Page last updated: 2024-12-07

4-ethoxyamphetamine

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth

Description

4-ethoxyamphetamine: structure given in first source [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

Cross-References

ID SourceID
PubMed CID125379
CHEMBL ID161985
SCHEMBL ID2553013
MeSH IDM0181121

Synonyms (23)

Synonym
4-ethoxyamphetamine
AKOS000155579
AKOS016298265
bdbm50005270
1-(4-ethoxyphenyl)propan-2-amine
2-(4-ethoxy-phenyl)-1-methyl-ethylamine
CHEMBL161985 ,
135014-85-6
129476-58-0
c1417507no ,
unii-c1417507no
dl-p-ethoxyamphetamine
benzeneethanamine, 4-ethoxy-alpha-methyl-, (+-)-
AKOS017269155
SCHEMBL2553013
1-(4-ethoxyphenyl)-2-propanamine #
CCAMEVFYMFXHEN-UHFFFAOYSA-N
benzeneethanamine, 4-ethoxy-.alpha.-methyl-
4-ethoxy-.alpha.-methylbenzeneethanamine
4-ethoxyamphetamine, (+/-)-
DTXSID40926412
Q7133613
PD178987

Research Excerpts

Toxicity

ExcerptReferenceRelevance
" The findings suggest that 4-substituted amphetamines exhibit a wide variation in their effects on maternal toxicity and pregnancy wastage, and produce adverse effects on parturition, pup survival, and postnatal development."( Developmental toxicity of 4-substituted amphetamines in mice.
Buttar, HS; Foster, BC; Moffatt, JH,
)
0.13
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Protein Targets (3)

Inhibition Measurements

ProteinTaxonomyMeasurementAverageMin (ref.)Avg (ref.)Max (ref.)Bioassay(s)
5-hydroxytryptamine receptor 2CRattus norvegicus (Norway rat)Ki10.00000.00020.667710.0000AID4763; AID5263
5-hydroxytryptamine receptor 2ARattus norvegicus (Norway rat)Ki10.00000.00010.601710.0000AID5263
5-hydroxytryptamine receptor 2BRattus norvegicus (Norway rat)Ki10.00000.00020.590910.0000AID5263
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Bioassays (5)

Assay IDTitleYearJournalArticle
AID395043Inhibition of MAOA in rat brain mitochondria2009Bioorganic & medicinal chemistry, Mar-15, Volume: 17, Issue:6
Naphthylisopropylamine and N-benzylamphetamine derivatives as monoamine oxidase inhibitors.
AID395042Inhibition of MAOB in rat brain mitochondria2009Bioorganic & medicinal chemistry, Mar-15, Volume: 17, Issue:6
Naphthylisopropylamine and N-benzylamphetamine derivatives as monoamine oxidase inhibitors.
AID5263Binding affinity towards 5-hydroxytryptamine 2 receptor from frontal cortical regions of male Sprague-Dawley rat homogenates, using [3H]ketanserin as radioligand1992Journal of medicinal chemistry, Feb-21, Volume: 35, Issue:4
Binding of phenylalkylamine derivatives at 5-HT1C and 5-HT2 serotonin receptors: evidence for a lack of selectivity.
AID4763Compound was tested for binding affinity towards 5-hydroxytryptamine 1C receptor from frontal cortical regions of male Sprague-Dawley rat homogenates, using [3H]mesulergine as radioligand1992Journal of medicinal chemistry, Feb-21, Volume: 35, Issue:4
Binding of phenylalkylamine derivatives at 5-HT1C and 5-HT2 serotonin receptors: evidence for a lack of selectivity.
AID241440Inhibitory concentration against monoamine oxidase A in rat brain mitochondrial suspension2005Journal of medicinal chemistry, Apr-07, Volume: 48, Issue:7
Sulfur-substituted alpha-alkyl phenethylamines as selective and reversible MAO-A inhibitors: biological activities, CoMFA analysis, and active site modeling.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (6)

TimeframeStudies, This Drug (%)All Drugs %
pre-19900 (0.00)18.7374
1990's4 (66.67)18.2507
2000's2 (33.33)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews0 (0.00%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other7 (100.00%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]