Compounds > carbocyclic 3-deazaadenosine
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carbocyclic 3-deazaadenosine

Description

carbocyclic 3-deazaadenosine: carboxylic analog of 3-deazaadenosine [MeSH]

Cross-References

ID SourceID
PubMed CID13145979
SCHEMBL ID11193735
MeSH IDM0105245

Synonyms (2)

Synonym
carbocyclic 3-deazaadenosine
SCHEMBL11193735

Research

Studies (13)

TimeframeStudies, This Drug (%)All Drugs %
pre-19908 (61.54)18.7374
1990's3 (23.08)18.2507
2000's2 (15.38)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews1 (6.67%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other14 (93.33%)84.16%
SubstanceStudiesClassesRolesFirst YearLast YearAverage AgeRelationship StrengthTrialspre-19901990's2000's2010'spost-2020
adenine
5
6-aminopurines;
purine nucleobase		Daphnia magna metabolite;
Escherichia coli metabolite;
human metabolite;
mouse metabolite;
Saccharomyces cerevisiae metabolite		1985198837.2low050000
thymidine
1
pyrimidine 2'-deoxyribonucleosideEscherichia coli metabolite;
human metabolite;
metabolite;
mouse metabolite		1987198737.0low010000
alanine
1
alanine zwitterion;
alanine;
L-alpha-amino acid;
proteinogenic amino acid;
pyruvate family amino acid		EC 4.3.1.15 (diaminopropionate ammonia-lyase) inhibitor;
fundamental metabolite		1988198836.0low010000
methionine
1
aspartate family amino acid;
L-alpha-amino acid;
methionine zwitterion;
methionine;
proteinogenic amino acid		antidote to paracetamol poisoning;
human metabolite;
micronutrient;
mouse metabolite;
nutraceutical		1988198836.0low010000
cytidine
2
cytidinesEscherichia coli metabolite;
human metabolite;
mouse metabolite;
Saccharomyces cerevisiae metabolite		1986199036.0low011000
tubercidin
13
antibiotic antifungal agent;
N-glycosylpyrrolopyrimidine;
ribonucleoside		antimetabolite;
antineoplastic agent;
bacterial metabolite		1982200134.1high084100
vidarabine
1
beta-D-arabinoside;
purine nucleoside		antineoplastic agent;
bacterial metabolite;
nucleoside antibiotic		1986198638.0low010000
3-deazaadenosine
1
1988198836.0low010000
coformycin
1
coformycinsEC 3.5.4.4 (adenosine deaminase) inhibitor1988198836.0low010000
zidovudine
1
azide;
pyrimidine 2',3'-dideoxyribonucleoside		antimetabolite;
antiviral drug;
HIV-1 reverse transcriptase inhibitor		1987198737.0low010000
ribavirin
3
1-ribosyltriazole;
aromatic amide;
monocarboxylic acid amide;
primary carboxamide		anticoronaviral agent;
antiinfective agent;
antimetabolite;
antiviral agent;
EC 2.7.7.49 (RNA-directed DNA polymerase) inhibitor		1986199036.3low021000
adefovir
1
6-aminopurines;
ether;
phosphonic acids		antiviral drug;
DNA synthesis inhibitor;
drug metabolite;
HIV-1 reverse transcriptase inhibitor;
nephrotoxic agent		1987198737.0low010000
adenosine
5
adenosines;
purines D-ribonucleoside		analgesic;
anti-arrhythmia drug;
fundamental metabolite;
human metabolite;
vasodilator agent		1985200034.8low041000
aristeromycin
1
1987198737.0low010000
neplanocin a
4
1985198837.5low040000
3-deazaneplanocin
2
1987200030.5low011000
9-(2,3-dihydroxypropyl)adenine
4
1985198837.5medium040000
organophosphonates
1
divalent inorganic anion;
phosphite ion		1987198737.0low010000
3-deazaadenine
1
1988198836.0low010000
s-adenosylhomocysteine
1
adenosines;
amino acid zwitterion;
homocysteine derivative;
homocysteines;
organic sulfide		cofactor;
EC 2.1.1.72 [site-specific DNA-methyltransferase (adenine-specific)] inhibitor;
EC 2.1.1.79 (cyclopropane-fatty-acyl-phospholipid synthase) inhibitor;
epitope;
fundamental metabolite		2000200024.0low001000
carbodine
2
1986199036.0medium011000
ribose
2
D-ribose;
ribopyranose		1986198737.5low020000
adenosine kinase
1
1988198836.0low010000
s-adenosylmethionine
1
organic cation;
sulfonium compound		coenzyme;
cofactor;
human metabolite;
micronutrient;
Mycoplasma genitalium metabolite;
nutraceutical;
Saccharomyces cerevisiae metabolite		1988198836.0low010000
hypoxanthine
1
nucleobase analogue;
oxopurine;
purine nucleobase		fundamental metabolite1988198836.0low010000
alanosine
1
1988198836.0low010000
pyrazofurin
2
C-glycosyl compound;
pyrazoles		antimetabolite;
antimicrobial agent;
antineoplastic agent;
EC 4.1.1.23 (orotidine-5'-phosphate decarboxylase) inhibitor		1986198737.5low020000
ConditionIndicatedStudiesFirst YearLast YearAverage AgeRelationship StrengthTrialspre-19901990's2000's2010'spost-2020
Disease Models, Animal0
1
1999199925.0medium001000
Ebola Hemorrhagic Fever0
2
1999200024.5high002000
Hemorrhagic Fever, Ebola0
2
1999200024.5high002000
Viral Diseases0
1
1983198341.0medium010000
Virus Diseases0
1
1983198341.0medium010000

Safety/Toxicity (1)

ArticleYear
Evaluation of the toxicity and antiviral activity of carbocyclic 3-deazaadenosine against respiratory syncytial and parainfluenza type 3 viruses in tissue culture and in cotton rats.
Antiviral research, , Volume: 14, Issue:4-5

Pharmacokinetics (1)

ArticleYear
Pharmacokinetics of the antiviral agent carbocyclic 3-deazaadenosine.
Drug metabolism and disposition: the biological fate of chemicals, , Volume: 21, Issue:4

Dosage (2)

ArticleYear
Intracellular phosphorylation of carbocyclic 3-deazaadenosine, an anti-Ebola virus agent.
Antiviral chemistry & chemotherapy, , Volume: 12, Issue:4		2001
Pharmacokinetics of the antiviral agent carbocyclic 3-deazaadenosine.
Drug metabolism and disposition: the biological fate of chemicals, , Volume: 21, Issue:4