boc-glycine profile

Boc-glycine, also known as tert-butoxycarbonylglycine, is a protected amino acid commonly used in peptide synthesis. It is synthesized by reacting glycine with di-tert-butyl dicarbonate in the presence of a base. The tert-butoxycarbonyl (Boc) group acts as a protecting group for the amino group of glycine, preventing unwanted side reactions during peptide chain elongation. Boc-glycine is a crucial building block in solid-phase peptide synthesis (SPPS), a widely employed method for synthesizing peptides. It is used to introduce glycine residues into the growing peptide chain. The Boc protecting group is stable under mild acidic conditions but can be easily removed using trifluoroacetic acid (TFA) at the end of the synthesis. Boc-glycine's importance stems from its role in enabling the efficient and controlled assembly of peptides, which have diverse biological functions and therapeutic applications. It is studied to understand its synthesis, reactivity, and its application in peptide synthesis.'

BOC-glycine: RN given refers to parent cpd [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

Cross-References

ID Source	ID
PubMed CID	78288
CHEMBL ID	508605
SCHEMBL ID	17906
MeSH ID	M0092948

Synonyms (146)

Synonym
AC-138
EN300-35227
n-((1,1-dimethylethoxy)carbonyl)glycine
einecs 224-864-5
nsc 127669
nalpha-tert-butyloxycarbonylglycine
glycine, n-carboxy-, n-tert-butyl ester
glycine, n-((1,1-dimethylethoxy)carbonyl)-
n.alpha.-tert-butyloxycarbonylglycine
n-tert-butyloxycarbonylglycine
tert-butoxycarbonylglycine
boc-gly-oh
glycine,1-dimethylethoxy)carbonyl]-
nsc-127669
tert-butyloxycarbonylglycine
4530-20-5
boc-glycine
n-(carbo-tert-butoxy)glycine
n-t-butyloxycarbonyl glycine
nsc127669
n-(tert-butoxycarbonyl)glycine
n(a)-tert-butyloxycarbonylglycine
n-[(1,1-dimethylethoxy)carbonyl]glycine
t-butoxycarbonylglycine
glycine, n-tert-butyl ester
glycine, n-[(1,1-dimethylethoxy)carbonyl]-
glycine,n-tert.butyloxycarbonyl
inchi=1/c7h13no4/c1-7(2,3)12-6(11)8-4-5(9)10/h4h2,1-3h3,(h,8,11)(h,9,10
boc-gly-oh, 98%
boc-gly-oh, >=99.0% (t)
B1185
n-boc-glycine
AKOS000163644
STL068907
n-alpha-t-boc-glycine
CHEMBL508605
2-[(2-methylpropan-2-yl)oxycarbonylamino]acetic acid
[(tert-butoxycarbonyl)amino]acetic acid
2-{[(tert-butoxy)carbonyl]amino}acetic acid
tert-butoxycarbonylamino-acetic acid
n-boc-l-glycine
A826767
M03287
2-[(tert-butoxy)carbonylamino]acetic acid
FT-0602334
AM20100157
AB00256
[(t-butoxycarbonyl)amino]acetic acid
BP-30202
AB01314432-03
2-((tert-butoxycarbonyl)amino)acetic acid
t-butoxycarbonyl- glycine
tert.butoxycarbonylglycine
n-tert.butyloxycarbonylglycine
(tert-butoxycarbonyl)-glycine
((tert-butoxycarbonyl)amino)acetic acid
n-tert.butyloxycarbonyl glycine
n-boc-gly
n-tert-butoxycarbonyl-glycine
n-bocglycine
(tert-butoxycarbonylamino)acetic acid
tert-butoxycarbonyl-glycine
n-(tert.butoxycarbonyl)glycine
n-tert-butoxycarbonyl glycine
t-butyloxycarbonyl glycine
tert-butoxycarbonylaminoacetic acid
t-butyloxycarbonylglycine
boc-gly
2-[(tert-butoxycarbonyl)amino]acetic acid
n-(1,1-dimethylethoxycarbonyl)glycine
tert.-butoxycarbonylglycine
n-tert-butyloxycarbonyl glycine
n-tert-butyloxycarbonyl-2-aminoacetic acid
n-(tert-butoxy-carbonyl)glycine
t-butoxycarbonylaminoacetic acid
t-butoxycarbonyl-glycine
tert-butyloxycarbonyl glycine
tert-butoxycarbonyl glycine
2-tert-butoxycarbonylaminoacetic acid
n-(t-butoxycarbonyl)glycine
boc glycine
tert. butoxycarbonyl glycine
n-t-butoxycarbonyl glycine
bocglyoh
n-tert-butoxycarbonylglycine
n-t-boc-glycine
n-t-butyloxycarbonylglycine
n-{[(1,1-dimethylethyl)oxy]carbonyl}glycine
n-tertbutoxycarbonylglycine
boc-glycine-oh
n-boc glycine
n-(tertiary butoxycarbonyl)glycine
nalpha-boc-glycine
n-(tert-butoxycarbonyl)-glycine
t-butoxycarbonyl glycine
carbotertbutoxyglycine
(tert-butoxycarbonyl)glycine
n-tert.-butoxycarbonylglycine
n-(tert.-butyloxycarbonyl)-glycine
n-tert-butyloxycarbonyl-glycine
n-(boc)-glycine
n-((tert-butyloxy)carbonyl)glycine
n-(tert-butoxycarbonyl) glycine
n-(tertbutoxycarbonyl)glycine
tert-butoxycarbonylamino acetic acid
2-(tert-butoxy-carbonyl-amino)acetic acid
n-t-butoxycarbonylglycine
2-{(tert-butoxycarbonyl)amino}acetic acid
2-(tert-butoxycarbonylamino) acetic acid
boc-glyoh
n-tert.butoxycarbonyl-glycine
t-boc-gly
boc-l-glycine
2-((tert-butoxycarbonyl)amino) acetic acid
boc-glycine oh
t-butoxycarbonylamino acetic acid
t-butoxy carbonylamino-acetic acid
n-(t-butoxycarbonyl)-glycine
n-boc-gly-oh
2-(tert-butoxycarbonylamino)acetic acid
n-t-butoxycarbonyl-glycine
boc gly-oh
n-carbo-tert-butoxyglycine
tert.-butyloxycarbonylglycine
n-tert-butoxy carbonyl-glycine
n-tertiarybutoxycarbonylglycine
n-[(1,1-dimethylethoxy)carbonyl]-glycine
t-boc-glycine
SCHEMBL17906
n-.alpha.-tert-butyloxycarbonylglycine
[(tert-butoxycarbonyl)amino]acetic acid #
DTXSID2063509
Q-200739
J-300132
Z56974835
F9995-1166
boc-gly-oh-15n;n-(tert-butoxycarbonyl)glycine-15n;glycine-15n,n-t-bocderivative;106665-75-2;boc-[15n]gly-oh;486701_aldrich
mfcd00002690
n-alpha-t-butyloxycarbonyl-glycine
CS-W008705
NCGC00334944-01
2-(boc-amino)acetic acid
AS-11190
BCP23287
n-tert-boc-glycine-oh
HY-Y0978

Protein	Taxonomy	Measurement	Average	Min (ref.)	Avg (ref.)	Max (ref.)	Bioassay(s)
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Assay ID	Title	Year	Journal	Article
AID388273	Ratio of Vm(app) to Km(app) for rat recombinant peptidylglycine alpha-amidating monooxygenase	2008	Bioorganic & medicinal chemistry, Dec-01, Volume: 16, Issue:23	Substituted hippurates and hippurate analogs as substrates and inhibitors of peptidylglycine alpha-hydroxylating monooxygenase (PHM).
AID388272	Activity of rat recombinant peptidylglycine alpha-amidating monooxygenase assessed as stimulation of oxygen consumption	2008	Bioorganic & medicinal chemistry, Dec-01, Volume: 16, Issue:23	Substituted hippurates and hippurate analogs as substrates and inhibitors of peptidylglycine alpha-hydroxylating monooxygenase (PHM).
AID388274	Ratio of Vm(app) to Km(app) for rat recombinant peptidylglycine alpha-amidating monooxygenase relative to hippuric acid	2008	Bioorganic & medicinal chemistry, Dec-01, Volume: 16, Issue:23	Substituted hippurates and hippurate analogs as substrates and inhibitors of peptidylglycine alpha-hydroxylating monooxygenase (PHM).
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Timeframe	Studies, This Drug (%)	All Drugs %
pre-1990	1 (12.50)	18.7374
1990's	1 (12.50)	18.2507
2000's	5 (62.50)	29.6817
2010's	1 (12.50)	24.3611
2020's	0 (0.00)	2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Publication Type	This drug (%)	All Drugs (%)
Trials	0 (0.00%)	5.53%
Reviews	0 (0.00%)	6.00%
Case Studies	0 (0.00%)	4.05%
Observational	0 (0.00%)	0.25%
Other	8 (100.00%)	84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Substance	Relationship Strength	Studies	Classes	Roles
benzaldehyde [no description available]	2.04	1	benzaldehydes	EC 3.1.1.3 (triacylglycerol lipase) inhibitor; EC 3.5.5.1 (nitrilase) inhibitor; flavouring agent; fragrance; odorant receptor agonist; plant metabolite
carbamates [no description available]	2.04	1	amino-acid anion
glycine [no description available]	3.39	7	alpha-amino acid; amino acid zwitterion; proteinogenic amino acid; serine family amino acid	EC 2.1.2.1 (glycine hydroxymethyltransferase) inhibitor; fundamental metabolite; hepatoprotective agent; micronutrient; neurotransmitter; NMDA receptor agonist; nutraceutical
p-aminohippuric acid p-Aminohippuric Acid: The glycine amide of 4-aminobenzoic acid. Its sodium salt is used as a diagnostic aid to measure effective renal plasma flow (ERPF) and excretory capacity.. p-aminohippurate : A hippurate that is the conjugate base of p-aminohippuric acid, arising from deprotonation of the carboxy group.. p-aminohippuric acid : An N-acylglycine that is the 4-amino derivative of hippuric acid; used as a diagnostic agent in the measurement of renal plasma flow.	2.04	1	N-acylglycine	Daphnia magna metabolite
furfurylamine [no description available]	2.04	1
alanine Alanine: A non-essential amino acid that occurs in high levels in its free state in plasma. It is produced from pyruvate by transamination. It is involved in sugar and acid metabolism, increases IMMUNITY, and provides energy for muscle tissue, BRAIN, and the CENTRAL NERVOUS SYSTEM.. alanine : An alpha-amino acid that consists of propionic acid bearing an amino substituent at position 2.	2.21	1	alanine zwitterion; alanine; L-alpha-amino acid; proteinogenic amino acid; pyruvate family amino acid	EC 4.3.1.15 (diaminopropionate ammonia-lyase) inhibitor; fundamental metabolite
lysine Lysine: An essential amino acid. It is often added to animal feed.. lysine : A diamino acid that is caproic (hexanoic) acid bearing two amino substituents at positions 2 and 6.. L-lysine : An L-alpha-amino acid; the L-isomer of lysine.	2.21	1	aspartate family amino acid; L-alpha-amino acid zwitterion; L-alpha-amino acid; lysine; organic molecular entity; proteinogenic amino acid	algal metabolite; anticonvulsant; Escherichia coli metabolite; human metabolite; micronutrient; mouse metabolite; nutraceutical; plant metabolite; Saccharomyces cerevisiae metabolite
iodohippuric acid Iodohippuric Acid: An iodine-containing compound used in pyelography as a radiopaque medium. If labeled with radioiodine, it can be used for studies of renal function.. 2-iodohippuric acid : A member of the class of benzamides resulting from the formal condensation of the carboxy group of 2-iodobenzoic acid with the amino group of glycine.	2.04	1	benzamides; N-acylglycine; organoiodine compound
salicylurate salicylurate: RN given refers to parent cpd. salicyluric acid : An N-acylglycine in which the acyl group is specified as 2-hydroxybenzoyl.. salicylurate : A monocarboxylic acid anion that is the conjugate base of salicyluric acid, obtained by deprotonation of the carboxy group; major species at pH 7.3.	2.04	1	N-acylglycine; secondary carboxamide	human xenobiotic metabolite; uremic toxin
aceturic acid aceturic acid: structure. N-acetylglycine : An N-acylglycine where the acyl group is specified as acetyl.	2.04	1	N-acetyl-amino acid; N-acylglycine	human metabolite
n-benzyloxycarbonylglycine N-benzyloxycarbonylglycine: structure given in first source. N-benzyloxycarbonylglycine : A derivative of glycine having a benzyloxycarbonyl protecting group attached to the nitrogen.	2.41	2	N-acylglycine
4-nitrohippuric acid 4-nitrohippuric acid: major metabolite of 4-nitrobenzoic acid	2.04	1
furoylglycine furoylglycine: structure given in first source. N-(2-furoyl)glycine : A glycine derivative that is the carboxamide obtained by the formal condensation of the amino group of glycine with 2-furoic acid.	2.04	1	furans; N-acylglycine	human metabolite
tert-butyl isocyanide tert-butylisonitrile: structure in first source	2.04	1
4-chlorohippuric acid 4-chlorohippuric acid: metabolite of zomepirac; RN given refers to parent cpd	2.04	1
thiophenoxyacetic acid thiophenoxyacetic acid: structure	2.04	1
salicylhydroxamic acid [no description available]	2.04	1	hydroxamic acid; phenols	antibacterial drug; EC 1.11.2.2 (myeloperoxidase) inhibitor; EC 3.5.1.5 (urease) inhibitor; trypanocidal drug
phenylacetylglycine phenylacetylglycine : A N-acylglycine that is glycine substituted on nitrogen with a phenylacetyl group.	2.04	1	monocarboxylic acid amide; monocarboxylic acid; N-acylglycine	human metabolite; mouse metabolite
nicotinuric acid nicotinuric acid: RN given refers to parent cpd. N-nicotinoylglycine : An N-acylglycine having nicotinoyl as the acyl substituent.	2.04	1	N-acylglycine	human urinary metabolite
benzoylpropionic acid benzoylpropionic acid: structure in first source. 4-oxo-4-phenylbutyric acid : A 4-oxo monocarboxylic acid that is butyric acid bearing oxo and phenyl substituents at position 4.	2.04	1	4-oxo monocarboxylic acid	hapten
n-benzylglycine [no description available]	2.04	1
2-methylhippuric acid 2-methylhippuric acid: urinary metabolite of o-xylene. o-methylhippuric acid : An N-acylglycine that is the ortho-methyl derivative of hippuric acid.	2.04	1	N-acylglycine	metabolite
hippuryl-glycyl-glycine hippuryl-glycyl-glycine: RN given refers to parent cpd; N1 from 9th CI Form Index	2.04	1
4-methylhippuric acid 4-methylhippuric acid: urinary metabolite of p-xylene. p-methylhippuric acid : An N-acylglycine in which the acyl group is specified as 4-methylbenzoyl.	2.04	1	N-acylglycine	metabolite
3-methylhippuric acid 3-methylhippuric acid: urinary metabolite of m-xylene. m-methylhippuric acid : An N-acylglycine that is the 3-methyl derivative of hippuric acid.	2.04	1	N-acylglycine	metabolite
4-methyoxybenzoyl-n-glycine [no description available]	2.04	1	N-acylglycine
4-hydroxyhippuric acid p-hydroxyhippuric acid : An N-acylglycine that is the 4-hydroxy derivative of hippuric acid.	2.04	1	N-acylglycine	human blood serum metabolite
cinnamoylglycine cinnamoylglycine: structure given in first source. N-cinnamoylglycine : An N-acylglycine in which the acyl group is specified as (2E)-3-phenylprop-2-enoyl (cinnamoyl).	2.04	1	N-acylglycine	metabolite
epsilon-tert-butyloxycarbonyl-lysine epsilon-tert-butyloxycarbonyl-lysine: RN given refers to (L)-isomer	2.21	1
2-aminohippuric acid [no description available]	2.04	1	N-acylglycine
fenretinide Fenretinide: A synthetic retinoid that is used orally as a chemopreventive against prostate cancer and in women at risk of developing contralateral breast cancer. It is also effective as an antineoplastic agent.. 4-hydroxyphenyl retinamide : A retinoid obtained by formal condensation of the carboxy group of all-trans retinoic acid and the anilino group of 4-hydroxyaniline. Synthetic retinoid agonist. Antiproliferative, antioxidant and anticancer agent with a long half-life in vivo. Apoptotic effects appear to be mediated by a mechanism distinct from that of 'classical' retinoids.	2.04	1	monocarboxylic acid amide; retinoid	antineoplastic agent; antioxidant
pentagastrin Pentagastrin: A synthetic pentapeptide that has effects like gastrin when given parenterally. It stimulates the secretion of gastric acid, pepsin, and intrinsic factor, and has been used as a diagnostic aid.	1.95	1	organic molecular entity
muramidase Muramidase: A basic enzyme that is present in saliva, tears, egg white, and many animal fluids. It functions as an antibacterial agent. The enzyme catalyzes the hydrolysis of 1,4-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues in peptidoglycan and between N-acetyl-D-glucosamine residues in chitodextrin. EC 3.2.1.17.	2.03	1

Condition	Indicated	Relationship Strength	Studies	Trials
Absence Seizure [description not available]	0	1.98	1	0
Seizures Clinical or subclinical disturbances of cortical function due to a sudden, abnormal, excessive, and disorganized discharge of brain cells. Clinical manifestations include abnormal motor, sensory and psychic phenomena. Recurrent seizures are usually referred to as EPILEPSY or seizure disorder.	0	1.98	1	0

boc-glycine

Description

Cross-References

Synonyms (146)

Protein Targets (1)

Other Measurements

Bioassays (3)

Research

Studies (8)

Market Indicators

Research Demand Index: 42.07

Study Types

boc-glycine

Description

Cross-References

Synonyms (146)

Protein Targets (1)

Other Measurements

Bioassays (3)

Research

Studies (8)

Market Indicators

Research Demand Index: 42.07

Study Types

Related Drugs (33)

Related Conditions (2)