Compounds > 4-dodecylaminophenol
Page last updated: 2024-11-12

4-dodecylaminophenol

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Cross-References

ID SourceID
PubMed CID16043298
CHEMBL ID376316
SCHEMBL ID1953355
MeSH IDM0593122

Synonyms (11)

Synonym
bdbm50048084
4-(dodecylamino)phenol
CHEMBL376316 ,
p-dodecylaminophenol
SCHEMBL1953355
p-ddap
25848-37-7
STARBLD0002530
CS-0139755
HY-131724
AKOS040747254
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Protein Targets (1)

Inhibition Measurements

ProteinTaxonomyMeasurementAverageMin (ref.)Avg (ref.)Max (ref.)Bioassay(s)
Polyphenol oxidase 2Agaricus bisporusIC50 (µMol)200.00000.03403.987110.0000AID1181361; AID1181365
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Bioassays (117)

Assay IDTitleYearJournalArticle
AID1464493Growth inhibition of human IMR32 cells at 0.01 uM after 72 hrs by MTT assay relative to control
AID654495Downregulation of K-ras in human HuCCT1 cells at 2 uM after 72 hrs by agarose gel electrophoresis2012Bioorganic & medicinal chemistry, Apr-15, Volume: 20, Issue:8
Growth inhibition and mechanism of action of p-dodecylaminophenol against refractory human pancreatic cancer and cholangiocarcinoma.
AID1464521Induction of apoptosis in human IMR32 cells assessed as decrease in Bcl-2 mRNA expression level at 0.4 to 4 uM after 8 hrs by real-time PCR method
AID654487Cytotoxicity against human MIAPaCa2 cells after 72 hrs by MTT assay2012Bioorganic & medicinal chemistry, Apr-15, Volume: 20, Issue:8
Growth inhibition and mechanism of action of p-dodecylaminophenol against refractory human pancreatic cancer and cholangiocarcinoma.
AID1464492Growth inhibition of human IMR32 cells at 0.4 uM after 72 hrs by MTT assay relative to control
AID1181364Inhibition of mushroom tyrosinase using L-DOPA as substrate at 200 uM by spectrophotometry relative to control2014Bioorganic & medicinal chemistry, Aug-01, Volume: 22, Issue:15
Effect of p-aminophenols on tyrosinase activity.
AID1464536Cell cycle arrest in human SK-N-AS cells assessed as accumulation at G2/M phase at 0.4 uM after 8 hrs by propidium iodide staining based flow cytometry (Rvb = 25.31 +/- 2.89%)
AID654502Inhibition of Akt phosphorylation in human HuCCT1 cells assessed as reduction in phospho-Akt levels at 2 uM after 48 hrs by immunoblotting2012Bioorganic & medicinal chemistry, Apr-15, Volume: 20, Issue:8
Growth inhibition and mechanism of action of p-dodecylaminophenol against refractory human pancreatic cancer and cholangiocarcinoma.
AID1464515Induction of apoptosis in human SK-N-AS cells assessed as decrease in Bcl-2 mRNA expression level after 8 hrs by real-time PCR method
AID654489Cellular uptake in human MIAPaCa2 cells at 10 uM up to 30 mins by HPLC analysis2012Bioorganic & medicinal chemistry, Apr-15, Volume: 20, Issue:8
Growth inhibition and mechanism of action of p-dodecylaminophenol against refractory human pancreatic cancer and cholangiocarcinoma.
AID767629Inhibition of MMP9 activity in human HT1080 cells at 1 uM after 24 hrs2013Bioorganic & medicinal chemistry, Oct-01, Volume: 21, Issue:19
Inhibitory effects of p-dodecylaminophenol on the invasiveness of human fibrosarcoma cell line HT1080.
AID654494Downregulation of K-ras in human MIAPaCa2 cells at 7 uM after 72 hrs by agarose gel electrophoresis2012Bioorganic & medicinal chemistry, Apr-15, Volume: 20, Issue:8
Growth inhibition and mechanism of action of p-dodecylaminophenol against refractory human pancreatic cancer and cholangiocarcinoma.
AID284541Growth inhibition of human estrogen receptor expressing MCF7 cells at 4 uM after 68 hrs relative to control2007Bioorganic & medicinal chemistry, Jan-15, Volume: 15, Issue:2
Potent anticancer activities of novel aminophenol analogues against various cancer cell lines.
AID1181358Inhibition of mushroom tyrosinase using L-DOPA as substrate at 50 uM by spectrophotometry relative to control2014Bioorganic & medicinal chemistry, Aug-01, Volume: 22, Issue:15
Effect of p-aminophenols on tyrosinase activity.
AID1181362Inhibition of mushroom tyrosinase using L-DOPA as substrate at 25 uM by spectrophotometry relative to control2014Bioorganic & medicinal chemistry, Aug-01, Volume: 22, Issue:15
Effect of p-aminophenols on tyrosinase activity.
AID654648Induction of apoptosis in human HuCCT1 cells after 72 hrs2012Bioorganic & medicinal chemistry, Apr-15, Volume: 20, Issue:8
Growth inhibition and mechanism of action of p-dodecylaminophenol against refractory human pancreatic cancer and cholangiocarcinoma.
AID1464533Cell cycle arrest in human SK-N-AS cells assessed as accumulation at G0/G1 phase at 0.4 uM after 8 hrs by propidium iodide staining based flow cytometry (Rvb = 46.14 +/- 3.63%)
AID767624Reduction of MMP2 level in human HT1080 cells after 24 to 72 hrs by gelatin zymography analysis2013Bioorganic & medicinal chemistry, Oct-01, Volume: 21, Issue:19
Inhibitory effects of p-dodecylaminophenol on the invasiveness of human fibrosarcoma cell line HT1080.
AID1181365Inhibition of mushroom tyrosinase using L-DOPA as substrate by spectrophotometry relative to control2014Bioorganic & medicinal chemistry, Aug-01, Volume: 22, Issue:15
Effect of p-aminophenols on tyrosinase activity.
AID654501Inhibition of ERK phosphorylation in human HuCCT1 cells assessed as reduction in phospho-ERK levels at 2 uM after 48 hrs by immunoblotting2012Bioorganic & medicinal chemistry, Apr-15, Volume: 20, Issue:8
Growth inhibition and mechanism of action of p-dodecylaminophenol against refractory human pancreatic cancer and cholangiocarcinoma.
AID1464530Cell cycle arrest in human SK-N-AS cells assessed as accumulation at sub-G1 phase at 0.4 uM after 8 hrs by propidium iodide staining based flow cytometry (Rvb = 1.13 +/- 0.13%)
AID1464531Cell cycle arrest in human SK-N-AS cells assessed as accumulation at sub-G1 phase at 0.4 uM after 48 hrs by propidium iodide staining based flow cytometry (Rvb = 1.13 +/- 0.13%)
AID1181360Inhibition of mushroom tyrosinase using L-tyrosine as substrate at 200 uM by spectrophotometry relative to control2014Bioorganic & medicinal chemistry, Aug-01, Volume: 22, Issue:15
Effect of p-aminophenols on tyrosinase activity.
AID767639Cell cycle arrest in human HT1080 cells assessed as accumulation at S phase at 10 uM after 72 hrs using propidium iodide staining by FACS analysis relative to control2013Bioorganic & medicinal chemistry, Oct-01, Volume: 21, Issue:19
Inhibitory effects of p-dodecylaminophenol on the invasiveness of human fibrosarcoma cell line HT1080.
AID654482Growth inhibition of human MIAPaCa2 cells at 4 uM after 72 hrs by MTT assay relative to control2012Bioorganic & medicinal chemistry, Apr-15, Volume: 20, Issue:8
Growth inhibition and mechanism of action of p-dodecylaminophenol against refractory human pancreatic cancer and cholangiocarcinoma.
AID767635Induction of apoptosis in human HT1080 cells assessed as increase in caspase-3 activity at 4 uM relative to control2013Bioorganic & medicinal chemistry, Oct-01, Volume: 21, Issue:19
Inhibitory effects of p-dodecylaminophenol on the invasiveness of human fibrosarcoma cell line HT1080.
AID767632Induction of apoptosis in human HT1080 cells assessed as increase in caspase-3 activity at 1 uM relative to control2013Bioorganic & medicinal chemistry, Oct-01, Volume: 21, Issue:19
Inhibitory effects of p-dodecylaminophenol on the invasiveness of human fibrosarcoma cell line HT1080.
AID767647Induction of RECK mRNA expression in human HT1080 cells at 1 uM after 24 hrs by RT-PCR analysis relative to control2013Bioorganic & medicinal chemistry, Oct-01, Volume: 21, Issue:19
Inhibitory effects of p-dodecylaminophenol on the invasiveness of human fibrosarcoma cell line HT1080.
AID767634Cell cycle arrest in human HT1080 cells assessed as accumulation at S phase after 72 hrs using propidium iodide staining by FACS analysis2013Bioorganic & medicinal chemistry, Oct-01, Volume: 21, Issue:19
Inhibitory effects of p-dodecylaminophenol on the invasiveness of human fibrosarcoma cell line HT1080.
AID1464513Induction of apoptosis in human SK-N-AS cells assessed as increase in caspase-3 activity at 4 uM by CPP32 based colorimetric assay
AID1181372Non-competitive inhibition of mushroom tyrosinase using L-DOPA as substrate by Lineweaver-Burk double reciprocal plot method2014Bioorganic & medicinal chemistry, Aug-01, Volume: 22, Issue:15
Effect of p-aminophenols on tyrosinase activity.
AID1464502Cell cycle arrest in human SK-N-AS cells assessed as decrease in G2/M phase population at 0.4 uM after 72 hrs by propidium iodide staining based flow cytometry relative to control
AID1181361Inhibition of mushroom tyrosinase using L-tyrosine as substrate by spectrophotometry2014Bioorganic & medicinal chemistry, Aug-01, Volume: 22, Issue:15
Effect of p-aminophenols on tyrosinase activity.
AID1464524Reduction in N-myc mRNA expression level in human IMR32 cells at 0.4 to 4 uM after 8 hrs by real-time PCR method
AID767630Antiinvasive activity in human HT1080 cells assessed as reduction of cell number at 1 uM after 22 hrs by matrigel invasion assay2013Bioorganic & medicinal chemistry, Oct-01, Volume: 21, Issue:19
Inhibitory effects of p-dodecylaminophenol on the invasiveness of human fibrosarcoma cell line HT1080.
AID1187717Inhibition of lipid peroxidation in rat liver microsomes2014Bioorganic & medicinal chemistry, Sep-01, Volume: 22, Issue:17
Inhibitory effects of p-alkylaminophenol on melanogenesis.
AID767650Induction of RECK protein expression in human HT1080 cells after 24 hrs by electrophoresis analysis relative to control2013Bioorganic & medicinal chemistry, Oct-01, Volume: 21, Issue:19
Inhibitory effects of p-dodecylaminophenol on the invasiveness of human fibrosarcoma cell line HT1080.
AID767642Cell cycle arrest in human HT1080 cells assessed as accumulation at G0/G1 phase at 10 uM after 72 hrs using propidium iodide staining by FACS analysis relative to control2013Bioorganic & medicinal chemistry, Oct-01, Volume: 21, Issue:19
Inhibitory effects of p-dodecylaminophenol on the invasiveness of human fibrosarcoma cell line HT1080.
AID284543Growth inhibition of human HepG2 cells at 4 uM after 68 hrs relative to control2007Bioorganic & medicinal chemistry, Jan-15, Volume: 15, Issue:2
Potent anticancer activities of novel aminophenol analogues against various cancer cell lines.
AID654496Downregulation of K-ras in human HuCCT1 cells at 6 uM after 72 hrs by agarose gel electrophoresis2012Bioorganic & medicinal chemistry, Apr-15, Volume: 20, Issue:8
Growth inhibition and mechanism of action of p-dodecylaminophenol against refractory human pancreatic cancer and cholangiocarcinoma.
AID1464487Growth inhibition of human SK-N-AS cells by MTT assay
AID767627Reduction of MMP9 level in human HT1080 cells after 24 to 72 hrs by gelatin zymography analysis2013Bioorganic & medicinal chemistry, Oct-01, Volume: 21, Issue:19
Inhibitory effects of p-dodecylaminophenol on the invasiveness of human fibrosarcoma cell line HT1080.
AID1464522Reduction in N-myc mRNA expression level in human IMR32 cells at 4 uM after 24 hrs by real-time PCR method relative to control
AID767646Reduction of MMP2 mRNA level in human HT1080 cells at 1 uM after 24 hrs by RT-PCR analysis relative to control2013Bioorganic & medicinal chemistry, Oct-01, Volume: 21, Issue:19
Inhibitory effects of p-dodecylaminophenol on the invasiveness of human fibrosarcoma cell line HT1080.
AID1181363Inhibition of mushroom tyrosinase using L-DOPA as substrate at 100 uM by spectrophotometry relative to control2014Bioorganic & medicinal chemistry, Aug-01, Volume: 22, Issue:15
Effect of p-aminophenols on tyrosinase activity.
AID767644Cell cycle arrest in human HT1080 cells assessed as accumulation at G0/G1 phase at 1 uM after 72 hrs using propidium iodide staining by FACS analysis relative to control2013Bioorganic & medicinal chemistry, Oct-01, Volume: 21, Issue:19
Inhibitory effects of p-dodecylaminophenol on the invasiveness of human fibrosarcoma cell line HT1080.
AID654484Growth inhibition of human HuCCT1 cells at 4 uM after 72 hrs by MTT assay relative to control2012Bioorganic & medicinal chemistry, Apr-15, Volume: 20, Issue:8
Growth inhibition and mechanism of action of p-dodecylaminophenol against refractory human pancreatic cancer and cholangiocarcinoma.
AID767636Cell cycle arrest in human HT1080 cells assessed as accumulation at G2/M phase at 10 uM after 72 hrs using propidium iodide staining by FACS analysis relative to control2013Bioorganic & medicinal chemistry, Oct-01, Volume: 21, Issue:19
Inhibitory effects of p-dodecylaminophenol on the invasiveness of human fibrosarcoma cell line HT1080.
AID654498Downregulation of N-ras in human HuCCT1 cells at 2 uM after 72 hrs by agarose gel electrophoresis2012Bioorganic & medicinal chemistry, Apr-15, Volume: 20, Issue:8
Growth inhibition and mechanism of action of p-dodecylaminophenol against refractory human pancreatic cancer and cholangiocarcinoma.
AID1464501Cell cycle arrest in human SK-N-AS cells assessed as decrease in G2/M phase population at 0.4 uM after 48 hrs by propidium iodide staining based flow cytometry relative to control
AID1464529Toxicity in specific-pathogen-free KSN athymic nude mouse xenografted with human SK-N-AS cells assessed as change in body weight at 12.5 to 50 mg/kg/day administered ip for 2 weeks measured on day 21
AID1464516Induction of apoptosis in human SK-N-AS cells assessed as decrease in Bcl-2 mRNA expression level at 0.4 uM after 24 hrs by real-time PCR method relative to control
AID1464514Induction of apoptosis in human SK-N-AS cells assessed as decrease in Bcl-2 mRNA expression level after 24 hrs by real-time PCR method
AID1464490Growth inhibition of human IMR32 cells at 0.1 uM after 24 hrs by MTT assay relative to control
AID767645Cytotoxicity against human HT1080 cells assessed as growth inhibition after 72 hrs by trypan blue dye exclusion assay2013Bioorganic & medicinal chemistry, Oct-01, Volume: 21, Issue:19
Inhibitory effects of p-dodecylaminophenol on the invasiveness of human fibrosarcoma cell line HT1080.
AID1464520Induction of apoptosis in human IMR32 cells assessed as decrease in Bcl-2 mRNA expression level at 0.4 to 4 uM after 24 hrs by real-time PCR method relative to control
AID284544Growth inhibition of human DU145 cells at 4 uM after 68 hrs relative to control2007Bioorganic & medicinal chemistry, Jan-15, Volume: 15, Issue:2
Potent anticancer activities of novel aminophenol analogues against various cancer cell lines.
AID767649Induction of RECK protein expression in human HT1080 cells at 4 uM after 24 hrs by electrophoresis analysis relative to control2013Bioorganic & medicinal chemistry, Oct-01, Volume: 21, Issue:19
Inhibitory effects of p-dodecylaminophenol on the invasiveness of human fibrosarcoma cell line HT1080.
AID767641Cell cycle arrest in human HT1080 cells assessed as accumulation at S phase at 1 uM after 72 hrs using propidium iodide staining by FACS analysis relative to control2013Bioorganic & medicinal chemistry, Oct-01, Volume: 21, Issue:19
Inhibitory effects of p-dodecylaminophenol on the invasiveness of human fibrosarcoma cell line HT1080.
AID767633Induction of apoptosis in human HT1080 cells assessed as increase in caspase-3 activity at 10 uM relative to control2013Bioorganic & medicinal chemistry, Oct-01, Volume: 21, Issue:19
Inhibitory effects of p-dodecylaminophenol on the invasiveness of human fibrosarcoma cell line HT1080.
AID654492Ratio of drug level in human MIAPaCa2 cells to human HuCCT1 cells at 30 mins2012Bioorganic & medicinal chemistry, Apr-15, Volume: 20, Issue:8
Growth inhibition and mechanism of action of p-dodecylaminophenol against refractory human pancreatic cancer and cholangiocarcinoma.
AID1464525Antitumor activity against human SK-N-AS cells xenografted in specific-pathogen-free KSN athymic nude mouse assessed as tumor growth inhibition at 12.5 mg/kg/day administered ip for 2 weeks measured on day 21 relative to control
AID284545Growth inhibition of human HL60 cells at 4 uM after 72 hrs relative to control2007Bioorganic & medicinal chemistry, Jan-15, Volume: 15, Issue:2
Potent anticancer activities of novel aminophenol analogues against various cancer cell lines.
AID1187701Inhibition of tyrosinase in mouse B16 cells using L-DOPA as substrate preincubated at 50 uM for 10 mins by spectrophotometry relative to control2014Bioorganic & medicinal chemistry, Sep-01, Volume: 22, Issue:17
Inhibitory effects of p-alkylaminophenol on melanogenesis.
AID1464496Cell cycle arrest in human SK-N-AS cells assessed as increase in G0/G1 cell population at 0.4 uM after 24 hrs by propidium iodide staining based flow cytometry relative to control
AID1464526Antitumor activity against human SK-N-AS cells xenografted in specific-pathogen-free KSN athymic nude mouse assessed as tumor growth inhibition at 50 mg/kg/day administered ip for 2 weeks measured on day 21 relative to control
AID1464532Cell cycle arrest in human SK-N-AS cells assessed as accumulation at sub-G1 phase at 0.4 uM after 72 hrs by propidium iodide staining based flow cytometry (Rvb = 1.13 +/- 0.13%)
AID654491Cellular uptake in human HuCCT1 cells at 10 uM measured after 30 mins up to 60 mins2012Bioorganic & medicinal chemistry, Apr-15, Volume: 20, Issue:8
Growth inhibition and mechanism of action of p-dodecylaminophenol against refractory human pancreatic cancer and cholangiocarcinoma.
AID1464509Induction of apoptosis in human SK-N-AS cells assessed as increase in caspase-3 activity at 4 uM after 8 hrs by CPP32 based colorimetric assay relative to control
AID767623Reduction of MMP9 mRNA level in human HT1080 cells at 1 uM after 24 hrs by RT-PCR analysis relative to control2013Bioorganic & medicinal chemistry, Oct-01, Volume: 21, Issue:19
Inhibitory effects of p-dodecylaminophenol on the invasiveness of human fibrosarcoma cell line HT1080.
AID1464508Induction of apoptosis in human SK-N-AS cells assessed as increase in caspase-3 activity at 0.4 uM after 8 hrs by CPP32 based colorimetric assay relative to control
AID1464505Cell cycle arrest in human SK-N-AS cells assessed as increase in sub-G1 phase population at 0.4 uM after 24 hrs by propidium iodide staining based flow cytometry relative to control
AID1464528Antitumor activity against human SK-N-AS cells xenografted in specific-pathogen-free KSN athymic nude mouse assessed as decrease in tumor weight at 50 mg/kg/day administered ip for 2 weeks measured on day 21 relative to control
AID654483Growth inhibition of human MIAPaCa2 cells at 10 uM after 72 hrs by MTT assay relative to control2012Bioorganic & medicinal chemistry, Apr-15, Volume: 20, Issue:8
Growth inhibition and mechanism of action of p-dodecylaminophenol against refractory human pancreatic cancer and cholangiocarcinoma.
AID1464511Induction of apoptosis in human SK-N-AS cells assessed as increase in caspase-3 activity at 4 uM after 24 hrs by CPP32 based colorimetric assay relative to control
AID1464534Cell cycle arrest in human SK-N-AS cells assessed as accumulation at S phase at 0.4 uM after 8 hrs by propidium iodide staining based flow cytometry (Rvb = 28.55 +/- 0.74%)
AID767651Cytotoxicity against human HT1080 cells assessed as growth inhibition at 4 to 10 uM after 72 hrs by trypan blue dye exclusion assay relative to control2013Bioorganic & medicinal chemistry, Oct-01, Volume: 21, Issue:19
Inhibitory effects of p-dodecylaminophenol on the invasiveness of human fibrosarcoma cell line HT1080.
AID1464504Cell cycle arrest in human SK-N-AS cells at 4 uM by propidium iodide staining based flow cytometry
AID1181359Inhibition of mushroom tyrosinase using L-tyrosine as substrate at 100 uM by spectrophotometry relative to control2014Bioorganic & medicinal chemistry, Aug-01, Volume: 22, Issue:15
Effect of p-aminophenols on tyrosinase activity.
AID1181371Non-competitive inhibition of mushroom tyrosinase using L-tyrosine as substrate by Lineweaver-Burk double reciprocal plot method2014Bioorganic & medicinal chemistry, Aug-01, Volume: 22, Issue:15
Effect of p-aminophenols on tyrosinase activity.
AID767637Cell cycle arrest in human HT1080 cells assessed as accumulation at G2/M phase at 4 uM after 72 hrs using propidium iodide staining by FACS analysis relative to control2013Bioorganic & medicinal chemistry, Oct-01, Volume: 21, Issue:19
Inhibitory effects of p-dodecylaminophenol on the invasiveness of human fibrosarcoma cell line HT1080.
AID654488Cytotoxicity against human HuCCT1 cells after 72 hrs by MTT assay2012Bioorganic & medicinal chemistry, Apr-15, Volume: 20, Issue:8
Growth inhibition and mechanism of action of p-dodecylaminophenol against refractory human pancreatic cancer and cholangiocarcinoma.
AID1464498Cell cycle arrest in human SK-N-AS cells assessed as increase in G0/G1 cell population at 0.4 uM after 72 hrs by propidium iodide staining based flow cytometry relative to control
AID767643Cell cycle arrest in human HT1080 cells assessed as accumulation at G0/G1 phase at 4 uM after 72 hrs using propidium iodide staining by FACS analysis relative to control2013Bioorganic & medicinal chemistry, Oct-01, Volume: 21, Issue:19
Inhibitory effects of p-dodecylaminophenol on the invasiveness of human fibrosarcoma cell line HT1080.
AID654490Cellular uptake in human HuCCT1 cells at 10 uM up to 30 mins by HPLC analysis2012Bioorganic & medicinal chemistry, Apr-15, Volume: 20, Issue:8
Growth inhibition and mechanism of action of p-dodecylaminophenol against refractory human pancreatic cancer and cholangiocarcinoma.
AID284546Induction of apoptosis in human HL60 cells assessed as DNA fragmentation at 4 uM after 20 hrs2007Bioorganic & medicinal chemistry, Jan-15, Volume: 15, Issue:2
Potent anticancer activities of novel aminophenol analogues against various cancer cell lines.
AID1464506Cell cycle arrest in human SK-N-AS cells assessed as increase in sub-G1 phase population at 4 uM after 24 hrs by propidium iodide staining based flow cytometry relative to control
AID767648Induction of RECK protein expression in human HT1080 cells at 1 uM after 24 hrs by electrophoresis analysis relative to control2013Bioorganic & medicinal chemistry, Oct-01, Volume: 21, Issue:19
Inhibitory effects of p-dodecylaminophenol on the invasiveness of human fibrosarcoma cell line HT1080.
AID1464510Induction of apoptosis in human SK-N-AS cells assessed as increase in caspase-3 activity at 0.4 uM after 24 hrs by CPP32 based colorimetric assay relative to control
AID284542Growth inhibition of human estrogen receptor deficient adriamycin-resistant MCF7 cells at 4 uM after 68 hrs relative to control2007Bioorganic & medicinal chemistry, Jan-15, Volume: 15, Issue:2
Potent anticancer activities of novel aminophenol analogues against various cancer cell lines.
AID767626Reduction of proMMP9 level in human HT1080 cells after 24 to 72 hrs by gelatin zymography analysis2013Bioorganic & medicinal chemistry, Oct-01, Volume: 21, Issue:19
Inhibitory effects of p-dodecylaminophenol on the invasiveness of human fibrosarcoma cell line HT1080.
AID767631Toxicity in human HT1080 cells assessed as reduction of cell growth at 1 uM after 24 hrs2013Bioorganic & medicinal chemistry, Oct-01, Volume: 21, Issue:19
Inhibitory effects of p-dodecylaminophenol on the invasiveness of human fibrosarcoma cell line HT1080.
AID1464527Antitumor activity against human SK-N-AS cells xenografted in specific-pathogen-free KSN athymic nude mouse assessed as decrease in tumor weight at 12.5 mg/kg/day administered ip for 2 weeks measured on day 21 relative to control
AID654646Growth inhibition of human HuCCT1 cells at 1 uM after 72 hrs by MTT assay relative to control2012Bioorganic & medicinal chemistry, Apr-15, Volume: 20, Issue:8
Growth inhibition and mechanism of action of p-dodecylaminophenol against refractory human pancreatic cancer and cholangiocarcinoma.
AID654503Inhibition of Akt phosphorylation in human MIAPaCa2 cells assessed as effect on phospho-ERK levels at 10 uM after 48 hrs by immunoblotting2012Bioorganic & medicinal chemistry, Apr-15, Volume: 20, Issue:8
Growth inhibition and mechanism of action of p-dodecylaminophenol against refractory human pancreatic cancer and cholangiocarcinoma.
AID767625Reduction of proMMP2 level in human HT1080 cells after 24 to 72 hrs by gelatin zymography analysis2013Bioorganic & medicinal chemistry, Oct-01, Volume: 21, Issue:19
Inhibitory effects of p-dodecylaminophenol on the invasiveness of human fibrosarcoma cell line HT1080.
AID1464488Growth inhibition of human SK-N-AS cells at 1 uM after 24 hrs by MTT assay relative to control
AID1464491Growth inhibition of human IMR32 cells at 0.1 uM after 72 hrs by MTT assay relative to control
AID654500Inhibition of ERK phosphorylation in human MIAPaCa2 cells assessed as reduction in phospho-ERK levels at 10 uM after 48 hrs by immunoblotting2012Bioorganic & medicinal chemistry, Apr-15, Volume: 20, Issue:8
Growth inhibition and mechanism of action of p-dodecylaminophenol against refractory human pancreatic cancer and cholangiocarcinoma.
AID1464517Induction of apoptosis in human SK-N-AS cells assessed as decrease in Bcl-2 mRNA expression level at 4 uM after 24 hrs by real-time PCR method relative to control
AID654485Growth inhibition of human HuCCT1 cells at 10 uM after 72 hrs by MTT assay relative to control2012Bioorganic & medicinal chemistry, Apr-15, Volume: 20, Issue:8
Growth inhibition and mechanism of action of p-dodecylaminophenol against refractory human pancreatic cancer and cholangiocarcinoma.
AID1464497Cell cycle arrest in human SK-N-AS cells assessed as increase in G0/G1 cell population at 0.4 uM after 48 hrs by propidium iodide staining based flow cytometry relative to control
AID654497Downregulation of H-ras in human HuCCT1 cells at 2 uM after 72 hrs by agarose gel electrophoresis2012Bioorganic & medicinal chemistry, Apr-15, Volume: 20, Issue:8
Growth inhibition and mechanism of action of p-dodecylaminophenol against refractory human pancreatic cancer and cholangiocarcinoma.
AID1464500Cell cycle arrest in human SK-N-AS cells assessed as decrease in S phase population at 0.4 uM after 48 hrs by propidium iodide staining based flow cytometry relative to control
AID1464489Growth inhibition of human SK-N-AS cells at 1 uM after 72 hrs by MTT assay relative to control
AID654647Induction of apoptosis in human MIAPaCa2 cells after 72 hrs2012Bioorganic & medicinal chemistry, Apr-15, Volume: 20, Issue:8
Growth inhibition and mechanism of action of p-dodecylaminophenol against refractory human pancreatic cancer and cholangiocarcinoma.
AID767652Cytotoxicity against human MIAPaCa2 cells2013Bioorganic & medicinal chemistry, Oct-01, Volume: 21, Issue:19
Inhibitory effects of p-dodecylaminophenol on the invasiveness of human fibrosarcoma cell line HT1080.
AID1464537Cell cycle arrest in human SK-N-AS cells assessed as accumulation at G2/M phase at 0.4 uM after 24 hrs by propidium iodide staining based flow cytometry (Rvb = 25.31 +/- 2.89%)
AID767628Inhibition of MMP2 activity in human HT1080 cells at 1 uM after 24 hrs2013Bioorganic & medicinal chemistry, Oct-01, Volume: 21, Issue:19
Inhibitory effects of p-dodecylaminophenol on the invasiveness of human fibrosarcoma cell line HT1080.
AID1181357Inhibition of mushroom tyrosinase using L-tyrosine as substrate at 50 uM by spectrophotometry relative to control2014Bioorganic & medicinal chemistry, Aug-01, Volume: 22, Issue:15
Effect of p-aminophenols on tyrosinase activity.
AID654493Downregulation of K-ras in human MIAPaCa2 cells at 10 uM after 72 hrs by agarose gel electrophoresis2012Bioorganic & medicinal chemistry, Apr-15, Volume: 20, Issue:8
Growth inhibition and mechanism of action of p-dodecylaminophenol against refractory human pancreatic cancer and cholangiocarcinoma.
AID767619Cytotoxicity against human HuCCT1 cells2013Bioorganic & medicinal chemistry, Oct-01, Volume: 21, Issue:19
Inhibitory effects of p-dodecylaminophenol on the invasiveness of human fibrosarcoma cell line HT1080.
AID654486Growth inhibition of human MIAPaCa2 cells at 1 uM after 72 hrs by MTT assay2012Bioorganic & medicinal chemistry, Apr-15, Volume: 20, Issue:8
Growth inhibition and mechanism of action of p-dodecylaminophenol against refractory human pancreatic cancer and cholangiocarcinoma.
AID1464535Cell cycle arrest in human SK-N-AS cells assessed as accumulation at S phase at 0.4 uM after 72 hrs by propidium iodide staining based flow cytometry (Rvb = 28.55 +/- 0.74%)
AID1464499Cell cycle arrest in human SK-N-AS cells assessed as decrease in S phase population at 0.4 uM after 24 hrs by propidium iodide staining based flow cytometry relative to control
AID767638Cell cycle arrest in human HT1080 cells assessed as accumulation at G2/M phase at 1 uM after 72 hrs using propidium iodide staining by FACS analysis relative to control2013Bioorganic & medicinal chemistry, Oct-01, Volume: 21, Issue:19
Inhibitory effects of p-dodecylaminophenol on the invasiveness of human fibrosarcoma cell line HT1080.
AID767640Cell cycle arrest in human HT1080 cells assessed as accumulation at S phase at 4 uM after 72 hrs using propidium iodide staining by FACS analysis relative to control2013Bioorganic & medicinal chemistry, Oct-01, Volume: 21, Issue:19
Inhibitory effects of p-dodecylaminophenol on the invasiveness of human fibrosarcoma cell line HT1080.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (6)

TimeframeStudies, This Drug (%)All Drugs %
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's1 (16.67)29.6817
2010's5 (83.33)24.3611
2020's0 (0.00)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 13.13

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be weak demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index13.13 (24.57)
Research Supply Index1.95 (2.92)
Research Growth Index5.08 (4.65)
Search Engine Demand Index0.00 (26.88)
Search Engine Supply Index0.00 (0.95)

This Compound (13.13)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews0 (0.00%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other6 (100.00%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]
SubstanceRelationship StrengthStudiesTrialsClassesRoles
fasudil
fasudil: intracellular calcium antagonist; structure in first source. fasudil : An isoquinoline substituted by a (1,4-diazepan-1-yl)sulfonyl group at position 5. It is a Rho-kinase inhibitor and its hydrochloride hydrate form is approved for the treatment of cerebral vasospasm and cerebral ischemia.		2.0810isoquinolines;
N-sulfonyldiazepane		antihypertensive agent;
calcium channel blocker;
EC 2.7.11.1 (non-specific serine/threonine protein kinase) inhibitor;
geroprotector;
neuroprotective agent;
nootropic agent;
vasodilator agent
kojic acid
[no description available]		2.5204-pyranones;
enol;
primary alcohol		Aspergillus metabolite;
EC 1.10.3.1 (catechol oxidase) inhibitor;
EC 1.10.3.2 (laccase) inhibitor;
EC 1.13.11.24 (quercetin 2,3-dioxygenase) inhibitor;
EC 1.14.18.1 (tyrosinase) inhibitor;
EC 1.4.3.3 (D-amino-acid oxidase) inhibitor;
NF-kappaB inhibitor;
skin lightening agent
vorinostat
Vorinostat: A hydroxamic acid and anilide derivative that acts as a HISTONE DEACETYLASE inhibitor. It is used in the treatment of CUTANEOUS T-CELL LYMPHOMA and SEZARY SYNDROME.. vorinostat : A dicarboxylic acid diamide comprising suberic (octanedioic) acid coupled to aniline and hydroxylamine. A histone deacetylase inhibitor, it is marketed under the name Zolinza for the treatment of cutaneous T cell lymphoma (CTCL).		2.0810dicarboxylic acid diamide;
hydroxamic acid		antineoplastic agent;
apoptosis inducer;
EC 3.5.1.98 (histone deacetylase) inhibitor
tretinoin
Tretinoin: An important regulator of GENE EXPRESSION during growth and development, and in NEOPLASMS. Tretinoin, also known as retinoic acid and derived from maternal VITAMIN A, is essential for normal GROWTH; and EMBRYONIC DEVELOPMENT. An excess of tretinoin can be teratogenic. It is used in the treatment of PSORIASIS; ACNE VULGARIS; and several other SKIN DISEASES. It has also been approved for use in promyelocytic leukemia (LEUKEMIA, PROMYELOCYTIC, ACUTE).. retinoic acid : A retinoid consisting of 3,7-dimethylnona-2,4,6,8-tetraenoic acid substituted at position 9 by a 2,6,6-trimethylcyclohex-1-en-1-yl group (geometry of the four exocyclic double bonds is not specified).. all-trans-retinoic acid : A retinoic acid in which all four exocyclic double bonds have E- (trans-) geometry.		3.1750retinoic acid;
vitamin A		anti-inflammatory agent;
antineoplastic agent;
antioxidant;
AP-1 antagonist;
human metabolite;
keratolytic drug;
retinoic acid receptor agonist;
retinoid X receptor agonist;
signalling molecule
ha 1100
HA 1100: intracellular calcium antagonist		2.0810
silybin
[no description available]		2.0810
fenretinide
Fenretinide: A synthetic retinoid that is used orally as a chemopreventive against prostate cancer and in women at risk of developing contralateral breast cancer. It is also effective as an antineoplastic agent.. 4-hydroxyphenyl retinamide : A retinoid obtained by formal condensation of the carboxy group of all-trans retinoic acid and the anilino group of 4-hydroxyaniline. Synthetic retinoid agonist. Antiproliferative, antioxidant and anticancer agent with a long half-life in vivo. Apoptotic effects appear to be mediated by a mechanism distinct from that of 'classical' retinoids.		3.1750monocarboxylic acid amide;
retinoid		antineoplastic agent;
antioxidant
p-decylaminophenol
p-decylaminophenol: a melanogenesis inhibitor; structure in first source		2.9940
ConditionIndicatedRelationship StrengthStudiesTrials
Breast Cancer
[description not available]		02.0310
Cancer of Prostate
[description not available]		02.0310
Breast Neoplasms
Tumors or cancer of the human BREAST.		02.0310
Prostatic Neoplasms
Tumors or cancer of the PROSTATE.		02.0310
Cholangiocellular Carcinoma
[description not available]		02.0710
Cancer of Pancreas
[description not available]		02.0710
Pancreatic Neoplasms
Tumors or cancer of the PANCREAS. Depending on the types of ISLET CELLS present in the tumors, various hormones can be secreted: GLUCAGON from PANCREATIC ALPHA CELLS; INSULIN from PANCREATIC BETA CELLS; and SOMATOSTATIN from the SOMATOSTATIN-SECRETING CELLS. Most are malignant except the insulin-producing tumors (INSULINOMA).		02.0710
Cholangiocarcinoma
A malignant tumor arising from the epithelium of the BILE DUCTS.		02.0710
Invasiveness, Neoplasm
[description not available]		02.0810
Fibrosarcoma
A sarcoma derived from deep fibrous tissue, characterized by bundles of immature proliferating fibroblasts with variable collagen formation, which tends to invade locally and metastasize by the bloodstream. (Stedman, 25th ed)		02.0810