Compounds > 6-methyl-3-phenethyl-3,4-dihydro-1h-quinazoline-2-thione

Page last updated: 2024-11-12

6-methyl-3-phenethyl-3,4-dihydro-1h-quinazoline-2-thione

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth

Description

6-methyl-3-phenethyl-3,4-dihydro-1H-quinazoline-2-thione: structure in first source [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

Cross-References

ID Source	ID
PubMed CID	11448938
CHEMBL ID	591208
SCHEMBL ID	6240249
MeSH ID	M0527486

Synonyms (6)

Synonym
CHEMBL591208 ,
bdbm50356184
6-methyl-3-phenethyl-3,4-dihydro-1h-quinazoline-2-thione
SCHEMBL6240249
3-phenethyl-6-methyl-1,2,3,4-tetrahydroquinazoline-2-thione
6-methyl-3-(2-phenylethyl)-1,4-dihydroquinazoline-2-thione

[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Protein Targets (1)

Inhibition Measurements

Protein	Taxonomy	Measurement	Average	Min (ref.)	Avg (ref.)	Max (ref.)	Bioassay(s)
Polyphenol oxidase 2	Agaricus bisporus	IC50 (µMol)	100.0000	0.0340	3.9871	10.0000	AID626570
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Bioassays (6)

Assay ID	Title	Year	Journal	Article
AID626572	Inhibition of alpha-MSH -stimulated melanogenesis in mouse B16 cells assessed as melanin release after 72 hrs by spectrometric analysis	2011	Bioorganic & medicinal chemistry letters, Nov-15, Volume: 21, Issue:22	Structural requirement of phenylthiourea analogs for their inhibitory activity of melanogenesis and tyrosinase.
AID457968	Inhibition of alpha-MSH-induced melanin production in mouse B16 cells after 72 hrs	2010	Bioorganic & medicinal chemistry, Feb-15, Volume: 18, Issue:4	Evaluation of 3,4-dihydroquinazoline-2(1H)-thiones as inhibitors of alpha-MSH-induced melanin production in melanoma B16 cells.
AID457970	Inhibition of alpha-MSH-induced melanin production in mouse B16 cells at 10 uM after 72 hrs	2010	Bioorganic & medicinal chemistry, Feb-15, Volume: 18, Issue:4	Evaluation of 3,4-dihydroquinazoline-2(1H)-thiones as inhibitors of alpha-MSH-induced melanin production in melanoma B16 cells.
AID494971	Antimelanogenic activity in mouse B16 cells assessed as inhibition of alpha-MSH-induced melanogenesis	2010	Bioorganic & medicinal chemistry letters, Aug-15, Volume: 20, Issue:16	Refinement of the pharmacophore of 3,4-dihydroquinazoline-2(1H)-thiones for their anti-melanogenesis activity.
AID626570	Inhibition of mushroom tyrosinase activity using L-tyrosine as substrate by spectrometric analysis	2011	Bioorganic & medicinal chemistry letters, Nov-15, Volume: 21, Issue:22	Structural requirement of phenylthiourea analogs for their inhibitory activity of melanogenesis and tyrosinase.
AID460789	Inhibition of alpha-MSH-induced melanin production in mouse B16 cells after 72 hrs	2010	Bioorganic & medicinal chemistry, Feb, Volume: 18, Issue:3	Inhibitory effect of novel tetrahydropyrimidine-2(1H)-thiones on melanogenesis.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (5)

Timeframe	Studies, This Drug (%)	All Drugs %
pre-1990	0 (0.00)	18.7374
1990's	0 (0.00)	18.2507
2000's	1 (20.00)	29.6817
2010's	4 (80.00)	24.3611
2020's	0 (0.00)	2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Study Types

Publication Type	This drug (%)	All Drugs (%)
Trials	0 (0.00%)	5.53%
Reviews	0 (0.00%)	6.00%
Case Studies	0 (0.00%)	4.05%
Observational	0 (0.00%)	0.25%
Other	6 (100.00%)	84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Substance	Relationship Strength	Studies	Trials	Classes	Roles
kojic acid [no description available]	2.75	3	0	4-pyranones; enol; primary alcohol	Aspergillus metabolite; EC 1.10.3.1 (catechol oxidase) inhibitor; EC 1.10.3.2 (laccase) inhibitor; EC 1.13.11.24 (quercetin 2,3-dioxygenase) inhibitor; EC 1.14.18.1 (tyrosinase) inhibitor; EC 1.4.3.3 (D-amino-acid oxidase) inhibitor; NF-kappaB inhibitor; skin lightening agent
n-phenylurea [no description available]	2.46	2	0	ureas
quinazolines Quinazolines: A group of aromatic heterocyclic compounds that contain a bicyclic structure with two fused six-membered aromatic rings, a benzene ring and a pyrimidine ring.. quinazoline : A mancude organic heterobicyclic parent that is naphthalene in which the carbon atoms at positions 1 and 3 have been replaced by nitrogen atoms.. quinazolines : Any organic heterobicyclic compound based on a quinazoline skeleton and its substituted derivatives.	2.04	1	0	azaarene; mancude organic heterobicyclic parent; ortho-fused heteroarene; quinazolines
arbutin hydroquinone O-beta-D-glucopyranoside : A monosaccharide derivative that is hydroquinone attached to a beta-D-glucopyranosyl residue at position 4 via a glycosidic linkage.	2.75	3	0	beta-D-glucoside; monosaccharide derivative	Escherichia coli metabolite; plant metabolite
phenylthiourea Phenylthiourea: Phenylthiourea is a THIOUREA derivative containing a phenyl ring. Depending on their genetic makeup, humans can find it either bitter-tasting or tasteless.. N-phenylthiourea : A member of the class of thioureas that is thiourea in which one of the hydrogens is replaced by a phenyl group. Depending on their genetic makeup, humans find it either very bitter-tasting or tasteless. This unusual property resulted in N-phenylthiourea being used in paternity testing prior to the advent of DNA testing.	2.75	3	0	thioureas	EC 1.14.18.1 (tyrosinase) inhibitor
diphenylthiourea N,N'-diphenylthiourea : Thiourea in which each nitrogen carries a phenyl substituent.	2.06	1	0	thioureas	allergen
benzylthiourea [no description available]	2.06	1	0
1-[(4-methylphenyl)methyl]-1,3-diazinan-2-one [no description available]	2.05	1	0	pyrimidone; ureas