Page last updated: 2024-12-07

2-mercaptoimidazole

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth

Cross-References

ID SourceID
PubMed CID1201386
CHEMBL ID3260774
SCHEMBL ID116
MeSH IDM0207482

Synonyms (56)

Synonym
1h-imidazolethiol
mercaptoimidazole
49556-19-6
2h-imidazole-2-thione, 1,3-dihydro-
einecs 212-823-4
nsc 112715
ai3-61065
2-imidazolethiol
nsc-112715
1,3-vinylenethiourea
1h-imidazole-2-thiol
wln: t5m cnj bsh
nsc112715
imidazole, 2-mercapto-
4-imidazoline-2-thione
imidazole-2-thiol
2-mercaptoimidazole ,
2-thioxo-2,3-dihydroimidazole
usaf el-57
872-35-5
2h-imidazole-2-thione,3-dihydro-
AP-836/41220351
inchi=1/c3h4n2s/c6-3-4-1-2-5-3/h1-2h,(h2,4,5,6
2-mercaptoimidazole, 98%
EN300-87124
fd37bld6l2 ,
unii-fd37bld6l2
AKOS006227877
1,3-dihydroimidazole-2-thione
FT-0612765
AB00386
AKOS015856745
2-mercapto-1h-imidazole
2-sulphanyl-1h-imidazole
CHEMBL3260774 ,
STL476661
82358-15-4
1h-imidazole-2(3h)-thione
SCHEMBL116
2,3-dihydro-1h-imidazole-2-thione
J-504670
2-mercapto-imidazole
1h-imidazol-2-thiol
1,3-dihydro-imidazole-2-thione
2,3-dihydro-1h-imidazol-2-thione
DTXSID6061236
1,3-dihydro-2h-imidazole-2-thione
PS-9324
mfcd00005188
F8889-0227
1-imidazole-2(3h)-thione
2-imidazolemercaptan
Q27463637
bdbm50497083
CS-W016653
Z1198723329
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Protein Targets (1)

Inhibition Measurements

ProteinTaxonomyMeasurementAverageMin (ref.)Avg (ref.)Max (ref.)Bioassay(s)
Polyphenol oxidase 2Agaricus bisporusIC50 (µMol)4,110.00000.03403.987110.0000AID1139760
Polyphenol oxidase 2Agaricus bisporusKi570.00000.00063.28838.8900AID1139761
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Other Measurements

ProteinTaxonomyMeasurementAverageMin (ref.)Avg (ref.)Max (ref.)Bioassay(s)
Polyphenol oxidase 2Agaricus bisporusKis2,800.00002.90005.33008.8500AID1139762
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Bioassays (5)

Assay IDTitleYearJournalArticle
AID1139762Mixed-type inhibition of mushroom tyrosinase-mediated L-tyrosine oxidation assessed as enzyme-substrate-inhibitor complex after 10 mins by Lineweaver-Burk plot analysis2014Bioorganic & medicinal chemistry, May-01, Volume: 22, Issue:9
Inhibitory effects of novel synthetic methimazole derivatives on mushroom tyrosinase and melanogenesis.
AID1139760Inhibition of mushroom tyrosinase-mediated L-tyrosine hydroxylation after 30 mins by ELISA2014Bioorganic & medicinal chemistry, May-01, Volume: 22, Issue:9
Inhibitory effects of novel synthetic methimazole derivatives on mushroom tyrosinase and melanogenesis.
AID1139767Antimelanogenic activity in mouse B16/F10 cells assessed as inhibition of alpha-MSH-induced melanin formation at 1 mM after 24 hrs by ELISA relative to control2014Bioorganic & medicinal chemistry, May-01, Volume: 22, Issue:9
Inhibitory effects of novel synthetic methimazole derivatives on mushroom tyrosinase and melanogenesis.
AID1139765Cytotoxicity against mouse B16/F10 cells at 1 mM after 24 hrs by MTT assay2014Bioorganic & medicinal chemistry, May-01, Volume: 22, Issue:9
Inhibitory effects of novel synthetic methimazole derivatives on mushroom tyrosinase and melanogenesis.
AID1139761Mixed-type inhibition of mushroom tyrosinase-mediated L-tyrosine oxidation assessed as enzyme-inhibitor complex after 10 mins by Lineweaver-Burk plot analysis2014Bioorganic & medicinal chemistry, May-01, Volume: 22, Issue:9
Inhibitory effects of novel synthetic methimazole derivatives on mushroom tyrosinase and melanogenesis.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (17)

TimeframeStudies, This Drug (%)All Drugs %
pre-19904 (23.53)18.7374
1990's1 (5.88)18.2507
2000's5 (29.41)29.6817
2010's7 (41.18)24.3611
2020's0 (0.00)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews0 (0.00%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other17 (100.00%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]