Compounds > 2-formylpyridine thiosemicarbazone
Page last updated: 2024-12-11

2-formylpyridine thiosemicarbazone

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Description

2-formylpyridine thiosemicarbazone: structure; RN given refers to parent cpd without isomeric designation [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

Cross-References

ID SourceID
PubMed CID5382559
CHEMBL ID25988
SCHEMBL ID293101
MeSH IDM0062207

Synonyms (42)

Synonym
(e)-2-(pyridin-2-ylmethylene)hydrazinecarbothioamide
{[(pyridin-2-yl)methylidene]amino}thiourea
EN300-43946
[(e)-2-pyridylmethyleneamino]thiourea
pyridine-2-carboxaldehyde thiosemicarbazone
ai3-51838
nsc 729
nsc-729
wln: t6nj b1unmyzus
2-pyridinecarboxaldehyde thiosemicarbazone
nsc729
2-formylpyridine thiosemicarbazone
pyridine-2-carboxaldehyde, thiosemicarbazone
picolinaldehyde, thiosemicarbazone
hydrazinecarbothioamide, 2-(2-pyridinylmethylene)-
picoline-2-aldehyde thiosemicarbazone
nsc-144418
61043-10-5
nsc144418
beta-pyridine-2yl thiosemicarbazone
CHEMBL25988 ,
AKOS005109625
[(e)-pyridin-2-ylmethylideneamino]thiourea
bdbm50341553
2-(pyridin-2-ylmethylene)hydrazinecarbothioamide
SCHEMBL293101
MS-7716
[(e)-[(pyridin-2-yl)methylidene]amino]thiourea
GXBCCUBTQFNGFA-BJMVGYQFSA-N
picolinaldehyde monothiosemicarbazone
2-pyridinecarbaldehyde thiosemicarbazone #
mfcd00160323
2-pyridinecarbaldehyde thiosemicarbazone
Z49561480
(e)-2-(pyridin-2-ylmethylene)hydrazine-1-carbothioamide
STL583038
(2e)-2-(pyridin-2-ylmethylidene)hydrazinecarbothioamide
hydrazinecarbothioamide, 2-(2-pyridinylmethylene)-, (e)-
CS-0110143
GUV6BG5RZX
(2e)-2-(2-pyridinylmethylene)hydrazinecarbothioamide
hydrazinecarbothioamide, 2-(2-pyridinylmethylene)-, (2e)-

Research Excerpts

Dosage Studied

ExcerptRelevanceReference
" Weak genotoxic activity was detected for [CuL](+) and [CuL'](+), with a significative dose-response effect for [CuL'](+), which was shown to be more cytotoxic in the Ames test and 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide cell proliferation assays."( Biological assays and noncovalent interactions of pyridine-2-carbaldehyde thiosemicarbazonecopper(II) drugs with [poly(dA-dT)](2), [poly(dG-dC)] (2), and calf thymus DNA.
Borrás, J; Busto, N; García, B; Garcia-Tojal, J; Gaspar, J; Gil-García, R; González-Alvarez, M; Ibeas, S; Leal, JM; Martins, C; Ruiz, R, 2010)		0.36
" The aims of this study were to elucidate the mechanisms underlying their potency disparity and to determine their kinetics of cell-kill in culture to aid in the formulation of their clinical dosing schedules."( Distinct mechanisms of cell-kill by triapine and its terminally dimethylated derivative Dp44mT due to a loss or gain of activity of their copper(II) complexes.
Baumann, RP; Ishiguro, K; Lin, ZP; Penketh, PG; Ratner, ES; Rutherford, TJ; Sartorelli, AC; Shyam, K; Zhu, R; Zhu, YL, 2014)		0.4
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Protein Targets (2)

Inhibition Measurements

ProteinTaxonomyMeasurementAverageMin (ref.)Avg (ref.)Max (ref.)Bioassay(s)
Polyphenol oxidase 2Agaricus bisporusIC50 (µMol)45.00000.03403.987110.0000AID613824
DNA topoisomerase 2-alphaHomo sapiens (human)IC50 (µMol)100.00000.48004.35649.9400AID591712
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Biological Processes (16)

Processvia Protein(s)Taxonomy
hematopoietic progenitor cell differentiationDNA topoisomerase 2-alphaHomo sapiens (human)
DNA topological changeDNA topoisomerase 2-alphaHomo sapiens (human)
DNA ligationDNA topoisomerase 2-alphaHomo sapiens (human)
DNA damage responseDNA topoisomerase 2-alphaHomo sapiens (human)
chromosome segregationDNA topoisomerase 2-alphaHomo sapiens (human)
female meiotic nuclear divisionDNA topoisomerase 2-alphaHomo sapiens (human)
apoptotic chromosome condensationDNA topoisomerase 2-alphaHomo sapiens (human)
embryonic cleavageDNA topoisomerase 2-alphaHomo sapiens (human)
regulation of circadian rhythmDNA topoisomerase 2-alphaHomo sapiens (human)
positive regulation of apoptotic processDNA topoisomerase 2-alphaHomo sapiens (human)
positive regulation of single stranded viral RNA replication via double stranded DNA intermediateDNA topoisomerase 2-alphaHomo sapiens (human)
positive regulation of transcription by RNA polymerase IIDNA topoisomerase 2-alphaHomo sapiens (human)
rhythmic processDNA topoisomerase 2-alphaHomo sapiens (human)
negative regulation of DNA duplex unwindingDNA topoisomerase 2-alphaHomo sapiens (human)
resolution of meiotic recombination intermediatesDNA topoisomerase 2-alphaHomo sapiens (human)
sister chromatid segregationDNA topoisomerase 2-alphaHomo sapiens (human)
[Information is prepared from geneontology information from the June-17-2024 release]

Molecular Functions (13)

Processvia Protein(s)Taxonomy
magnesium ion bindingDNA topoisomerase 2-alphaHomo sapiens (human)
DNA bindingDNA topoisomerase 2-alphaHomo sapiens (human)
chromatin bindingDNA topoisomerase 2-alphaHomo sapiens (human)
RNA bindingDNA topoisomerase 2-alphaHomo sapiens (human)
DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activityDNA topoisomerase 2-alphaHomo sapiens (human)
protein kinase C bindingDNA topoisomerase 2-alphaHomo sapiens (human)
protein bindingDNA topoisomerase 2-alphaHomo sapiens (human)
ATP bindingDNA topoisomerase 2-alphaHomo sapiens (human)
ATP-dependent activity, acting on DNADNA topoisomerase 2-alphaHomo sapiens (human)
DNA binding, bendingDNA topoisomerase 2-alphaHomo sapiens (human)
protein homodimerization activityDNA topoisomerase 2-alphaHomo sapiens (human)
ubiquitin bindingDNA topoisomerase 2-alphaHomo sapiens (human)
protein heterodimerization activityDNA topoisomerase 2-alphaHomo sapiens (human)
[Information is prepared from geneontology information from the June-17-2024 release]

Ceullar Components (12)

Processvia Protein(s)Taxonomy
nucleolusDNA topoisomerase 2-alphaHomo sapiens (human)
nuclear chromosomeDNA topoisomerase 2-alphaHomo sapiens (human)
centrioleDNA topoisomerase 2-alphaHomo sapiens (human)
chromosome, centromeric regionDNA topoisomerase 2-alphaHomo sapiens (human)
condensed chromosomeDNA topoisomerase 2-alphaHomo sapiens (human)
male germ cell nucleusDNA topoisomerase 2-alphaHomo sapiens (human)
nucleusDNA topoisomerase 2-alphaHomo sapiens (human)
nucleoplasmDNA topoisomerase 2-alphaHomo sapiens (human)
nucleolusDNA topoisomerase 2-alphaHomo sapiens (human)
cytoplasmDNA topoisomerase 2-alphaHomo sapiens (human)
DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) complexDNA topoisomerase 2-alphaHomo sapiens (human)
protein-containing complexDNA topoisomerase 2-alphaHomo sapiens (human)
ribonucleoprotein complexDNA topoisomerase 2-alphaHomo sapiens (human)
nucleusDNA topoisomerase 2-alphaHomo sapiens (human)
[Information is prepared from geneontology information from the June-17-2024 release]

Bioassays (24)

Assay IDTitleYearJournalArticle
AID1131030Iron chelating activity assessed as removal of iron from ferritin after 20 hrs by atomic absorption spectrophotometric analysis1979Journal of medicinal chemistry, Nov, Volume: 22, Issue:11
Synthesis and evaluation of the thiosemicarbazone, dithiocarbazonate, and 2'-pyrazinylhydrazone of pyrazinecarboxaldehyde as agents for the treatment of iron overload.
AID95953Percent inhibition on the biosynthesis of proteins of promastigotes of Leishmania donovani at 53 uM concentration1989Journal of medicinal chemistry, Jun, Volume: 32, Issue:6
Hybrid molecules: growth inhibition of Leishmania donovani promastigotes by thiosemicarbazones of 3-carboxy-beta-carbolines.
AID95930Concentration of compound provoking 50% inhibition on growth of Leishmania donovani promastigotes multiplication1989Journal of medicinal chemistry, Jun, Volume: 32, Issue:6
Hybrid molecules: growth inhibition of Leishmania donovani promastigotes by thiosemicarbazones of 3-carboxy-beta-carbolines.
AID1131029Iron chelating activity assessed as removal of [59]-Fe from [59]-Fe-labeled transferrin at 1 mM measured per hr by spectrometric analysis1979Journal of medicinal chemistry, Nov, Volume: 22, Issue:11
Synthesis and evaluation of the thiosemicarbazone, dithiocarbazonate, and 2'-pyrazinylhydrazone of pyrazinecarboxaldehyde as agents for the treatment of iron overload.
AID95948Percent inhibition on the biosynthesis of proteins of promastigotes of Leishmania donovani at 26.6 uM concentration1989Journal of medicinal chemistry, Jun, Volume: 32, Issue:6
Hybrid molecules: growth inhibition of Leishmania donovani promastigotes by thiosemicarbazones of 3-carboxy-beta-carbolines.
AID96100Percent inhibition on the growth of the promastigotes of Leishmania donovani at 53 uM concentration1989Journal of medicinal chemistry, Jun, Volume: 32, Issue:6
Hybrid molecules: growth inhibition of Leishmania donovani promastigotes by thiosemicarbazones of 3-carboxy-beta-carbolines.
AID613823Dissociation constant, pKa of the compound2011European journal of medicinal chemistry, Sep, Volume: 46, Issue:9
Refinement of arylthiosemicarbazone pharmacophore in inhibition of mushroom tyrosinase.
AID95946Percent inhibition on the biosynthesis of RNA of promastigotes of Leishmania donovani at 53 uM concentration1989Journal of medicinal chemistry, Jun, Volume: 32, Issue:6
Hybrid molecules: growth inhibition of Leishmania donovani promastigotes by thiosemicarbazones of 3-carboxy-beta-carbolines.
AID95941Percent inhibition on the biosynthesis of RNA of promastigotes of Leishmania donovani at 26.6 uM concentration1989Journal of medicinal chemistry, Jun, Volume: 32, Issue:6
Hybrid molecules: growth inhibition of Leishmania donovani promastigotes by thiosemicarbazones of 3-carboxy-beta-carbolines.
AID591714Growth inhibition against human SK-BR-3 cells after 24 hrs by MTT assay2011Journal of medicinal chemistry, Apr-14, Volume: 54, Issue:7
Role of metalation in the topoisomerase IIα inhibition and antiproliferation activity of a series of α-heterocyclic-N4-substituted thiosemicarbazones and their Cu(II) complexes.
AID95955Percent inhibition on the growth of the promastigotes of Leishmania donovani at 26.6 uM concentration1989Journal of medicinal chemistry, Jun, Volume: 32, Issue:6
Hybrid molecules: growth inhibition of Leishmania donovani promastigotes by thiosemicarbazones of 3-carboxy-beta-carbolines.
AID527288Inhibition of melanogenesis in mouse B16 cells at 10 uM2010Bioorganic & medicinal chemistry letters, Nov-15, Volume: 20, Issue:22
Structural characteristics of thiosemicarbazones as inhibitors of melanogenesis.
AID95939Percent inhibition on the biosynthesis of DNA of promastigotes of Leishmania donovani at 53 uM concentration1989Journal of medicinal chemistry, Jun, Volume: 32, Issue:6
Hybrid molecules: growth inhibition of Leishmania donovani promastigotes by thiosemicarbazones of 3-carboxy-beta-carbolines.
AID1188739Inhibition of recombinant Trypanosoma cruzi cruzain using Z-Phe-Argaminomethylcoumarin as fluorogenic substrate preincubated for 10 mins before substrate addition by fluorimetry2014European journal of medicinal chemistry, Oct-30, Volume: 862-Pyridyl thiazoles as novel anti-Trypanosoma cruzi agents: structural design, synthesis and pharmacological evaluation.
AID95932Concentration of compound provoking >99% irreversible after removal of drugs from culture medium inhibition on growth of Leishmania donovani promastigotes multiplication1989Journal of medicinal chemistry, Jun, Volume: 32, Issue:6
Hybrid molecules: growth inhibition of Leishmania donovani promastigotes by thiosemicarbazones of 3-carboxy-beta-carbolines.
AID591712Inhibition of human topoisomerase 2 alpha-mediated relaxation of supercoiled pHOT DNA after 30 mins by agarose gel electrophoresis2011Journal of medicinal chemistry, Apr-14, Volume: 54, Issue:7
Role of metalation in the topoisomerase IIα inhibition and antiproliferation activity of a series of α-heterocyclic-N4-substituted thiosemicarbazones and their Cu(II) complexes.
AID1188736Inhibition of recombinant Trypanosoma cruzi cruzain using Z-Phe-Argaminomethylcoumarin as fluorogenic substrate preincubated at 100 uM for 10 mins before substrate addition by fluorimetry2014European journal of medicinal chemistry, Oct-30, Volume: 862-Pyridyl thiazoles as novel anti-Trypanosoma cruzi agents: structural design, synthesis and pharmacological evaluation.
AID1188734Antitrypanosomal activity against trypomastigote forms of Trypanosoma cruzi Y infected in LLC-MK2 cells assessed as reduction in viable parasites after 24 hrs by Neubauer chamber counting method2014European journal of medicinal chemistry, Oct-30, Volume: 862-Pyridyl thiazoles as novel anti-Trypanosoma cruzi agents: structural design, synthesis and pharmacological evaluation.
AID527289Inhibition of melanogenesis in mouse B16 cells2010Bioorganic & medicinal chemistry letters, Nov-15, Volume: 20, Issue:22
Structural characteristics of thiosemicarbazones as inhibitors of melanogenesis.
AID613824Inhibition of diphenolase activity of mushroom tyrosinase using L-DOPA as substrate preincubated for 5 mins by spectroscopic method2011European journal of medicinal chemistry, Sep, Volume: 46, Issue:9
Refinement of arylthiosemicarbazone pharmacophore in inhibition of mushroom tyrosinase.
AID95934Percent inhibition on the biosynthesis of DNA of promastigotes of Leishmania donovani at 26.6 uM concentration1989Journal of medicinal chemistry, Jun, Volume: 32, Issue:6
Hybrid molecules: growth inhibition of Leishmania donovani promastigotes by thiosemicarbazones of 3-carboxy-beta-carbolines.
AID1188733Cytotoxicity against human HepG2 cells after 48 hrs by2014European journal of medicinal chemistry, Oct-30, Volume: 862-Pyridyl thiazoles as novel anti-Trypanosoma cruzi agents: structural design, synthesis and pharmacological evaluation.
AID1188735Trypanocidal activity against epimastigote forms of Trypanosoma cruzi Y assessed as reduction in viable parasites after 11 days by Neubauer chamber counting method2014European journal of medicinal chemistry, Oct-30, Volume: 862-Pyridyl thiazoles as novel anti-Trypanosoma cruzi agents: structural design, synthesis and pharmacological evaluation.
AID591713Inhibition of human topoisomerase 2 alpha-mediated relaxation of supercoiled pHOT DNA at 100 uM after 30 mins by agarose gel electrophoresis2011Journal of medicinal chemistry, Apr-14, Volume: 54, Issue:7
Role of metalation in the topoisomerase IIα inhibition and antiproliferation activity of a series of α-heterocyclic-N4-substituted thiosemicarbazones and their Cu(II) complexes.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (20)

TimeframeStudies, This Drug (%)All Drugs %
pre-19907 (35.00)18.7374
1990's3 (15.00)18.2507
2000's2 (10.00)29.6817
2010's6 (30.00)24.3611
2020's2 (10.00)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews3 (13.64%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other19 (86.36%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]
SubstanceRelationship StrengthStudiesTrialsClassesRoles
1,10-phenanthroline
1,10-phenanthroline: RN given refers to parent cpd; inhibits Zn-dependent metalloproteinases		7.2510phenanthrolineEC 2.7.1.1 (hexokinase) inhibitor;
EC 3.4.19.3 (pyroglutamyl-peptidase I) inhibitor
mercaptoethanol
Mercaptoethanol: A water-soluble thiol derived from hydrogen sulfide and ethanol. It is used as a reducing agent for disulfide bonds and to protect sulfhydryl groups from oxidation.		210alkanethiol;
primary alcohol		geroprotector
deferoxamine
Deferoxamine: Natural product isolated from Streptomyces pilosus. It forms iron complexes and is used as a chelating agent, particularly in the mesylate form.. desferrioxamine B : An acyclic desferrioxamine that is butanedioic acid in which one of the carboxy groups undergoes formal condensation with the primary amino group of N-(5-aminopentyl)-N-hydroxyacetamide and the second carboxy group undergoes formal condensation with the hydroxyamino group of N(1)-(5-aminopentyl)-N(1)-hydroxy-N(4)-[5-(hydroxyamino)pentyl]butanediamide. It is a siderophore native to Streptomyces pilosus biosynthesised by the DesABCD enzyme cluster as a high affinity Fe(III) chelator.		1.9510acyclic desferrioxaminebacterial metabolite;
ferroptosis inhibitor;
iron chelator;
siderophore
kojic acid
[no description available]		2.06104-pyranones;
enol;
primary alcohol		Aspergillus metabolite;
EC 1.10.3.1 (catechol oxidase) inhibitor;
EC 1.10.3.2 (laccase) inhibitor;
EC 1.13.11.24 (quercetin 2,3-dioxygenase) inhibitor;
EC 1.14.18.1 (tyrosinase) inhibitor;
EC 1.4.3.3 (D-amino-acid oxidase) inhibitor;
NF-kappaB inhibitor;
skin lightening agent
pentamidine
Pentamidine: Antiprotozoal agent effective in trypanosomiasis, leishmaniasis, and some fungal infections; used in treatment of PNEUMOCYSTIS pneumonia in HIV-infected patients. It may cause diabetes mellitus, central nervous system damage, and other toxic effects.. pentamidine : A diether consisting of pentane-1,5-diol in which both hydroxyl hydrogens have been replaced by 4-amidinophenyl groups. A trypanocidal drug that is used for treatment of cutaneous leishmaniasis and Chagas disease.		1.9710aromatic ether;
carboxamidine;
diether		anti-inflammatory agent;
antifungal agent;
calmodulin antagonist;
chemokine receptor 5 antagonist;
EC 2.3.1.48 (histone acetyltransferase) inhibitor;
NMDA receptor antagonist;
S100 calcium-binding protein B inhibitor;
trypanocidal drug;
xenobiotic
3-mercaptopropionic acid
3-Mercaptopropionic Acid: An inhibitor of glutamate decarboxylase. It decreases the GAMMA-AMINOBUTYRIC ACID concentration in the brain, thereby causing convulsions.. 3-mercaptopropanoic acid : A mercaptopropanoic acid that is propanoic acid carrying a sulfanyl group at position 3.		2.0510mercaptopropanoic acidalgal metabolite
tropolone
Tropolone: A seven-membered aromatic ring compound. It is structurally related to a number of naturally occurring antifungal compounds (ANTIFUNGAL AGENTS).. tropolone : A cyclic ketone that is cyclohepta-2,4,6-trien-1-one substituted by a hydroxy group at position 2. It is a toxin produced by the agricultural pathogen Burkholderia plantarii.		1.9510alpha-hydroxy ketone;
cyclic ketone;
enol		bacterial metabolite;
fungicide;
toxin
dithiothreitol
1,4-dimercaptobutane-2,3-diol : A glycol that is butane-2,3-diol in which a hydrogen from each of the methyl groups is replaced by a thiol group.. 1,4-dithiothreitol : The threo-diastereomer of 1,4-dimercaptobutane-2,3-diol.		2.05101,4-dimercaptobutane-2,3-diol;
butanediols;
dithiol;
glycol;
thiol		chelator;
human metabolite;
reducing agent
palladium
Palladium: A chemical element having an atomic weight of 106.4, atomic number of 46, and the symbol Pd. It is a white, ductile metal resembling platinum, and following it in abundance and importance of applications. It is used in dentistry in the form of gold, silver, and copper alloys.. palladium : Chemical element (nickel group element atom) with atomic number 46.		210metal allergen;
nickel group element atom;
platinum group metal atom
silver
Silver: An element with the atomic symbol Ag, atomic number 47, and atomic weight 107.87. It is a soft metal that is used medically in surgical instruments, dental prostheses, and alloys. Long-continued use of silver salts can lead to a form of poisoning known as ARGYRIA.		7.2510copper group element atom;
elemental silver		Escherichia coli metabolite
benzonidazole
benzonidazole: used in treatment of Chagas' disease. benznidazole : A monocarboxylic acid amide obtained by formal condensation of the carboxy group of (2-nitroimidazol-1-yl)acetic acid with the aromatic amino group of benzylamine. Used for treatment of Chagas disease.		2.110C-nitro compound;
imidazoles;
monocarboxylic acid amide		antiprotozoal drug
1,7-phenanthroline
[no description available]		2.2510phenanthroline
beta-carboline-3-carboxylic acid methyl ester
beta-carboline-3-carboxylic acid methyl ester: structure given in first source		1.9710beta-carbolines
merbarone
merbarone: structure given in first source		2.0610
sulfur
Sulfur: An element that is a member of the chalcogen family. It has an atomic symbol S, atomic number 16, and atomic weight [32.059; 32.076]. It is found in the amino acids cysteine and methionine.		1.9910chalcogen;
nonmetal atom		macronutrient
2-acetylpyridine thiosemicarbazone
2-acetylpyridine thiosemicarbazone: RN given refers to parent cpd		7.4320
1-formylisoquinoline thiosemicarbazone
1-formylisoquinoline thiosemicarbazone: structure; RN given refers to parent cpd without isomeric designation		4.630
2-acetylpyridine-4-methyl-3-thiosemicarbazone
[no description available]		2.0610
4-methyl-5-amino-1-formylisoquinoline thiosemicarbazone
4-methyl-5-amino-1-formylisoquinoline thiosemicarbazone: structure		3.0610
2-(quinolin-2-ylmethylene)hydrazinecarbothioamide
2-(quinolin-2-ylmethylene)hydrazinecarbothioamide: a topoisomerase II alpha inhibitor; has antineoplastic activity; structure in first source		2.0610
3-aminopyridine-2-carboxaldehyde thiosemicarbazone
3-aminopyridine-2-carboxaldehyde thiosemicarbazone: a neuroprotective agent; structure given in first source		2.110
salicylaldehyde thiosemicarbazone
salicylaldehyde thiosemicarbazone: structure given in first source		2.0510
ConditionIndicatedRelationship StrengthStudiesTrials
B16 Melanoma
[description not available]		02.0510
Experimental Leukemia
[description not available]		01.9310
Leucocythaemia
[description not available]		02.910
Leukemia
A progressive, malignant disease of the blood-forming organs, characterized by distorted proliferation and development of leukocytes and their precursors in the blood and bone marrow. Leukemias were originally termed acute or chronic based on life expectancy but now are classified according to cellular maturity. Acute leukemias consist of predominately immature cells; chronic leukemias are composed of more mature cells. (From The Merck Manual, 2006)		02.910
Cancer of Colon
[description not available]		01.9910
Colonic Neoplasms
Tumors or cancer of the COLON.		01.9910