| Assay ID | Title | Year | Journal | Article |
|---|
| AID291179 | Activity at Wistar rat cortex AMPA receptor expressed in Xenopus laevis oocytes assessed as 5-fold increase of (S)-AMPA-induced current | 2007 | Journal of medicinal chemistry, Jun-28, Volume: 50, Issue:13
| Design, synthesis, and pharmacology of novel 7-substituted 3,4-dihydro-2H-1,2,4-benzothiadiazine 1,1-dioxides as positive allosteric modulators of AMPA receptors. |
| AID777162 | Binding affinity to rat LBD of GluA2 receptor L483Y and N754S mutant at 243 uM by isothermal titration calorimetry analysis | 2013 | Journal of medicinal chemistry, Nov-14, Volume: 56, Issue:21
| Synthesis, pharmacological and structural characterization, and thermodynamic aspects of GluA2-positive allosteric modulators with a 3,4-dihydro-2H-1,2,4-benzothiadiazine 1,1-dioxide scaffold. |
| AID291185 | Cognitive-enhancing effect in Wistar rat at 3 mg/kg, po by object recognition test | 2007 | Journal of medicinal chemistry, Jun-28, Volume: 50, Issue:13
| Design, synthesis, and pharmacology of novel 7-substituted 3,4-dihydro-2H-1,2,4-benzothiadiazine 1,1-dioxides as positive allosteric modulators of AMPA receptors. |
| AID291178 | Activity at Wistar rat cortex AMPA receptor expressed in Xenopus laevis oocytes assessed as 2-fold increase of (S)-AMPA-induced current | 2007 | Journal of medicinal chemistry, Jun-28, Volume: 50, Issue:13
| Design, synthesis, and pharmacology of novel 7-substituted 3,4-dihydro-2H-1,2,4-benzothiadiazine 1,1-dioxides as positive allosteric modulators of AMPA receptors. |
| AID345813 | Potentiation of Wistar rat AMPA receptor expressed in Xenopus laevis oocytes assessed as increase in amplitude of (S)-AMP-induced current by two electrode voltage-clamp method relative to AMPA | 2008 | Bioorganic & medicinal chemistry, Dec-01, Volume: 16, Issue:23
| Synthesis and pharmacological evaluation of a second generation of pyridothiadiazine 1,1-dioxides acting as AMPA potentiators. |
| AID458611 | Induction of amplitude current in Xenopus laevis oocytes assessed as 2 fold increase in AMPA-induced current by voltage clamp method | 2010 | Journal of medicinal chemistry, Feb-25, Volume: 53, Issue:4
| New fluorinated 1,2,4-benzothiadiazine 1,1-dioxides: discovery of an orally active cognitive enhancer acting through potentiation of the 2-amino-3-(3-hydroxy-5-methylisoxazol-4-yl)propionic acid receptors. |
| AID291184 | Cognitive-enhancing effect in Wistar rat at 0.3 mg/kg, po by object recognition test | 2007 | Journal of medicinal chemistry, Jun-28, Volume: 50, Issue:13
| Design, synthesis, and pharmacology of novel 7-substituted 3,4-dihydro-2H-1,2,4-benzothiadiazine 1,1-dioxides as positive allosteric modulators of AMPA receptors. |
| AID291183 | Increase in (S)-AMPA-stimulated [3H]noradrenaline release in Wistar rat hippocampus at 30 uM relative to control | 2007 | Journal of medicinal chemistry, Jun-28, Volume: 50, Issue:13
| Design, synthesis, and pharmacology of novel 7-substituted 3,4-dihydro-2H-1,2,4-benzothiadiazine 1,1-dioxides as positive allosteric modulators of AMPA receptors. |
| AID345812 | Potentiation of Wistar rat AMPA receptor expressed in Xenopus laevis oocytes assessed as 5-fold increase in amplitude of (S)-AMPA-induced current by two electrode voltage-clamp method | 2008 | Bioorganic & medicinal chemistry, Dec-01, Volume: 16, Issue:23
| Synthesis and pharmacological evaluation of a second generation of pyridothiadiazine 1,1-dioxides acting as AMPA potentiators. |
| AID291182 | Increase of EPSfP evoked response in Wistar rat hippocampus at 30 uM relative to control | 2007 | Journal of medicinal chemistry, Jun-28, Volume: 50, Issue:13
| Design, synthesis, and pharmacology of novel 7-substituted 3,4-dihydro-2H-1,2,4-benzothiadiazine 1,1-dioxides as positive allosteric modulators of AMPA receptors. |
| AID291181 | Activity at Wistar rat cortex AMPA receptor expressed in Xenopus laevis oocytes assessed as maximum increase of (S)-AMPA-induced current | 2007 | Journal of medicinal chemistry, Jun-28, Volume: 50, Issue:13
| Design, synthesis, and pharmacology of novel 7-substituted 3,4-dihydro-2H-1,2,4-benzothiadiazine 1,1-dioxides as positive allosteric modulators of AMPA receptors. |
| AID458612 | Induction of membrane depolarization in rat E16 cells assessed as 2 fold increase in AMPA-induced fluorescence by flipR method | 2010 | Journal of medicinal chemistry, Feb-25, Volume: 53, Issue:4
| New fluorinated 1,2,4-benzothiadiazine 1,1-dioxides: discovery of an orally active cognitive enhancer acting through potentiation of the 2-amino-3-(3-hydroxy-5-methylisoxazol-4-yl)propionic acid receptors. |
| AID345811 | Potentiation of Wistar rat AMPA receptor expressed in Xenopus laevis oocytes assessed as 2-fold increase in amplitude of (S)-AMPA-induced current by two electrode voltage-clamp method | 2008 | Bioorganic & medicinal chemistry, Dec-01, Volume: 16, Issue:23
| Synthesis and pharmacological evaluation of a second generation of pyridothiadiazine 1,1-dioxides acting as AMPA potentiators. |
| AID1170667 | Binding affinity to GluA2-LBD-L483Y-N754S complex (unknown origin) by isothermal titration calorimetry | 2014 | Journal of medicinal chemistry, Nov-26, Volume: 57, Issue:22
| Positive allosteric modulators of 2-amino-3-(3-hydroxy-5-methylisoxazol-4-yl)propionic acid receptors belonging to 4-cyclopropyl-3,4-dihydro-2h-1,2,4-pyridothiadiazine dioxides and diversely chloro-substituted 4-cyclopropyl-3,4-dihydro-2H-1,2,4-benzothiad |
| AID291180 | Activity at Wistar rat cortex AMPA receptor expressed in Xenopus laevis oocytes assessed as effect on (S)-AMPA-induced current | 2007 | Journal of medicinal chemistry, Jun-28, Volume: 50, Issue:13
| Design, synthesis, and pharmacology of novel 7-substituted 3,4-dihydro-2H-1,2,4-benzothiadiazine 1,1-dioxides as positive allosteric modulators of AMPA receptors. |
| AID977611 | Experimentally measured binding affinity data (Kd) for protein-ligand complexes derived from PDB | 2012 | The Biochemical journal, Jan-01, Volume: 441, Issue:1
| Thermodynamics and structural analysis of positive allosteric modulation of the ionotropic glutamate receptor GluA2. |
| [information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023] |