| Assay ID | Title | Year | Journal | Article |
|---|
| AID160222 | Compound was tested in vitro for inhibition of Prolyl endopeptidase | 1996 | Journal of medicinal chemistry, May-10, Volume: 39, Issue:10
| Structure-activity relationships of boronic acid inhibitors of dipeptidyl peptidase IV. 1. Variation of the P2 position of Xaa-boroPro dipeptides. |
| AID1539747 | Inhibition of POP (unknown origin) | 2019 | Journal of medicinal chemistry, 09-12, Volume: 62, Issue:17
| Integrated Synthetic, Biophysical, and Computational Investigations of Covalent Inhibitors of Prolyl Oligopeptidase and Fibroblast Activation Protein α. |
| AID1709024 | Inhibition of PREP (unknown origin) using AMC substrate by fluorometric assay | 2021 | Bioorganic & medicinal chemistry letters, 04-01, Volume: 37 | Identification of BR102910 as a selective fibroblast activation protein (FAP) inhibitor. |
| AID736686 | Inhibition of human DPP9 using H-Gly-Pro-AMC as substrate preincubated for 10 mins prior to substrate addition by fluorescence assay | 2013 | Journal of medicinal chemistry, May-09, Volume: 56, Issue:9
| Identification of selective and potent inhibitors of fibroblast activation protein and prolyl oligopeptidase. |
| AID305099 | Inhibition of human FAP | 2007 | Bioorganic & medicinal chemistry letters, Jan-15, Volume: 17, Issue:2
| Synthesis and activity of a potent, specific azabicyclo[3.3.0]-octane-based DPP II inhibitor. |
| AID56223 | Compound was tested in vitro for inhibition of Dipeptidylpeptidase II | 1996 | Journal of medicinal chemistry, May-10, Volume: 39, Issue:10
| Structure-activity relationships of boronic acid inhibitors of dipeptidyl peptidase IV. 1. Variation of the P2 position of Xaa-boroPro dipeptides. |
| AID748313 | Inhibition of DPP4 in human seminal plasma using Gly-Pro-p-nitroanilide as substrate incubated for 15 mins prior to substrate addition | 2013 | ACS medicinal chemistry letters, May-09, Volume: 4, Issue:5
| Selective Inhibitors of Fibroblast Activation Protein (FAP) with a (4-Quinolinoyl)-glycyl-2-cyanopyrrolidine Scaffold. |
| AID56218 | Inhibitory activity of compound against Dipeptidylpeptidase IV (DPP IV) | 2003 | Journal of medicinal chemistry, Nov-06, Volume: 46, Issue:23
| Design, synthesis, and SAR of potent and selective dipeptide-derived inhibitors for dipeptidyl peptidases. |
| AID390984 | Inhibition of human recombinant DPP9 expressed in HEK293T cells relative to Ala-boroPro | 2008 | Journal of medicinal chemistry, Oct-09, Volume: 51, Issue:19
| Dipeptide boronic acid inhibitors of dipeptidyl peptidase IV: determinants of potency and in vivo efficacy and safety. |
| AID736682 | Selectivity ratio of IC50 for human FAP to IC50 for human PREP | 2013 | Journal of medicinal chemistry, May-09, Volume: 56, Issue:9
| Identification of selective and potent inhibitors of fibroblast activation protein and prolyl oligopeptidase. |
| AID56232 | In vitro for inhibition of Dipeptidylpeptidase IV. | 1996 | Journal of medicinal chemistry, May-10, Volume: 39, Issue:10
| Structure-activity relationships of boronic acid inhibitors of dipeptidyl peptidase IV. 1. Variation of the P2 position of Xaa-boroPro dipeptides. |
| AID659185 | Inhibition of human seminal plasma DPP2 assessed as pNA release from Lys-Ala-p-nitroanilide substrate pre-incubated with enzyme for 15 min prior to substrate addition by fluorescence technique | 2012 | Bioorganic & medicinal chemistry letters, May-15, Volume: 22, Issue:10
| Acylated Gly-(2-cyano)pyrrolidines as inhibitors of fibroblast activation protein (FAP) and the issue of FAP/prolyl oligopeptidase (PREP)-selectivity. |
| AID390983 | Inhibition of human placental DPP4 after 2 hrs relative to Ala-boroPro | 2008 | Journal of medicinal chemistry, Oct-09, Volume: 51, Issue:19
| Dipeptide boronic acid inhibitors of dipeptidyl peptidase IV: determinants of potency and in vivo efficacy and safety. |
| AID736675 | Cytotoxicity against human HEK293 cells expressing murine FAP at 0.0001 uM to 100 uM after 48 hrs by CellTiter-Blue assay | 2013 | Journal of medicinal chemistry, May-09, Volume: 56, Issue:9
| Identification of selective and potent inhibitors of fibroblast activation protein and prolyl oligopeptidase. |
| AID56222 | Inhibitory activity of compound against Dipeptidylpeptidase II (DPP II) | 2003 | Journal of medicinal chemistry, Nov-06, Volume: 46, Issue:23
| Design, synthesis, and SAR of potent and selective dipeptide-derived inhibitors for dipeptidyl peptidases. |
| AID592150 | Antidiabetic activity in po dosed C57BL/KS01HSDLeprdb mouse assessed as decrease in serum glucose AUC level by oral glucose tolerance test | 2011 | Journal of medicinal chemistry, Apr-14, Volume: 54, Issue:7
| Pro-soft Val-boroPro: a strategy for enhancing in vivo performance of boronic acid inhibitors of serine proteases. |
| AID57546 | Inhibition of Dipeptidyl Peptidase II (Quiescent cell proline peptidase) | 2002 | Bioorganic & medicinal chemistry letters, Oct-21, Volume: 12, Issue:20
| Development of potent and selective dipeptidyl peptidase II inhibitors. |
| AID305117 | Inhibition of DPP2 expressed in Jurkat cells assessed as remaining Ala-Pro-AFC substrate cleavage activity at 10 uM | 2007 | Bioorganic & medicinal chemistry letters, Jan-15, Volume: 17, Issue:2
| Synthesis and activity of a potent, specific azabicyclo[3.3.0]-octane-based DPP II inhibitor. |
| AID390967 | Inhibition of human recombinant DPP8 expressed in HEK293T cells | 2008 | Journal of medicinal chemistry, Oct-09, Volume: 51, Issue:19
| Dipeptide boronic acid inhibitors of dipeptidyl peptidase IV: determinants of potency and in vivo efficacy and safety. |
| AID390981 | Inhibition of human recombinant DPP9 expressed in intact HEK293T cells assessed as residual enzyme activity at 10 uM | 2008 | Journal of medicinal chemistry, Oct-09, Volume: 51, Issue:19
| Dipeptide boronic acid inhibitors of dipeptidyl peptidase IV: determinants of potency and in vivo efficacy and safety. |
| AID592152 | Toxicity in po dosed Fisher rat assessed as mortality measured up to 24 hrs | 2011 | Journal of medicinal chemistry, Apr-14, Volume: 54, Issue:7
| Pro-soft Val-boroPro: a strategy for enhancing in vivo performance of boronic acid inhibitors of serine proteases. |
| AID305101 | Inhibition of human DPP9 | 2007 | Bioorganic & medicinal chemistry letters, Jan-15, Volume: 17, Issue:2
| Synthesis and activity of a potent, specific azabicyclo[3.3.0]-octane-based DPP II inhibitor. |
| AID240875 | Inhibitory concentration against dipeptidyl peptidase IV | 2004 | Bioorganic & medicinal chemistry letters, Nov-15, Volume: 14, Issue:22
| Ketopyrrolidines and ketoazetidines as potent dipeptidyl peptidase IV (DPP IV) inhibitors. |
| AID390966 | Inhibition of human recombinant DPP9 expressed in HEK293T cells | 2008 | Journal of medicinal chemistry, Oct-09, Volume: 51, Issue:19
| Dipeptide boronic acid inhibitors of dipeptidyl peptidase IV: determinants of potency and in vivo efficacy and safety. |
| AID1709022 | Inhibition of FAP (unknown origin) using AMC substrate by fluorometric assay | 2021 | Bioorganic & medicinal chemistry letters, 04-01, Volume: 37 | Identification of BR102910 as a selective fibroblast activation protein (FAP) inhibitor. |
| AID659183 | Inhibition of mouse recombinant FAP expressed in HEK293 cells assessed as pNA release from Ala-Pro-p-nitroanilide pre-incubated with enzyme for 15 mins prior to substrate addition by fluorescence technique | 2012 | Bioorganic & medicinal chemistry letters, May-15, Volume: 22, Issue:10
| Acylated Gly-(2-cyano)pyrrolidines as inhibitors of fibroblast activation protein (FAP) and the issue of FAP/prolyl oligopeptidase (PREP)-selectivity. |
| AID659186 | Inhibition of human seminal plasma DPP4 assessed as pNA release from Gly-Pro-p-nitroanilide substrate pre-incubated with enzyme for 15 min prior to substrate addition by fluorescence technique | 2012 | Bioorganic & medicinal chemistry letters, May-15, Volume: 22, Issue:10
| Acylated Gly-(2-cyano)pyrrolidines as inhibitors of fibroblast activation protein (FAP) and the issue of FAP/prolyl oligopeptidase (PREP)-selectivity. |
| AID390975 | Inhibition of human recombinant DPP9 expressed in intact HEK293T cells after 2 hrs | 2008 | Journal of medicinal chemistry, Oct-09, Volume: 51, Issue:19
| Dipeptide boronic acid inhibitors of dipeptidyl peptidase IV: determinants of potency and in vivo efficacy and safety. |
| AID1129904 | Inhibition of DPP9 purified from bovine testes using Ala-Pro-p-nitroanilide as substrate by spectrophotometry | 2014 | Journal of medicinal chemistry, Apr-10, Volume: 57, Issue:7
| Extended structure-activity relationship and pharmacokinetic investigation of (4-quinolinoyl)glycyl-2-cyanopyrrolidine inhibitors of fibroblast activation protein (FAP). |
| AID390969 | Selectivity ratio of Ki for human recombinant DPP8 to Ki for human placental DPP4 | 2008 | Journal of medicinal chemistry, Oct-09, Volume: 51, Issue:19
| Dipeptide boronic acid inhibitors of dipeptidyl peptidase IV: determinants of potency and in vivo efficacy and safety. |
| AID390978 | Reduction of glucose level in po dosed C57BL/6 mouse assessed as drug level causing maximal reduction of glucose AUC by oral glucose tolerance test | 2008 | Journal of medicinal chemistry, Oct-09, Volume: 51, Issue:19
| Dipeptide boronic acid inhibitors of dipeptidyl peptidase IV: determinants of potency and in vivo efficacy and safety. |
| AID1129901 | Inhibition of recombinant mouse FAP purified from HEK293 cell supernatant using Ala-Pro-p-nitroanilide as substrate by spectrophotometry | 2014 | Journal of medicinal chemistry, Apr-10, Volume: 57, Issue:7
| Extended structure-activity relationship and pharmacokinetic investigation of (4-quinolinoyl)glycyl-2-cyanopyrrolidine inhibitors of fibroblast activation protein (FAP). |
| AID1129905 | Inhibition of DPP2 purified from human seminal plasma using Lys-Ala-p-nitroanilide as substrate by spectrophotometry | 2014 | Journal of medicinal chemistry, Apr-10, Volume: 57, Issue:7
| Extended structure-activity relationship and pharmacokinetic investigation of (4-quinolinoyl)glycyl-2-cyanopyrrolidine inhibitors of fibroblast activation protein (FAP). |
| AID1896136 | Selectivity ratio of Ki for POP (unknown origin) to Ki for FAP ( unknown origin) | 2022 | European journal of medicinal chemistry, Oct-05, Volume: 240 | Modulating the selectivity of inhibitors for prolyl oligopeptidase inhibitors and fibroblast activation protein-α for different indications. |
| AID390986 | Therapeutic index, ratio of MTD to drug level causing maximal reduction of glucose AUC in po dosed Sprague-Dawley rat | 2008 | Journal of medicinal chemistry, Oct-09, Volume: 51, Issue:19
| Dipeptide boronic acid inhibitors of dipeptidyl peptidase IV: determinants of potency and in vivo efficacy and safety. |
| AID305125 | Effect on cell death in resting PBMCs assessed as reduction of annexin V positive cells in presence of 100 uM Zvad-fmk | 2007 | Bioorganic & medicinal chemistry letters, Jan-15, Volume: 17, Issue:2
| Synthesis and activity of a potent, specific azabicyclo[3.3.0]-octane-based DPP II inhibitor. |
| AID659184 | Inhibition of human recombinant PREP expressed in Escherichia coli assessed as pNA release from Z-Gly-Pro-p-nitroanilide pre-incubated with enzyme for 15 mins prior to substrate addition by fluorescence technique | 2012 | Bioorganic & medicinal chemistry letters, May-15, Volume: 22, Issue:10
| Acylated Gly-(2-cyano)pyrrolidines as inhibitors of fibroblast activation protein (FAP) and the issue of FAP/prolyl oligopeptidase (PREP)-selectivity. |
| AID305098 | Inhibition of human DPP2 | 2007 | Bioorganic & medicinal chemistry letters, Jan-15, Volume: 17, Issue:2
| Synthesis and activity of a potent, specific azabicyclo[3.3.0]-octane-based DPP II inhibitor. |
| AID748311 | Inhibition of DPP2 in human seminal plasma using Lys-Ala-p-nitroanilide as substrate incubated for 15 mins prior to substrate addition | 2013 | ACS medicinal chemistry letters, May-09, Volume: 4, Issue:5
| Selective Inhibitors of Fibroblast Activation Protein (FAP) with a (4-Quinolinoyl)-glycyl-2-cyanopyrrolidine Scaffold. |
| AID390971 | Reduction of glucose level in po dosed C57BL/6 mouse by oral glucose tolerance test | 2008 | Journal of medicinal chemistry, Oct-09, Volume: 51, Issue:19
| Dipeptide boronic acid inhibitors of dipeptidyl peptidase IV: determinants of potency and in vivo efficacy and safety. |
| AID659187 | Inhibition of bovine testes DPP9 assessed as pNA release from Ala-Pro-p-nitroanilide substrate pre-incubated with enzyme for 15 min prior to substrate addition by fluorescence technique | 2012 | Bioorganic & medicinal chemistry letters, May-15, Volume: 22, Issue:10
| Acylated Gly-(2-cyano)pyrrolidines as inhibitors of fibroblast activation protein (FAP) and the issue of FAP/prolyl oligopeptidase (PREP)-selectivity. |
| AID748312 | Inhibition of DPP9 in bovine testis using Ala-Pro-p-nitroanilide as substrate incubated for 15 mins prior to substrate addition | 2013 | ACS medicinal chemistry letters, May-09, Volume: 4, Issue:5
| Selective Inhibitors of Fibroblast Activation Protein (FAP) with a (4-Quinolinoyl)-glycyl-2-cyanopyrrolidine Scaffold. |
| AID1850425 | Binding affinity to DPP-4 (unknown origin) assessed as inhibition constant | 2022 | Bioorganic & medicinal chemistry, 06-01, Volume: 63 | Boron-Containing heterocycles as promising pharmacological agents. |
| AID390977 | Inhibition of human recombinant DPP9 expressed in intact HEK293T cells assessed as residual enzyme activity at 1 mM | 2008 | Journal of medicinal chemistry, Oct-09, Volume: 51, Issue:19
| Dipeptide boronic acid inhibitors of dipeptidyl peptidase IV: determinants of potency and in vivo efficacy and safety. |
| AID736688 | Inhibition of human DPP4 using H-Gly-Pro-AMC as substrate preincubated for 10 mins prior to substrate addition by fluorescence assay | 2013 | Journal of medicinal chemistry, May-09, Volume: 56, Issue:9
| Identification of selective and potent inhibitors of fibroblast activation protein and prolyl oligopeptidase. |
| AID736687 | Inhibition of human DPP8 using H-Gly-Pro-AMC as substrate preincubated for 10 mins prior to substrate addition by fluorescence assay | 2013 | Journal of medicinal chemistry, May-09, Volume: 56, Issue:9
| Identification of selective and potent inhibitors of fibroblast activation protein and prolyl oligopeptidase. |
| AID1850424 | Binding affinity to FAP (unknown origin) assessed as inhibition constant | 2022 | Bioorganic & medicinal chemistry, 06-01, Volume: 63 | Boron-Containing heterocycles as promising pharmacological agents. |
| AID1896133 | Inhibition of POP (unknown origin) | 2022 | European journal of medicinal chemistry, Oct-05, Volume: 240 | Modulating the selectivity of inhibitors for prolyl oligopeptidase inhibitors and fibroblast activation protein-α for different indications. |
| AID287010 | Ratio of IC50 for human placental DPP4 at pH 2 to IC50 for human placental DPP4 at pH 8 | 2007 | Journal of medicinal chemistry, May-17, Volume: 50, Issue:10
| Synthesis and characterization of constrained peptidomimetic dipeptidyl peptidase IV inhibitors: amino-lactam boroalanines. |
| AID1539749 | Inhibition of DPP4 (unknown origin) | 2019 | Journal of medicinal chemistry, 09-12, Volume: 62, Issue:17
| Integrated Synthetic, Biophysical, and Computational Investigations of Covalent Inhibitors of Prolyl Oligopeptidase and Fibroblast Activation Protein α. |
| AID748314 | Inhibition of mouse recombinant FAP expressed in HEK293 cells using Ala-Pro-p-nitroanilide as substrate incubated for 15 mins prior to substrate addition | 2013 | ACS medicinal chemistry letters, May-09, Volume: 4, Issue:5
| Selective Inhibitors of Fibroblast Activation Protein (FAP) with a (4-Quinolinoyl)-glycyl-2-cyanopyrrolidine Scaffold. |
| AID1663821 | Inhibition of FAP in human U87MG cells using Suc-Gly-Pro-AMC as substrate by fluorescence based assay | 2020 | Bioorganic & medicinal chemistry letters, 07-15, Volume: 30, Issue:14
| A cell-based fluorescent assay for FAP inhibitor discovery. |
| AID1709025 | Inhibition of DPP2 (unknown origin) using AMC substrate by fluorometric assay | 2021 | Bioorganic & medicinal chemistry letters, 04-01, Volume: 37 | Identification of BR102910 as a selective fibroblast activation protein (FAP) inhibitor. |
| AID390982 | Inhibition of human recombinant DPP9 expressed in intact HEK293T cells assessed as residual enzyme activity at 1 uM | 2008 | Journal of medicinal chemistry, Oct-09, Volume: 51, Issue:19
| Dipeptide boronic acid inhibitors of dipeptidyl peptidase IV: determinants of potency and in vivo efficacy and safety. |
| AID287008 | Inhibition of human placental DPP4 at pH 2 | 2007 | Journal of medicinal chemistry, May-17, Volume: 50, Issue:10
| Synthesis and characterization of constrained peptidomimetic dipeptidyl peptidase IV inhibitors: amino-lactam boroalanines. |
| AID592141 | Inhibition of DDP4 at pH 2 preincubated for 10 mins | 2011 | Journal of medicinal chemistry, Apr-14, Volume: 54, Issue:7
| Pro-soft Val-boroPro: a strategy for enhancing in vivo performance of boronic acid inhibitors of serine proteases. |
| AID287009 | Inhibition of human placental DPP4 at pH 8 | 2007 | Journal of medicinal chemistry, May-17, Volume: 50, Issue:10
| Synthesis and characterization of constrained peptidomimetic dipeptidyl peptidase IV inhibitors: amino-lactam boroalanines. |
| AID736685 | Inhibition of human FAP using Z-Gly-Pro-AMC as substrate preincubated for 10 mins prior to substrate addition by fluorescence assay | 2013 | Journal of medicinal chemistry, May-09, Volume: 56, Issue:9
| Identification of selective and potent inhibitors of fibroblast activation protein and prolyl oligopeptidase. |
| AID305102 | Inhibition of prolyl oligopeptidase | 2007 | Bioorganic & medicinal chemistry letters, Jan-15, Volume: 17, Issue:2
| Synthesis and activity of a potent, specific azabicyclo[3.3.0]-octane-based DPP II inhibitor. |
| AID390980 | Inhibition of human recombinant DPP9 expressed in intact HEK293T cells assessed as residual enzyme activity at 100 uM | 2008 | Journal of medicinal chemistry, Oct-09, Volume: 51, Issue:19
| Dipeptide boronic acid inhibitors of dipeptidyl peptidase IV: determinants of potency and in vivo efficacy and safety. |
| AID1539748 | Inhibition of FAP (unknown origin) | 2019 | Journal of medicinal chemistry, 09-12, Volume: 62, Issue:17
| Integrated Synthetic, Biophysical, and Computational Investigations of Covalent Inhibitors of Prolyl Oligopeptidase and Fibroblast Activation Protein α. |
| AID235490 | Selectivity for Dipeptidylpeptidase IV over Dipeptidylpeptidase II. | 2002 | Bioorganic & medicinal chemistry letters, Oct-21, Volume: 12, Issue:20
| Development of potent and selective dipeptidyl peptidase II inhibitors. |
| AID238649 | Inhibition of quiescent cell proline dipeptidase (QPP) | 2004 | Journal of medicinal chemistry, Aug-12, Volume: 47, Issue:17
| Dipeptidyl peptidase IV inhibitors for the treatment of diabetes. |
| AID390979 | Toxicity in po dosed Sprague-Dawley rat assessed as maximum tolerated dose | 2008 | Journal of medicinal chemistry, Oct-09, Volume: 51, Issue:19
| Dipeptide boronic acid inhibitors of dipeptidyl peptidase IV: determinants of potency and in vivo efficacy and safety. |
| AID390968 | Inhibition of human placental DPP4 | 2008 | Journal of medicinal chemistry, Oct-09, Volume: 51, Issue:19
| Dipeptide boronic acid inhibitors of dipeptidyl peptidase IV: determinants of potency and in vivo efficacy and safety. |
| AID390970 | Selectivity ratio of Ki for human recombinant DPP9 to Ki for human placental DPP4 | 2008 | Journal of medicinal chemistry, Oct-09, Volume: 51, Issue:19
| Dipeptide boronic acid inhibitors of dipeptidyl peptidase IV: determinants of potency and in vivo efficacy and safety. |
| AID56229 | Selectivity index of compound was determined as value for DPP IV divided by value for DPP II | 2003 | Journal of medicinal chemistry, Nov-06, Volume: 46, Issue:23
| Design, synthesis, and SAR of potent and selective dipeptide-derived inhibitors for dipeptidyl peptidases. |
| AID390976 | Inhibition of human recombinant DPP9 expressed in intact HEK293T cells after 2 hrs relative to Val-boroPro | 2008 | Journal of medicinal chemistry, Oct-09, Volume: 51, Issue:19
| Dipeptide boronic acid inhibitors of dipeptidyl peptidase IV: determinants of potency and in vivo efficacy and safety. |
| AID305110 | Inhibition of DPP expressed in HEK 293T cells assessed as remaining Ala-Pro-AFC substrate cleavage activity at 10 uM | 2007 | Bioorganic & medicinal chemistry letters, Jan-15, Volume: 17, Issue:2
| Synthesis and activity of a potent, specific azabicyclo[3.3.0]-octane-based DPP II inhibitor. |
| AID1129906 | Selectivity index, ratio of IC50 for recombinant human PREP purified from Escherichia coli to IC50 for recombinant mouse FAP purified from HEK293 cell supernatant | 2014 | Journal of medicinal chemistry, Apr-10, Volume: 57, Issue:7
| Extended structure-activity relationship and pharmacokinetic investigation of (4-quinolinoyl)glycyl-2-cyanopyrrolidine inhibitors of fibroblast activation protein (FAP). |
| AID592151 | Antidiabetic activity in C57BL/KS01HSDLeprdb mouse assessed as decrease in serum glucose AUC level at 0.5 mg/kg, po by oral glucose tolerance test | 2011 | Journal of medicinal chemistry, Apr-14, Volume: 54, Issue:7
| Pro-soft Val-boroPro: a strategy for enhancing in vivo performance of boronic acid inhibitors of serine proteases. |
| AID1129903 | Inhibition of recombinant human PREP purified from Escherichia coli using Z-Gly-Pro-p-nitroanilide as substrate by spectrophotometry | 2014 | Journal of medicinal chemistry, Apr-10, Volume: 57, Issue:7
| Extended structure-activity relationship and pharmacokinetic investigation of (4-quinolinoyl)glycyl-2-cyanopyrrolidine inhibitors of fibroblast activation protein (FAP). |
| AID1129902 | Inhibition of DPP4 purified from human seminal plasma using Gly-Pro-p-nitroanilide as substrate by spectrophotometry | 2014 | Journal of medicinal chemistry, Apr-10, Volume: 57, Issue:7
| Extended structure-activity relationship and pharmacokinetic investigation of (4-quinolinoyl)glycyl-2-cyanopyrrolidine inhibitors of fibroblast activation protein (FAP). |
| AID238304 | Binding affinity for dipeptidylpeptidase IV | 2004 | Journal of medicinal chemistry, Aug-12, Volume: 47, Issue:17
| Dipeptidyl peptidase IV inhibitors for the treatment of diabetes. |
| AID390973 | Inhibition of DPP4 in po dosed Sprague-Dawley rat plasma after 24 hrs | 2008 | Journal of medicinal chemistry, Oct-09, Volume: 51, Issue:19
| Dipeptide boronic acid inhibitors of dipeptidyl peptidase IV: determinants of potency and in vivo efficacy and safety. |
| AID736684 | Inhibition of human PREP using Z-Gly-Pro-AMC as substrate preincubated for 10 mins prior to substrate addition by fluorescence assay | 2013 | Journal of medicinal chemistry, May-09, Volume: 56, Issue:9
| Identification of selective and potent inhibitors of fibroblast activation protein and prolyl oligopeptidase. |
| AID592142 | Inhibition of DDP4 at pH 7.4 preincubated for 10 mins | 2011 | Journal of medicinal chemistry, Apr-14, Volume: 54, Issue:7
| Pro-soft Val-boroPro: a strategy for enhancing in vivo performance of boronic acid inhibitors of serine proteases. |
| AID390985 | Toxicity in po dosed Sprague-Dawley rat assessed as maximum tolerated dose relative to Val-boroPro | 2008 | Journal of medicinal chemistry, Oct-09, Volume: 51, Issue:19
| Dipeptide boronic acid inhibitors of dipeptidyl peptidase IV: determinants of potency and in vivo efficacy and safety. |
| AID748310 | Inhibition of human recombinant PREP expressed in Escherichia coli using Z-Gly-Pro-p-nitroanilide as substrate incubated for 15 mins prior to substrate addition | 2013 | ACS medicinal chemistry letters, May-09, Volume: 4, Issue:5
| Selective Inhibitors of Fibroblast Activation Protein (FAP) with a (4-Quinolinoyl)-glycyl-2-cyanopyrrolidine Scaffold. |
| AID305100 | Inhibition of human DPP8 | 2007 | Bioorganic & medicinal chemistry letters, Jan-15, Volume: 17, Issue:2
| Synthesis and activity of a potent, specific azabicyclo[3.3.0]-octane-based DPP II inhibitor. |
| AID1709023 | Inhibition of DPP4 (unknown origin) using AMC substrate by fluorometric assay | 2021 | Bioorganic & medicinal chemistry letters, 04-01, Volume: 37 | Identification of BR102910 as a selective fibroblast activation protein (FAP) inhibitor. |
| AID305124 | Effect on cell death in resting PBMCs at 10 uM | 2007 | Bioorganic & medicinal chemistry letters, Jan-15, Volume: 17, Issue:2
| Synthesis and activity of a potent, specific azabicyclo[3.3.0]-octane-based DPP II inhibitor. |
| AID1896134 | Inhibition of FAP (unknown origin) | 2022 | European journal of medicinal chemistry, Oct-05, Volume: 240 | Modulating the selectivity of inhibitors for prolyl oligopeptidase inhibitors and fibroblast activation protein-α for different indications. |
| AID1896135 | Inhibition of DPP4 (unknown origin) | 2022 | European journal of medicinal chemistry, Oct-05, Volume: 240 | Modulating the selectivity of inhibitors for prolyl oligopeptidase inhibitors and fibroblast activation protein-α for different indications. |
| AID305103 | Inhibition of DPP2 expressed in HEK 293T cells assessed as remaining Ala-Pro-AFC substrate cleavage activity at 10 uM | 2007 | Bioorganic & medicinal chemistry letters, Jan-15, Volume: 17, Issue:2
| Synthesis and activity of a potent, specific azabicyclo[3.3.0]-octane-based DPP II inhibitor. |
| AID287007 | Inhibition of human placental DPP4 | 2007 | Journal of medicinal chemistry, May-17, Volume: 50, Issue:10
| Synthesis and characterization of constrained peptidomimetic dipeptidyl peptidase IV inhibitors: amino-lactam boroalanines. |
| AID305097 | Inhibition of human DPP4 | 2007 | Bioorganic & medicinal chemistry letters, Jan-15, Volume: 17, Issue:2
| Synthesis and activity of a potent, specific azabicyclo[3.3.0]-octane-based DPP II inhibitor. |
| AID56048 | Inhibition of Dipeptidyl Peptidase IV | 2002 | Bioorganic & medicinal chemistry letters, Oct-21, Volume: 12, Issue:20
| Development of potent and selective dipeptidyl peptidase II inhibitors. |
| AID1345889 | Human dipeptidyl peptidase 9 (S9: Prolyl oligopeptidase) | 2008 | Journal of medicinal chemistry, Oct-09, Volume: 51, Issue:19
| Dipeptide boronic acid inhibitors of dipeptidyl peptidase IV: determinants of potency and in vivo efficacy and safety. |
| AID1345443 | Human dipeptidyl peptidase 4 (S9: Prolyl oligopeptidase) | 2008 | Journal of medicinal chemistry, Oct-09, Volume: 51, Issue:19
| Dipeptide boronic acid inhibitors of dipeptidyl peptidase IV: determinants of potency and in vivo efficacy and safety. |
| [information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023] |