Page last updated: 2024-08-02 09:32:35

halometasone

Description

halometasone : no description available [CHeBI]

Cross-References

ID SourceID
PubMed CID9846332
CHEMBL ID1587228
SCHEMBL ID4872
CHEBI ID135724
MeSH IDM0111181

Synonyms (39)

Synonym
AC-3528
50629-82-8
D07202
halometasone (inn)
MLS001424089
smr000466330
MLS000759439
CHEBI:135724
halometasone
HMS2051C16
HMS2232N17
CCG-100880
halometasone [inn]
j69z9uu41z ,
einecs 256-664-9
2-chlor-6alpha,9-difluor-11beta,17,21-trihydroxy-16alpha-methyl-1,4-pregnadien-3,20-dion
pregna-1,4-diene-3,20-dione, 2-chloro-6,9-difluoro-11,17,21-trihydroxy-16-methyl-, (6alpha,11beta,16alpha)-
halometasonum [inn-latin]
2-chloro-6alpha,9-difluoro-11beta,17,21-trihydroxy-16alpha-methylpregna-1,4-diene-3,20-dione
halometasona
halometasona [inn-spanish]
halometasonum
unii-j69z9uu41z
2-chloro-6.alpha.,9-difluoro-11.beta.,17,21-trihydroxy-16.alpha.-methylpregna-1,4-diene-3,20-dione
halometasone [mart.]
halometasone [who-dd]
halometasone [mi]
CHEMBL1587228
AB00639905-06
NC00130
SCHEMBL4872
DTXSID1048382
Q-101370
AKOS025402048
DB13728
Q10910139
CS-0453061
(6s,8s,9r,10s,11s,13s,14s,16r,17r)-2-chloro-6,9-difluoro-11,17-dihydroxy-17-(2-hydroxyacetyl)-10,13,16-trimethyl-6,7,8,9,10,11,12,13,14,15,16,17-dodecahydro-3h-cyclopenta[a]phenanthren-3-one
AS-78199

Drug Classes (1)

ClassDescription
21-hydroxy steroid

Protein Targets (3)

Potency Measurements

ProteinTaxonomyMeasurementAverage (mM)Bioassay(s)
lysosomal alpha-glucosidase preproproteinHomo sapiens (human)Potency5.0119AID1466; AID2242
Neuronal acetylcholine receptor subunit alpha-4Rattus norvegicus (Norway rat)Potency5.0119AID1466
Neuronal acetylcholine receptor subunit beta-2Rattus norvegicus (Norway rat)Potency5.0119AID1466

Bioassays (3)

Assay IDTitleYearJournalArticle
AID504810Antagonists of the Thyroid Stimulating Hormone Receptor: HTS campaign2010Endocrinology, Jul, Volume: 151, Issue:7
ISSN: 1945-7170
A small molecule inverse agonist for the human thyroid-stimulating hormone receptor.
AID504812Inverse Agonists of the Thyroid Stimulating Hormone Receptor: HTS campaign2010Endocrinology, Jul, Volume: 151, Issue:7
ISSN: 1945-7170
A small molecule inverse agonist for the human thyroid-stimulating hormone receptor.
AID1159607Screen for inhibitors of RMI FANCM (MM2) intereaction2016Journal of biomolecular screening, Jul, Volume: 21, Issue:6
ISSN: 1552-454X
A High-Throughput Screening Strategy to Identify Protein-Protein Interaction Inhibitors That Block the Fanconi Anemia DNA Repair Pathway.

Research

Studies (33)

TimeframeStudies, This Drug (%)All Drugs %
pre-199020 (60.61)18.7374
1990's1 (3.03)18.2507
2000's1 (3.03)29.6817
2010's10 (30.30)24.3611
2020's1 (3.03)2.80

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials24 (61.54%)5.53%
Reviews0 (0.00%)6.00%
Case Studies3 (7.69%)4.05%
Observational0 (0.00%)0.25%
Other12 (30.77%)84.16%
SubstanceStudiesClassesRolesFirst YearLast YearAverage AgeRelationship StrengthTrialspre-19901990's2000's2010'spost-2020
betamethasone21-hydroxy steroid00low000000
11,17-dihydroxy-17-(2-hydroxy-1-oxoethyl)-10,13-dimethyl-2,6,7,8,9,11,12,14,15,16-decahydro-1H-cyclopenta[a]phenanthren-3-one21-hydroxy steroid00low000000
corticosterone11beta-hydroxy steroid;
20-oxo steroid;
21-hydroxy steroid;
3-oxo-Delta(4) steroid;
C21-steroid;
glucocorticoid;
primary alpha-hydroxy ketone
human metabolite;
mouse metabolite
00low000000
prednisolone11beta-hydroxy steroid;
17alpha-hydroxy steroid;
20-oxo steroid;
21-hydroxy steroid;
3-oxo-Delta(1),Delta(4)-steroid;
C21-steroid;
glucocorticoid;
primary alpha-hydroxy ketone;
tertiary alpha-hydroxy ketone
adrenergic agent;
anti-inflammatory drug;
antineoplastic agent;
drug metabolite;
environmental contaminant;
immunosuppressive agent;
xenobiotic
00low000000
aldosterone11beta-hydroxy steroid;
18-oxo steroid;
20-oxo steroid;
21-hydroxy steroid;
3-oxo-Delta(4) steroid;
C21-steroid hormone;
mineralocorticoid;
primary alpha-hydroxy ketone;
steroid aldehyde
human metabolite;
mouse metabolite
00low000000
tetrahydrocortisol11beta-hydroxy steroid;
17alpha-hydroxy steroid;
20-oxo steroid;
21-hydroxy steroid;
3alpha-hydroxy steroid;
glucocorticoid;
primary alpha-hydroxy ketone;
tertiary alpha-hydroxy ketone
00low000000
prednisone11-oxo steroid;
17alpha-hydroxy steroid;
20-oxo steroid;
21-hydroxy steroid;
3-oxo-Delta(1),Delta(4)-steroid;
C21-steroid;
glucocorticoid;
primary alpha-hydroxy ketone;
tertiary alpha-hydroxy ketone
adrenergic agent;
anti-inflammatory drug;
antineoplastic agent;
immunosuppressive agent;
prodrug
00low000000
tetrahydrocortisone21-hydroxy steroid00low000000
desoxycorticosterone20-oxo steroid;
21-hydroxy steroid;
3-oxo-Delta(4) steroid;
mineralocorticoid;
primary alpha-hydroxy ketone
human metabolite;
mouse metabolite
00low000000
fluocinolone acetonide11beta-hydroxy steroid;
20-oxo steroid;
21-hydroxy steroid;
3-oxo-Delta(1),Delta(4)-steroid;
cyclic ketal;
fluorinated steroid;
glucocorticoid;
organic heteropentacyclic compound;
primary alpha-hydroxy ketone
anti-inflammatory drug;
antipruritic drug
00low000000
triamcinolone acetonide11beta-hydroxy steroid;
20-oxo steroid;
21-hydroxy steroid;
3-oxo-Delta(4) steroid;
cyclic ketal;
fluorinated steroid;
glucocorticoid;
primary alpha-hydroxy ketone
anti-allergic agent;
anti-inflammatory drug
00low000000
fluocortolone21-hydroxy steroid00low000000
betamethasone11beta-hydroxy steroid;
17alpha-hydroxy steroid;
20-oxo steroid;
21-hydroxy steroid;
3-oxo-Delta(1),Delta(4)-steroid;
fluorinated steroid;
glucocorticoid;
primary alpha-hydroxy ketone;
tertiary alpha-hydroxy ketone
anti-asthmatic agent;
anti-inflammatory drug;
immunosuppressive agent
00low000000
18-hydroxycorticosterone11beta-hydroxy steroid;
18-hydroxy steroid;
20-oxo steroid;
21-hydroxy steroid;
3-oxo steroid;
primary alpha-hydroxy ketone
human metabolite;
mouse metabolite
00low000000
flurandrenolone21-hydroxy steroid00low000000
flumethasone11beta-hydroxy steroid;
17alpha-hydroxy steroid;
20-oxo steroid;
21-hydroxy steroid;
3-oxo-Delta(1),Delta(4)-steroid;
fluorinated steroid;
glucocorticoid;
primary alpha-hydroxy ketone;
tertiary alpha-hydroxy ketone
anti-inflammatory drug00low000000
betamethasone valerate11beta-hydroxy steroid;
20-oxo steroid;
21-hydroxy steroid;
3-oxo-Delta(1),Delta(4)-steroid;
fluorinated steroid;
primary alpha-hydroxy ketone;
steroid ester
anti-inflammatory drug00low000000
beclomethasone11beta-hydroxy steroid;
17alpha-hydroxy steroid;
20-oxo steroid;
21-hydroxy steroid;
3-oxo-Delta(1),Delta(4)-steroid;
chlorinated steroid;
corticosteroid;
glucocorticoid;
primary alpha-hydroxy ketone;
tertiary alpha-hydroxy ketone
anti-asthmatic drug;
anti-inflammatory drug
00low000000
triamcinolone11beta-hydroxy steroid;
16alpha-hydroxy steroid;
17alpha-hydroxy steroid;
20-oxo steroid;
21-hydroxy steroid;
3-oxo-Delta(4) steroid;
C21-steroid hormone;
fluorinated steroid;
glucocorticoid;
primary alpha-hydroxy ketone;
tertiary alpha-hydroxy ketone
anti-allergic agent;
anti-inflammatory drug
00low000000
fludrocortisone11beta-hydroxy steroid;
17alpha-hydroxy steroid;
20-oxo steroid;
21-hydroxy steroid;
3-oxo-Delta(4) steroid;
C21-steroid;
fluorinated steroid;
mineralocorticoid
adrenergic agent;
anti-inflammatory drug
00low000000
dexamethasone 17-valerate21-hydroxy steroid00low000000
18-hydroxydeoxycorticosterone18-hydroxy steroid;
20-oxo steroid;
21-hydroxy steroid;
3-oxo-Delta(4) steroid
00low000000
tetrahydrocorticosterone21-hydroxy steroid00low000000
tetrahydro-11-deoxycortisol21-hydroxy steroid00low000000
diflorasone11beta-hydroxy steroid;
17alpha-hydroxy steroid;
20-oxo steroid;
21-hydroxy steroid;
3-oxo-Delta(1),Delta(4)-steroid;
fluorinated steroid;
glucocorticoid;
primary alpha-hydroxy ketone;
tertiary alpha-hydroxy ketone
anti-inflammatory drug00low000000
flunisolide11beta-hydroxy steroid;
20-oxo steroid;
21-hydroxy steroid;
3-oxo-Delta(1),Delta(4)-steroid;
cyclic ketal;
fluorinated steroid;
primary alpha-hydroxy ketone
anti-asthmatic drug;
anti-inflammatory drug;
immunosuppressive agent
00low000000
tetrahydrodeoxycorticosterone21-hydroxy steroid00low000000
cyasterone14alpha-hydroxy steroid;
20-hydroxy steroid;
21-hydroxy steroid;
2beta-hydroxy steroid;
3beta-hydroxy steroid;
6-oxo steroid;
phytoecdysteroid;
steroid lactone
00low000000
19-noraldosterone21-hydroxy steroid00low000000
9-fluoroprednisolone21-hydroxy steroid00low000000
cortolone21-hydroxy steroid00low000000
19-hydroxydeoxycorticosterone19-hydroxydeoxycorticosterone;
20-oxo steroid;
21-hydroxy steroid;
3-oxo-Delta(4) steroid
00low000000
19-oxo-deoxycorticosterone21-hydroxy steroid00low000000
cortisone11-oxo steroid;
17alpha-hydroxy steroid;
20-oxo steroid;
21-hydroxy steroid;
3-oxo-Delta(4) steroid;
C21-steroid;
glucocorticoid;
primary alpha-hydroxy ketone;
tertiary alpha-hydroxy ketone
human metabolite;
mouse metabolite
00low000000
cortodoxone21-hydroxy steroid00low000000
cortol21-hydroxy steroid00low000000
21-hydroxypregnenolone21-hydroxy steroid;
hydroxypregnenolone;
primary alpha-hydroxy ketone
mouse metabolite00low000000
hydroxydione20-oxo steroid;
21-hydroxy steroid;
3-oxo-5beta-steroid;
primary alpha-hydroxy ketone
human xenobiotic metabolite00low000000
pulmicort11beta-hydroxy steroid;
20-oxo steroid;
21-hydroxy steroid;
3-oxo-Delta(1),Delta(4)-steroid;
cyclic acetal;
glucocorticoid;
primary alpha-hydroxy ketone
anti-inflammatory drug;
bronchodilator agent;
drug allergen
00low000000
betamethasone benzoate21-hydroxy steroid00low000000
cloprednol21-hydroxy steroid00low000000
meprednisone21-hydroxy steroid00low000000
desonide11beta-hydroxy steroid;
20-oxo steroid;
21-hydroxy steroid;
3-oxo-Delta(1),Delta(4)-steroid;
corticosteroid;
cyclic ketal;
primary alpha-hydroxy ketone
anti-inflammatory drug00low000000
desoximetasone11beta-hydroxy steroid;
20-oxo steroid;
21-hydroxy steroid;
3-oxo-Delta(1),Delta(4)-steroid;
fluorinated steroid;
glucocorticoid;
primary alpha-hydroxy ketone
anti-inflammatory drug;
antipruritic drug
00low000000
11-dehydrocorticosterone11-oxo steroid;
20-oxo steroid;
21-hydroxy steroid;
3-oxo-Delta(4) steroid;
corticosteroid;
primary alpha-hydroxy ketone
human metabolite;
mouse metabolite
00low000000
MLS00133265221-hydroxy steroid00low000000
6 beta-hydroxycortisol11beta-hydroxy steroid;
17alpha-hydroxy steroid;
20-oxo steroid;
21-hydroxy steroid;
3-oxo-Delta(4) steroid;
6beta-hydroxy steroid;
C21-steroid;
primary alpha-hydroxy ketone;
tertiary alpha-hydroxy ketone
human metabolite;
mammalian metabolite;
probe
00low000000
anecortave21-hydroxy steroid00low000000
diflucortolone21-hydroxy steroid00low000000
5-dihydrocortisol21-hydroxy steroid00low000000
(9R)-9-chloro-11,17-dihydroxy-17-(2-hydroxy-1-oxoethyl)-10,13,16-trimethyl-6,7,8,11,12,14,15,16-octahydrocyclopenta[a]phenanthren-3-one21-hydroxy steroid00low000000
flucloronide21-hydroxy steroid00low000000
prednylidene21-hydroxy steroid00low000000
SubstanceStudiesClassesRolesFirst YearLast YearAverage AgeRelationship StrengthTrialspre-19901990's2000's2010'spost-2020
gentamicin1983198341.0low110000
propranololnaphthalenes;
propanolamine;
secondary amine
anti-arrhythmia drug;
antihypertensive agent;
anxiolytic drug;
beta-adrenergic antagonist;
environmental contaminant;
human blood serum metabolite;
vasodilator agent;
xenobiotic
201920195.0low000010
triclosanaromatic ether;
dichlorobenzene;
monochlorobenzenes;
phenols
antibacterial agent;
antimalarial;
drug allergen;
EC 1.3.1.9 [enoyl-[acyl-carrier-protein] reductase (NADH)] inhibitor;
EC 1.5.1.3 (dihydrofolate reductase) inhibitor;
fungicide;
persistent organic pollutant;
xenobiotic
1983201932.0low430010
prednisolone11beta-hydroxy steroid;
17alpha-hydroxy steroid;
20-oxo steroid;
21-hydroxy steroid;
3-oxo-Delta(1),Delta(4)-steroid;
C21-steroid;
glucocorticoid;
primary alpha-hydroxy ketone;
tertiary alpha-hydroxy ketone
adrenergic agent;
anti-inflammatory drug;
antineoplastic agent;
drug metabolite;
environmental contaminant;
immunosuppressive agent;
xenobiotic
1991199133.0low101000
fluocinolone acetonide11beta-hydroxy steroid;
20-oxo steroid;
21-hydroxy steroid;
3-oxo-Delta(1),Delta(4)-steroid;
cyclic ketal;
fluorinated steroid;
glucocorticoid;
organic heteropentacyclic compound;
primary alpha-hydroxy ketone
anti-inflammatory drug;
antipruritic drug
1983198341.0low110000
chlorquinaldolmonohydroxyquinoline;
organochlorine compound
antibacterial drug;
antiprotozoal drug;
antiseptic drug
1983198341.0low110000
framycetinaminoglycosideallergen;
antibacterial drug;
Escherichia coli metabolite
1983198341.0low110000
fluocortolone21-hydroxy steroid1983198341.0low220000
betamethasone11beta-hydroxy steroid;
17alpha-hydroxy steroid;
20-oxo steroid;
21-hydroxy steroid;
3-oxo-Delta(1),Delta(4)-steroid;
fluorinated steroid;
glucocorticoid;
primary alpha-hydroxy ketone;
tertiary alpha-hydroxy ketone
anti-asthmatic agent;
anti-inflammatory drug;
immunosuppressive agent
1982202129.5high21202081
betamethasone valerate11beta-hydroxy steroid;
20-oxo steroid;
21-hydroxy steroid;
3-oxo-Delta(1),Delta(4)-steroid;
fluorinated steroid;
primary alpha-hydroxy ketone;
steroid ester
anti-inflammatory drug1984198838.0low330000
diflucortolone valeratecorticosteroid hormone1983198341.0low110000
betamethasone-17,21-dipropionate1983198341.0low220000
tacrolimusmacrolide lactambacterial metabolite;
immunosuppressive agent
201920195.0low200020
methimazole1,3-dihydroimidazole-2-thionesantithyroid drug201920195.0low000010
leukotriene b4dihydroxy monocarboxylic acid;
hydroxy polyunsaturated fatty acid;
leukotriene;
long-chain fatty acid
human metabolite;
mouse metabolite;
plant metabolite;
vasoconstrictor agent
202120213.0low000001
clobetasol11beta-hydroxy steroid;
17alpha-hydroxy steroid;
20-oxo steroid;
3-oxo-Delta(1),Delta(4)-steroid;
chlorinated steroid;
fluorinated steroid;
glucocorticoid;
tertiary alpha-hydroxy ketone
anti-inflammatory drug;
SMO receptor agonist
1982198242.0low110000
desonide11beta-hydroxy steroid;
20-oxo steroid;
21-hydroxy steroid;
3-oxo-Delta(1),Delta(4)-steroid;
corticosteroid;
cyclic ketal;
primary alpha-hydroxy ketone
anti-inflammatory drug1988198836.0low110000
hoe 777corticosteroid hormone1991199133.0low101000
diflucortolone21-hydroxy steroid1983198341.0low110000
chiniofon1983198341.0low110000
ConditionIndicatedStudiesFirst YearLast YearAverage AgeRelationship StrengthTrialspre-19901990's2000's2010'spost-2020
Acute Disease01983199139.0low431000
Anemia, Fanconi0201620168.0low000010
Bacterial Disease01983198341.0low110000
Bacterial Infections01983198341.0low110000
Chronic Disease01983201934.5low550010
Chronic Illness01983201934.5low550010
Contact Dermatitis01986198638.0low110000
Dermatitis01982198242.0low110000
Dermatitis Seborrheica01984198639.0low220000
Dermatitis, Atopic01984201829.2low421010
Dermatitis, Contact01986198638.0low110000
Dermatitis, Eczematous01983202130.8medium980021
Dermatitis, Seborrheic01984198639.0low220000
Dermatomycoses01983198341.0low110000
Eczema01983202130.8medium980021
Eczema, Atopic01984201829.2low421010
Fanconi Anemia0201620168.0low000010
Hyperthyroid0201920195.0low000010
Hyperthyroidism0201920195.0low000010
Infections, Staphylococcal0201920195.0low100010
Infectious Skin Diseases01983198341.0low110000
Itching0201820186.0low100010
Leg Dermatoses0201920195.0low000010
Lichen Planus01987198737.0low010000
Lichen Ruber Planus01987198737.0low010000
Lichen Simplex Chronicus01987198737.0low010000
Myxedema0201920195.0low000010
Nail Diseases02012201212.0low000010
Neurodermatitis01987198737.0low010000
Palmoplantaris Pustulosis01983201336.1low460010
Pruritus0201820186.0low100010
Psoriasis01983201336.1low460010
Skin Diseases, Infectious01983198341.0low110000
Staphylococcal Infections0201920195.0low100010
Vitiligo01986201918.0low211020

Safety/Toxicity (1)

ArticleYear
Efficacy and Safety of Halometasone Cream to Treat Chronic Generalized Eczema and the Effects of Halometasone Cream on Serum Cortisol Levels.
BioMed research international, , Volume: 2017
2017

Long-term Use (1)

ArticleYear
Clinical evaluation on the long-term use of halometasone ointment in chronic eczema and psoriasis.
The Journal of international medical research, , Volume: 11 Suppl 1
1983

Interactions (1)

ArticleYear
Effect of halometasone cream combined with Simiao pill on the therapeutic effect and expression of serum leukotriene B4 (LTB4) and thymic stromal lymphopoietin (TSLP) in patients with eczema, and the factors influencing its clinical efficacy.
Annals of palliative medicine, , Volume: 10, Issue:11
2021