refers to parent cpd		2.4120
n-benzylglycine
[no description available]		2.0410
2-methylhippuric acid
2-methylhippuric acid: urinary metabolite of o-xylene. o-methylhippuric acid : An N-acylglycine that is the ortho-methyl derivative of hippuric acid.		2.0410N-acylglycinemetabolite
hippuryl-glycyl-glycine
hippuryl-glycyl-glycine: RN given refers to parent cpd; N1 from 9th CI Form Index		2.0410
4-methylhippuric acid
4-methylhippuric acid: urinary metabolite of p-xylene. p-methylhippuric acid : An N-acylglycine in which the acyl group is specified as 4-methylbenzoyl.		2.0410N-acylglycinemetabolite
3-methylhippuric acid
3-methylhippuric acid: urinary metabolite of m-xylene. m-methylhippuric acid : An N-acylglycine that is the 3-methyl derivative of hippuric acid.		2.0410N-acylglycinemetabolite
benzyloxycarbonyltryptophan
benzyloxycarbonyltryptophan: receptor antagonist for peptides from gastrin family; RN given refers to (L)-isomer		1.9510
carbobenzoxyproline
carbobenzoxyproline: an inhibitor of prolidase		1.9510
4-methyoxybenzoyl-n-glycine
[no description available]		2.0410N-acylglycine
4-hydroxyhippuric acid
p-hydroxyhippuric acid : An N-acylglycine that is the 4-hydroxy derivative of hippuric acid.		2.0410N-acylglycinehuman blood serum metabolite
tosylphenylalanyl chloromethyl ketone
Tosylphenylalanyl Chloromethyl Ketone: An inhibitor of Serine Endopeptidases. Acts as alkylating agent and is known to interfere with the translation process.. N-tosyl-L-phenylalanyl chloromethyl ketone : The N-tosyl derivative of L-phenylalanyl chloromethyl ketone.		1.9510alpha-chloroketone;
sulfonamide		alkylating agent;
serine proteinase inhibitor
melphalan
Melphalan: An alkylating nitrogen mustard that is used as an antineoplastic in the form of the levo isomer - MELPHALAN, the racemic mixture - MERPHALAN, and the dextro isomer - MEDPHALAN; toxic to bone marrow, but little vesicant action; potential carcinogen.. melphalan : A phenylalanine derivative comprising L-phenylalanine having [bis(2-chloroethyl)amino group at the 4-position on the phenyl ring.		1.9510L-phenylalanine derivative;
nitrogen mustard;
non-proteinogenic L-alpha-amino acid;
organochlorine compound		alkylating agent;
antineoplastic agent;
carcinogenic agent;
drug allergen;
immunosuppressive agent
mercaptopurine
Mercaptopurine: An antimetabolite antineoplastic agent with immunosuppressant properties. It interferes with nucleic acid synthesis by inhibiting purine metabolism and is used, usually in combination with other drugs, in the treatment of or in remission maintenance programs for leukemia.. purine-6-thiol : A thiol that is the tautomer of mercaptopurine.. mercaptopurine : A member of the class of purines that is 6,7-dihydro-1H-purine carrying a thione group at position 6. An adenine analogue, it is used in the treatment of acute lymphocytic leukemia (ALL), chronic myeloid leukemia (CML), Crohn's disease, and ulcerative colitis.		1.9510aryl thiol;
purines;
thiocarbonyl compound		anticoronaviral agent;
antimetabolite;
antineoplastic agent
cinnamoylglycine
cinnamoylglycine: structure given in first source. N-cinnamoylglycine : An N-acylglycine in which the acyl group is specified as (2E)-3-phenylprop-2-enoyl (cinnamoyl).		2.0410N-acylglycinemetabolite
2-aminohippuric acid
[no description available]		2.0410N-acylglycine
fenretinide
Fenretinide: A synthetic retinoid that is used orally as a chemopreventive against prostate cancer and in women at risk of developing contralateral breast cancer. It is also effective as an antineoplastic agent.. 4-hydroxyphenyl retinamide : A retinoid obtained by formal condensation of the carboxy group of all-trans retinoic acid and the anilino group of 4-hydroxyaniline. Synthetic retinoid agonist. Antiproliferative, antioxidant and anticancer agent with a long half-life in vivo. Apoptotic effects appear to be mediated by a mechanism distinct from that of 'classical' retinoids.		2.0410monocarboxylic acid amide;
retinoid		antineoplastic agent;
antioxidant
ConditionIndicatedRelationship StrengthStudiesTrials
Carcinoma 256, Walker
A transplantable carcinoma of the rat that originally appeared spontaneously in the mammary gland of a pregnant albino rat, and which now resembles a carcinoma in young transplants and a sarcoma in older transplants. (Stedman, 25th ed)		01.9510
Carcinoma, Ehrlich Tumor
A transplantable, poorly differentiated malignant tumor which appeared originally as a spontaneous breast carcinoma in a mouse. It grows in both solid and ascitic forms.		01.9510
Experimental Leukemia
[description not available]		01.9510
Absence Seizure
[description not available]		02.3920
Seizures
Clinical or subclinical disturbances of cortical function due to a sudden, abnormal, excessive, and disorganized discharge of brain cells. Clinical manifestations include abnormal motor, sensory and psychic phenomena. Recurrent seizures are usually referred to as EPILEPSY or seizure disorder.		02.3920