Compounds > 5-hydroxybenzimidazole
Page last updated: 2024-12-10

5-hydroxybenzimidazole

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

Description

5-hydroxybenzimidazole: only base detected in cobamide cpds from methanol-grown Methanosarcina barkeri [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

5-hydroxybenzimidazole : A member of the class of benzimidazoles that is 1H-benzimidazole carrying a single hydroxy substituent at position 5. [Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Cross-References

ID SourceID
PubMed CID3082533
CHEMBL ID4551859
CHEBI ID137404
SCHEMBL ID352025
MeSH IDM0111002

Synonyms (43)

Synonym
5-hydroxybenzimidazole
5-hydroxy-1h-benzimidazole
benzimidazol-5-ol
CHEBI:137404
41292-65-3
1h-benzimidazol-5-ol
3h-benzimidazol-5-ol
149471-91-0
AKOS006239555
1h-benzimidazol-6-ol
1h-benzo[d]imidazol-6-ol
1h-benzo[d]imidazol-5-ol
1h-1,3-benzodiazol-6-ol
AKOS015856357
CL3532
STL329143
SCHEMBL352025
3h-benzoimidazol-5-ol
PS-4150
KRKSOBREFNTJJY-UHFFFAOYSA-N
1h-benzoimidazol-5-ol
4-phosphonobutyricacid
W-205690
FD13050
AC-28886
J-517611
1h-benzimidazol-5-ol, aldrichcpr
DTXSID00194276
CS-W001209
mfcd02241303
SY037386
6-hydroxy-1h-benzimidazole
FT-0764977
C21764
AMY12070
1h-benzimidazol-6-ol(9ci)
EN300-108831
mfcd09998714
3h-benzoimidazol-5-ol;1h-benzo[d]imidazol-5-ol
A849566
CHEMBL4551859
AB92482
Z1042386518
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Roles (3)

RoleDescription
human metaboliteAny mammalian metabolite produced during a metabolic reaction in humans (Homo sapiens).
rat metaboliteAny mammalian metabolite produced during a metabolic reaction in rat (Rattus norvegicus).
bacterial metaboliteAny prokaryotic metabolite produced during a metabolic reaction in bacteria.
[role information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Drug Classes (2)

ClassDescription
benzimidazolesAn organic heterocyclic compound containing a benzene ring fused to an imidazole ring.
phenolsOrganic aromatic compounds having one or more hydroxy groups attached to a benzene or other arene ring.
[compound class information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Pathways (2)

PathwayProteinsCompounds
5-hydroxybenzimidazolyl adenosylcobamide biosynthesis from adenosylcobinamide-GDP38
5,6-dimethylbenzimidazole biosynthesis II (anaerobic)614

Protein Targets (1)

Other Measurements

ProteinTaxonomyMeasurementAverageMin (ref.)Avg (ref.)Max (ref.)Bioassay(s)
Sulfotransferase 1A1Homo sapiens (human)Km19.30000.17001.83436.6200AID1639868
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Biological Processes (8)

Processvia Protein(s)Taxonomy
sulfationSulfotransferase 1A1Homo sapiens (human)
ethanol catabolic processSulfotransferase 1A1Homo sapiens (human)
catecholamine metabolic processSulfotransferase 1A1Homo sapiens (human)
xenobiotic metabolic processSulfotransferase 1A1Homo sapiens (human)
estrogen metabolic processSulfotransferase 1A1Homo sapiens (human)
amine metabolic processSulfotransferase 1A1Homo sapiens (human)
flavonoid metabolic processSulfotransferase 1A1Homo sapiens (human)
3'-phosphoadenosine 5'-phosphosulfate metabolic processSulfotransferase 1A1Homo sapiens (human)
sulfationSulfotransferase 1A1Homo sapiens (human)
[Information is prepared from geneontology information from the June-17-2024 release]

Molecular Functions (6)

Processvia Protein(s)Taxonomy
aryl sulfotransferase activitySulfotransferase 1A1Homo sapiens (human)
protein bindingSulfotransferase 1A1Homo sapiens (human)
sulfotransferase activitySulfotransferase 1A1Homo sapiens (human)
flavonol 3-sulfotransferase activitySulfotransferase 1A1Homo sapiens (human)
steroid sulfotransferase activitySulfotransferase 1A1Homo sapiens (human)
3'-phosphoadenosine 5'-phosphosulfate bindingSulfotransferase 1A1Homo sapiens (human)
[Information is prepared from geneontology information from the June-17-2024 release]

Ceullar Components (2)

Processvia Protein(s)Taxonomy
cytosolSulfotransferase 1A1Homo sapiens (human)
cytoplasmSulfotransferase 1A1Homo sapiens (human)
[Information is prepared from geneontology information from the June-17-2024 release]

Research

Studies (7)

TimeframeStudies, This Drug (%)All Drugs %
pre-19902 (28.57)18.7374
1990's2 (28.57)18.2507
2000's1 (14.29)29.6817
2010's2 (28.57)24.3611
2020's0 (0.00)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 12.47

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be weak demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index12.47 (24.57)
Research Supply Index2.20 (2.92)
Research Growth Index4.66 (4.65)
Search Engine Demand Index0.00 (26.88)
Search Engine Supply Index0.00 (0.95)

This Compound (12.47)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews0 (0.00%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other8 (100.00%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]
SubstanceRelationship StrengthStudiesTrialsClassesRoles
5,6-dimethylbenzimidazole
5,6-dimethylbenzimidazole: RN given refers to parent cpd. 5,6-dimethylbenzimidazole : A dimethylbenzimidazole carrying methyl substituents at positions 5 and 6.		2.730dimethylbenzimidazoleEscherichia coli metabolite;
human metabolite
thiamine
thiamine(1+) : A primary alcohol that is 1,3-thiazol-3-ium substituted by (4-amino-2-methylpyrimidin-5-yl)methyl, methyl and 2-hydroxyethyl groups at positions 3, 4 and 5, respectively.		2.1110primary alcohol;
vitamin B1		Escherichia coli metabolite;
human metabolite;
mouse metabolite;
Saccharomyces cerevisiae metabolite
3-hydroxypyridine
3-hydroxypyridine: RN given refeirs to parent cpd. 3-pyridinol : A monohydroxypyridine that is pyridine in which the hydrogen at position 3 has been replaced by a hydroxy group. It has been detected as a thermal degradation product from the smoke of the burning leaves of Salvia divinorum, a Mexican psychoactive plant.		2.0510monohydroxypyridine
thiazoles
[no description available]		2.05101,3-thiazoles;
mancude organic heteromonocyclic parent;
monocyclic heteroarene
6-hydroxybenzothiazole
[no description available]		2.0510
aminoimidazole ribotide
5-amino-1-(5-phospho-beta-D-ribosyl)imidazole : A 1-(phosphoribosyl)imidazole that is 5-aminoimidazole in which the proton at position 1 has been replaced by a 5-phospho-beta-D-ribofuranosyl group.		7.11101-(phosphoribosyl)imidazole;
aminoimidazole		bacterial metabolite
s-adenosylmethionine
(R)-S-adenosyl-L-methionine : An S-adenosyl-L-methionine that has R-configuration.. S-adenosyl-L-methionine zwitterion : A zwitterionic tautomer of S-adenosyl-L-methionine arising from shift of the proton from the carboxy group to the amino group.. (R)-S-adenosyl-L-methionine zwitterion : An S-adenosyl-L-methionine zwitterion that has R-configuration; major species at pH 7.3.. (S)-S-adenosyl-L-methionine zwitterion : An S-adenosyl-L-methionine zwitterion that has S-configuration; major species at pH 7.3.. S-adenosyl-L-methionine : A sulfonium compound that is the S-adenosyl derivative of L-methionine. It is an intermediate in the metabolic pathway of methionine.		2.1710organic cation;
sulfonium compound		coenzyme;
cofactor;
human metabolite;
micronutrient;
Mycoplasma genitalium metabolite;
nutraceutical;
Saccharomyces cerevisiae metabolite
vitamin b 12
Vitamin B 12: A cobalt-containing coordination compound produced by intestinal micro-organisms and found also in soil and water. Higher plants do not concentrate vitamin B 12 from the soil and so are a poor source of the substance as compared with animal tissues. INTRINSIC FACTOR is important for the assimilation of vitamin B 12.		3.2360
ConditionIndicatedRelationship StrengthStudiesTrials