kaempferol-3-o-sophoroside and eckol

In this Letter, we first investigated the barrier protective effects of eckol and its derivatives against pro-inflammatory responses in human umbilical vein endothelial cells (HUVECs) and in mice. Data showed that eckol (1) and dieckol (2) inhibited lipopolysaccharide (LPS)-mediated barrier disruption and transendothelial migration of leukocytes to human endothelial cells. Eckol (1) also suppressed acetic acid induced-hyperpermeability and carboxymethylcellulose-induced leukocytes migration in vivo. Interestingly, the barrier protective effects of dieckol (2) were better than those of eckol (1) and hydroxyl groups in dieckol (2) positively regulate protective effects.

Topics: Acetic Acid; Animals; Carboxymethylcellulose Sodium; Cell Membrane Permeability; Cell Movement; Dioxins; Human Umbilical Vein Endothelial Cells; Humans; Leukocytes; Lipopolysaccharides; Mice; Protective Agents