| Assay ID | Title | Year | Journal | Article |
|---|
| AID5727 | Binding affinity towards cloned rat 5-hydroxytryptamine 2C receptor from fundus tissue by [3H]mesulergine displacement. | 2003 | Bioorganic & medicinal chemistry letters, Dec-15, Volume: 13, Issue:24
| Binding of beta-carbolines at 5-HT(2) serotonin receptors. |
| AID37366 | Compound was tested in vitro for its affinity towards rat Alpha-2 adrenergic receptor | 1999 | Journal of medicinal chemistry, Sep-09, Volume: 42, Issue:18
| Synthesis and biochemical evaluation of 3-fluoromethyl-1,2,3, 4-tetrahydroisoquinolines as selective inhibitors of phenylethanolamine N-methyltransferase versus the alpha(2)-adrenoceptor. |
| AID37094 | Binding affinity to alpha-2 adrenergic receptor by displacement of [3H]clonidine | 2001 | Journal of medicinal chemistry, Aug-16, Volume: 44, Issue:17
| Synthesis and evaluation of 4-fluoro-8-substituted-2,3,4,5-tetrahydro-1H-2-benzazapines as selective inhibitors of phenylethanolamine N-methyltransferase versus the alpha(2)-adrenoceptor. |
| AID6500 | Binding affinity towards 5-hydroxytryptamine 5A receptor using lysergic acid diethylamide (LSD) as radioligand | 2003 | Journal of medicinal chemistry, Aug-28, Volume: 46, Issue:18
| Binding of tetrahydrocarboline derivatives at human 5-HT5A receptors. |
| AID155137 | Affinity for bovine Phenylethanolamine N-Methyltransferase (PNMT) | 1999 | Journal of medicinal chemistry, Sep-09, Volume: 42, Issue:18
| Synthesis and biochemical evaluation of 3-fluoromethyl-1,2,3, 4-tetrahydroisoquinolines as selective inhibitors of phenylethanolamine N-methyltransferase versus the alpha(2)-adrenoceptor. |
| AID223253 | Binding affinity at rat imidazoline receptor I-2 | 2004 | Bioorganic & medicinal chemistry letters, Feb-23, Volume: 14, Issue:4
| Binding of beta-carbolines at imidazoline I2 receptors: a structure-affinity investigation. |
| AID35335 | Selectivity determined by Ki of alpha 2 receptor / Ki of PNMT | 1999 | Journal of medicinal chemistry, Aug-26, Volume: 42, Issue:17
| Synthesis and evaluation of 3-trifluoromethyl-7-substituted-1,2,3, 4-tetrahydroisoquinolines as selective inhibitors of phenylethanolamine N-methyltransferase versus the alpha(2)-adrenoceptor. |
| AID5541 | Binding affinity towards cloned rat 5-hydroxytryptamine 2A receptor by [3H]ketanserin displacement. | 2003 | Bioorganic & medicinal chemistry letters, Dec-15, Volume: 13, Issue:24
| Binding of beta-carbolines at 5-HT(2) serotonin receptors. |
| AID35216 | Ratio for binding affinity towards alpha-2 adrenoceptor to PNMT | 1999 | Journal of medicinal chemistry, Sep-09, Volume: 42, Issue:18
| Synthesis and biochemical evaluation of 3-fluoromethyl-1,2,3, 4-tetrahydroisoquinolines as selective inhibitors of phenylethanolamine N-methyltransferase versus the alpha(2)-adrenoceptor. |
| AID156051 | Ability to inhibit phenylethanolamine N-methyl-transferase (PNMT) | 2001 | Journal of medicinal chemistry, Aug-16, Volume: 44, Issue:17
| Synthesis and evaluation of 4-fluoro-8-substituted-2,3,4,5-tetrahydro-1H-2-benzazapines as selective inhibitors of phenylethanolamine N-methyltransferase versus the alpha(2)-adrenoceptor. |
| AID35193 | The compound was tested in vitro for binding affinity against Alpha-2 adrenergic receptor using [3H]clonidine | 1999 | Journal of medicinal chemistry, Aug-26, Volume: 42, Issue:17
| Synthesis and evaluation of 3-trifluoromethyl-7-substituted-1,2,3, 4-tetrahydroisoquinolines as selective inhibitors of phenylethanolamine N-methyltransferase versus the alpha(2)-adrenoceptor. |
| AID5539 | Binding affinity for rat 5-hydroxytryptamine 2A receptor using [3H]DOB | 2003 | Bioorganic & medicinal chemistry letters, Dec-15, Volume: 13, Issue:24
| Binding of beta-carbolines at 5-HT(2) serotonin receptors. |
| AID37089 | Binding affinity at alpha-2 adrenergic receptors of rat. | 2004 | Bioorganic & medicinal chemistry letters, Feb-23, Volume: 14, Issue:4
| Binding of beta-carbolines at imidazoline I2 receptors: a structure-affinity investigation. |
| AID234631 | Selectivity ratio (alpha2/PNMT) | 2001 | Journal of medicinal chemistry, Aug-16, Volume: 44, Issue:17
| Synthesis and evaluation of 4-fluoro-8-substituted-2,3,4,5-tetrahydro-1H-2-benzazapines as selective inhibitors of phenylethanolamine N-methyltransferase versus the alpha(2)-adrenoceptor. |
| AID223254 | Displacement of [3H]2-BFI from imidazoline receptor I-2 | 2004 | Bioorganic & medicinal chemistry letters, Feb-23, Volume: 14, Issue:4
| Pyrazino[1,2-a]indoles as novel high-affinity and selective imidazoline I(2) receptor ligands. |
| AID155146 | Inhibition of PNMT (Phenylethanolamine N-Methyltransferase) in vitro | 1999 | Journal of medicinal chemistry, Aug-26, Volume: 42, Issue:17
| Synthesis and evaluation of 3-trifluoromethyl-7-substituted-1,2,3, 4-tetrahydroisoquinolines as selective inhibitors of phenylethanolamine N-methyltransferase versus the alpha(2)-adrenoceptor. |
| [information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023] |