Compounds > prosomatostatin
Page last updated: 2024-11-12

prosomatostatin

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

Cross-References

ID SourceID
PubMed CID16133849
CHEMBL ID501796
MeSH IDM0091574

Synonyms (10)

Synonym
gtpl2020
sst-28
somatostatin 1-28
srif-28
74315-46-1
CHEMBL501796
AKOS024456430
somatostatin 28,cyclic
GLXC-26294
ser-ala-asn-ser-asn-pro-ala-met-ala-pro-arg-glu-arg-lys-ala-gly-cys(1)-lys-asn-phe-phe-trp-lys-thr-phe-thr-ser-cys(1)-oh

Research Excerpts

Dosage Studied

ExcerptRelevanceReference
" Increasing concentrations of somatostatin-14 cause a concentration-dependent rightward shift of the dose-response curves for J-2156, without affecting its maximal response."( Superagonism at the human somatostatin receptor subtype 4.
Ahman, M; El-Darwish, K; Engström, M; Savola, JM; Tomperi, J; Wurster, S, 2005)		0.33
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Roles (3)

RoleDescription
fungal metaboliteAny eukaryotic metabolite produced during a metabolic reaction in fungi, the kingdom that includes microorganisms such as the yeasts and moulds.
rat metaboliteAny mammalian metabolite produced during a metabolic reaction in rat (Rattus norvegicus).
mouse metaboliteAny mammalian metabolite produced during a metabolic reaction in a mouse (Mus musculus).
[role information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Drug Classes (2)

ClassDescription
heterodetic cyclic peptideA heterodetic cyclic peptide is a peptide consisting only of amino-acid residues, but in which the linkages forming the ring are not solely peptide bonds; one or more is an isopeptide, disulfide, ester, or other bond.
peptide hormoneAny peptide with hormonal activity in animals, whether endocrine, neuroendocrine, or paracrine.
[compound class information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Protein Targets (1)

Activation Measurements

ProteinTaxonomyMeasurementAverageMin (ref.)Avg (ref.)Max (ref.)Bioassay(s)
Somatostatin receptor type 2Homo sapiens (human)EC50 (µMol)0.00230.00000.00080.0023AID1638695
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Biological Processes (12)

Processvia Protein(s)Taxonomy
G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messengerSomatostatin receptor type 2Homo sapiens (human)
adenylate cyclase-inhibiting G protein-coupled receptor signaling pathwaySomatostatin receptor type 2Homo sapiens (human)
spermatogenesisSomatostatin receptor type 2Homo sapiens (human)
negative regulation of cell population proliferationSomatostatin receptor type 2Homo sapiens (human)
cerebellum developmentSomatostatin receptor type 2Homo sapiens (human)
peristalsisSomatostatin receptor type 2Homo sapiens (human)
forebrain developmentSomatostatin receptor type 2Homo sapiens (human)
somatostatin signaling pathwaySomatostatin receptor type 2Homo sapiens (human)
response to starvationSomatostatin receptor type 2Homo sapiens (human)
cellular response to glucocorticoid stimulusSomatostatin receptor type 2Homo sapiens (human)
cellular response to estradiol stimulusSomatostatin receptor type 2Homo sapiens (human)
neuropeptide signaling pathwaySomatostatin receptor type 2Homo sapiens (human)
[Information is prepared from geneontology information from the June-17-2024 release]

Molecular Functions (4)

Processvia Protein(s)Taxonomy
protein bindingSomatostatin receptor type 2Homo sapiens (human)
PDZ domain bindingSomatostatin receptor type 2Homo sapiens (human)
somatostatin receptor activitySomatostatin receptor type 2Homo sapiens (human)
neuropeptide bindingSomatostatin receptor type 2Homo sapiens (human)
[Information is prepared from geneontology information from the June-17-2024 release]

Ceullar Components (3)

Processvia Protein(s)Taxonomy
cytosolSomatostatin receptor type 2Homo sapiens (human)
plasma membraneSomatostatin receptor type 2Homo sapiens (human)
neuron projectionSomatostatin receptor type 2Homo sapiens (human)
plasma membraneSomatostatin receptor type 2Homo sapiens (human)
[Information is prepared from geneontology information from the June-17-2024 release]

Bioassays (40)

Assay IDTitleYearJournalArticle
AID1346359Human SST4 receptor (Somatostatin receptors)1996Metabolism: clinical and experimental, Aug, Volume: 45, Issue:8 Suppl 1
Binding properties of somatostatin receptor subtypes.
AID1346321Rat SST3 receptor (Somatostatin receptors)1998Reviews of physiology, biochemistry and pharmacology, , Volume: 133The elucidation of somatostatin receptor functions: a current view.
AID1346413Human SST5 receptor (Somatostatin receptors)1996Metabolism: clinical and experimental, Aug, Volume: 45, Issue:8 Suppl 1
Binding properties of somatostatin receptor subtypes.
AID1346359Human SST4 receptor (Somatostatin receptors)1998Reviews of physiology, biochemistry and pharmacology, , Volume: 133The elucidation of somatostatin receptor functions: a current view.
AID1345392Human MRGPRX2 (Class A Orphans)2013Journal of biomolecular screening, Jun, Volume: 18, Issue:5
Screening β-arrestin recruitment for the identification of natural ligands for orphan G-protein-coupled receptors.
AID1346332Human SST3 receptor (Somatostatin receptors)2005The Journal of pharmacology and experimental therapeutics, Jan, Volume: 312, Issue:1
Superagonism at the human somatostatin receptor subtype 4.
AID1346413Human SST5 receptor (Somatostatin receptors)1998Reviews of physiology, biochemistry and pharmacology, , Volume: 133The elucidation of somatostatin receptor functions: a current view.
AID1346420Rat SST5 receptor (Somatostatin receptors)1998Reviews of physiology, biochemistry and pharmacology, , Volume: 133The elucidation of somatostatin receptor functions: a current view.
AID1346424Human SST2 receptor (Somatostatin receptors)1998Naunyn-Schmiedeberg's archives of pharmacology, May, Volume: 357, Issue:5
[125I]Tyr10-cortistatin14 labels all five somatostatin receptors.
AID1346424Human SST2 receptor (Somatostatin receptors)1994Endocrinology, Dec, Volume: 135, Issue:6
Subtype selectivity of peptide analogs for all five cloned human somatostatin receptors (hsstr 1-5).
AID1346384Human SST1 receptor (Somatostatin receptors)1998Reviews of physiology, biochemistry and pharmacology, , Volume: 133The elucidation of somatostatin receptor functions: a current view.
AID1346424Human SST2 receptor (Somatostatin receptors)1998European journal of pharmacology, May-08, Volume: 348, Issue:2-3
[125I][Tyr3]octreotide labels human somatostatin sst2 and sst5 receptors.
AID1346332Human SST3 receptor (Somatostatin receptors)1994Endocrinology, Dec, Volume: 135, Issue:6
Subtype selectivity of peptide analogs for all five cloned human somatostatin receptors (hsstr 1-5).
AID1346332Human SST3 receptor (Somatostatin receptors)1998Reviews of physiology, biochemistry and pharmacology, , Volume: 133The elucidation of somatostatin receptor functions: a current view.
AID1346359Human SST4 receptor (Somatostatin receptors)2005The Journal of pharmacology and experimental therapeutics, Jan, Volume: 312, Issue:1
Superagonism at the human somatostatin receptor subtype 4.
AID1346359Human SST4 receptor (Somatostatin receptors)1999Naunyn-Schmiedeberg's archives of pharmacology, Nov, Volume: 360, Issue:5
Characterisation of human recombinant somatostatin receptors. 1. Radioligand binding studies.
AID1346413Human SST5 receptor (Somatostatin receptors)1998Naunyn-Schmiedeberg's archives of pharmacology, May, Volume: 357, Issue:5
[125I]Tyr10-cortistatin14 labels all five somatostatin receptors.
AID1346397Mouse SST5 receptor (Somatostatin receptors)2000Neuropharmacology, Jun-08, Volume: 39, Issue:8
Cloning, expression and pharmacological characterisation of the mouse somatostatin sst(5) receptor.
AID1346359Human SST4 receptor (Somatostatin receptors)1994Endocrinology, Dec, Volume: 135, Issue:6
Subtype selectivity of peptide analogs for all five cloned human somatostatin receptors (hsstr 1-5).
AID1346359Human SST4 receptor (Somatostatin receptors)1998Naunyn-Schmiedeberg's archives of pharmacology, May, Volume: 357, Issue:5
[125I]Tyr10-cortistatin14 labels all five somatostatin receptors.
AID1346413Human SST5 receptor (Somatostatin receptors)1994Endocrinology, Dec, Volume: 135, Issue:6
Subtype selectivity of peptide analogs for all five cloned human somatostatin receptors (hsstr 1-5).
AID1346413Human SST5 receptor (Somatostatin receptors)1998European journal of pharmacology, May-08, Volume: 348, Issue:2-3
[125I][Tyr3]octreotide labels human somatostatin sst2 and sst5 receptors.
AID1346424Human SST2 receptor (Somatostatin receptors)1999Naunyn-Schmiedeberg's archives of pharmacology, Nov, Volume: 360, Issue:5
Characterisation of human recombinant somatostatin receptors. 1. Radioligand binding studies.
AID1346419Rat SST2 receptor (Somatostatin receptors)1998Reviews of physiology, biochemistry and pharmacology, , Volume: 133The elucidation of somatostatin receptor functions: a current view.
AID1346424Human SST2 receptor (Somatostatin receptors)1996Metabolism: clinical and experimental, Aug, Volume: 45, Issue:8 Suppl 1
Binding properties of somatostatin receptor subtypes.
AID1346332Human SST3 receptor (Somatostatin receptors)1999Naunyn-Schmiedeberg's archives of pharmacology, Nov, Volume: 360, Issue:5
Characterisation of human recombinant somatostatin receptors. 1. Radioligand binding studies.
AID1346413Human SST5 receptor (Somatostatin receptors)1999Naunyn-Schmiedeberg's archives of pharmacology, Nov, Volume: 360, Issue:5
Characterisation of human recombinant somatostatin receptors. 1. Radioligand binding studies.
AID1346384Human SST1 receptor (Somatostatin receptors)2005The Journal of pharmacology and experimental therapeutics, Jan, Volume: 312, Issue:1
Superagonism at the human somatostatin receptor subtype 4.
AID1346384Human SST1 receptor (Somatostatin receptors)1998Naunyn-Schmiedeberg's archives of pharmacology, May, Volume: 357, Issue:5
[125I]Tyr10-cortistatin14 labels all five somatostatin receptors.
AID1346413Human SST5 receptor (Somatostatin receptors)2005The Journal of pharmacology and experimental therapeutics, Jan, Volume: 312, Issue:1
Superagonism at the human somatostatin receptor subtype 4.
AID1346332Human SST3 receptor (Somatostatin receptors)1993FEBS letters, Apr-26, Volume: 321, Issue:2-3
A human somatostatin receptor (SSTR3), located on chromosome 22, displays preferential affinity for somatostatin-14 like peptides.
AID1346332Human SST3 receptor (Somatostatin receptors)1998Naunyn-Schmiedeberg's archives of pharmacology, May, Volume: 357, Issue:5
[125I]Tyr10-cortistatin14 labels all five somatostatin receptors.
AID1346404Mouse SST3 receptor (Somatostatin receptors)1993Molecular pharmacology, Jun, Volume: 43, Issue:6
Cloned somatostatin receptors: identification of subtype-selective peptides and demonstration of high affinity binding of linear peptides.
AID1346424Human SST2 receptor (Somatostatin receptors)2005The Journal of pharmacology and experimental therapeutics, Jan, Volume: 312, Issue:1
Superagonism at the human somatostatin receptor subtype 4.
AID1346332Human SST3 receptor (Somatostatin receptors)1996Metabolism: clinical and experimental, Aug, Volume: 45, Issue:8 Suppl 1
Binding properties of somatostatin receptor subtypes.
AID1346384Human SST1 receptor (Somatostatin receptors)1996Metabolism: clinical and experimental, Aug, Volume: 45, Issue:8 Suppl 1
Binding properties of somatostatin receptor subtypes.
AID1346384Human SST1 receptor (Somatostatin receptors)1994Endocrinology, Dec, Volume: 135, Issue:6
Subtype selectivity of peptide analogs for all five cloned human somatostatin receptors (hsstr 1-5).
AID1346384Human SST1 receptor (Somatostatin receptors)1999Naunyn-Schmiedeberg's archives of pharmacology, Nov, Volume: 360, Issue:5
Characterisation of human recombinant somatostatin receptors. 1. Radioligand binding studies.
AID1346311Mouse SST2 receptor (Somatostatin receptors)1998Reviews of physiology, biochemistry and pharmacology, , Volume: 133The elucidation of somatostatin receptor functions: a current view.
AID1638695Binding affinity to human SSTR2 expressed in CHO-K1 cells assessed as induction of SSTR2 internalization after 4 hrs by chemiluminescent assay2019Journal of medicinal chemistry, 03-14, Volume: 62, Issue:5
Discovery of an SSTR2-Targeting Maytansinoid Conjugate (PEN-221) with Potent Activity in Vitro and in Vivo.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (12)

TimeframeStudies, This Drug (%)All Drugs %
pre-19900 (0.00)18.7374
1990's8 (66.67)18.2507
2000's2 (16.67)29.6817
2010's2 (16.67)24.3611
2020's0 (0.00)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 12.04

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be weak demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index12.04 (24.57)
Research Supply Index2.56 (2.92)
Research Growth Index4.61 (4.65)
Search Engine Demand Index0.00 (26.88)
Search Engine Supply Index0.00 (0.95)

This Compound (12.04)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews2 (16.67%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other10 (83.33%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]
SubstanceRelationship StrengthStudiesTrialsClassesRoles
alpha-ketoglutaric acid
2-oxoglutaric acid : An oxo dicarboxylic acid that consists of glutaric acid bearing an oxo substituent at position 2. It is an intermediate metabolite in Krebs cycle.		2.0810oxo dicarboxylic acidfundamental metabolite
beta-alanine
[no description available]		2.0810amino acid zwitterion;
beta-amino acid		agonist;
fundamental metabolite;
human metabolite;
inhibitor;
neurotransmitter
succinic acid
Succinic Acid: A water-soluble, colorless crystal with an acid taste that is used as a chemical intermediate, in medicine, the manufacture of lacquers, and to make perfume esters. It is also used in foods as a sequestrant, buffer, and a neutralizing agent. (Hawley's Condensed Chemical Dictionary, 12th ed, p1099; McGraw-Hill Dictionary of Scientific and Technical Terms, 4th ed, p1851). succinic acid : An alpha,omega-dicarboxylic acid resulting from the formal oxidation of each of the terminal methyl groups of butane to the corresponding carboxy group. It is an intermediate metabolite in the citric acid cycle.		2.0810alpha,omega-dicarboxylic acid;
C4-dicarboxylic acid		anti-ulcer drug;
fundamental metabolite;
micronutrient;
nutraceutical;
radiation protective agent
decanoic acid
decanoate : A fatty acid anion 10:0 that is the conjugate base of decanoic acid.. decanoic acid : A C10, straight-chain saturated fatty acid.		2.0810medium-chain fatty acid;
straight-chain saturated fatty acid		algal metabolite;
anti-inflammatory agent;
antibacterial agent;
human metabolite;
plant metabolite;
volatile oil component
kynurenic acid
Kynurenic Acid: A broad-spectrum excitatory amino acid antagonist used as a research tool.. kynurenic acid : A quinolinemonocarboxylic acid that is quinoline-2-carboxylic acid substituted by a hydroxy group at C-4.		2.0810monohydroxyquinoline;
quinolinemonocarboxylic acid		G-protein-coupled receptor agonist;
human metabolite;
neuroprotective agent;
nicotinic antagonist;
NMDA receptor antagonist;
Saccharomyces cerevisiae metabolite
lanreotide acetate
[no description available]		4.9870
l-lactic acid
(S)-lactic acid : An optically active form of lactic acid having (S)-configuration.		2.0810(2S)-2-hydroxy monocarboxylic acid;
2-hydroxypropanoic acid		Escherichia coli metabolite;
human metabolite
octreotide
[no description available]		5.2190
n-oleoylethanolamine
N-oleoylethanolamine: ceramidase inhibitor. oleoyl ethanolamide : An N-(long-chain-acyl)ethanolamine that is the ethanolamide of oleic acid. The monounsaturated analogue of the endocannabinoid anandamide.		2.0810endocannabinoid;
N-(long-chain-acyl)ethanolamine;
N-acylethanolamine 18:1		EC 3.5.1.23 (ceramidase) inhibitor;
geroprotector;
PPARalpha agonist
bim 23268
[no description available]		3.0910
seglitide
seglitide: more potent than somatostatin for inhibition of insulin, glucagon & growth hormone release; used experimentally in treatment of Alzheimer's disease; somatostatin receptor antagonist		5.180
lysophosphatidic acid
[no description available]		2.0810
cabazitaxel
cabazitaxel: an antineoplastic agent; structure in first source. cabazitaxel : A tetracyclic diterpenoid that is 10-deacetylbaccatin III having O-methyl groups attached at positions 7 and 10 as well as an O-(2R,3S)-3-[(tert-butoxycarbonyl)amino]-2-hydroxy-3-phenylpropanoyl group attached at position 13. Acts as a microtubule inhibitor, binds tubulin and promotes microtubule assembly and simultaneously inhibits disassembly.		2.2110tetracyclic diterpenoidantineoplastic agent;
microtubule-stabilising agent
tan 67
[no description available]		2.0810quinolines
monomethyl auristatin e
[no description available]		2.2110
cgp 23996
CGP 23996: nonreducible analog of somatostatin; used to test binding sites for somatostatin		4.1950
bam 22p
[no description available]		2.0810
lysophosphatidylinositol
[no description available]		2.0810
ConditionIndicatedRelationship StrengthStudiesTrials