Page last updated: 2024-12-05

idra 21

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

Description

IDRA 21: modulates AMPA receptor desensitization ; structure given in first source [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

Cross-References

ID SourceID
PubMed CID3688
CHEMBL ID77862
CHEBI ID111162
SCHEMBL ID195328
MeSH IDM0241418

Synonyms (57)

Synonym
CHEMBL77862
7-chloro-3,4-dihydro-3-methyl-2h-1,2,4-benzothiadiazine 1,1-dioxide
HMS3267D13
BRD-A14344385-001-01-6
BIOMOL-NT_000225
BPBIO1_001088
idra 21, >=98%
NCGC00025050-02
CHEBI:111162
22503-72-6
(+)-idra-21
7-chloro-3-methyl-3,4-dihydro-2h-1,2,4-benzothiadiazine 1,1-dioxide
(-)-idra-21
163936-79-6
163936-78-5
2h-1,2,4-benzothiadiazine, 7-chloro-3,4-dihydro-3-methyl-, 1,1-dioxide, (+)-
2h-1,2,4-benzothiadiazine, 7-chloro-3,4-dihydro-3-methyl-, 1,1-dioxide, (-)-
idra 21
689uw7pt68 ,
7-chloro-3-methyl-3,4-dihydro-2h-1,2,4-benzothiadiazine-s,s-dioxide
idra-21
unii-689uw7pt68
2h-1,2,4-benzothiadiazine, 7-chloro-3,4-dihydro-3-methyl-, 1,1-dioxide
2h-1,2,4-benzothiadiazine,7-chloro-3,4-dihydro-3-methyl-, 1,1-dioxide
S2434
gtpl4219
7-chloro-3-methyl-3,4-dihydro-2h-1$l^{6},2,4-benzothiadiazine-1,1-dione
SCHEMBL195328
7-chloro-3-methyl-3,4-dihydro-2h-1,2,4-benzothiadiazine s,s-dioxide
HB0334
7-chloro-3-methyl-3,4-dihydro-2h-benzo[e][1,2,4]thiadiazine 1,1-dioxide
AKOS024456473
EX-A737
sr-01000597374
SR-01000597374-1
mfcd00270874
J-014742
CS-0021632
7-chloro-3-methyl-3,4-dihydro-2h-1,2,4-benzothiadiazine
FT-0700269
BCP19065
s 18986;s18986;idra-21;idra21;idra 21;ampakine
Q5970086
HMS3676O19
7-chloro-3-methyl-3-4-dihydro-2h-1,2,4 benzothiadiazine s,s-dioxide
DS-11824
7-chloro-3-methyl-3,4-dihydro-1lambda~6~,2,4-benzothiadiazine-1,1(2h)-dione
DTXSID70936887
HMS3412O19
BRD-A14344385-001-02-4
XAA50372
7-chloro-3-methyl-3,4-dihydro-2h-1lambda6,2,4-benzothiadiazine 1,1-dioxide
idra21
7-chloro-3-methyl-3,4-dihydro-2h-benzo(e)(1,2,4)thiadiazine 1,1-dioxide
A878525
HY-101528
SY105342

Research Excerpts

Overview

IDRA 21 is a positive allosteric modulator of glutamate AMPA receptors.

ExcerptReferenceRelevance
"IDRA 21 is a positive allosteric modulator of glutamate AMPA receptors."( The effects of huperzine A and IDRA 21 on visual recognition memory in young macaques.
Gale, K; Kozikowski, AP; Malkova, L, 2011
)
1.38

Dosage Studied

IDRA 21 is 10-fold more potent than aniracetam in antagonizing alprazolam-induced learning deficit. IDRA 21 produced a gradual increase in task accuracy.

ExcerptRelevanceReference
" From dose-response studies, it can be estimated that IDRA 21 is approximately 10-fold more potent than aniracetam in antagonizing alprazolam-induced learning deficit."( 7-Chloro-3-methyl-3,4-dihydro-2H-1,2,4-benzothiadiazine S,S-dioxide (IDRA 21), a congener of aniracetam, potently abates pharmacologically induced cognitive impairments in patas monkeys.
Costa, E; DiBella, M; Guidotti, A; Thompson, DM, 1995
)
0.77
" IDRA 21 produced a gradual increase in task accuracy that was maintained on average above vehicle performance levels over an intermittent dosing schedule during a total period of 3 weeks."( The effects of IDRA 21, a positive modulator of the AMPA receptor, on delayed matching performance by young and aged rhesus monkeys.
Buccafusco, JJ; Klinder, K; Terry, AV; Weiser, T; Winter, K, 2004
)
1.59
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Drug Classes (1)

ClassDescription
benzothiadiazineHeterocyclic compound of a ring with sulfur and two nitrogen atoms fused to a benzene ring. Members inhibit sodium-potassium-chloride symporters and are used as diuretics.
[compound class information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Bioassays (12)

Assay IDTitleYearJournalArticle
AID345813Potentiation of Wistar rat AMPA receptor expressed in Xenopus laevis oocytes assessed as increase in amplitude of (S)-AMP-induced current by two electrode voltage-clamp method relative to AMPA2008Bioorganic & medicinal chemistry, Dec-01, Volume: 16, Issue:23
Synthesis and pharmacological evaluation of a second generation of pyridothiadiazine 1,1-dioxides acting as AMPA potentiators.
AID392788Potentiation of AMPA receptor mediated KA-induced current in Sprague-Dawley rat primary cerebellar granule neurons at 200 uM2009Bioorganic & medicinal chemistry letters, Feb-15, Volume: 19, Issue:4
A novel class of allosteric modulators of AMPA/Kainate receptors.
AID291179Activity at Wistar rat cortex AMPA receptor expressed in Xenopus laevis oocytes assessed as 5-fold increase of (S)-AMPA-induced current2007Journal of medicinal chemistry, Jun-28, Volume: 50, Issue:13
Design, synthesis, and pharmacology of novel 7-substituted 3,4-dihydro-2H-1,2,4-benzothiadiazine 1,1-dioxides as positive allosteric modulators of AMPA receptors.
AID459002Binding affinity to subsite C/C' in S1S2 domain of GluA2 receptor expressed in Escherichia coli by crystallography2010Journal of medicinal chemistry, Mar-11, Volume: 53, Issue:5
Piracetam defines a new binding site for allosteric modulators of alpha-amino-3-hydroxy-5-methyl-4-isoxazole-propionic acid (AMPA) receptors.
AID291181Activity at Wistar rat cortex AMPA receptor expressed in Xenopus laevis oocytes assessed as maximum increase of (S)-AMPA-induced current2007Journal of medicinal chemistry, Jun-28, Volume: 50, Issue:13
Design, synthesis, and pharmacology of novel 7-substituted 3,4-dihydro-2H-1,2,4-benzothiadiazine 1,1-dioxides as positive allosteric modulators of AMPA receptors.
AID291178Activity at Wistar rat cortex AMPA receptor expressed in Xenopus laevis oocytes assessed as 2-fold increase of (S)-AMPA-induced current2007Journal of medicinal chemistry, Jun-28, Volume: 50, Issue:13
Design, synthesis, and pharmacology of novel 7-substituted 3,4-dihydro-2H-1,2,4-benzothiadiazine 1,1-dioxides as positive allosteric modulators of AMPA receptors.
AID146417Variation of kainate-activated (KA) currents in primary cultures of cerebellar granule neurons at 1 mM using patch-clamp technique2002Journal of medicinal chemistry, Jun-06, Volume: 45, Issue:12
Synthesis of 3,4-dihydro-2H-1,2,4-benzo-thiadiazine 1,1-dioxide derivatives as potential allosteric modulators of AMPA/kainate receptors.
AID1187719Positive allosteric modulator activity at AMPA receptor in 7 days old Sprague-Dawley rat cerebellar granule neurons assessed as potentiation of 5-Will-evoked current at 10 uM by whole cell patch clamp technique2014Bioorganic & medicinal chemistry, Sep-01, Volume: 22, Issue:17
Design, stereoselective synthesis, configurational stability and biological activity of 7-chloro-9-(furan-3-yl)-2,3,3a,4-tetrahydro-1H-benzo[e]pyrrolo[2,1-c][1,2,4]thiadiazine 5,5-dioxide.
AID291180Activity at Wistar rat cortex AMPA receptor expressed in Xenopus laevis oocytes assessed as effect on (S)-AMPA-induced current2007Journal of medicinal chemistry, Jun-28, Volume: 50, Issue:13
Design, synthesis, and pharmacology of novel 7-substituted 3,4-dihydro-2H-1,2,4-benzothiadiazine 1,1-dioxides as positive allosteric modulators of AMPA receptors.
AID345812Potentiation of Wistar rat AMPA receptor expressed in Xenopus laevis oocytes assessed as 5-fold increase in amplitude of (S)-AMPA-induced current by two electrode voltage-clamp method2008Bioorganic & medicinal chemistry, Dec-01, Volume: 16, Issue:23
Synthesis and pharmacological evaluation of a second generation of pyridothiadiazine 1,1-dioxides acting as AMPA potentiators.
AID345811Potentiation of Wistar rat AMPA receptor expressed in Xenopus laevis oocytes assessed as 2-fold increase in amplitude of (S)-AMPA-induced current by two electrode voltage-clamp method2008Bioorganic & medicinal chemistry, Dec-01, Volume: 16, Issue:23
Synthesis and pharmacological evaluation of a second generation of pyridothiadiazine 1,1-dioxides acting as AMPA potentiators.
AID1187718Positive allosteric modulator activity at AMPA receptor in 7 days old Sprague-Dawley rat cerebellar granule neurons assessed as potentiation of kainite-evoked current at 10 uM by whole cell patch clamp technique2014Bioorganic & medicinal chemistry, Sep-01, Volume: 22, Issue:17
Design, stereoselective synthesis, configurational stability and biological activity of 7-chloro-9-(furan-3-yl)-2,3,3a,4-tetrahydro-1H-benzo[e]pyrrolo[2,1-c][1,2,4]thiadiazine 5,5-dioxide.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (24)

TimeframeStudies, This Drug (%)All Drugs %
pre-19900 (0.00)18.7374
1990's8 (33.33)18.2507
2000's12 (50.00)29.6817
2010's4 (16.67)24.3611
2020's0 (0.00)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 45.96

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be strong demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index45.96 (24.57)
Research Supply Index3.22 (2.92)
Research Growth Index4.32 (4.65)
Search Engine Demand Index71.60 (26.88)
Search Engine Supply Index2.11 (0.95)

This Compound (45.96)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews1 (4.17%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other23 (95.83%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]